Contribuições clínicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de cães e gatos

Detalhes bibliográficos
Autor(a) principal: Oliveira, Priscila Cardim de
Data de Publicação: 2019
Tipo de documento: Tese
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFRRJ
Texto Completo: https://rima.ufrrj.br/jspui/handle/20.500.14407/9794
Resumo: Os ectoparasitos de cães e gatos são pulgas, carrapatos, moscas, piolhos e sarnas. As infestações decorrentes destes parasitos podem levar a infecções graves tanto para os animais como para seres humanos. O objetivo deste trabalho foi avaliar as contribuições do sarolaner nos tratamentos clínicos de infestações controladas de Ctenocephalides felis felis em cães e gatos, Rhipicephalus sanguineus em cães e no tratamento de miíases de ocorrência natural causadas por Cochliomyia hominivorax em cães. Sendo assim, quatro estudos foram realizados e separados em capítulos. Os capítulos foram intitulados I “Eficácia do sarolaner no controle de carrapatos Rhipicephalus sanguineus em cães infestados artificialmente”, II “Eficácia do sarolaner no controle de pulgas Ctenocephalides felis felis em cães infestados artificialmente”, III “Eficácia do sarolaner no controle de pulgas Ctenocephalides felis felis em gatos infestados artificialmente” e IV “Eficácia do sarolaner no tratamento de miíases causadas por Cochliomyia hominivorax em cães naturalmente infestados”. No estudo de eficácia carrapaticida foram selecionados 20 cães beagles adultos. As infestações foram realizadas com 25 machos e 25 fêmeas adultos não alimentados de R. sanguineus semanalmente por 5 semanas. As contagens foram realizadas semanalmente 48 horas após as infestações. Os animais receberam 2,0 a 4,0mg/kg do sarolaner por via oral em dose única. A eficácia média do sarolaner foi 97,3%, por 35 dias. Para eficácia pulguicida em cães foram incluídos 20 animais da raça Beagle, machos e fêmeas, com idade entre 1 e 4 anos que receberam por via oral 2,0 a 4,0mg/kg do sarolaner em dose única. As infestações ocorreram semanalmente com 50 (+-5) casais de pulgas C felis adultas não alimentadas. As desinfestações ou penteações foram realizadas 24 horas após as infestações. A média de eficácia foi de 99,75% no período de 35 dias. Para avaliação da eficácia pulguicida em gatos, foram incluídos 14 animais sem raça definida machos e fêmeas em igual proporção, idade entre um e seis anos. Os animais receberam 2,0-3,5mg/kg de sarolaner por via oral em dose única. As infestações foram realizadas semanalmente com 50(+-5) casais de pulgas C felis por 12 semanas. As contagens ocorreram 48 horas após as infestações e a eficácia do sarolaner foi de 100% em todos os dias experimentais, totalizando 84 dias. No tratamento de miíases de ocorrência natural por Cochliomyia hominivorax foram avaliados oito cães beagles adultos que receberam a dose de 2,0 – 4,0mg/kg de sarolaner por via oral e a medicação de suporte para tratamento da ferida. A expulsão das larvas foi avaliada a cada 15 minutos na primeira hora e a cada hora nas seis horas subsequentes e com 24 horas de tratamento. As larvas foram avaliadas quanto à motilidade para diferenciação entre mortas e vivas. Após 24 horas os animais foram sedados para a limpeza da ferida e a retirada manual de todas as larvas. A média de expulsão das larvas foi de 50,9% ocorrendo principalmente após quatro horas do tratamento. O efeito larvicida foi de 70,6% nas seis horas após o tratamento e de 100% em 24 horas. A eficácia global foi de 100%. O sarolaner se mostrou eficaz em todos os tratamentos propostos podendo ser uma boa escolha em casos de infestações múltiplas. Não foram observadas alterações clinicas ou comportamentais durante os estudos que pudessem estar relacionadas ao tratamento ou aos procedimentos realizados
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spelling Oliveira, Priscila Cardim deScott, Fabio Barbour001.382.167-97https://orcid.org/0000-0003-1683-8724http://lattes.cnpq.br/1217253540572819Scott, Fabio Barbour001.382.167-97https://orcid.org/0000-0003-1683-8724http://lattes.cnpq.br/1217253540572819Azevedo, Thaís Ribeiro Correiahttps://orcid.org/0000-0003-3045-8787http://lattes.cnpq.br/6049103053269712Martins, Isabella Vilhena Freirehttps://orcid.org/0000-0002-8700-3065http://lattes.cnpq.br/6446528818006897Campos, Diefrey Ribeirohttps://orcid.org/0000-0002-5434-1463http://lattes.cnpq.br/8547992443497955Freire, Licius de Sahttp://lattes.cnpq.br/8536627339990442721.473.507-53http://lattes.cnpq.br/60694740858211362023-12-21T18:44:27Z2023-12-21T18:44:27Z2019-07-12OLIVEIRA, Priscila Cardim de. Contribuições clínicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de cães e gatos. 2019.79 f. Tese (Doutorado em Ciências Veterinárias) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2019.https://rima.ufrrj.br/jspui/handle/20.500.14407/9794Os ectoparasitos de cães e gatos são pulgas, carrapatos, moscas, piolhos e sarnas. As infestações decorrentes destes parasitos podem levar a infecções graves tanto para os animais como para seres humanos. O objetivo deste trabalho foi avaliar as contribuições do sarolaner nos tratamentos clínicos de infestações controladas de Ctenocephalides felis felis em cães e gatos, Rhipicephalus sanguineus em cães e no tratamento de miíases de ocorrência natural causadas por Cochliomyia hominivorax em cães. Sendo assim, quatro estudos foram realizados e separados em capítulos. Os capítulos foram intitulados I “Eficácia do sarolaner no controle de carrapatos Rhipicephalus sanguineus em cães infestados artificialmente”, II “Eficácia do sarolaner no controle de pulgas Ctenocephalides felis felis em cães infestados artificialmente”, III “Eficácia do sarolaner no controle de pulgas Ctenocephalides felis felis em gatos infestados artificialmente” e IV “Eficácia do sarolaner no tratamento de miíases causadas por Cochliomyia hominivorax em cães naturalmente infestados”. No estudo de eficácia carrapaticida foram selecionados 20 cães beagles adultos. As infestações foram realizadas com 25 machos e 25 fêmeas adultos não alimentados de R. sanguineus semanalmente por 5 semanas. As contagens foram realizadas semanalmente 48 horas após as infestações. Os animais receberam 2,0 a 4,0mg/kg do sarolaner por via oral em dose única. A eficácia média do sarolaner foi 97,3%, por 35 dias. Para eficácia pulguicida em cães foram incluídos 20 animais da raça Beagle, machos e fêmeas, com idade entre 1 e 4 anos que receberam por via oral 2,0 a 4,0mg/kg do sarolaner em dose única. As infestações ocorreram semanalmente com 50 (+-5) casais de pulgas C felis adultas não alimentadas. As desinfestações ou penteações foram realizadas 24 horas após as infestações. A média de eficácia foi de 99,75% no período de 35 dias. Para avaliação da eficácia pulguicida em gatos, foram incluídos 14 animais sem raça definida machos e fêmeas em igual proporção, idade entre um e seis anos. Os animais receberam 2,0-3,5mg/kg de sarolaner por via oral em dose única. As infestações foram realizadas semanalmente com 50(+-5) casais de pulgas C felis por 12 semanas. As contagens ocorreram 48 horas após as infestações e a eficácia do sarolaner foi de 100% em todos os dias experimentais, totalizando 84 dias. No tratamento de miíases de ocorrência natural por Cochliomyia hominivorax foram avaliados oito cães beagles adultos que receberam a dose de 2,0 – 4,0mg/kg de sarolaner por via oral e a medicação de suporte para tratamento da ferida. A expulsão das larvas foi avaliada a cada 15 minutos na primeira hora e a cada hora nas seis horas subsequentes e com 24 horas de tratamento. As larvas foram avaliadas quanto à motilidade para diferenciação entre mortas e vivas. Após 24 horas os animais foram sedados para a limpeza da ferida e a retirada manual de todas as larvas. A média de expulsão das larvas foi de 50,9% ocorrendo principalmente após quatro horas do tratamento. O efeito larvicida foi de 70,6% nas seis horas após o tratamento e de 100% em 24 horas. A eficácia global foi de 100%. O sarolaner se mostrou eficaz em todos os tratamentos propostos podendo ser uma boa escolha em casos de infestações múltiplas. Não foram observadas alterações clinicas ou comportamentais durante os estudos que pudessem estar relacionadas ao tratamento ou aos procedimentos realizadosCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorDog and cat ectoparasites are fleas, ticks, flies, lice and scabies. Infestation from these parasites can lead to serious infections for both animals and humans. The aim of this study was to evaluate the contributions of sarolaner in the clinical treatment of controlled Ctenocephalides felis felis infestations in dogs and cats, Rhipicephalus sanguineus in dogs and in the treatment of naturally occurring myiasis caused by Cochliomyia hominivorax in dogs. Thus, four studies were conducted and separated into chapters. The chapters were titled I “Efficacy of sarolaner in the control of Rhipicephalus sanguineus ticks in artificially infested dogs”, II “Efficacy of sarolaner in the control of Ctenocephalides felis felis fleas”, III “Efficacy of sarolaner in the control of Ctenocephalides felis fleas felis in artificially infested cats ”and IV“ Effectiveness of sarolaner in the treatment of myiasis caused by Cochliomyia hominivorax in naturally infested dogs ”. In the tick efficacy study, 20 adult beagles were selected. Infestations were carried out with 25 male and 25 non-fed R. sanguineus adult females weekly for 5 weeks. Counts were performed weekly 48 hours after infestations. The animals received 2.0 to 4.0 mg/kg of sarolaner orally in a single dose. The average efficacy of sarolaner was 97.3% for 35 days. For efficacy in dogs, 20 male and female Beagle animals, aged between 1 and 4 years, who received orally 2.0 to 4.0 mg/kg of sarolaner in a single dose. Infestations occurred weekly with 50 (+ -5) pairs of unfeeded adult C felis. Desinfestations or combing were performed 24 hours after the infestations. The average efficacy was 99.75% over the 35 day period. To evaluate the efficacy of cats, 14 male and female mongrel animals were included in the same proportion, aged between one and six years. The animals received 2.0 to 3.5 mg/kg sarolaner orally in a single dose. Infestations were performed weekly with 50 (+/- 5) C flea couples for 12 weeks. Counts occurred 48 hours after infestations and sarolaner was 100% effective on all experimental days, totaling 84 days. In the treatment of naturally occurring myiasis by Cochliomyia hominivorax, eight adult beagle dogs receiving oral 2.0 to 4.0mg/kg sarolaner and supportive wound care medication were evaluated. Larval expulsion was evaluated every 15 minutes in the first hour and every hour for the next six hours and with 24 hours of treatment. Larvae were evaluated for motility for differentiation between dead and alive. After 24 hours the animals were sedated for wound cleaning and manual removal of all larvae. The average expulsion of the larvae was 50.9% occurring mainly after four hours of treatment. The larvicidal effect was 70.6% at six hours after treatment and 100% at 24 hours. Overall efficacy was 100%. Sarolaner was effective in all proposed treatments and may be a good choice in cases of multiple infestations. No clinical or behavioral changes were observed during studies that could be related to treatment or procedures performedapplication/pdfporUniversidade Federal Rural do Rio de JaneiroPrograma de Pós-Graduação em Ciências VeterináriasUFRRJBrasilInstituto de VeterináriaIsoxazolinasEctoparasitasMiíasesMyiasisIsoxazolinesEctoparasitesMedicina VeterináriaContribuições clínicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de cães e gatosClinical contributions of sarolaner in ectoparasitosis of dog and catinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisACHA, P.N.; SZYFRES, B. Zoonosis y enfermedades transmisibles comunes al hombre y los animales. 