Quantificação do HBsAg : uma nova alternativa para o monitoramento da hepatite B crônica?
Autor(a) principal: | |
---|---|
Data de Publicação: | 2014 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFS |
Texto Completo: | https://ri.ufs.br/handle/riufs/3900 |
Resumo: | Although the level of HBsAg is determined only qualitatively in routine clinical practice, recent data suggest that its quantification can assist or replace the viral load of HBV DNA in monitoring of HBV replication, which would be an easier and more economical alternative. Thus, the aim of this study was to correlate the levels of HBsAg with viral load of HBV DNA and other laboratory (HBeAg, ALT and AST) and histological (activity and fibrosis) findings in patients with chronic hepatitis B. A prospective, observational, cross-sectional study was performed on 128 patients with chronic hepatitis B, aged over 18 years, from the Hepatology Service of the University Hospital of Sergipe. Categorical variables were presented as frequencies and percentages with range of 95% where applicable. For the correlation analysis we used the Spearman test. It was considered that the correlations had statistical significance when ρ≤ 0.05. The overall correlation between HBV viral load and quantitative HBsAg was weak (ρ= 0.197, ρ= 0.026), and this same correlation was also weak and not statistically significant in HBeAg-positive patients (ρ= 0.233, ρ= 0.263). However, a strong correlation between HBsAg and HBV DNA >20,000 in HBeAgpositive patients was found. A regular correlation between HBsAg and HBV DNA in patients who were not on treatment (*ρ= 0394; ρ<0.001) was found and there was no significant correlation in patients receiving treatment (*ρ= -0.061; ρ= 0.673). No statistically significant association was observed between the levels of HBsAg and HBeAg, even when considering only the positive HBeAg (ρ: 0.121; ρ=0.565) and even not only the negative HBeAg (ρ =-0.067; ρ=0.501). The correlation between HBV DNA and HBeAg positive was fair (ρ =0.444; ρ=0.026). There was no statistical correlation between the levels of HBsAg and aminotransferases (ALT and AST). The distribution of HBsAg values did not differ between the degree of activity (ρ= 0.17) and fibrosis (ρ= 0.20). Conclusion: Our results show that, in general, the correlation between levels of HBsAg and HBV DNA exists, but it proved to be weak. Also, they suggest that HBsAg better reflects HBV DNA in the initial replicative phase of chronic hepatitis B, when patients present HBV reagent and high titers of HBeAg viral load. They also show that there is no association of HBsAg with aminotransferases or with the degree of activity and liver fibrosis. |
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Moura, Renata Dultra Torreshttp://lattes.cnpq.br/6185407445596761França, Alex Vianey Calladohttp://lattes.cnpq.br/12542233091634672017-09-26T12:18:49Z2017-09-26T12:18:49Z2014-04-22MOURA, Renata Dultra Torres. Quantification of hbsag: a new alternative for monitoring of chronic hepatitis b?. 2014. 74 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Sergipe, Aracaju, 2014.https://ri.ufs.br/handle/riufs/3900Although the level of HBsAg is determined only qualitatively in routine clinical practice, recent data suggest that its quantification can assist or replace the viral load of HBV DNA in monitoring of HBV replication, which would be an easier and more economical alternative. Thus, the aim of this study was to correlate the levels of HBsAg with viral load of HBV DNA and other laboratory (HBeAg, ALT and AST) and histological (activity and fibrosis) findings in patients with chronic hepatitis B. A prospective, observational, cross-sectional study was performed on 128 patients with chronic hepatitis B, aged over 18 years, from the Hepatology Service of the University Hospital of Sergipe. Categorical variables were presented as frequencies and percentages with range of 95% where applicable. For the correlation analysis we used the Spearman test. It was considered that the correlations had statistical significance when ρ≤ 0.05. The overall correlation between HBV viral load and quantitative HBsAg was weak (ρ= 0.197, ρ= 0.026), and this same correlation was also weak and not statistically significant in HBeAg-positive patients (ρ= 0.233, ρ= 0.263). However, a strong correlation between HBsAg and HBV DNA >20,000 in HBeAgpositive patients was found. A regular correlation between HBsAg and HBV DNA in patients who were not on treatment (*ρ= 0394; ρ<0.001) was found and there was no significant correlation in patients receiving treatment (*ρ= -0.061; ρ= 0.673). No statistically significant association was observed between the levels of HBsAg and HBeAg, even when considering only the positive HBeAg (ρ: 0.121; ρ=0.565) and even not only the negative HBeAg (ρ =-0.067; ρ=0.501). The correlation between HBV DNA and HBeAg positive was fair (ρ =0.444; ρ=0.026). There was no statistical correlation between the levels of HBsAg and aminotransferases (ALT and AST). The distribution of HBsAg values did not differ between the degree of activity (ρ= 