Antinociceptive action and redox properties of citronellal, an essential oil present in lemongrass

Detalhes bibliográficos
Autor(a) principal: Quintans-Júnior, Lucindo José
Data de Publicação: 2011
Outros Autores: Rocha, Ricardo Fagundes da, Caregnato, Fernanda Freitas, Moreira, José Cláudio Fonseca, Silva, Francilene Amaral da, Araújo, Adriano Antunes de Souza, Santos, João Paulo Almeida dos, Melo, Mônica Santos de, Sousa, Damião Pergentino de, Bonjardim, Leonardo Rigoldi, Gelain, Daniel Pens
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFS
Texto Completo: http://online.liebertpub.com/doi/full/10.1089/jmf.2010.0125
https://ri.ufs.br/handle/riufs/620
Resumo: This is a copy of an article published in the Journal of Medicinal Food© 2011 - copyright Mary Ann Liebert, Inc.; Journal of Medicinal Food is available online at: http://online.liebertpub.com
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spelling Quintans-Júnior, Lucindo JoséRocha, Ricardo Fagundes daCaregnato, Fernanda FreitasMoreira, José Cláudio FonsecaSilva, Francilene Amaral daAraújo, Adriano Antunes de SouzaSantos, João Paulo Almeida dosMelo, Mônica Santos deSousa, Damião Pergentino deBonjardim, Leonardo RigoldiGelain, Daniel Pens2013-06-21T23:40:05Z2013-06-21T23:40:05Z2011-05QUINTANS-JÚNIOR, L. J. et al. Antinociceptive action and redox properties of citronellal, an essential oil present in lemongrass. Journal of Medicinal Food, San Diego, v. 14, n. 6, p. 630-639, maio 2011. Disponível em: <http://online.liebertpub.com/doi/full/10.1089/jmf.2010.0125>. Acesso em: 21 jun. 2013.1557-7600http://online.liebertpub.com/doi/full/10.1089/jmf.2010.0125https://ri.ufs.br/handle/riufs/620Mary Ann Liebert, Inc.This is a copy of an article published in the Journal of Medicinal Food© 2011 - copyright Mary Ann Liebert, Inc.; Journal of Medicinal Food is available online at: http://online.liebertpub.comCitronellal (CT) is a monoterpenoid and the major constituent of the mixture of terpenoids that give the citronella oil its lemon scent. Citronella oil is widely used around the world for various purposes and is mainly obtained from plants of the Cymbopogon genus, which are known as “lemongrass.” Considering these plants have been used worldwide for various medicinal purposes, the interest of researchers to understand the biological activities of monoterpenoids related to the Cymbopogon genus has been increasing. In the present work, we investigated the antinociceptive action and the redox properties of CT. Our results indicate that intraperitoneal injection of CT was effective in reducing nociceptive face-rubbing behavior in both phases of the formalin test, which was also naloxone-sensitive. CT also evoked antinociceptive response in the capsaicin and glutamate tests. The total radical-trapping antioxidant parameter and total antioxidant reactivity assays indicate that CT at doses of 0.1 and 1 mg/mL exerts a significant antioxidant activity, which is probably related to its ability to scavenge superoxide and nitric oxide, but not H2O2 or hydroxyl radicals, as evaluated separately by specific in vitro tests. These results show for the first time the antinociceptive potential of CT and indicate that the antioxidant properties of this compound may rely on its mechanism of biological actions because CT-containing natural products are used to treat various diseases related to oxidative stress and reactive species.Mary Ann Liebert, Inc.Atividade antinociceptivaPropriedades redoxCitronelaÓleos essenciaisCapim-limãoAntinociceptive action and redox properties of citronellal, an essential oil present in lemongrassinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTHUMBNAILAntinociceptiveActionLemongrass.pdf.jpgAntinociceptiveActionLemongrass.pdf.jpgGenerated Thumbnailimage/jpeg1641https://ri.ufs.br/jspui/bitstream/riufs/620/4/AntinociceptiveActionLemongrass.pdf.jpg0539cb0f465aef1ef182f5fe58da0a28MD54ORIGINALAntinociceptiveActionLemongrass.pdfAntinociceptiveActionLemongrass.pdfapplication/pdf390329https://ri.ufs.br/jspui/bitstream/riufs/620/1/AntinociceptiveActionLemongrass.pdff090cebfac018f38e5fd7494a55ed4cbMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://ri.ufs.br/jspui/bitstream/riufs/620/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTAntinociceptiveActionLemongrass.pdf.txtAntinociceptiveActionLemongrass.pdf.txtExtracted texttext/plain48561https://ri.ufs.br/jspui/bitstream/riufs/620/3/AntinociceptiveActionLemongrass.pdf.txt0a99654e360b52ec08d5678af934c7abMD53riufs/6202013-12-20 16:50:18.741oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2013-12-20T19:50:18Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false