2ed. Washington: OPS/OMS, 989, 1986. AGUIAR, C.L.G. et al. Parâmetros da fase de vida livre de Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae): adaptado ao clima subtropical. Arquivos do Instituto Biológico, v.80, n.4, p. 375-380, 2013. BECK, W. et al. Qualitative and quantitative observations on the flea population dynamics of dogs and cats in several areas of Germany. Veterinary Parasitology, v.137, p. 130–136,2006. BECSKEI, C. et al. Efficacy and safety of a novel oral isoxazoline, sarolaner (Simparica®) in the treatment of naturally occurring flea and tick infestation in dogs presented as veterinary patients in Europe. Veterinary Parasitology, v. 222, p. 49-55, 2016a. BECSKEI, C. et al. Comparative speed of kill of oral treatments with Simparica TM (sarolaner) and Bravecto® (fluralaner) against induced infestations of Rhipicephalus sanguineus on dogs. Parasites & Vectors, v. 9, p. 103, 2016b. BECSKEI, C. et al. Efficacy and speed of kill of a new spot-on formulation of selamectin plus sarolaner against flea infestations in cats. Veterinary Parasitology, v.238, s18 - s21, 2017a. BECSKEI, C. et al. Efficacy of a new spot-on formulation of selamectin plus sarolaner in the treatment of Otodectes cynotis in cats. Veterinary Parasitology, v. 238, s. 27-S30, 2017b. BECSKEI, C.; CUPPENS, O.; MAHABIR, S.P. Efficacy and safety of sarolaner in the treatment of canine ear mite infestation caused by Otodectes cynotis: a non- inferiority study. Veterinary Dermatology, v.29, 2018a. BECSKEI, C.; CUPPENS, O.; MAHABIR, S.P. Efficacy and safety of sarolaner against generalized demodicosis in dogs in European countries: a non- inferiority study. Veterinary Dermatology, v.29, n.3, p. 203-e72, 2018b. BEUGNET, F.; FRANC, M. Insecticide and acaricide molecules and/or combinations to prevent pet infestation by ectoparasites. Trends of Parasitology, v.28, p.267–279, 2012. BEUGNET, F.; LIEBENBERG, J.; HALOS, L. Comparative efficacy of two oral treatments for dogs containing either afoxolaner or fluralaner against Rhipicephalus sanguineus sensu lato and Dermacentor reticulatus. Veterinary Parasitology, v.209, n.1-2, p.142-145, 2015. BEUGNET, F. et al. Efficacy of oral afoxolaner for the treatment of canine generalised demodicosis. Parasite, v.2, 2016a. BEUGNET, F. et al. Efficacy of afoxolaner in a clinical field study in dogs naturally infested with Sarcoptes scabiei. Parasite, v.23, 2016b. BLAGBURN, B.L.; DRYDEN, M.W. Biology, treatment and control of flea and tick infestations. The Veteterinary Clinicof North America: Small Animal Prcatice. v.39, p.1173–1200, 2009. 61 BOND, R. et al. Survey of flea infestation in dogs and cats in the United Kingdom during 2005. Veterinary Record, v.160, p.503–506, 2007. BOSCO, A. et al. Efficacy of fluralaner spot-on solution for the treatment of Ctenocephalides felis and Otodectes cynotis mixed infestation in naturally infested cats. BMC Veterinary Research, v.15, n.1, p.28, 2019. BOWMAN, D.D. et al. Efficacy of milbemycin oxime in combination with spinosad in the treatment of larval and immature adult stages of Ancylostoma caninum and Toxocara canis in experimentally infected dogs. Veterinary Parasitology, v.205, n.1-2, p.134-139, 2014. CADIERGUES, M.C; CAUBET, C.; FRANC, M. Comparison of the activity of selamectin, imidacloprid and fipronil for the treatment of dogs infested experimentally with Ctenocephalides canis and Ctenocephalides felis felis. Veterinary Record, v.149, p.704–706, 2001. CADIERGUES, M.C. et al. Efficacy of an adulticide used alone or in combination with an insect growth regulator for flea infestations of dogs housed in simulated home environments. American Journal of Veteterinary Research, v.60, p.1122–1125, 1989. CADIERGUES, M.C.; PRESSANTI, C. A. A.; MUMCUOGLU, K. Y. Efficacy of Spinosad Tablets Administered to a Colony of 15 Indoor Cats Naturally Infested with Fleas ISRN Veterinary Science, v.2014, 2014. CASIDA, J.E. et al. Mechanism of seective action of pyrethroid insecticides. Annual Review of Pharmacology Toxicology, v.23, p.413-38, 1983. CASIDA, J. E.; DURKIN, K. A. Novel GABA receptor pesticide targets. Pesticide Biochemistry and Physiology, v.121, p.2-30, 2015. CAVALLERI, D. et al. Assessment of the speed of flea kill of lotilaner (Credelio™) throughout the month following oral administration to dogs. Parasites & vectors, v.10, s.1, p.529, 2017. CAVALLERI, D. et al. Laboratory evaluation of the efficacy and speed of kill of lotilaner (Credelio™) against Ctenocephalides felis on cats. Parasites & vectors, v.11, s.1, p.408, 2018. CHERNI, J. A.; MAHABIR, S. P.; SIX, R. H. Efficacy and safety of sarolaner (Simparica®) against fleas on dogs presented as veterinary patients in the United States. Veterinary Parasitology, v.222, p.43-48, 2016. COHEN, E. Chitin biochemistry: synthesis and inhibition. Annual Review of Entomology, v.32, n.1, p.71-93, 1987. Companion Animal Parasites Council: CAPC General Guidlines, 2015. https://capcvet.org/guidelines/ehrlichia-spp-and-anaplasma-spp/. Acessado em 4/07/ 2019. CORREIA, T.R. et al. Eficácia do regulador de crescimento de insetos piriproxifen associado ap piretróide d-fenotrina (Mypet® Aerosol) no controle ambiental de Ctenocephalides felis felis (Bouché, 1835) (Siphonaptera : Pulicidae). A Hora Veterinária, v.25, n.146, p.27-31, 2005. 62 CORREIA, T.R. et al. Larvicidal efficacy of nitenpyram on the treatment of myiasis caused by Cochliomyia hominivorax (Diptera: Calliphoridae) in dogs. Veterinary Parasitology, v.173, s.1-2, p.169-172, 2010. COUTINHO, M.T.Z. et al. Participation of Rhipicephalus sanguineus (Acari: Ixodidae) in the epidemiology of canine visceral leishmaniasis. Veterinary Parasitology, v.128, p.149–155, 2005. COYNE, M.J. Efficacy of a topical ectoparasiticide containing dinotefuran, pyryproxyfen, and permethrin against Amblyomma americanum (Lorne Star Tick) and Amblyomma maculatum (Gulf Coast Tick) on dogs. Veterinary Therapeutics, v.10, n.1-2, p.17-23, 2009. CROSAZ, O. et al. Usefulness of a topical combination of dinotefuran and pyriproxyfen for long-term control of clinical signs of allergic dermatitis in privately-owned cats in Ile-de-France region. Parasites & Vectors, v.10, n.1, p.392, 2017. COLES, T. B.; DRYDEN, M. W. Insecticide/acaricide resistance in fleas and ticks infesting dogs and cats. Parasites & Vectors, v.7, p.1–10, 2014. CUNHA, N.C. et al. First identification of natural infection of Rickettsia rickettsii in the Rhipicephalus sanguineus tick, in the State of Rio de Janeiro. Pesquisa Veterinária Brasileira, v.29, n.2, p.1-9, 2009. CUNHA, N.C. et al. Rickettsiae of the Spotted Fever group in dog, horses and ticks: na epidemilogical study in an endemic region of the State of Rio de Janeiro, Brazil. Revista Brasileira de Medicina Veterinária, v.36, n.2, p.1-7, 2014. CURTIS, C. Use and abuse of topical dermatological therapy in dogs and cats. Part 2. In Practice, v.21, p.448-54, 1999. CURTIS, M.P. et al. Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs. Bioorganic & medicinal chemistry letters, v.26, n.7, p.1831-1835, 2016. DANIEL, E.; JULIAN, E. Efficacy of lotilaner a novel oral isoxazoline against naturally occurring mange mite infestations in dogs caused by Demodex spp. Parasites & Vectors, v.10, s1, p.532, 2017. DANTAS-TORRES, F. Biology and eclogy of the brown dog tick, Rhipicephalus sanguineus. Parasites & Vectors, v.3, n.26, 2007. DANTAS-TORRES, F. The brown dog tick, Rhipicephalus sanguineus (Latreille, 1806)(Acari: Ixodidae): From taxonomy to control. Veterinary Parasitology. v.152, p.173–185, 2008. DANTAS-TORRES, F. et al. Effects of prolonged exposure o low temperature on eggs of the brown dog tick, Rhipicephalus sanguineus (Latreille, 1806)(Acari: Ixodidae).Veterinary Parasitology, v.171, p.327-330, 2010. 63 DANTAS-TORRES, F. et al. Efficacy of an imidacloprid/ flumethrin colar against fleas, ticks and tick-borne pathogens in dogs. Parasites Vectors, v.6, p.245, 2012. DANTAS-TORRES, F.; CHOMEL, B.; OTRANTO, D. Ticks and tick-borne diseases: a One Health perspective. Trends Parasitology. v.28, p.437–446, 2012b. DOBLER, G.; PFEFFER, M. Fleas as parasites of the family Canidae. Parasites & Vectors, p.4, v.1, p.139, 2011. DOBSON, P. et al. Efficacy of nitenpyram as a systemic flea adulticide in dogs and cats. Veterinary. Records, v.147, p.709–713, 2000. DONGUS, H.; MEYER, L.; ARMSTRONG, R. Water immersion of dogs close to the time of topical fluralaner treatment does not reduce efficacy against a subsequent experimental challenge with Rhipicephalus sanguineus (sensu lato). Parasites & Vectors, v.10, n.1, 2017. DRAG, M.; SAIK, J.; HARRIMAN J. Safety evaluation of orally administered afoxolaner in 8-week-old dogs. Veterinary Parasitology, v.201, p.198-203, 2014. DRYDEN, M.; GAAFAR, S. Blood consumption by the cat flea, Ctenocephalides felis felis (Siphonaptera: Pulicidae). Journal Medical Entomology, v.28, n.3, p.394-400, 1991. DRYDEN, M.W. Biology of fleas of dogs and cats. Compendium of Continuing Education Practice Veterinary, v.15, p. 569-579, 1993. DRYDEN, M.W.; BROCE, A.B. Development of trap for collecting newly emerged Ctenocephalides felis (Siphonaptera:Pulicidae) in homes. Journal of Medical Entomology, v.30, n.5, p.901-906, 1993. DRYDEN, M.W.; RUST, M.K. The cat flea: biology, ecology and control. Veterinary Parasitology, v.52, n.1, p.19, 1994. DRYDEN, M.W.; PEREZ, H.R.; ULITCHNY, D.M. Efficacy of imidacloprid against Ctenocephalides felis in dogs and cats under field conditions. In: Proceedings of the Bayer International Flea Control Symposium, Birningham, p.5-10, 1997. DRYDEN, M.W.; PAYNE, P. A. Biology and control of ticks infesting dogs and cats in North America. Veterinary Therapeutics, v.5, p.139-154, 2004. DRYDEN, M.W. et al. Comparative speed of kill of selamectin, imidacloprid, and fipronil-(S)-methoprene spot-on formulations against fleas on cats. Veterinary Therapeutics, v.6, p. 228–236, 2005. DRYDEN, M.W. et al. Evaluation of an imidacloprid (8.8% w/w) permethrin (44% w/w) topical spot-on and a fipronil (9.8% w/w)–(S)-methoprene (8.8% w/w) topical spot-on to repel, prevent attachment, and kill adult Rhipicephalus sanguineus and Dermacentor variabilis ticks on dogs. Veterinary Therapeutics, v.7, p.187–198, 2006. 64 DRYDEN, M.W; PAYNE, P.; SMITH, V. Efficacy of selamectin and fipronil- (S)-methoprene spot on formulation applied to cats against adult cat fleas (Ctenocephalides felis) flea eggs and adult fleaemergence. Veterinary Therapeutics, v.8, p.255-262, 2007. DRYDEN, M. et al. Efficacy of a topically applied spot-on formulation of a novel insecticide, metaflumizone, applied to cats against a flea strain (KS1) with documented reduced susceptibility to various insecticides. Veterinary Parasitology, v.151, p.74–79, 2008. DRYDEN, M.W. Fleas and tick control in the 21st century: challenges and opportunities. Veterinary Dermatology. v.20, p.435–440, 2009. DRYDEN, M. W.; PAYNE, P. A.; VICKI, Set al. Evaluation of the Ovicidal Activity of Lufenuron and Spinosad on Fleas' Eggs from Treated Dogs. International Journal of Applied Research in Veterinary Medicine, v.10, s.3, p.198-205, 2012. DRYDEN, M. W.et al. Evaluation of sarolaner and spinosad oral treatments to eliminate fleas, reduce dermatologic lesions and minimize pruritus in naturally infested dogs in west Central Florida, USA. Parasites & vectors, v.10, n.1, p.389, 2017. DRYDEN, M. W. et al. In-home assessment of either topical fluralaner or topical selamectin for flea control in naturally infested cats in West Central Florida, USA. Parasites & Vectors, v.11, n.1, p.422, 2018. EBEL, G.D.; KRAMER, L.D. Short report: duration oftick attachmentfor transmission of Powassan virus by deer ticks. The American Journal of Tropical Medicine and Hygiene, v.71, p.268–271, 2004 ELLIOTT, M.; JANES, N. F. Synthetic pyrethroids -a new class of insecticides. Chemical Society Reviews, v.7, p. 473, 1978. FARKAS, R. et al. Prevalence of flea infestation in dogs and cats in Hungary combined with a survey of owner awareness. Medical and Veterinary Entomology, v.23, p.187–194, 2009. FERNANDES, F.D.F. In vitro activity of permethrin, cipermethrin and deltamethrin on larvae of Rhipicephalus sanguineus (Latreille, 1806)(Acari, Ixodidae). Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v.52, s.6, p.621-626, 2000. FISHER, M.A. et al. Evaluation of flea control programmes for cats using fenthion and lufenuron. The Veterinary Record, v.138, n.4, p. 79-81, 1996. FOURIE, J. J. et al. Efficacy of orally administered fluralaner (Bravecto TM) or topically applied imidacloprid/moxidectin (Advocate®) against generalized demodicosis in dogs. Parasites & vectors, v.8, n.1, p.187, 2015. FRANC, M.; CADIERGUES, M.C. Comparative activity in dogs of deltanethrin and diazinon impregnated collars against Ctenocephalides felis. American Journal of Veterinary Research, v.59, n.1, p.59-60, 1998. 65 FRANC, M. et al. Efficacy of fipronil-(S) methoprene on fleas, flea egg collection, and flea egg development following transplantation of gravid fleas onto treated cats. Veterinary Therapeutics, v.8, p.285–292, 2007. FRANC, M.; BOUSHIRA, E. Efficacy of a combination of a fipronil-(S)-methoprene spot on formulation and a deltamethrinimpregnated collar in controlling fleas and sandflies on dogs. Veterinary Therapeutics, v.71, p.71–77, 2009. GARCÍA-REYNAGA, P.; ZHAO, C.; SARPONG, R. New GABA/ Glutamate receptor target for hisoxazoline insecticide. Chemical Research in Toxicology, v.26, p.514-516, 2013. GASSEL, M. et al. The novel isoxazoline ectoparasiticide fluralaner: selective inhibition of arthropod γ-aminobutyric acid-and L-glutamate-gated chloride channels and insecticidal/acaricidal activity. Insect biochemistry and molecular biology, v.45, p.111-124, 2014. GEURDEN, T. et al. HEfficacy of a novel oral formulation of sarolaner (Simparica®) against four common tick species infesting dogs in Europe. Veterinary parasitology, v.222, p.33-36, 2016. GEURDEN, T. et al. Efficacy and safety of a new spot-on formulation of selamectin plus sarolaner in the treatment of naturally occurring flea and tick infestations in cats presented as veterinary patients in Europe. Veterinary parasitology, v.238, S12-S17, 2017a. GEURDEN, T. et al. Efficacy of a new spot-on formulation of selamectin plus sarolaner against four common tick species infesting cats in Europe. Veterinary parasitology, v.238, S3-S7, 2017b. GEURDEN, T. et al. Efficacy of a new spot-on formulation of selamectin plus sarolaner against Ancylostoma tubaeforme and Toxocara cati in cats. Veterinary Parasitology, v.238, S31-S35, 2017c. GEURDEN, T. et al. Comparative efficacy of a new spot-on combination product containing selamectin and sarolaner (Stronghold® Plus) versus fluralaner (Bravecto®) against induced infestations with Ixodes ricinus ticks on cats. Parasites & vectors, v.10, s.1, p.319, 2017d. GODDARD, J. Flies whose maggots cause myiasis inhumans. In: Physician’s Guide to Arthropods of Medical Importance, 2nd edn. Florida (1996) CRC Press, p.169–187. GRAF. J.F. The role of insect growth regulators in arthropod control. Parasitology Today, v.9, n.12, p.471-474, 1993. GRAHAM, O.H. Symposium on Eradication of the Screwworm from the United States and Mexico. Miscellaneous Publications 62. Entomological Society of America, College Park, MD, USA., 1985. GUIMARÃES, J.H.; PAPAVERO, N. Myiasis caused by obligatory parasites II. Cochhliomya Townsend (Calliphoridae) In: Myiasis in man and animals in the neotropical region, p.97-165, 1999. 66 HALL, M.J.L; WALL, R. Myiasis of humans and domestic animals. Advances in Parasitology, v. 35, p.257-334, 1995. HALOS, L. et al. Defining the concept of ‘tick repellency’ in veterinary medicine. Parasitology, v.139, p.419–423, 2012. HAN, H. S.; NOLI, C.; CENA, T. Efficacy and duration of action of oral fluralaner and spot‐on moxidectin/imidacloprid in cats infested with Lynxacarus radovskyi. Veterinary dermatology, v.27, s.6, p.474-e127, 2016. HAN, H.S.; SHARMA, R.; JEFFERY, J. Chrysomya bezziana (Diptera: Calliphoridae) infestation: case report of three dogs in Malaysia treated with spinosad/milbemycin. Veterinary dermatology, v.28, p.239– e62, 2017. HAN, H. S. et al. The comparative efficacy of afoxolaner, spinosad, milbemycin, spinosad plus milbemycin, and nitenpyram for the treatment of canine cutaneous myiasis. Veterinary dermatology. 2018a. HAN, H. S. et al. Canine and feline cutaneous screw‐worm myiasis in Malaysia: clinical aspects in 76 cases. Veterinary dermatology, v.29, s.5, p.442-e148, 2018b. HARRUS, S.; WANER, T. Diagnosis of canine monocytotropic ehrlichiosis (Ehrlichia canis): an overview. Veterinary Journal, v.187, p.292-6, 2011. HENDRIX, C.M. Facultative myiasis in dogs and cats. Compendium Continue Education, v.13, n.1, p. 86, 1991. HOPKINS, K.D.; MARCELLA, K.L.; STRECKER, A.E. Ivermectin toxicosis in a dog. Journal of the American Veterinary Medical Association, v.197, p.93-4, 1990. HOPKINS, T.J. et al. Efficacy of imidacloprid to remove and prevent Ctenocephalides felis infestation on dogs and cats. Australian Vetrrinary Practioner, v.26, n.3, p.150-153, 1996. HOUSTON, D.M.; PARENT, J.; MATUSHER, K.J. Ivermectin toxicosis in a dog. Journal of the American Veterinary Medical Association, v.191, p.78-80, 1987. HUNTER, J.S.; KEISTER, D.M.; JEANNIN, P. The effect of fipronil treated dog hair on the survival of the immature stages of the cat flea Ctenocephalides felis. In: Proccedings of the Annual Veterinary Medical Forum, San Antonio, v.6, 1996. HUNTER, J. S. et al. Evaluation of the curative and preventive efficacy of a single oral administration of afoxolaner against cat flea Ctenocephalides felis infestations on dogs. Veterinary Parasitology, v.201, p.207-211, 2014. JACOBS, D.E. et al. A novel approach to flea control on cats, using pyriproxyfen. Veterinary Records, v.139, p.559–561, 1996. JACOBS, D.E.; HUTCHINSON, M.J.; KRIEGER, K.J. Duration of activity of imidacloprid a novel adulticide for flea control, against Ctenocephalides felis on cats. Veterinary Records, v.140, p.59–260, 1997. 67 JACOBS, D.E. et al. Control of flea populations in a simulated home environment model using lufenuron, imidacloprid or fipronil. Medical Veterinary Entomology, v.25, p.73–77, 2001. JAENSON, T.G. et al. Why is tick-borne encephalitis increasing? A review of the key factors causing the increasing incidence of human TBE in Sweden. Parasites & Vectors, v.5, p.184–197, 2012. JONGEJAN, F.; UILENBERG, G. The global importance of ticks. Parasitology, v.129, s3-14, 2004. KARADZOVSKA D; CHAPPELL K; COBLE S. A randomized, controlled field study to assess the efficacy and safety of lotilaner flavored chewable tablets (CredelioTM) in eliminating fleas in client-owned dogs in the USA. Parasites & Vectors, v.10, p.528, 2017. KILP, S.; RAMIREZ, D.; ALLAN, J. Comparative pharmacokinetics of fluralaner in dogs and cats following single topical or intravenous administration. Parasites & Vectors, v.9, p.296, 2016. KNAUS, M. et al. Characterisation of ecto- and endoparasites in domestic cats from Tirana, Albania. Parasitology Research., v.113, p.3361–3371, 2014. KNIPLING, E. F. Possibilities of insect control or eradication through the use of sexually sterile males. Journal of Economic Entomology, v.48, p.459–462, 1955. KONNAI, S. et al. Attachment duration required for Rhipicephalus appendiculatus to transmit Theileria parva to the host. Vector Borne Zoonotic Disease, v.7, p.241–248, 2007. KOUTINAS, C.K. Treatment of canine sarcoptic mange with fipronil spray: a fiels trial. Australian Veterinary Practioner, v.31, p.115-119, 2001. KRAFSUR, E.S.; LINDQUIST, D.A. Did the sterile insect technique or weather eradicate screwworms (Diptera: Calliphoridae) from Lybia? Journal of Medical Entomology, v.33, p.877-887, 1996. KRÄMER, F.; MENCKE, N. Flea biology and control: the biology of the cat flea control and prevention with imidacloprid in small animals. Springer Science & Business Media, 2012. KUNKLE, B. N. et al. Assessment of the onset of action of afoxolaner against existing adult flea (Ctenocephalides felis) infestations on dogs. Veterinary parasitology, v.201, s.3-4, p.204-206, 2014a. KUNKLE, B. et al. Assessment of the efficacy of orally administered afoxolaner against Rhipicephalus sanguineus sensu lato. Veterinary parasitology, v.20, s.3-4, p.226-228, 2014b. LABRUNA, M. B.; PEREIRA, M.C. Carrapatos em cães no Brasil. Clínica Veterinária, n.30, p.24-32, 2001. 68 LABRUNA, M. B. Biológica-ecologia de Rhipicephalus sanguineus (ACARI: IXODIDAE). Revista Brasileira de Parasitologia Veterinária, v.13, s.1, p.123-124, 2004. LAMBERT, M. M. et al. Eficácia da associação de fipronil e permetrina no controle de Ctenocephalides felis felis e Rhipicephalus sanguineus sensu lato em cães artificialmente infestados. Brazilian Journal of Veterinary Medicine, v.39, s.4, p.246-251. 2017. LAPPIN, M. R. Update on flea and tick associated disease of cats. Veterinary Parasitology, v.254, p.26-29, 2018. LAVAN, R. et al. Dog owner flea/tick medication purchases in the USA. Parasites & Vectors, v.11, p.581, 2018. LEBON, W. et al. Prevention of Flea Egg Development in a Simulated Home Environment by Frontline® Gold (fipronil, (S)-methoprene, pyriproxyfen) Applied Topically to Cats. International Journal of Applied Research in Veterinary Medicine, v.16, s.1, p.67-74, 2018. LEFKADITIS, M.A. et al. Urban stray cats infested by ectoparasites with zoonotic potential in Greece. Parasitology. Research, v.114, p.3931–3934, 2015. LEIGHTON, P.A. et al. Predicting the speed of tick invasion: an empirical model of range expansion for the Lyme disease vector Ixodes scapularis in Canada. Journal Applied Ecology, v.49, p.457–464, 2012. LETENDRE, L.; HUANG, R.; KVATERNICK, V. The intravenous and oral pharmacokinetics of afoxolaner used as monthly chewable antiparasitic for dogs. Veterinary Parasitology, v.201, p.190-197, 2014. LIEBISCH, A.; HEESCHEN, K. Controled laboratory study on the efficacy of imidacloprid spot-on for controlo of the cat flea in dogs. In: Proccedings of The Bayer Internation Flea Control Symposium, Birningham, p.25-28, 1997. LINARDI, P. M.; GUIMARÃES, L. R. Siphonapteros do Brasil. São Paulo, Museu de Zoologia, USP/FAPESP. 2000. 291 p. LINDGREN, E.; TÄLLEKLINT, L.; POLFELDT, T. Impact of climatic change on the northern latitude limit and population density of the disease-transmitting European tick Ixodes ricinus. Environ. Health Perspective, v.108, p.119–123, 2000. LINNETT, P.J. Permethrin toxicosis in cats. Australian Veterinary Journal, v. 86, p.32-5, 2008. LITTLE, S.; OTRANTO. D. Tradition and innovation: Selamectin plus sarolaner. A new tool to control endo- and ectoparasites of cats – Studies from North America and Japan. Veterinary parasitology, v.270, S1-S2, 2019. 