Compara??o entre o efeito analg?sico da morfina e do tramadol epidural em gatos (Felis catus domesticus)
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFRRJ |
Texto Completo: | https://tede.ufrrj.br/jspui/handle/tede/887 |
Resumo: | The purpose of this study was to compare the effectiveness and duration of the analgesic tramadol to the morphine, administered by the epidural route in cats (Felis catus domesticus) For this, six females cats were used, without defined breed, weighing between three and four kilograms and age ranging from one to three years. After fasting food, in 12 hours and water, four hours, the animals were subjected to general anesthesia with isoflurane through an anesthetic box, in order to allow the completion of the epidural technique. Each animal received at random, in a blind study, three epidural route treatments at intervals of one week between them, with: saline solution to 0.9% in a volume equivalent to 0.22ml.kg-1 (Control Group), tramadol 1 mg.kg-1 diluted in saline solution and volume equivalent to 0.22 ml.kg-1 (Tramadol Group) and morphine 0.1mg.kg-1 diluted in saline solution and volume equivalent to 0.22ml.kg-1 (Morphine Group). One hour after administration of each drug and general anesthesia recovery, the animals were subjected to painful stimuli in three pre-defined places: in the dorsal tail basis, the side of the right and left thigh, giving continuity, 2, 3, 4, 6, 8, 10 and 12 hours respectively. The pain was qualified by the implementation of two Simple Descriptive Scales (SDS), a Visual Analog Scale (VAS), measurement of heart and respiratory rate. For qualitative variables used in the Latin Square design 3 x 3 with the Kruskal-Wallis test and for the quantitative variables used in Analysis of Variance (ANOVA). There was no difference in relation to the time of anesthesia and respiratory frequency, However, the heart rate was significantly different (p<0.05) in hours two and four between control group and tramadol. In all scales used there were significant difference (p<0.05) in hours 8, 10 and 12. In these times the morphine produced more quality analgesia than the tramadol. Based on the results obtained, it can be concluded that the tramadol administered in epidural route resulted a satisfactory analgesia, without an adverse effects, but poorer than the morphine analgesia administered by the same route. |
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Scherer, Paulo Oldemar157.275.809-00http://lattes.cnpq.br/0841638987926915Silva, Marta Fernanda Albuquerque da876.584.457-20http://lattes.cnpq.br/0544591266946007094.521.277-16http://lattes.cnpq.br/3567484495853227Castro, Douglas dos Santos e2016-04-28T20:18:27Z2008-04-242008-01-17CASTRO, Douglas dos Santos e. Compara??o entre o efeito analg?sico da morfina e do tramadol epidural em gatos (Felis catus domesticus). 2008. 4 f. Disserta??o (Mestrado em Medicina Veterin?ria, Patologia e Ci?ncias Cl?nicas) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica - RJ, 2008.https://tede.ufrrj.br/jspui/handle/tede/887The purpose of this study was to compare the effectiveness and duration of the analgesic tramadol to the morphine, administered by the epidural route in cats (Felis catus domesticus) For this, six females cats were used, without defined breed, weighing between three and four kilograms and age ranging from one to three years. After fasting food, in 12 hours and water, four hours, the animals were subjected to general anesthesia with isoflurane through an anesthetic box, in order to allow the completion of the epidural technique. Each animal received at random, in a blind study, three epidural route treatments at intervals of one week between them, with: saline solution to 0.9% in a volume equivalent to 0.22ml.kg-1 (Control Group), tramadol 1 mg.kg-1 diluted in saline solution and volume equivalent to 0.22 ml.kg-1 (Tramadol Group) and morphine 0.1mg.kg-1 diluted in saline solution and volume equivalent to 0.22ml.kg-1 (Morphine Group). One hour after administration of each drug and general anesthesia recovery, the animals were subjected to painful stimuli in three pre-defined places: in the dorsal tail basis, the side of the right and left thigh, giving continuity, 2, 3, 4, 6, 8, 10 and 12 hours respectively. The pain was qualified by the implementation of two Simple Descriptive Scales (SDS), a Visual Analog Scale (VAS), measurement of heart and respiratory rate. For qualitative variables used in the Latin Square design 3 x 3 with the Kruskal-Wallis test and for the quantitative variables used in Analysis of Variance (ANOVA). There was no difference in relation to the time of anesthesia and respiratory frequency, However, the heart rate was significantly different (p<0.05) in hours two and four between control group and tramadol. In all scales used there were significant difference (p<0.05) in hours 8, 10 and 12. In these times the morphine produced more quality analgesia than the tramadol. Based on the results obtained, it can be concluded that the tramadol administered in epidural route resulted a satisfactory analgesia, without an adverse effects, but poorer than the morphine analgesia administered by the same route.O objetivo do presente estudo foi comparar a efic?cia e dura??o analg?sica do tramadol ?s da morfina, administrados por via epidural em gatos (Felis catus domesticus). Para tanto, utilizaram-se seis f?meas da esp?cie felina, sem ra?a definida, com peso entre tr?s a quatro quilos e idade variando de um a tr?s anos. Ap?s o jejum alimentar, de 12 horas e h?drico, de quatro horas, os animais foram submetidos ? anestesia geral com isoflurano por meio de uma c?mara anest?sica, com a finalidade de realizar a t?cnica epidural, evitando o estresse. Cada animal recebeu de forma aleat?ria, em um estudo cego, tr?s tratamentos por via epidural com intervalos de uma semana entre estes, com: solu??o salina a 0,9% num volume equivalente a 0,22ml.kg-1 (Grupo Controle), tramadol 1mg.kg-1 dilu?do em solu??o salina e volume equivalente a 0,22ml.kg-1 (Grupo Tramadol) e morfina 0,1mg.kg-1 dilu?do em solu??o salina e volume equivalente a 0,22ml.kg-1 (Grupo Morfina). Uma hora ap?s a administra??o de cada f?rmaco e o completo retorno da anestesia geral, os animais foram submetidos a est?mulos dolorosos em tr?s locais pr?-definidos: base da cauda, face lateral da coxa direita e esquerda, dando continuidade, 2, 3, 4, 6, 8, 10 e 12 horas respectivamente. A dor foi qualificada pela implementa??o de duas Escalas Simples Descritivas (SDS), uma Escala Anal?gica Visual (VAS), mensura??o da freq??ncia card?aca e respirat?ria. Para as vari?veis qualitativas utilizou-se o delineamento em Quadrado Latino 3 x 3 com o teste de Kruskal-Wallis e para as quantitativas a An?lise de Vari?ncias (ANOVA). N?o houve diferen?a em rela??o ao tempo de anestesia e freq??ncia respirat?ria, entretanto, houve diferen?a estat?stica significante (p<0,05) na freq??ncia card?aca nas horas dois e quatro entre os animais do grupo controle e do tramadol. Em todas as escalas utilizadas houve diferen?a significante (p<0,05) nas horas 8, 10 e 12, sendo que a morfina apresentou qualidade analg?sica superior ao do tramadol nesses momentos. Com base nos resultados obtidos, pode-se concluir que o tramadol administrado por via epidural resultou analgesia satisfat?ria, isenta de efeitos adversos, por?m inferior ? analgesia da morfina, administrada pela mesma via.Made available in DSpace on 2016-04-28T20:18:27Z (GMT). No. of bitstreams: 1 2008 - Douglas dos Santos e Castro.pdf: 335295 bytes, checksum: b504eb6279e1e52327a6a9bf05f4f955 (MD5) Previous issue date: 2008-01-17application/pdfhttps://tede.ufrrj.br/retrieve/60291/2008%20-%20Douglas%20dos%20Santos%20e%20Castro.pdf.jpgporUniversidade