dc.title.pt_BR.fl_str_mv Antinociceptive action and redox properties of citronellal, an essential oil present in lemongrass
title Antinociceptive action and redox properties of citronellal, an essential oil present in lemongrass
spellingShingle Antinociceptive action and redox properties of citronellal, an essential oil present in lemongrass
Quintans-Júnior, Lucindo José
Atividade antinociceptiva
Propriedades redox
Citronela
Óleos essenciais
Capim-limão
title_short Antinociceptive action and redox properties of citronellal, an essential oil present in lemongrass
title_full Antinociceptive action and redox properties of citronellal, an essential oil present in lemongrass
title_fullStr Antinociceptive action and redox properties of citronellal, an essential oil present in lemongrass
title_full_unstemmed Antinociceptive action and redox properties of citronellal, an essential oil present in lemongrass
title_sort Antinociceptive action and redox properties of citronellal, an essential oil present in lemongrass
author Quintans-Júnior, Lucindo José
author_facet Quintans-Júnior, Lucindo José
Rocha, Ricardo Fagundes da
Caregnato, Fernanda Freitas
Moreira, José Cláudio Fonseca
Silva, Francilene Amaral da
Araújo, Adriano Antunes de Souza
Santos, João Paulo Almeida dos
Melo, Mônica Santos de
Sousa, Damião Pergentino de
Bonjardim, Leonardo Rigoldi
Gelain, Daniel Pens
author_role author
author2 Rocha, Ricardo Fagundes da
Caregnato, Fernanda Freitas
Moreira, José Cláudio Fonseca
Silva, Francilene Amaral da
Araújo, Adriano Antunes de Souza
Santos, João Paulo Almeida dos
Melo, Mônica Santos de
Sousa, Damião Pergentino de
Bonjardim, Leonardo Rigoldi
Gelain, Daniel Pens
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Quintans-Júnior, Lucindo José
Rocha, Ricardo Fagundes da
Caregnato, Fernanda Freitas
Moreira, José Cláudio Fonseca
Silva, Francilene Amaral da
Araújo, Adriano Antunes de Souza
Santos, João Paulo Almeida dos
Melo, Mônica Santos de
Sousa, Damião Pergentino de
Bonjardim, Leonardo Rigoldi
Gelain, Daniel Pens
dc.subject.por.fl_str_mv Atividade antinociceptiva
Propriedades redox
Citronela
Óleos essenciais
Capim-limão
topic Atividade antinociceptiva
Propriedades redox
Citronela
Óleos essenciais
Capim-limão
description This is a copy of an article published in the Journal of Medicinal Food© 2011 - copyright Mary Ann Liebert, Inc.; Journal of Medicinal Food is available online at: http://online.liebertpub.com
publishDate 2011
dc.date.issued.fl_str_mv 2011-05
dc.date.accessioned.fl_str_mv 2013-06-21T23:40:05Z
dc.date.available.fl_str_mv 2013-06-21T23:40:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv QUINTANS-JÚNIOR, L. J. et al. Antinociceptive action and redox properties of citronellal, an essential oil present in lemongrass. Journal of Medicinal Food, San Diego, v. 14, n. 6, p. 630-639, maio 2011. Disponível em: <http://online.liebertpub.com/doi/full/10.1089/jmf.2010.0125>. Acesso em: 21 jun. 2013.
dc.identifier.uri.fl_str_mv http://online.liebertpub.com/doi/full/10.1089/jmf.2010.0125
https://ri.ufs.br/handle/riufs/620
dc.identifier.issn.none.fl_str_mv 1557-7600
dc.identifier.license.pt_BR.fl_str_mv Mary Ann Liebert, Inc.
identifier_str_mv QUINTANS-JÚNIOR, L. J. et al. Antinociceptive action and redox properties of citronellal, an essential oil present in lemongrass. Journal of Medicinal Food, San Diego, v. 14, n. 6, p. 630-639, maio 2011. Disponível em: <http://online.liebertpub.com/doi/full/10.1089/jmf.2010.0125>. Acesso em: 21 jun. 2013.
1557-7600
Mary Ann Liebert, Inc.
url http://online.liebertpub.com/doi/full/10.1089/jmf.2010.0125
https://ri.ufs.br/handle/riufs/620
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dc.publisher.none.fl_str_mv Mary Ann Liebert, Inc.
publisher.none.fl_str_mv Mary Ann Liebert, Inc.
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