Toxicidade aguda e efeitos analgésico e depressor do extrato aquoso obtido das folhas de Pluchea sagittalis (Lam.) Cabrera (quitoco)

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Sheyla Alves
Data de Publicação: 2007
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFS
Texto Completo: https://ri.ufs.br/handle/riufs/3844
Resumo: The Pluchea sagittalis (Lam) Cabreira, Family Asteraceae, is a plant of the Atlantic Reainforest used in traditional medicine for the treatment of inflammation, as well as of digestive and respiratory diseases. The objective of this dissertation work was to study the possible effects of the aqueous extract of Pluchea sagittalis (Lam) Cabreira, on the Central Nervous System and acute toxicity in mice. This plant is used in traditional medicine for the treatment of inflammation, as well as of digestive and respiratory diseases. The Acute Toxicity (DL50) was gotten by the administration of the doses 1000, 2000 and 3000 mg/Kg, in according to legislation by National Agency of Sanitary Vigilance (ANVISA), but not being observed toxic effect. The possibilities of pharmacological actions had been analyzed by the test of screening pharmacological that showed the possible action of the extract as depress of the CNS. The antinociceptive effect was evaluated by using two models: acetic acid induced writhing and Tail-Flick test. In the first one was showed the analgesic effect of the extract with values of p > 0,01 in the dose of 200mg/Kg and p < 0,001 in the dose of 100 and 400 mg/Kg, when compared with the control group. The Tail-Flick test confirmed the analgesic effect of the extract with values of p<0,001, for all the doses, in the time of 30 and 60 minutes, with detach it 120 minutes after dose of 400 mg/Kg that kept p<0,001. On the sleep-induced by thiopental the extract was showed significance with p<0,05 at the return of the righting reflex and p<0,001, in the total time of sleep, for all the doses, with detach for the dose of 400 mg/Kg that showed the best effect. Thus the tests acetic acid induced writhing, Tail-Flick and sleep-induced by thiopental come to confirm the effect depress of this plant on the central nervous system initially identified for the screening pharmacological e for the traditional medicine.
id UFS-2_0f2a70e2fbe67c073772cb73c7a9a315
oai_identifier_str oai:ufs.br:riufs/3844
network_acronym_str UFS-2
network_name_str Repositório Institucional da UFS
repository_id_str
spelling Rodrigues, Sheyla Alveshttp://lattes.cnpq.br/0236515445675827Marchioro, Murilohttp://lattes.cnpq.br/14000388753154102017-09-26T12:17:58Z2017-09-26T12:17:58Z2007-04-03RODRIGUES, Sheyla Alves. TOXICIDADE AGUDA E EFEITOS ANALGÉSICO E DEPRESSOR DO EXTRATO AQUOSO OBTIDO DAS FOLHAS DE Pluchea sagittalis (Lam.) Cabrera (quitoco).. 2007. 70 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Sergipe, Aracaju, 2007.https://ri.ufs.br/handle/riufs/3844The Pluchea sagittalis (Lam) Cabreira, Family Asteraceae, is a plant of the Atlantic Reainforest used in traditional medicine for the treatment of inflammation, as well as of digestive and respiratory diseases. The objective of this dissertation work was to study the possible effects of the aqueous extract of Pluchea sagittalis (Lam) Cabreira, on the Central Nervous System and acute toxicity in mice. This plant is used in traditional medicine for the treatment of inflammation, as well as of digestive and respiratory diseases. The Acute Toxicity (DL50) was gotten by the administration of the doses 1000, 2000 and 3000 mg/Kg, in according to legislation by National Agency of Sanitary Vigilance (ANVISA), but not being observed toxic effect. The possibilities of pharmacological actions had been analyzed by the test of screening pharmacological that showed the possible action of the extract as depress of the CNS. The antinociceptive effect was evaluated by using two models: acetic acid induced writhing and Tail-Flick test. In the first one was showed the analgesic effect of the extract with values of p > 0,01 in the dose of 200mg/Kg and p < 0,001 in the dose of 100 and 400 mg/Kg, when compared with the control group. The Tail-Flick test confirmed the analgesic effect of the extract with values of p<0,001, for all the doses, in the time of 30 and 60 minutes, with detach it 120 minutes after dose of 400 mg/Kg that kept p<0,001. On the sleep-induced by thiopental the extract was showed significance with p<0,05 at the return of the righting reflex and p<0,001, in the total time of sleep, for all the doses, with detach for the dose of 400 mg/Kg that showed the best effect. Thus the tests acetic acid