Federal Rural do Rio de JaneiroPrograma de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas)UFRRJBrasilInstituto de Veterin?riatramadolmorfinagatosanalgesia epiduralmorphinecatsepidural analgesiaMedicina Veterin?riaCompara??o entre o efeito analg?sico da morfina e do tramadol epidural em gatos (Felis catus domesticus)Comparison between the analgesic effect of the epidural morphine and tramadol in cats (Felis catus domesticus)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFRRJinstname:Universidade Federal Rural do Rio de Janeiro (UFRRJ)instacron:UFRRJTHUMBNAIL2008 - Douglas dos Santos e Castro.pdf.jpg2008 - Douglas dos Santos e Castro.pdf.jpgimage/jpeg1943http://localhost:8080/tede/bitstream/tede/887/3/2008+-+Douglas+dos+Santos+e+Castro.pdf.jpgcc73c4c239a4c332d642ba1e7c7a9fb2MD53TEXT2008 - Douglas dos Santos e Castro.pdf.txt2008 - Douglas dos Santos e Castro.pdf.txttext/plain112258http://localhost:8080/tede/bitstream/tede/887/2/2008+-+Douglas+dos+Santos+e+Castro.pdf.txtb690444d73e7259a39b6755b98c3f2e3MD52ORIGINAL2008 - Douglas dos Santos e Castro.pdf2008 - Douglas dos Santos e Castro.pdfapplication/pdf335092http://localhost:8080/tede/bitstream/tede/887/1/2008+-+Douglas+dos+Santos+e+Castro.pdfa687261865425b118036fbfb52ad09fdMD51tede/8872022-06-14 12:14:02.489oai:localhost:tede/887Biblioteca Digital de Teses e Dissertaçõeshttps://tede.ufrrj.br/PUBhttps://tede.ufrrj.br/oai/requestbibliot@ufrrj.br||bibliot@ufrrj.bropendoar:2022-06-14T15:14:02Biblioteca Digital de Teses e Dissertações da UFRRJ - Universidade Federal Rural do Rio de Janeiro (UFRRJ)false |
dc.title.por.fl_str_mv |
Compara??o entre o efeito analg?sico da morfina e do tramadol epidural em gatos (Felis catus domesticus) |
dc.title.alternative.eng.fl_str_mv |
Comparison between the analgesic effect of the epidural morphine and tramadol in cats (Felis catus domesticus) |
title |
Compara??o entre o efeito analg?sico da morfina e do tramadol epidural em gatos (Felis catus domesticus) |
spellingShingle |
Compara??o entre o efeito analg?sico da morfina e do tramadol epidural em gatos (Felis catus domesticus) Castro, Douglas dos Santos e tramadol morfina gatos analgesia epidural morphine cats epidural analgesia Medicina Veterin?ria |
title_short |
Compara??o entre o efeito analg?sico da morfina e do tramadol epidural em gatos (Felis catus domesticus) |
title_full |
Compara??o entre o efeito analg?sico da morfina e do tramadol epidural em gatos (Felis catus domesticus) |
title_fullStr |
Compara??o entre o efeito analg?sico da morfina e do tramadol epidural em gatos (Felis catus domesticus) |
title_full_unstemmed |
Compara??o entre o efeito analg?sico da morfina e do tramadol epidural em gatos (Felis catus domesticus) |
title_sort |
Compara??o entre o efeito analg?sico da morfina e do tramadol epidural em gatos (Felis catus domesticus) |
author |
Castro, Douglas dos Santos e |
author_facet |
Castro, Douglas dos Santos e |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Scherer, Paulo Oldemar |
dc.contributor.advisor1ID.fl_str_mv |
157.275.809-00 |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/0841638987926915 |
dc.contributor.advisor-co1.fl_str_mv |
Silva, Marta Fernanda Albuquerque da |
dc.contributor.advisor-co1ID.fl_str_mv |
876.584.457-20 |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/0544591266946007 |
dc.contributor.authorID.fl_str_mv |
094.521.277-16 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/3567484495853227 |
dc.contributor.author.fl_str_mv |
Castro, Douglas dos Santos e |
contributor_str_mv |
Scherer, Paulo Oldemar Silva, Marta Fernanda Albuquerque da |
dc.subject.por.fl_str_mv |
tramadol morfina gatos analgesia epidural |
topic |
tramadol morfina gatos analgesia epidural morphine cats epidural analgesia Medicina Veterin?ria |
dc.subject.eng.fl_str_mv |
morphine cats epidural analgesia |
dc.subject.cnpq.fl_str_mv |