0.17) and fibrosis (ρ= 0.20). Conclusion: Our results show that, in general, the correlation between levels of HBsAg and HBV DNA exists, but it proved to be weak. Also, they suggest that HBsAg better reflects HBV DNA in the initial replicative phase of chronic hepatitis B, when patients present HBV reagent and high titers of HBeAg viral load. They also show that there is no association of HBsAg with aminotransferases or with the degree of activity and liver fibrosis.Embora o nível de HBsAg seja determinado apenas qualitativamente na prática clínica rotineira, dados recentes sugerem que a sua quantificação pode auxiliar ou substituir a carga viral do VHB DNA no monitoramento da replicação do VHB, o que seria uma alternativa mais fácil e econômica. Desta forma, objetivou-se com este estudo, correlacionar os níveis de HBsAg com a carga viral do VHB DNA e com outros achados laboratoriais (HBeAg, ALT e AST) e histológicos (atividade e fibrose) em pacientes com hepatite B Crônica. Foi realizado um estudo observacional, prospectivo, transversal, com 128 pacientes portadores de hepatite B crônica, com idade igual ou superior a 18 anos, oriundos do Serviço de Hepatologia do Hospital Universitário de Sergipe. As variáveis categóricas foram apresentadas através de frequências e percentuais com intervalo de 95% quando pertinente. Para a análise das correlações utilizou-se o teste de Spearman. Considerou-se que as correlações possuíam significância estatística quando p ≤ 0,05. A correlação global entre a carga viral do VHB e o HBsAg quantitativo foi fraca (ρ=0,197; p=0,026); esta mesma correlação também foi fraca e sem significância estatística nos pacientes HBeAg positivos (ρ =0.233; p=0,263). Porém, foi encontrada uma forte correlação entre o HBsAg e o VHB DNA > 20.000, nos pacientes HBeAg positivos. Foi observada uma correlação regular entre o HBsAg e o VHB DNA nos pacientes que não estavam em tratamento (*ρ= 0394; p <0,001) e não existiu correlação significante nos pacientes em tratamento (*ρ= -0,061; p= 0,673). Não se observou associação estatisticamente significante entre os níveis de HBsAg e HBeAg, nem quando se considerou apenas os HBeAg positivos (ρ: 0,121; p=0,565) e nem apenas os HBeAg negativos (ρ =-0,067; p=0,501). A correlação entre o VHB DNA e o HBeAg positivo foi regular (ρ =0,444; p=0,026). Não foi verificada correlação estatística entre os níveis de HBsAg e as aminotransferases (ALT e AST). A distribuição dos valores de HBsAg não diferiu entre os graus de atividade (p=0,17) e fibrose (p=0,20). Conclusão: Os nossos resultados mostram que, de uma forma geral, a correlação entre os níveis de HBsAg e VHB DNA existe, mas é fraca. E sugerem que o HBsAg reflete melhor o VHB DNA na fase replicativa inicial da hepatite B crônica, quando os pacientes possuem HBeAg reagente e altos títulos de carga viral do VHB. Demonstram também que não existe associação do HBsAg com aminotransferases nem com o grau de atividade e fibrose hepática.application/pdfporUniversidade Federal de SergipePós-Graduação em Ciências da SaúdeUFSBRHepatite BAntígenos de superfície da hepatite BFígado - DoençasHepatologiaHepatite B crônicaHBsAg quantitativoVHB DNAChronic hepatitis BQuantitative HBsAgHBV DNACNPQ::CIENCIAS DA SAUDEQuantificação do HBsAg : uma nova alternativa para o monitoramento da hepatite B crônica?Quantification of hbsag: a new alternative for monitoring of chronic hepatitis b?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSTEXTRENATA_DULTRA_TORRES_MOURA.pdf.txtRENATA_DULTRA_TORRES_MOURA.pdf.txtExtracted texttext/plain141268https://ri.ufs.br/jspui/bitstream/riufs/3900/2/RENATA_DULTRA_TORRES_MOURA.pdf.txt21cf9791dc94d9128a76250064072acbMD52THUMBNAILRENATA_DULTRA_TORRES_MOURA.pdf.jpgRENATA_DULTRA_TORRES_MOURA.pdf.jpgGenerated Thumbnailimage/jpeg1264https://ri.ufs.br/jspui/bitstream/riufs/3900/3/RENATA_DULTRA_TORRES_MOURA.pdf.jpg6dc36ad87c517f5d86e22156b4605b64MD53ORIGINALRENATA_DULTRA_TORRES_MOURA.pdfapplication/pdf6756257https://ri.ufs.br/jspui/bitstream/riufs/3900/1/RENATA_DULTRA_TORRES_MOURA.pdfb79ff78018c5f03aa3bc2a8fa14846f7MD51riufs/39002017-11-28 17:00:27.59oai:ufs.br:riufs/3900Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2017-11-28T20:00:27Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
dc.title.por.fl_str_mv |
Quantificação do HBsAg : uma nova alternativa para o monitoramento da hepatite B crônica? |
dc.title.alternative.eng.fl_str_mv |
Quantification of hbsag: a new alternative for monitoring of chronic hepatitis b? |
title |
Quantificação do HBsAg : uma nova alternativa para o monitoramento da hepatite B crônica? |
spellingShingle |
Quantificação do HBsAg : uma nova alternativa para o monitoramento da hepatite B crônica? Moura, Renata Dultra Torres Hepatite B Antígenos de superfície da hepatite B Fígado - Doenças Hepatologia Hepatite B crônica HBsAg quantitativo VHB DNA Chronic hepatitis B Quantitative HBsAg HBV DNA CNPQ::CIENCIAS DA SAUDE |
title_short |
Quantificação do HBsAg : uma nova alternativa para o monitoramento da hepatite B crônica? |
title_full |
Quantificação do HBsAg : uma nova alternativa para o monitoramento da hepatite B crônica? |