induced writhing, Tail-Flick and sleep-induced by thiopental come to confirm the effect depress of this plant on the central nervous system initially identified for the screening pharmacological e for the traditional medicine.A Pluchea sagittalis (Lam.) Cabrera, da Família Asteraceae, é uma planta da Mata Atlântica utilizada na medicina tradicional no tratamento de inflamação, assim como de doenças digestivas e respiratórias. O objetivo deste trabalho de dissertação foi estudar os possíveis efeitos do extrato aquoso das folhas de Pluchea sagittalis (Lam.) Cabrera, sobre o Sistema Nervoso Central em modelo murino, e, como a toxicidade aguda do extrato. A Toxicidade Aguda ou DL50 foi obtida pela administração das doses 1000, 2000 e 3000mg/Kg, segundo a legislação de medicamentos fitoterápicos da Agência Nacional de Vigilância Sanitária (ANVISA), não sendo observado efeito tóxico. As possibilidades de ação farmacológica foram analisadas pelo teste de triagem farmacológica que demonstrou a possível ação do extrato como depressor do SNC. O efeito anti-nociceptivo foi estudado usando dois modelos: Teste de Contorção abdominal induzida por ácido acético e Tail-Flick. No primeiro observou-se o efeito analgésico do extrato com valores de p<0,01 na dose de 200mg/Kg e p<0,001 nas de 100mg/Kg e 400mg/Kg, quando comparado ao grupo controle. O Tail-Flick confirmou o efeito analgésico do extrato com valores de p<0,001, nos tempos de 30 e 60 minutos para todas as doses, destacando-se a dose de 400mg/Kg que manteve p<0,001 após 120 min. No Teste de Tempo de Sono Induzido por Barbitúrico observou-se diferença significativa com p<0,05 para retornar o reflexo de endireitamento e p<0,001, no tempo total de sono, para todas as doses, com destaque para a dose de 400 mg/Kg que apresentou melhor efeito. Assim os testes de contorção abdominal, Tail-Flick e tempo de sono induzido por barbitúrico confirmaram o efeito depressor dessa planta sobre o sistema nervoso central identificado inicialmente pela triagem farmacológica e a medicina tradicional.Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorapplication/pdfporUniversidade Federal de SergipePós-Graduação em Ciências da SaúdeUFSBRPluchea sagittalisToxicidade agudaDepressorAnti-nocicepçãoPluchea sagittalisAcute toxicityDepressAnti-nociceptiveCNPQ::CIENCIAS DA SAUDE::MEDICINAToxicidade aguda e efeitos analgésico e depressor do extrato aquoso obtido das folhas de Pluchea sagittalis (Lam.) Cabrera (quitoco)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSTEXTSHEYLA_ALVES_RODRIGUES.pdf.txtSHEYLA_ALVES_RODRIGUES.pdf.txtExtracted texttext/plain105473https://ri.ufs.br/jspui/bitstream/riufs/3844/2/SHEYLA_ALVES_RODRIGUES.pdf.txt1ccd3ed77ed3994d7489c0424cec5194MD52THUMBNAILSHEYLA_ALVES_RODRIGUES.pdf.jpgSHEYLA_ALVES_RODRIGUES.pdf.jpgGenerated Thumbnailimage/jpeg1203https://ri.ufs.br/jspui/bitstream/riufs/3844/3/SHEYLA_ALVES_RODRIGUES.pdf.jpgc62dfa7a4b6393f489a3b150748951ccMD53ORIGINALSHEYLA_ALVES_RODRIGUES.pdfapplication/pdf644610https://ri.ufs.br/jspui/bitstream/riufs/3844/1/SHEYLA_ALVES_RODRIGUES.pdf845ee8710186843790459edefbec4b7eMD51riufs/38442017-11-28 17:02:40.556oai:ufs.br:riufs/3844Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2017-11-28T20:02:40Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false
dc.title.por.fl_str_mv Toxicidade aguda e efeitos analgésico e depressor do extrato aquoso obtido das folhas de Pluchea sagittalis (Lam.) Cabrera (quitoco)
title Toxicidade aguda e efeitos analgésico e depressor do extrato aquoso obtido das folhas de Pluchea sagittalis (Lam.) Cabrera (quitoco)
spellingShingle Toxicidade aguda e efeitos analgésico e depressor do extrato aquoso obtido das folhas de Pluchea sagittalis (Lam.) Cabrera (quitoco)
Rodrigues, Sheyla Alves
Pluchea sagittalis
Toxicidade aguda
Depressor
Anti-nocicepção
Pluchea sagittalis
Acute toxicity
Depress
Anti-nociceptive
CNPQ::CIENCIAS DA SAUDE::MEDICINA
title_short Toxicidade aguda e efeitos analgésico e depressor do extrato aquoso obtido das folhas de Pluchea sagittalis (Lam.) Cabrera (quitoco)
title_full Toxicidade aguda e efeitos analgésico e depressor do extrato aquoso obtido das folhas de Pluchea sagittalis (Lam.) Cabrera (quitoco)
title_fullStr Toxicidade aguda e efeitos analgésico e depressor do extrato aquoso obtido das folhas de Pluchea sagittalis (Lam.) Cabrera (quitoco)
title_full_unstemmed Toxicidade aguda e efeitos analgésico e depressor do extrato aquoso obtido das folhas de Pluchea sagittalis (Lam.) Cabrera (quitoco)
title_sort Toxicidade aguda e efeitos analgésico e depressor do extrato aquoso obtido das folhas de Pluchea sagittalis (Lam.) Cabrera (quitoco)