69 MACHADO, M.L.S.; RODRIGUES, E.M.P. Emprego do nitempyram como larvicida em miíases caninas por Cochliomyia hominivorax. Acta Scientiae Veterinariae, v.30, n.1, p.59-62, 2002. MACHADO, M. A. et al. Efficacy of afoxolaner in the treatment of otodectic mange in naturally infested cats. Veterinary parasitology, v.256, p.29-31, 2018. MARCHIONDO, A.A. et al. World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) second edition: guidelines for evaluating the efficacy of parasiticides for the treatment, prevention and control of flea and tick infestations on dogs and cats. Veterinary parasitology, v.194, s.1, p.84-97, 2013. MASON, K.V.; RING, J.; DUGGAN, J. Fenthion for flea controlo n dogs under field conditions: dose response efficacy studies and effect on cholinesterase activity. Journal of the American Animal Hospital Association, v.20, p.591-595, 1984. MASTRANGELO, T.; WELCH, J.B. An overview of the components of AW-IPM campaigns against the New World screwworm. Insects, v.3, p.930–955, 2012. MCCALL, J. W. et al. The ability of a topical novel combination of fipronil, amitraz and (S)-methoprene to protect dogs from Borrelia burgdorferi and Anaplasma phagocytophilum infections transmitted by Ixodes scapularis. Veterinary parasitology, v.179, s.4, p.335-342, 2011. MCNAIR, C. M. Ectoparasites of medical and veterinary importance: drug resistance and the need for alternative control methods. Journal of Pharmacy and Pharmacology, v.67,s.3, p.351-363, 2015. MCTIER, T. L. et al. Efficacy of selamectin against adult flea infestations (Ctenocephalides felis felis and Ctenocephalides canis) on dogs and cats. Veterinary parasitology, v.91, s.3-4, p.187-199, 2000. MCTIER, T. L. et al. Discovery of sarolaner: a novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs. Veterinary parasitology, v.222, p.3-11, 2016. MCTIER, T. L. et al. The efficacy of a novel topical formulation of selamectin plus sarolaner (Revolution Plus/ Stronghold Plus) in preventing the development of Dirofilaria immitis in cats. Veterinary Parasitology, v.270, p.56-62, 2019. MEDLEAU, L. Using ivermectin to treat parasitic dermatoses in small animals. Veterinary Medicine, p.770-4, 1994. MEO, N.J.; KEISTER, D.M.; TANNER, P.A. A comparison of the flea control efficacy of Frontline spray treatment against the flea infestation prevention pack (Vet-Kem) in the dog and cat. In: Proccedings of the American Association of the Veterinary Parasitologists. 41 Louisville, p. 17, 1996. MOYA, G.E. Erradidacaçao ou manejo integrado das miíases neotropicais das Américas. Pesquisa Veterinária Brasileira, v.23, p.131-138, 2003. 70 MURPHY, M.; BALL, C. A., GROSS, S. Comparative in vivo adulticidal activity of a topical dinotefuran versus imidacloprid based formulation against cat fleas (Ctenocephalides felis) on cats. Veterinary Therapeutics. v.10, p.9–16, 2009. MURPHY, M. et al. Laboratory evaluations of the immediate and sustained efficacy of lotilaner (Credelio™) against four common species of ticks affecting dogs in North America. Parasites & vectors, v.10, s.1, p.523, 2017. NATHANSON, J.A. Characterization of octopamine sensitive adenylate cyclase: elucidation of a class potent and selective octopamine-2 receptor agonist with toxic effects in insects. Procedings of National Academy of Science, v. 82, p.599-603, In: TAYLOR, M.A. Recent developments in ectoparasiticides. The Veterinary Journal, v.161, n.3, p.253-268, 2001. NICHOLSON, W.L. et al. Rocky mountain spotted fever in Arizona: Documentation of heavy environmental infestations of Rhipicephalus sanguineus at an endemic site. Annals of the New York Academy of Sciences. v.1078, p.338–341, 2006. NUNES, T.A.P. et al. Brazilian Journal of Veterinary Medicine, v.35, s.2, pp.81-84, 2014. O’DWYER, L. H.; MASSARD, C. L.; SOUZA, J. C. P. Hepatozoon canis infection associated with dog ticks of rural areas of Rio de Janeiro State, Brazil. Veterinary Parasitology, v. 94, n.3, p.143-150, 2001. OLIVEIRA, P.R. et al. Fluazuron-induced morphological changes in Rhipicephalus sanguineus Latreille, 1806 (Acari: Ixodidae) nymphs: An ultra-structural evaluation of the cuticle formation and digestive processes. Acta tropica, v.133, p.45-55, 2014. OLIVEIRA, P.C. et al. Efficacy of spinosad on the treatment of myiasis caused by Cochliomyia hominivorax (Diptera: Calliphoridae) in dogs. Veterinary Parasitology, v.258, p.53-56, 2018. OTRANTO, D.; DANTAS-TORRES, F.; Breitschwerdt, E.B. Managing canine vector-borne diseases of zoonotic concern: Part I. Trends Parasitology, v.25, p.157–163, 2009. OZOE, Y.; ASAHI, M.; OZOE, F. The antiparasitic isoxazoline A1443 is a potent blocker of insect ligand-gated chloride channels. Biochem Biophys Res Commun, v.391, p.744-749, 2010. PACKIANATHAN, R. et al. Efficacy and safety of sarolaner (Simparica®) in the treatment and control of naturally occurring flea infestations in dogs presented as veterinary patients in Australia. Parasites & vectors, v.10, s.1, p.387, 2017. PAROLA, P.; SOCOLOVSCHI, C.; RAOULT, D. Deciphering the relationships between rickettsia conorii conorii and Rhipicephalus sanguineus in the ecology and epidemiology of Mediterranean spotted fever. Annals of the New York Academy of Sciences, v.1166, p.49–54, 2009. PEGRAM, R. G. et al. classification of the Rhipicephalus sanguineus group (Acari, Ixodoidea, Ixodidae). Part I: R. sulcatus (Neuman, 1908) and R. turanicus (Pomerantseu, 1936). Systematic Parasitology, v.10, 1987. 71 PFISTER, K. Fipronil, amitraz and (S)-methoprene – a novel ectoparasiticide combination for dogs. Veterinary parasitology, v.179, p.293–356, 2011. PHILLIPS, P. L.; WELCH, J.B.; KRAMER, M. Seasonal and spatial distributions of adults screwworms (Diptera: Calliphoridae) in the Panama Canal Area, Republic of Panama. Journal Medical Entomololy, v.41, p.121-129, 2004. PIRANDA, E.M. et al. Experimental Infection of Rhipicephalus sanguineus Ticks with the Bacterium Rickettsia rickettsii, Using Experimentally Infected Dogs. Vector-Borne and Zoonotic Diseases, v.11, n.1, p.29-36, 2011. PRULLAGE, J. et al. The prevention of attachment and the detachment effects of a novel combination of fipronil, amitraz and (S)-methoprene for Rhipicephalus sanguineus and Dermacentor variabilis on dogs. Veterinary parasitology, v.179, p.311–317, 2011. PULLIAM, J.D. et al. Investigation ivermectin toxicity in Collies. Veterinary Medicine Companion Animal Practice, v.80, p.33-40, 1985. RANJAN, S.; YOUNG, D.; SUN, F. A single topical fluralaner application to cats and to dogs controls fleas for 12 weeks in a simulated home environment. Parasites & vectors, v.11, s.1, p.385, 2018. REICHARD, M.V. et al. Efficacy of a topical formulation of selamectin plus sarolaner against induced infestations of Amblyomma americanum on cats and prevention of Cytauxzoon felis transmission. Veterinary parasitology, v.270, S31-S37, November 2018. RICHARDSON, J.A. Permethrin spot-on toxicoses in cats. Journal Veterinary Emergency and Critical Care, v.10, p.103-106, 2000. ROBERTSON-PLOUCH, C. et al Clinical field study of the safety and efficacy of spinosad chewable tablets for controlling fleas on dogs. Veterinary Therapeutics, v.9, p.26–36. 2008. ROCHA, U.F. O verdadeiro nome da mosca “Bicheira” (Diptera: Calliphoridae). Boletim de Industria Animal, v.15, p.53-58, 1956. ROZENTAL, T. et al. Evidence of Spotted Fever Group Rickettsiae in State of rio de Janeiro, Brasil. Revista do Instituto de Medicina Tropical de São Paulo, v.4, n.3, p.155-158, 2002. RUST, M.K. et al. Efficacy and longevity of nitenpyram against adult cat fleas (Siphonaptera: Pulicidae). Journal of medical entomology, v.40, s.5, p.678-681, 2003. RUST, M.K. Advances in the control of Ctenocephalides felis (cat flea) on cats and dogs. Trends in parasitology, v.21, s.5, p.232-236, 2005. RUST, M. The biology and ecology of cat fleas and advancements in their pest management: a review. Insects, v.8, s.4, p.118, 2017. SANTORA, K.A. et al. Development of a mouse model to determine the systemic activity of potencial flea-control compounds. Veterinary Parasitology, v.104, n.3, p.257-264, 2002. 72 SCHENKER, R.; LUEMPERT, L.G.; BARNETT, S.H. Efficacy of nitenpyram against fleas on dogs and cats in a clinical field study. Compendium on Continuing Education for the Practicing Veterinarian, v.23, n.3(a), p. 12-15, 2001a. SCHENKER, R. et al. A brief introduction to nitenpyram: a new systemic flea adulticide for cats and dogs. Compendium on Continuing Education for the Practicing Veterinarian, v.23, n.3 (a), p.4-6, 2001b. SCOTT, F. et al. Efficacy of sarolaner (Simparica®) against induced infestations of Amblyomma cajennense on dogs. Parasites & Vectors, v.10, s.1, p.390, 2017. SIX, R.H. et al. Efficacy of sarolaner, a novel oral isoxazoline, against two common mite infestations in dogs: Demodex spp. and Otodectes cynotis . Veterinary Parasitology, v. 222, p.62-69, 2016a. SIX, R.H. et al. Evaluation of the speed of kill of sarolaner (Simparica®) against induced infestations of three species of ticks (Amblyomma maculatum, Ixodes scapularis, Ixodes ricinus) on dogs. Veterinary parasitology, v.222, p.37-42, 2016b. SIX, R. H. et al. Comparative speed of kill of sarolaner (Simparica®) and afoxolaner (NexGard®) against induced infestations of Rhipicephalus sanguineus sl on dogs. Parasites & vectors, v.9, s.1, p.91, 2016c. SIX, R.H. et al. Efficacy of a novel oral formulation of sarolaner (Simparica®) against five common tick species infesting dogs in the United States. Veterinary parasitology, v.222, p.28–32, 2016d. SIX, R.H. et al. Evaluation of the effectiveness of a novel oral formulation of sarolaner (Simparica®) for the treatment and control of fleas on dogs. Veterinary parasitology, v.222, p.18-22. 2016e. SIX, R. H. et al. Comparative speed of kill of sarolaner (Simparica®) and fluralaner (Bravecto®) against induced infestations of Ctenocephalides felis on dogs. Parasites & vectors, v.9, s.1, p.92, 2016f. SNYDER, D.E. et al. Preliminary studies on the effectiveness of the novel pulicide, spinosad, for the treatment and control of fleas on dogs. Veterinary parasitology, v.150, p.345–451, 2007. SNYDER, D.E. et al. Speed of kill efficacy and efficacy of flavored spinosad tablets administered orally to cats in a simulated home environment for the treatment and prevention of cat flea (Ctenocephalides felis) infestations. Veterinary Parasitology, vol.196, s.3-4, p.492-496, 2013. SNYDER, D.E.; WISEMAN, S.; LIEBENBERG, J.E. Efficacy of lotilaner (Credelio™), a novel oral isoxazoline against naturally occurring mange mite infestations in dogs caused by Demodex spp. Parasites & vectors, v.10, s.1, p.532, 2017. SOJKA, P.A. Therapeutic review–isoxazolines. Journal of Exotic Pet Medicine, v.27, p. 118-122, 2018. 73 SOLANO-GALLEGO, L. et al. Detection of Leishmania infantum DNA mainly in Rhipicephalus sanguineus male ticks removed from dogs living in endemic areas of canine leishmaniosis, Parasites & Vectors, v.5, p.1-6, 2012. SONENSHINE, D.E.; ROE, R.M. Biology of Ticks, 2nd ed, Biology of Ticks. Oxford University Press, New York , 2014. SONG, Y. et al. Key Considerations in Designing Oral Drug Delivery Systems for Dogs. Journal of pharmaceutical sciences, v.105, s.5, p.1576-1585, 2016. SOULSBY, E.J.L. Parasitologia y enfermidades parasitárias en los animales domésticos. 