title_fullStr |
Quantificação do HBsAg : uma nova alternativa para o monitoramento da hepatite B crônica? |
title_full_unstemmed |
Quantificação do HBsAg : uma nova alternativa para o monitoramento da hepatite B crônica? |
title_sort |
Quantificação do HBsAg : uma nova alternativa para o monitoramento da hepatite B crônica? |
author |
Moura, Renata Dultra Torres |
author_facet |
Moura, Renata Dultra Torres |
author_role |
author |
dc.contributor.author.fl_str_mv |
Moura, Renata Dultra Torres |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/6185407445596761 |
dc.contributor.advisor1.fl_str_mv |
França, Alex Vianey Callado |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/1254223309163467 |
contributor_str_mv |
França, Alex Vianey Callado |
dc.subject.por.fl_str_mv |
Hepatite B Antígenos de superfície da hepatite B Fígado - Doenças Hepatologia Hepatite B crônica HBsAg quantitativo VHB DNA |
topic |
Hepatite B Antígenos de superfície da hepatite B Fígado - Doenças Hepatologia Hepatite B crônica HBsAg quantitativo VHB DNA Chronic hepatitis B Quantitative HBsAg HBV DNA CNPQ::CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
Chronic hepatitis B Quantitative HBsAg HBV DNA |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS DA SAUDE |
description |
Although the level of HBsAg is determined only qualitatively in routine clinical practice, recent data suggest that its quantification can assist or replace the viral load of HBV DNA in monitoring of HBV replication, which would be an easier and more economical alternative. Thus, the aim of this study was to correlate the levels of HBsAg with viral load of HBV DNA and other laboratory (HBeAg, ALT and AST) and histological (activity and fibrosis) findings in patients with chronic hepatitis B. A prospective, observational, cross-sectional study was performed on 128 patients with chronic hepatitis B, aged over 18 years, from the Hepatology Service of the University Hospital of Sergipe. Categorical variables were presented as frequencies and percentages with range of 95% where applicable. For the correlation analysis we used the Spearman test. It was considered that the correlations had statistical significance when ρ≤ 0.05. The overall correlation between HBV viral load and quantitative HBsAg was weak (ρ= 0.197, ρ= 0.026), and this same correlation was also weak and not statistically significant in HBeAg-positive patients (ρ= 0.233, ρ= 0.263). However, a strong correlation between HBsAg and HBV DNA >20,000 in HBeAgpositive patients was found. A regular correlation between HBsAg and HBV DNA in patients who were not on treatment (*ρ= 0394; ρ<0.001) was found and there was no significant correlation in patients receiving treatment (*ρ= -0.061; ρ= 0.673). No statistically significant association was observed between the levels of HBsAg and HBeAg, even when considering only the positive HBeAg (ρ: 0.121; ρ=0.565) and even not only the negative HBeAg (ρ =-0.067; ρ=0.501). The correlation between HBV DNA and HBeAg positive was fair (ρ =0.444; ρ=0.026). There was no statistical correlation between the levels of HBsAg and aminotransferases (ALT and AST). The distribution of HBsAg values did not differ between the degree of activity (ρ= 0.17) and fibrosis (ρ= 0.20). Conclusion: Our results show that, in general, the correlation between levels of HBsAg and HBV DNA exists, but it proved to be weak. Also, they suggest that HBsAg better reflects HBV DNA in the initial replicative phase of chronic hepatitis B, when patients present HBV reagent and high titers of HBeAg viral load. They also show that there is no association of HBsAg with aminotransferases or with the degree of activity and liver fibrosis. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-04-22 |
dc.date.accessioned.fl_str_mv |
2017-09-26T12:18:49Z |
dc.date.available.fl_str_mv |
2017-09-26T12:18:49Z |
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info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
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masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MOURA, Renata Dultra Torres. Quantification of hbsag: a new alternative for monitoring of chronic hepatitis b?. 2014. 74 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Sergipe, Aracaju, 2014. |
dc.identifier.uri.fl_str_mv |
https://ri.ufs.br/handle/riufs/3900 |
identifier_str_mv |
MOURA, Renata Dultra Torres. Quantification of hbsag: a new alternative for monitoring of chronic hepatitis b?. 2014. 74 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Sergipe, Aracaju, 2014. |
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https://ri.ufs.br/handle/riufs/3900 |
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Universidade Federal de Sergipe |
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Pós-Graduação em Ciências da Saúde |
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UFS |
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BR |
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Universidade Federal de Sergipe |
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