author Rodrigues, Sheyla Alves
author_facet Rodrigues, Sheyla Alves
author_role author
dc.contributor.author.fl_str_mv Rodrigues, Sheyla Alves
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/0236515445675827
dc.contributor.advisor1.fl_str_mv Marchioro, Murilo
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/1400038875315410
contributor_str_mv Marchioro, Murilo
dc.subject.por.fl_str_mv Pluchea sagittalis
Toxicidade aguda
Depressor
Anti-nocicepção
topic Pluchea sagittalis
Toxicidade aguda
Depressor
Anti-nocicepção
Pluchea sagittalis
Acute toxicity
Depress
Anti-nociceptive
CNPQ::CIENCIAS DA SAUDE::MEDICINA
dc.subject.eng.fl_str_mv Pluchea sagittalis
Acute toxicity
Depress
Anti-nociceptive
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS DA SAUDE::MEDICINA
description The Pluchea sagittalis (Lam) Cabreira, Family Asteraceae, is a plant of the Atlantic Reainforest used in traditional medicine for the treatment of inflammation, as well as of digestive and respiratory diseases. The objective of this dissertation work was to study the possible effects of the aqueous extract of Pluchea sagittalis (Lam) Cabreira, on the Central Nervous System and acute toxicity in mice. This plant is used in traditional medicine for the treatment of inflammation, as well as of digestive and respiratory diseases. The Acute Toxicity (DL50) was gotten by the administration of the doses 1000, 2000 and 3000 mg/Kg, in according to legislation by National Agency of Sanitary Vigilance (ANVISA), but not being observed toxic effect. The possibilities of pharmacological actions had been analyzed by the test of screening pharmacological that showed the possible action of the extract as depress of the CNS. The antinociceptive effect was evaluated by using two models: acetic acid induced writhing and Tail-Flick test. In the first one was showed the analgesic effect of the extract with values of p > 0,01 in the dose of 200mg/Kg and p < 0,001 in the dose of 100 and 400 mg/Kg, when compared with the control group. The Tail-Flick test confirmed the analgesic effect of the extract with values of p<0,001, for all the doses, in the time of 30 and 60 minutes, with detach it 120 minutes after dose of 400 mg/Kg that kept p<0,001. On the sleep-induced by thiopental the extract was showed significance with p<0,05 at the return of the righting reflex and p<0,001, in the total time of sleep, for all the doses, with detach for the dose of 400 mg/Kg that showed the best effect. Thus the tests acetic acid induced writhing, Tail-Flick and sleep-induced by thiopental come to confirm the effect depress of this plant on the central nervous system initially identified for the screening pharmacological e for the traditional medicine.
publishDate 2007
dc.date.issued.fl_str_mv 2007-04-03
dc.date.accessioned.fl_str_mv 2017-09-26T12:17:58Z
dc.date.available.fl_str_mv 2017-09-26T12:17:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv RODRIGUES, Sheyla Alves. TOXICIDADE AGUDA E EFEITOS ANALGÉSICO E DEPRESSOR DO EXTRATO AQUOSO OBTIDO DAS FOLHAS DE Pluchea sagittalis (Lam.) Cabrera (quitoco).. 2007. 70 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Sergipe, Aracaju, 2007.
dc.identifier.uri.fl_str_mv https://ri.ufs.br/handle/riufs/3844
identifier_str_mv RODRIGUES, Sheyla Alves. TOXICIDADE AGUDA E EFEITOS ANALGÉSICO E DEPRESSOR DO EXTRATO AQUOSO OBTIDO DAS FOLHAS DE Pluchea sagittalis (Lam.) Cabrera (quitoco).. 2007. 70 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Sergipe, Aracaju, 2007.
url https://ri.ufs.br/handle/riufs/3844
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Sergipe
dc.publisher.program.fl_str_mv Pós-Graduação em Ciências da Saúde
dc.publisher.initials.fl_str_mv UFS
dc.publisher.country.fl_str_mv BR
publisher.none.fl_str_mv Universidade Federal de Sergipe
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFS
instname:Universidade Federal de Sergipe (UFS)
instacron:UFS
instname_str Universidade Federal de Sergipe (UFS)
instacron_str UFS
institution UFS
reponame_str Repositório Institucional da UFS
collection Repositório Institucional da UFS
bitstream.url.fl_str_mv https://ri.ufs.br/jspui/bitstream/riufs/3844/2/SHEYLA_ALVES_RODRIGUES.pdf.txt
https://ri.ufs.br/jspui/bitstream/riufs/3844/3/SHEYLA_ALVES_RODRIGUES.pdf.jpg
https://ri.ufs.br/jspui/bitstream/riufs/3844/1/SHEYLA_ALVES_RODRIGUES.pdf
bitstream.checksum.fl_str_mv 1ccd3ed77ed3994d7489c0424cec5194
c62dfa7a4b6393f489a3b150748951cc
845ee8710186843790459edefbec4b7e
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)
repository.mail.fl_str_mv repositorio@academico.ufs.br
_version_ 1802110741465006080