2nd edn. Mexico: Interamericana, 1987. STANNECK, D; LARSEN, K. S.; MCNCKE, N. An evaluation of the effect of pyriproxyfen on eggs and adults of the cat flea, Ctenocephalides felis felis (Siphonaptera: Pulicidae). Irish Veterinary Journal, v.55, p.383–387, 2002. SZABÓ, M. P. J. et al. Biological and DNA evidence of two dissimilar populations of the Rhipicephalus sanguineus tick group (ACARI: IXODIDAE) in South America. Veterinary Parasitology, v.130, p.131-140, 2005. TAENZLER, J. et al. Efficacy of fluralaner against Otodectes cynotis infestations in dogs and cats. Parasites & vectors, v.10, s.1, p.30, 2017. TAENZLER, J. et al. Onset of activity of fluralaner (BRAVECTO™) against Ctenocephalides felis on dogs. Parasites & vectors, v.7, s.1, p.567, 2014. TANNER, P.A. et al. Advances in the treatment of heartworms, fleas and ticks. Canine Practice, v.22, n.2-3, p.40-47, 1997. TAYLOR, M.A. Drugs used in the treatment and control of parasitic infections. Ectoparasiticides. In The Veterinary Formulary, 5 edição, editora Y. Bishop, p.265-305, Pharmaceutical Press, London, 2000. TAYLOR, M.A. Recent developments in ectoparasiticides. The Veterinary Journal, v. 161, s.3, p.253-268, 2001. TOUTAIN, C. E.; SEEWALD, W.; JUNG, M. The intravenous and oral pharmacokinetics of lotilaner in dogs. Parasites & Vectors, v.10, s.1, p.522, 2017. TRAPP, S. M. et al. Babesia gibsoni genotype Asia in dogs from Brazil. Veterinary Parasitology. v.141, n.1, p.177-180, 2006. TROTTA, M. et al. Detection of Leishmania infantum, Babesia canis, and rickettsiae in ticks removed from dogs living in Italy, Ticks and Tick-borne Diseases, v.3, p.293–296, 2012. VARGAS-TERAN, M.; HOFMANN, H.C.; TWEDDLE, N.E. Impact of screwworm eradication programmes using the sterile insect technique. IN: Sterile InsectTechnique– 74 Principles and Practicein Area-Wide Integrated Pest Management (2005) ed. by VA Dyck, J Hendrichs&ASRobinson, p.629–650, Springer, Dordrecht, The Netherlands. VARLOUD, M.; FOURIE, J. J. Onset of efficacy and residual speed of kill over one month of a topical dinotefuran-permethrin-pyriproxyfen combination (Vectra® 3D) against the adult cat flea (Ctenocephalides felis felis) on dogs. Veterinary parasitology, v.211, s.1-2, p.89-92, 2015. VATTA, A. F. et al. Efficacy of a new spot-on formulation of selamectin plus sarolaner for cats against adult Ctenocephalides felis, flea egg production and adult flea emergence. Veterinary parasitology, v.238, S22-S26, 2017. VATTA, A. F. et al. Efficacy of a new topical formulation containing selamectin plus sarolaner against three common tick species infesting cats in the United States. Veterinary parasitology, v.270, S19-S25, 2018. VATTA, A. F. et al. Efficacy and safety of a combination of selamectin plus sarolaner for the treatment and prevention of flea infestations and the treatment of ear mites in cats presented as veterinary patients in the United States. Veterinary parasitology, v.270, S3-S11, 2019a. VATTA, A. F. et al. Comparative efficacy of topical treatments with Revolution Plus (selamectin and sarolaner) and Bravecto for cats (fluralaner) against Ixodes scapularis ticks on cats. Veterinary parasitology, v.270, S58-S63, 2019b. VINCENZI, P.; GENCHI, C. Efficacy of Fipronil against ear mites (Otodectes cynotis, in dogs and cats. In: Proceedings of the 14th Annual Congresso of the ESVD-ECVD, Pisa, Itália, p.177, 1997. VIOL, M.A. et al. Identification of Leishmania spp. promastigotes in the intestines, ovaries, and salivary glands of Rhipicephalus sanguineus actively infesting dogs. Parasitology Research, v.115, s.9, p.3479-3484, 2016. WALKER, J.B.; KEIRANS, J.E.; HORAK, I.G. The genus Rhipicephalus (Acari, Ixodidae): a guide to the brown ticks of the world. Cambridge University Press. p.643, 2005. WALTHER, F.M. et al. Safety of fluralaner, a novel systemic antiparasitic drug, in MDR1 (-/-) Collies after oral administration. Parasites & vectors, v.7, s.86, 2014a. WALTHER, F.M. et al: The effect of food on the pharmacokinetics of oral fluralaner in dogs. Parasites & vectors, v.7, s.1, p.84, 2014b. WEBER, T.; SELZER, P.M. Isoxazolines: A novel Chemotype Highly Effective on Ectoparasites. ChemMedChem, v.11, p.270-276, 2016. WHITTEM T. Pyrethrin and pyrethroid insecticide intoxication in cats. Compendium Continue Education Practice Veteterinary, v.17, p.489-94, 1995. WISMER, T.; MEANS, C. Toxicology of newer insecticides in small animals. Veterinary of North America: Small Animal Practice, v.42, s.2, 2012. 75 WOLKEN, S. et al. Evaluation of spinosad for the oral treatment and control of flea infestations on dogs in Europe. Veterinary Record, v.170, s.4, p.99, 2012. WOODS, D.J.; MCTIER T.L. Discovery, development and commercialization of sarolaner (Simparica®), a novel oral isozaxoline ectoparasiticide for dogs. In: Ectoparasites – Drug Discovery Against Moving Targets v.8, p. 295-318, 2018. WOODS, D.J.; MCTIER T.L.; DEROSA A.A. Comparison of the Anti-ectoparasite and Anti-endoparasite Therapies and Control Strategies. In: Ectoparasites – Drug Discovery Against Moving Targets v.8, p.3-24, 2018. WYSS, J. H. Screwworm eradication in the Americas.Ann.N.Y. Proceedings of the National Academy of Sciences, v.916, p.186–193, 2000. YONETAKE, W. et al. Efficacy and safety of a new formulation containing selamctin and sarolaner in the prevention of heartworm disease and the treatment of roundworm infection in cats presented as veterinary patients in Japan. Veterinary Parasitology, v.270, S38-S44, 2019. YOUNG, D. R.; JEANNIN, P.C.; BOECKH, A. Efficacy of fipronil/(S)-methoprene combination spot-on for dogs against shed eggs, emerging and existing adult cat fleas (Ctenocephalides felis, Bouché). Veterinary parasitology, v.125, s.3-4, p.397-407, 2004. ZAKSON-AIKEN, M. et al. Systemic activity of the avermectins against the cat flea, Ctenocephalides felis (Siphonaptera: Pulicidae). 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dc.title.por.fl_str_mv Contribuições clínicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de cães e gatos
dc.title.alternative.eng.fl_str_mv Clinical contributions of sarolaner in ectoparasitosis of dog and cat
title Contribuições clínicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de cães e gatos
spellingShingle Contribuições clínicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de cães e gatos
Oliveira, Priscila Cardim de
Isoxazolinas
Ectoparasitas
Miíases
Myiasis
Isoxazolines
Ectoparasites
Medicina Veterinária
title_short Contribuições clínicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de cães e gatos
title_full Contribuições clínicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de cães e gatos
title_fullStr Contribuições clínicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de cães e gatos
title_full_unstemmed Contribuições clínicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de cães e gatos
title_sort Contribuições clínicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de cães e gatos
author Oliveira, Priscila Cardim de
author_facet Oliveira, Priscila Cardim de
author_role author
dc.contributor.author.fl_str_mv Oliveira, Priscila Cardim de
dc.contributor.advisor1.fl_str_mv Scott, Fabio Barbour
dc.contributor.advisor1ID.fl_str_mv 001.382.167-97
https://orcid.org/0000-0003-1683-8724
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/1217253540572819
dc.contributor.referee1.fl_str_mv Scott, Fabio Barbour
dc.contributor.referee1ID.fl_str_mv 001.382.167-97
https://orcid.org/0000-0003-1683-8724
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/1217253540572819
dc.contributor.referee2.fl_str_mv Azevedo, Thaís Ribeiro Correia
dc.contributor.referee2ID.fl_str_mv https://orcid.org/0000-0003-3045-8787
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/6049103053269712
dc.contributor.referee3.fl_str_mv Martins, Isabella Vilhena Freire
dc.contributor.referee3ID.fl_str_mv https://orcid.org/0000-0002-8700-3065
dc.contributor.referee3Lattes.fl_str_mv http://lattes.cnpq.br/6446528818006897
dc.contributor.referee4.fl_str_mv Campos, Diefrey Ribeiro
dc.contributor.referee4ID.fl_str_mv https://orcid.org/0000-0002-5434-1463
dc.contributor.referee4Lattes.fl_str_mv http://lattes.cnpq.br/8547992443497955
dc.contributor.referee5.fl_str_mv Freire, Licius de Sa
dc.contributor.referee5Lattes.fl_str_mv http://lattes.cnpq.br/8536627339990442
dc.contributor.authorID.fl_str_mv 721.473.507-53
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/6069474085821136
contributor_str_mv Scott, Fabio Barbour
Scott, Fabio Barbour
Azevedo, Thaís Ribeiro Correia
Martins, Isabella Vilhena Freire
Campos, Diefrey Ribeiro
Freire, Licius de Sa
dc.subject.por.fl_str_mv Isoxazolinas
Ectoparasitas
Miíases
Myiasis
topic Isoxazolinas
Ectoparasitas
Miíases
Myiasis
Isoxazolines
Ectoparasites
Medicina Veterinária
dc.subject.eng.fl_str_mv Isoxazolines
Ectoparasites
dc.subject.cnpq.fl_str_mv Medicina Veterinária
description Os ectoparasitos de cães e gatos são pulgas, carrapatos, moscas, piolhos e sarnas. As infestações decorrentes destes parasitos podem levar a infecções graves tanto para os animais como para seres humanos. O objetivo deste trabalho foi avaliar as contribuições do sarolaner nos tratamentos clínicos de infestações controladas de Ctenocephalides felis felis em cães e gatos, Rhipicephalus sanguineus em cães e no tratamento de miíases de ocorrência natural causadas por Cochliomyia hominivorax em cães. Sendo assim, quatro estudos foram realizados e separados em capítulos. Os capítulos foram intitulados I “Eficácia do sarolaner no controle de carrapatos Rhipicephalus sanguineus em cães infestados artificialmente”, II “Eficácia do sarolaner no controle de pulgas Ctenocephalides felis felis em cães infestados artificialmente”, III “Eficácia do sarolaner no controle de pulgas Ctenocephalides felis felis em gatos infestados artificialmente” e IV “Eficácia do sarolaner no tratamento de miíases causadas por Cochliomyia hominivorax em cães naturalmente infestados”. No estudo de eficácia carrapaticida foram selecionados 20 cães beagles adultos. As infestações foram realizadas com 25 machos e 25 fêmeas adultos não alimentados de R. sanguineus semanalmente por 5 semanas. As contagens foram realizadas semanalmente 48 horas após as infestações. Os animais receberam 2,0 a 4,0mg/kg do sarolaner por via oral em dose única. A eficácia média do sarolaner foi 97,3%, por 35 dias. Para eficácia pulguicida em cães foram incluídos 20 animais da raça Beagle, machos e fêmeas, com idade entre 1 e 4 anos que receberam por via oral 2,0 a 4,0mg/kg do sarolaner em dose única. As infestações ocorreram semanalmente com 50 (+-5) casais de pulgas C felis adultas não alimentadas. As desinfestações ou penteações foram realizadas 24 horas após as infestações. A média de eficácia foi de 99,75% no período de 35 dias. Para avaliação da eficácia pulguicida em gatos, foram incluídos 14 animais sem raça definida machos e fêmeas em igual proporção, idade entre um e seis anos. Os animais receberam 2,0-3,5mg/kg de sarolaner por via oral em dose única. As infestações foram realizadas semanalmente com 50(+-5) casais de pulgas C felis por 12 semanas. As contagens ocorreram 48 horas após as infestações e a eficácia do sarolaner foi de 100% em todos os dias experimentais, totalizando 84 dias. No tratamento de miíases de ocorrência natural por Cochliomyia hominivorax foram avaliados oito cães beagles adultos que receberam a dose de 2,0 – 4,0mg/kg de sarolaner por via oral e a medicação de suporte para tratamento da ferida. A expulsão das larvas foi avaliada a cada 15 minutos na primeira hora e a cada hora nas seis horas subsequentes e com 24 horas de tratamento. As larvas foram avaliadas quanto à motilidade para diferenciação entre mortas e vivas. Após 24 horas os animais foram sedados para a limpeza da ferida e a retirada manual de todas as larvas. A média de expulsão das larvas foi de 50,9% ocorrendo principalmente após quatro horas do tratamento. O efeito larvicida foi de 70,6% nas seis horas após o tratamento e de 100% em 24 horas. A eficácia global foi de 100%. O sarolaner se mostrou eficaz em todos os tratamentos propostos podendo ser uma boa escolha em casos de infestações múltiplas. Não foram observadas alterações clinicas ou comportamentais durante os estudos que pudessem estar relacionadas ao tratamento ou aos procedimentos realizados
publishDate 2019
dc.date.issued.fl_str_mv 2019-07-12
dc.date.accessioned.fl_str_mv 2023-12-21T18:44:27Z
dc.date.available.fl_str_mv 2023-12-21T18:44:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Priscila Cardim de. Contribuições clínicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de cães e gatos. 2019.79 f. Tese (Doutorado em Ciências Veterinárias) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2019.