Medicina Veterin?ria |
description |
The purpose of this study was to compare the effectiveness and duration of the analgesic tramadol to the morphine, administered by the epidural route in cats (Felis catus domesticus) For this, six females cats were used, without defined breed, weighing between three and four kilograms and age ranging from one to three years. After fasting food, in 12 hours and water, four hours, the animals were subjected to general anesthesia with isoflurane through an anesthetic box, in order to allow the completion of the epidural technique. Each animal received at random, in a blind study, three epidural route treatments at intervals of one week between them, with: saline solution to 0.9% in a volume equivalent to 0.22ml.kg-1 (Control Group), tramadol 1 mg.kg-1 diluted in saline solution and volume equivalent to 0.22 ml.kg-1 (Tramadol Group) and morphine 0.1mg.kg-1 diluted in saline solution and volume equivalent to 0.22ml.kg-1 (Morphine Group). One hour after administration of each drug and general anesthesia recovery, the animals were subjected to painful stimuli in three pre-defined places: in the dorsal tail basis, the side of the right and left thigh, giving continuity, 2, 3, 4, 6, 8, 10 and 12 hours respectively. The pain was qualified by the implementation of two Simple Descriptive Scales (SDS), a Visual Analog Scale (VAS), measurement of heart and respiratory rate. For qualitative variables used in the Latin Square design 3 x 3 with the Kruskal-Wallis test and for the quantitative variables used in Analysis of Variance (ANOVA). There was no difference in relation to the time of anesthesia and respiratory frequency, However, the heart rate was significantly different (p<0.05) in hours two and four between control group and tramadol. In all scales used there were significant difference (p<0.05) in hours 8, 10 and 12. In these times the morphine produced more quality analgesia than the tramadol. Based on the results obtained, it can be concluded that the tramadol administered in epidural route resulted a satisfactory analgesia, without an adverse effects, but poorer than the morphine analgesia administered by the same route. |
publishDate |
2008 |
dc.date.available.fl_str_mv |
2008-04-24 |
dc.date.issued.fl_str_mv |
2008-01-17 |
dc.date.accessioned.fl_str_mv |
2016-04-28T20:18:27Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
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masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CASTRO, Douglas dos Santos e. Compara??o entre o efeito analg?sico da morfina e do tramadol epidural em gatos (Felis catus domesticus). 2008. 4 f. Disserta??o (Mestrado em Medicina Veterin?ria, Patologia e Ci?ncias Cl?nicas) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica - RJ, 2008. |
dc.identifier.uri.fl_str_mv |
https://tede.ufrrj.br/jspui/handle/tede/887 |
identifier_str_mv |
CASTRO, Douglas dos Santos e. Compara??o entre o efeito analg?sico da morfina e do tramadol epidural em gatos (Felis catus domesticus). 2008. 4 f. Disserta??o (Mestrado em Medicina Veterin?ria, Patologia e Ci?ncias Cl?nicas) - Instituto de Veterin?ria, Universidade Federal Rural do Rio de Janeiro, Serop?dica - RJ, 2008. |
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por |
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Universidade Federal Rural do Rio de Janeiro |
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Programa de P?s-Gradua??o em Medicina Veterin?ria (Patologia e Ci?ncias Cl?nicas) |
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UFRRJ |
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Brasil |
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Instituto de Veterin?ria |
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Universidade Federal Rural do Rio de Janeiro |
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