dc.identifier.uri.fl_str_mv https://rima.ufrrj.br/jspui/handle/20.500.14407/9794
identifier_str_mv OLIVEIRA, Priscila Cardim de. Contribuições clínicas sobre o uso do Sarolaner no tratamento das principais ectoparasitoses de cães e gatos. 2019.79 f. Tese (Doutorado em Ciências Veterinárias) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2019.
url https://rima.ufrrj.br/jspui/handle/20.500.14407/9794
dc.language.iso.fl_str_mv por
language por
dc.relation.references.por.fl_str_mv ACHA, P.N.; SZYFRES, B. Zoonosis y enfermedades transmisibles comunes al hombre y los animales. 2ed. Washington: OPS/OMS, 989, 1986. AGUIAR, C.L.G. et al. Parâmetros da fase de vida livre de Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae): adaptado ao clima subtropical. Arquivos do Instituto Biológico, v.80, n.4, p. 375-380, 2013. BECK, W. et al. Qualitative and quantitative observations on the flea population dynamics of dogs and cats in several areas of Germany. Veterinary Parasitology, v.137, p. 130–136,2006. BECSKEI, C. et al. Efficacy and safety of a novel oral isoxazoline, sarolaner (Simparica®) in the treatment of naturally occurring flea and tick infestation in dogs presented as veterinary patients in Europe. Veterinary Parasitology, v. 222, p. 49-55, 2016a. BECSKEI, C. et al. Comparative speed of kill of oral treatments with Simparica TM (sarolaner) and Bravecto® (fluralaner) against induced infestations of Rhipicephalus sanguineus on dogs. Parasites & Vectors, v. 9, p. 103, 2016b. BECSKEI, C. et al. Efficacy and speed of kill of a new spot-on formulation of selamectin plus sarolaner against flea infestations in cats. Veterinary Parasitology, v.238, s18 - s21, 2017a. BECSKEI, C. et al. Efficacy of a new spot-on formulation of selamectin plus sarolaner in the treatment of Otodectes cynotis in cats. Veterinary Parasitology, v. 238, s. 27-S30, 2017b. BECSKEI, C.; CUPPENS, O.; MAHABIR, S.P. Efficacy and safety of sarolaner in the treatment of canine ear mite infestation caused by Otodectes cynotis: a non- inferiority study. Veterinary Dermatology, v.29, 2018a. BECSKEI, C.; CUPPENS, O.; MAHABIR, S.P. Efficacy and safety of sarolaner against generalized demodicosis in dogs in European countries: a non- inferiority study. Veterinary Dermatology, v.29, n.3, p. 203-e72, 2018b. BEUGNET, F.; FRANC, M. Insecticide and acaricide molecules and/or combinations to prevent pet infestation by ectoparasites. Trends of Parasitology, v.28, p.267–279, 2012. BEUGNET, F.; LIEBENBERG, J.; HALOS, L. Comparative efficacy of two oral treatments for dogs containing either afoxolaner or fluralaner against Rhipicephalus sanguineus sensu lato and Dermacentor reticulatus. Veterinary Parasitology, v.209, n.1-2, p.142-145, 2015. BEUGNET, F. et al. Efficacy of oral afoxolaner for the treatment of canine generalised demodicosis. Parasite, v.2, 2016a. BEUGNET, F. et al. Efficacy of afoxolaner in a clinical field study in dogs naturally infested with Sarcoptes scabiei. Parasite, v.23, 2016b. BLAGBURN, B.L.; DRYDEN, M.W. Biology, treatment and control of flea and tick infestations. The Veteterinary Clinicof North America: Small Animal Prcatice. v.39, p.1173–1200, 2009. 61 BOND, R. et al. Survey of flea infestation in dogs and cats in the United Kingdom during 2005. Veterinary Record, v.160, p.503–506, 2007. BOSCO, A. et al. Efficacy of fluralaner spot-on solution for the treatment of Ctenocephalides felis and Otodectes cynotis mixed infestation in naturally infested cats. BMC Veterinary Research, v.15, n.1, p.28, 2019. BOWMAN, D.D. et al. Efficacy of milbemycin oxime in combination with spinosad in the treatment of larval and immature adult stages of Ancylostoma caninum and Toxocara canis in experimentally infected dogs. Veterinary Parasitology, v.205, n.1-2, p.134-139, 2014. CADIERGUES, M.C; CAUBET, C.; FRANC, M. Comparison of the activity of selamectin, imidacloprid and fipronil for the treatment of dogs infested experimentally with Ctenocephalides canis and Ctenocephalides felis felis. Veterinary Record, v.149, p.704–706, 2001. CADIERGUES, M.C. et al. Efficacy of an adulticide used alone or in combination with an insect growth regulator for flea infestations of dogs housed in simulated home environments. American Journal of Veteterinary Research, v.60, p.1122–1125, 1989. CADIERGUES, M.C.; PRESSANTI, C. A. A.; MUMCUOGLU, K. Y. Efficacy of Spinosad Tablets Administered to a Colony of 15 Indoor Cats Naturally Infested with Fleas ISRN Veterinary Science, v.2014, 2014. CASIDA, J.E. et al. Mechanism of seective action of pyrethroid insecticides. Annual Review of Pharmacology Toxicology, v.23, p.413-38, 1983. CASIDA, J. E.; DURKIN, K. A. Novel GABA receptor pesticide targets. Pesticide Biochemistry and Physiology, v.121, p.2-30, 2015. CAVALLERI, D. et al. Assessment of the speed of flea kill of lotilaner (Credelio™) throughout the month following oral administration to dogs. Parasites & vectors, v.10, s.1, p.529, 2017. CAVALLERI, D. et al. Laboratory evaluation of the efficacy and speed of kill of lotilaner (Credelio™) against Ctenocephalides felis on cats. Parasites & vectors, v.11, s.1, p.408, 2018. CHERNI, J. A.; MAHABIR, S. P.; SIX, R. H. Efficacy and safety of sarolaner (Simparica®) against fleas on dogs presented as veterinary patients in the United States. Veterinary Parasitology, v.222, p.43-48, 2016. COHEN, E. Chitin biochemistry: synthesis and inhibition. Annual Review of Entomology, v.32, n.1, p.71-93, 1987. Companion Animal Parasites Council: CAPC General Guidlines, 2015. https://capcvet.org/guidelines/ehrlichia-spp-and-anaplasma-spp/. Acessado em 4/07/ 2019. CORREIA, T.R. et al. Eficácia do regulador de crescimento de insetos piriproxifen associado ap piretróide d-fenotrina (Mypet® Aerosol) no controle ambiental de Ctenocephalides felis felis (Bouché, 1835) (Siphonaptera : Pulicidae). A Hora Veterinária, v.25, n.146, p.27-31, 2005. 62 CORREIA, T.R. et al. Larvicidal efficacy of nitenpyram on the treatment of myiasis caused by Cochliomyia hominivorax (Diptera: Calliphoridae) in dogs. Veterinary Parasitology, v.173, s.1-2, p.169-172, 2010. COUTINHO, M.T.Z. et al. Participation of Rhipicephalus sanguineus (Acari: Ixodidae) in the epidemiology of canine visceral leishmaniasis. Veterinary Parasitology, v.128, p.149–155, 2005. COYNE, M.J. Efficacy of a topical ectoparasiticide containing dinotefuran, pyryproxyfen, and permethrin against Amblyomma americanum (Lorne Star Tick) and Amblyomma maculatum (Gulf Coast Tick) on dogs. Veterinary Therapeutics, v.10, n.1-2, p.17-23, 2009. CROSAZ, O. et al. Usefulness of a topical combination of dinotefuran and pyriproxyfen for long-term control of clinical signs of allergic dermatitis in privately-owned cats in Ile-de-France region. Parasites & Vectors, v.10, n.1, p.392, 2017. COLES, T. B.; DRYDEN, M. W. Insecticide/acaricide resistance in fleas and ticks infesting dogs and cats. Parasites & Vectors, v.7, p.1–10, 2014. CUNHA, N.C. et al. First identification of natural infection of Rickettsia rickettsii in the Rhipicephalus sanguineus tick, in the State of Rio de Janeiro. Pesquisa Veterinária Brasileira, v.29, n.2, p.1-9, 2009. CUNHA, N.C. et al. Rickettsiae of the Spotted Fever group in dog, horses and ticks: na epidemilogical study in an endemic region of the State of Rio de Janeiro, Brazil. Revista Brasileira de Medicina Veterinária, v.36, n.2, p.1-7, 2014. CURTIS, C. Use and abuse of topical dermatological therapy in dogs and cats. Part 2. In Practice, v.21, p.448-54, 1999. CURTIS, M.P. et al. Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs. Bioorganic & medicinal chemistry letters, v.26, n.7, p.1831-1835, 2016. DANIEL, E.; JULIAN, E. Efficacy of lotilaner a novel oral isoxazoline against naturally occurring mange mite infestations in dogs caused by Demodex spp. Parasites & Vectors, v.10, s1, p.532, 2017. DANTAS-TORRES, F. Biology and eclogy of the brown dog tick, Rhipicephalus sanguineus. Parasites & Vectors, v.3, n.26, 2007. DANTAS-TORRES, F. The brown dog tick, Rhipicephalus sanguineus (Latreille, 1806)(Acari: Ixodidae): From taxonomy to control. Veterinary Parasitology. v.152, p.173–185, 2008. DANTAS-TORRES, F. et al. Effects of prolonged exposure o low temperature on eggs of the brown dog tick, Rhipicephalus sanguineus (Latreille, 1806)(Acari: Ixodidae).Veterinary Parasitology, v.171, p.327-330, 2010. 63 DANTAS-TORRES, F. et al. Efficacy of an imidacloprid/ flumethrin colar against fleas, ticks and tick-borne pathogens in dogs. Parasites Vectors, v.6, p.245, 2012. DANTAS-TORRES, F.; CHOMEL, B.; OTRANTO, D. Ticks and tick-borne diseases: a One Health perspective. Trends Parasitology. v.28, p.437–446, 2012b. DOBLER, G.; PFEFFER, M. Fleas as parasites of the family Canidae. Parasites & Vectors, p.4, v.1, p.139, 2011. DOBSON, P. et al. Efficacy of nitenpyram as a systemic flea adulticide in dogs and cats. Veterinary. Records, v.147, p.709–713, 2000. DONGUS, H.; MEYER, L.; ARMSTRONG, R. Water immersion of dogs close to the time of topical fluralaner treatment does not reduce efficacy against a subsequent experimental challenge with Rhipicephalus sanguineus (sensu lato). Parasites & Vectors, v.10, n.1, 2017. DRAG, M.; SAIK, J.; HARRIMAN J. Safety evaluation of orally administered afoxolaner in 8-week-old dogs. Veterinary Parasitology, v.201, p.198-203, 2014. DRYDEN, M.; GAAFAR, S. Blood consumption by the cat flea, Ctenocephalides felis felis (Siphonaptera: Pulicidae). Journal Medical Entomology, v.28, n.3, p.394-400, 1991. DRYDEN, M.W. Biology of fleas of dogs and cats. Compendium of Continuing Education Practice Veterinary, v.15, p. 569-579, 1993. DRYDEN, M.W.; BROCE, A.B. Development of trap for collecting newly emerged Ctenocephalides felis (Siphonaptera:Pulicidae) in homes. Journal of Medical Entomology, v.30, n.5, p.901-906, 1993. DRYDEN, M.W.; RUST, M.K. The cat flea: biology, ecology and control. Veterinary Parasitology, v.52, n.1, p.19, 1994. DRYDEN, M.W.; PEREZ, H.R.; ULITCHNY, D.M. Efficacy of imidacloprid against Ctenocephalides felis in dogs and cats under field conditions. In: Proceedings of the Bayer International Flea Control Symposium, Birningham, p.5-10, 1997. DRYDEN, M.W.; PAYNE, P. A. Biology and control of ticks infesting dogs and cats in North America. Veterinary Therapeutics, v.5, p.139-154, 2004. DRYDEN, M.W. et al. Comparative speed of kill of selamectin, imidacloprid, and fipronil-(S)-methoprene spot-on formulations against fleas on cats. Veterinary Therapeutics, v.6, p. 228–236, 2005. DRYDEN, M.W. et al. Evaluation of an imidacloprid (8.8% w/w) permethrin (44% w/w) topical spot-on and a fipronil (9.8% w/w)–(S)-methoprene (8.8% w/w) topical spot-on to repel, prevent attachment, and kill adult Rhipicephalus sanguineus and Dermacentor variabilis ticks on dogs. Veterinary Therapeutics, v.7, p.187–198, 2006. 64 DRYDEN, M.W; PAYNE, P.; SMITH, V. Efficacy of selamectin and fipronil- (S)-methoprene spot on formulation applied to cats against adult cat fleas (Ctenocephalides felis) flea eggs and adult fleaemergence. Veterinary Therapeutics, v.8, p.255-262, 2007. DRYDEN, M. et al. Efficacy of a topically applied spot-on formulation of a novel insecticide, metaflumizone, applied to cats against a flea strain (KS1) with documented reduced susceptibility to various insecticides. Veterinary Parasitology, v.151, p.74–79, 2008. DRYDEN, M.W. Fleas and tick control in the 21st century: challenges and opportunities. Veterinary Dermatology. v.20, p.435–440, 2009. DRYDEN, M. W.; PAYNE, P. A.; VICKI, Set al. Evaluation of the Ovicidal Activity of Lufenuron and Spinosad on Fleas' Eggs from Treated Dogs. International Journal of Applied Research in Veterinary Medicine, v.10, s.3, p.198-205, 2012. DRYDEN, M. W.et al. Evaluation of sarolaner and spinosad oral treatments to eliminate fleas, reduce dermatologic lesions and minimize pruritus in naturally infested dogs in west Central Florida, USA. Parasites & vectors, v.10, n.1, p.389, 2017. DRYDEN, M. W. et al. In-home assessment of either topical fluralaner or topical selamectin for flea control in naturally infested cats in West Central Florida, USA. Parasites & Vectors, v.11, n.1, p.422, 2018. EBEL, G.D.; KRAMER, L.D. Short report: duration oftick attachmentfor transmission of Powassan virus by deer ticks. The American Journal of Tropical Medicine and Hygiene, v.71, p.268–271, 2004 ELLIOTT, M.; JANES, N. F. Synthetic pyrethroids -a new class of insecticides. Chemical Society Reviews, v.7, p. 473, 1978. FARKAS, R. et al. Prevalence of flea infestation in dogs and cats in Hungary combined with a survey of owner awareness. Medical and Veterinary Entomology, v.23, p.187–194, 2009. FERNANDES, F.D.F. In vitro activity of permethrin, cipermethrin and deltamethrin on larvae of Rhipicephalus sanguineus (Latreille, 1806)(Acari, Ixodidae). Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v.52, s.6, p.621-626, 2000. FISHER, M.A. et al. Evaluation of flea control programmes for cats using fenthion and lufenuron. The Veterinary Record, v.138, n.4, p. 79-81, 1996. FOURIE, J. J. et al. Efficacy of orally administered fluralaner (Bravecto TM) or topically applied imidacloprid/moxidectin (Advocate®) against generalized demodicosis in dogs. Parasites & vectors, v.8, n.1, p.187, 2015. FRANC, M.; CADIERGUES, M.C. Comparative activity in dogs of deltanethrin and diazinon impregnated collars against Ctenocephalides felis. American Journal of Veterinary Research, v.59, n.1, p.59-60, 1998. 65 FRANC, M. et al. Efficacy of fipronil-(S) methoprene on fleas, flea egg collection, and flea egg development following transplantation of gravid fleas onto treated cats. Veterinary Therapeutics, v.8, p.285–292, 2007. FRANC, M.; BOUSHIRA, E. Efficacy of a combination of a fipronil-(S)-methoprene spot on formulation and a deltamethrinimpregnated collar in controlling fleas and sandflies on dogs. Veterinary Therapeutics, v.71, p.71–77, 2009. GARCÍA-REYNAGA, P.; ZHAO, C.; SARPONG, R. New GABA/ Glutamate receptor target for hisoxazoline insecticide. Chemical Research in Toxicology, v.26, p.514-516, 2013. GASSEL, M. et al. The novel isoxazoline ectoparasiticide fluralaner: selective inhibition of arthropod γ-aminobutyric acid-and L-glutamate-gated chloride channels and insecticidal/acaricidal activity. Insect biochemistry and molecular biology, v.45, p.111-124, 2014. GEURDEN, T. et al. HEfficacy of a novel oral formulation of sarolaner (Simparica®) against four common tick species infesting dogs in Europe. Veterinary parasitology, v.222, p.33-36, 2016. GEURDEN, T. et al. Efficacy and safety of a new spot-on formulation of selamectin plus sarolaner in the treatment of naturally occurring flea and tick infestations in cats presented as veterinary patients in Europe. Veterinary parasitology, v.238, S12-S17, 2017a. GEURDEN, T. et al. Efficacy of a new spot-on formulation of selamectin plus sarolaner against four common tick species infesting cats in Europe. Veterinary parasitology, v.238, S3-S7, 2017b. GEURDEN, T. et al. Efficacy of a new spot-on formulation of selamectin plus sarolaner against Ancylostoma tubaeforme and Toxocara cati in cats. Veterinary Parasitology, v.238, S31-S35, 2017c. GEURDEN, T. et al. Comparative efficacy of a new spot-on combination product containing selamectin and sarolaner (Stronghold® Plus) versus fluralaner (Bravecto®) against induced infestations with Ixodes ricinus ticks on cats. Parasites & vectors, v.10, s.1, p.319, 2017d. GODDARD, J. Flies whose maggots cause myiasis inhumans. In: Physician’s Guide to Arthropods of Medical Importance, 2nd edn. Florida (1996) CRC Press, p.169–187. GRAF. J.F. The role of insect growth regulators in arthropod control. Parasitology Today, v.9, n.12, p.471-474, 1993. GRAHAM, O.H. Symposium on Eradication of the Screwworm from the United States and Mexico. Miscellaneous Publications 62. Entomological Society of America, College Park, MD, USA., 1985. GUIMARÃES, J.H.; PAPAVERO, N. Myiasis caused by obligatory parasites II. Cochhliomya Townsend (Calliphoridae) In: Myiasis in man and animals in the neotropical region, p.97-165, 1999. 66 HALL, M.J.L; WALL, R. Myiasis of humans and domestic animals. Advances in Parasitology, v. 35, p.257-334, 1995. HALOS, L. et al. Defining the concept of ‘tick repellency’ in veterinary medicine. Parasitology, v.139, p.419–423, 2012. HAN, H. S.; NOLI, C.; CENA, T. Efficacy and duration of action of oral fluralaner and spot‐on moxidectin/imidacloprid in cats infested with Lynxacarus radovskyi. Veterinary dermatology, v.27, s.6, p.474-e127, 2016. HAN, H.S.; SHARMA, R.; JEFFERY, J. Chrysomya bezziana (Diptera: Calliphoridae) infestation: case report of three dogs in Malaysia treated with spinosad/milbemycin. Veterinary dermatology, v.28, p.239– e62, 2017. HAN, H. S. et al. The comparative efficacy of afoxolaner, spinosad, milbemycin, spinosad plus milbemycin, and nitenpyram for the treatment of canine cutaneous myiasis. Veterinary dermatology. 2018a. HAN, H. S. et al. Canine and feline cutaneous screw‐worm myiasis in Malaysia: clinical aspects in 76 cases. Veterinary dermatology, v.29, s.5, p.442-e148, 2018b. HARRUS, S.; WANER, T. Diagnosis of canine monocytotropic ehrlichiosis (Ehrlichia canis): an overview. Veterinary Journal, v.187, p.292-6, 2011. HENDRIX, C.M. Facultative myiasis in dogs and cats. Compendium Continue Education, v.13, n.1, p. 86, 1991. HOPKINS, K.D.; MARCELLA, K.L.; STRECKER, A.E. Ivermectin toxicosis in a dog. Journal of the American Veterinary Medical Association, v.197, p.93-4, 1990. HOPKINS, T.J. et al. Efficacy of imidacloprid to remove and prevent Ctenocephalides felis infestation on dogs and cats. Australian Vetrrinary Practioner, v.26, n.3, p.150-153, 1996. HOUSTON, D.M.; PARENT, J.; MATUSHER, K.J. Ivermectin toxicosis in a dog. Journal of the American Veterinary Medical Association, v.191, p.78-80, 1987. HUNTER, J.S.; KEISTER, D.M.; JEANNIN, P. The effect of fipronil treated dog hair on the survival of the immature stages of the cat flea Ctenocephalides felis. In: Proccedings of the Annual Veterinary Medical Forum, San Antonio, v.6, 1996. HUNTER, J. S. et al. Evaluation of the curative and preventive efficacy of a single oral administration of afoxolaner against cat flea Ctenocephalides felis infestations on dogs. Veterinary Parasitology, v.201, p.207-211, 2014. JACOBS, D.E. et al. A novel approach to flea control on cats, using pyriproxyfen. Veterinary Records, v.139, p.559–561, 1996. JACOBS, D.E.; HUTCHINSON, M.J.; KRIEGER, K.J. Duration of activity of imidacloprid a novel adulticide for flea control, against Ctenocephalides felis on cats. Veterinary Records, v.140, p.59–260, 1997. 67 JACOBS, D.E. et al. Control of flea populations in a simulated home environment model using lufenuron, imidacloprid or fipronil. Medical Veterinary Entomology, v.25, p.73–77, 2001. JAENSON, T.G. et al. Why is tick-borne encephalitis increasing? A review of the key factors causing the increasing incidence of human TBE in Sweden. Parasites & Vectors, v.5, p.184–197, 2012. JONGEJAN, F.; UILENBERG, G. The global importance of ticks. Parasitology, v.129, s3-14, 2004. KARADZOVSKA D; CHAPPELL K; COBLE S. A randomized, controlled field study to assess the efficacy and safety of lotilaner flavored chewable tablets (CredelioTM) in eliminating fleas in client-owned dogs in the USA. Parasites & Vectors, v.10, p.528, 2017. KILP, S.; RAMIREZ, D.; ALLAN, J. Comparative pharmacokinetics of fluralaner in dogs and cats following single topical or intravenous administration. Parasites & Vectors, v.9, p.296, 2016. KNAUS, M. et al. Characterisation of ecto- and endoparasites in domestic cats from Tirana, Albania. Parasitology Research., v.113, p.3361–3371, 2014. KNIPLING, E. F. Possibilities of insect control or eradication through the use of sexually sterile males. Journal of Economic Entomology, v.48, p.459–462, 1955. KONNAI, S. et al. Attachment duration required for Rhipicephalus appendiculatus to transmit Theileria parva to the host. Vector Borne Zoonotic Disease, v.7, p.241–248, 2007. KOUTINAS, C.K. Treatment of canine sarcoptic mange with fipronil spray: a fiels trial. Australian Veterinary Practioner, v.31, p.115-119, 2001. KRAFSUR, E.S.; LINDQUIST, D.A. Did the sterile insect technique or weather eradicate screwworms (Diptera: Calliphoridae) from Lybia? Journal of Medical Entomology, v.33, p.877-887, 1996. KRÄMER, F.; MENCKE, N. Flea biology and control: the biology of the cat flea control and prevention with imidacloprid in small animals. Springer Science & Business Media, 2012. KUNKLE, B. N. et al. Assessment of the onset of action of afoxolaner against existing adult flea (Ctenocephalides felis) infestations on dogs. Veterinary parasitology, v.201, s.3-4, p.204-206, 2014a. KUNKLE, B. et al. Assessment of the efficacy of orally administered afoxolaner against Rhipicephalus sanguineus sensu lato. Veterinary parasitology, v.20, s.3-4, p.226-228, 2014b. LABRUNA, M. B.; PEREIRA, M.C. Carrapatos em cães no Brasil. Clínica Veterinária, n.30, p.24-32, 2001. 68 LABRUNA, M. B. Biológica-ecologia de Rhipicephalus sanguineus (ACARI: IXODIDAE). Revista Brasileira de Parasitologia Veterinária, v.13, s.1, p.123-124, 2004. LAMBERT, M. M. et al. Eficácia da associação de fipronil e permetrina no controle de Ctenocephalides felis felis e Rhipicephalus sanguineus sensu lato em cães artificialmente infestados. Brazilian Journal of Veterinary Medicine, v.39, s.4, p.246-251. 2017. LAPPIN, M. R. Update on flea and tick associated disease of cats. Veterinary Parasitology, v.254, p.26-29, 2018. LAVAN, R. et al. Dog owner flea/tick medication purchases in the USA. Parasites & Vectors, v.11, p.581, 2018. LEBON, W. et al. Prevention of Flea Egg Development in a Simulated Home Environment by Frontline® Gold (fipronil, (S)-methoprene, pyriproxyfen) Applied Topically to Cats. International Journal of Applied Research in Veterinary Medicine, v.16, s.1, p.67-74, 2018. LEFKADITIS, M.A. et al. Urban stray cats infested by ectoparasites with zoonotic potential in Greece. Parasitology. Research, v.114, p.3931–3934, 2015. LEIGHTON, P.A. et al. Predicting the speed of tick invasion: an empirical model of range expansion for the Lyme disease vector Ixodes scapularis in Canada. Journal Applied Ecology, v.49, p.457–464, 2012. LETENDRE, L.; HUANG, R.; KVATERNICK, V. The intravenous and oral pharmacokinetics of afoxolaner used as monthly chewable antiparasitic for dogs. Veterinary Parasitology, v.201, p.190-197, 2014. LIEBISCH, A.; HEESCHEN, K. Controled laboratory study on the efficacy of imidacloprid spot-on for controlo of the cat flea in dogs. In: Proccedings of The Bayer Internation Flea Control Symposium, Birningham, p.25-28, 1997. LINARDI, P. M.; GUIMARÃES, L. R. Siphonapteros do Brasil. São Paulo, Museu de Zoologia, USP/FAPESP. 2000. 291 p. LINDGREN, E.; TÄLLEKLINT, L.; POLFELDT, T. Impact of climatic change on the northern latitude limit and population density of the disease-transmitting European tick Ixodes ricinus. Environ. Health Perspective, v.108, p.119–123, 2000. LINNETT, P.J. Permethrin toxicosis in cats. Australian Veterinary Journal, v. 86, p.32-5, 2008. LITTLE, S.; OTRANTO. D. Tradition and innovation: Selamectin plus sarolaner. A new tool to control endo- and ectoparasites of cats – Studies from North America and Japan. Veterinary parasitology, v.270, S1-S2, 2019. 69 MACHADO, M.L.S.; RODRIGUES, E.M.P. Emprego do nitempyram como larvicida em miíases caninas por Cochliomyia hominivorax. Acta Scientiae Veterinariae, v.30, n.1, p.59-62, 2002. MACHADO, M. A. et al. Efficacy of afoxolaner in the treatment of otodectic mange in naturally infested cats. Veterinary parasitology, v.256, p.29-31, 2018. MARCHIONDO, A.A. et al. World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) second edition: guidelines for evaluating the efficacy of parasiticides for the treatment, prevention and control of flea and tick infestations on dogs and cats. Veterinary parasitology, v.194, s.1, p.84-97, 2013. MASON, K.V.; RING, J.; DUGGAN, J. Fenthion for flea controlo n dogs under field conditions: dose response efficacy studies and effect on cholinesterase activity. Journal of the American Animal Hospital Association, v.20, p.591-595, 1984. MASTRANGELO, T.; WELCH, J.B. An overview of the components of AW-IPM campaigns against the New World screwworm. Insects, v.3, p.930–955, 2012. MCCALL, J. W. et al. The ability of a topical novel combination of fipronil, amitraz and (S)-methoprene to protect dogs from Borrelia burgdorferi and Anaplasma phagocytophilum infections transmitted by Ixodes scapularis. Veterinary parasitology, v.179, s.4, p.335-342, 2011. MCNAIR, C. M. Ectoparasites of medical and veterinary importance: drug resistance and the need for alternative control methods. Journal of Pharmacy and Pharmacology, v.67,s.3, p.351-363, 2015. MCTIER, T. L. et al. Efficacy of selamectin against adult flea infestations (Ctenocephalides felis felis and Ctenocephalides canis) on dogs and cats. Veterinary parasitology, v.91, s.3-4, p.187-199, 2000. MCTIER, T. L. et al. Discovery of sarolaner: a novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs. Veterinary parasitology, v.222, p.3-11, 2016. MCTIER, T. L. et al. The efficacy of a novel topical formulation of selamectin plus sarolaner (Revolution Plus/ Stronghold Plus) in preventing the development of Dirofilaria immitis in cats. Veterinary Parasitology, v.270, p.56-62, 2019. MEDLEAU, L. Using ivermectin to treat parasitic dermatoses in small animals. Veterinary Medicine, p.770-4, 1994. MEO, N.J.; KEISTER, D.M.; TANNER, P.A. A comparison of the flea control efficacy of Frontline spray treatment against the flea infestation prevention pack (Vet-Kem) in the dog and cat. In: Proccedings of the American Association of the Veterinary Parasitologists. 41 Louisville, p. 17, 1996. MOYA, G.E. Erradidacaçao ou manejo integrado das miíases neotropicais das Américas. Pesquisa Veterinária Brasileira, v.23, p.131-138, 2003. 70 MURPHY, M.; BALL, C. A., GROSS, S. Comparative in vivo adulticidal activity of a topical dinotefuran versus imidacloprid based formulation against cat fleas (Ctenocephalides felis) on cats. Veterinary Therapeutics. v.10, p.9–16, 2009. MURPHY, M. et al. Laboratory evaluations of the immediate and sustained efficacy of lotilaner (Credelio™) against four common species of ticks affecting dogs in North America. Parasites & vectors, v.10, s.1, p.523, 2017. NATHANSON, J.A. Characterization of octopamine sensitive adenylate cyclase: elucidation of a class potent and selective octopamine-2 receptor agonist with toxic effects in insects. Procedings of National Academy of Science, v. 82, p.599-603, In: TAYLOR, M.A. Recent developments in ectoparasiticides. The Veterinary Journal, v.161, n.3, p.253-268, 2001. NICHOLSON, W.L. et al. Rocky mountain spotted fever in Arizona: Documentation of heavy environmental infestations of Rhipicephalus sanguineus at an endemic site. Annals of the New York Academy of Sciences. v.1078, p.338–341, 2006. NUNES, T.A.P. et al. Brazilian Journal of Veterinary Medicine, v.35, s.2, pp.81-84, 2014. O’DWYER, L. H.; MASSARD, C. L.; SOUZA, J. C. P. Hepatozoon canis infection associated with dog ticks of rural areas of Rio de Janeiro State, Brazil. Veterinary Parasitology, v. 94, n.3, p.143-150, 2001. OLIVEIRA, P.R. et al. Fluazuron-induced morphological changes in Rhipicephalus sanguineus Latreille, 1806 (Acari: Ixodidae) nymphs: An ultra-structural evaluation of the cuticle formation and digestive processes. Acta tropica, v.133, p.45-55, 2014. OLIVEIRA, P.C. et al. Efficacy of spinosad on the treatment of myiasis caused by Cochliomyia hominivorax (Diptera: Calliphoridae) in dogs. Veterinary Parasitology, v.258, p.53-56, 2018. OTRANTO, D.; DANTAS-TORRES, F.; Breitschwerdt, E.B. Managing canine vector-borne diseases of zoonotic concern: Part I. Trends Parasitology, v.25, p.157–163, 2009. OZOE, Y.; ASAHI, M.; OZOE, F. The antiparasitic isoxazoline A1443 is a potent blocker of insect ligand-gated chloride channels. Biochem Biophys Res Commun, v.391, p.744-749, 2010. PACKIANATHAN, R. et al. Efficacy and safety of sarolaner (Simparica®) in the treatment and control of naturally occurring flea infestations in dogs presented as veterinary patients in Australia. Parasites & vectors, v.10, s.1, p.387, 2017. PAROLA, P.; SOCOLOVSCHI, C.; RAOULT, D. Deciphering the relationships between rickettsia conorii conorii and Rhipicephalus sanguineus in the ecology and epidemiology of Mediterranean spotted fever. Annals of the New York Academy of Sciences, v.1166, p.49–54, 2009. PEGRAM, R. G. et al. classification of the Rhipicephalus sanguineus group (Acari, Ixodoidea, Ixodidae). Part I: R. sulcatus (Neuman, 1908) and R. turanicus (Pomerantseu, 1936). Systematic Parasitology, v.10, 1987. 71 PFISTER, K. Fipronil, amitraz and (S)-methoprene – a novel ectoparasiticide combination for dogs. Veterinary parasitology, v.179, p.293–356, 2011. PHILLIPS, P. L.; WELCH, J.B.; KRAMER, M. Seasonal and spatial distributions of adults screwworms (Diptera: Calliphoridae) in the Panama Canal Area, Republic of Panama. Journal Medical Entomololy, v.41, p.121-129, 2004. PIRANDA, E.M. et al. Experimental Infection of Rhipicephalus sanguineus Ticks with the Bacterium Rickettsia rickettsii, Using Experimentally Infected Dogs. Vector-Borne and Zoonotic Diseases, v.11, n.1, p.29-36, 2011. PRULLAGE, J. et al. The prevention of attachment and the detachment effects of a novel combination of fipronil, amitraz and (S)-methoprene for Rhipicephalus sanguineus and Dermacentor variabilis on dogs. Veterinary parasitology, v.179, p.311–317, 2011. PULLIAM, J.D. et al. Investigation ivermectin toxicity in Collies. Veterinary Medicine Companion Animal Practice, v.80, p.33-40, 1985. RANJAN, S.; YOUNG, D.; SUN, F. A single topical fluralaner application to cats and to dogs controls fleas for 12 weeks in a simulated home environment. Parasites & vectors, v.11, s.1, p.385, 2018. REICHARD, M.V. et al. Efficacy of a topical formulation of selamectin plus sarolaner against induced infestations of Amblyomma americanum on cats and prevention of Cytauxzoon felis transmission. Veterinary parasitology, v.270, S31-S37, November 2018. RICHARDSON, J.A. Permethrin spot-on toxicoses in cats. Journal Veterinary Emergency and Critical
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