Efeitos do treinamento resistido de baixa intensidade em variáveis cardiovasculares e reatividade vascular de ratos

Detalhes bibliográficos
Autor(a) principal: Macedo, Fabrício Nunes
Data de Publicação: 2014
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFS
Texto Completo: https://ri.ufs.br/handle/riufs/3987
Resumo: Low intensity aerobic training increases cardiac vagal modulation and reduces sympathetic activity. These adaptations are factors to prediction of healthy. Resistance training (TR) is am usual component of fitness programs, however the effects on autonomic regulation are not totally clear. Our hypothesis is low intensity resistance training promotes beneficial adaptations in cardiac autonomic modulation, as aerobic exercise. Therefore, the aim was to evaluate the effects of low intensity TR on blood pressure, cardiovascular autonomic balance and vascular reactivity. One group of animals were submitted to TR, trained group (GT). Control animals (CO) were fictitious trained (no exercise). After 8 weeks of TR with 40% of 1RM (1 Maximal Repetition) or fictitious exercise, blood pressure and pulse interval were recorded and mesenteric artery was removed and sliced in rings for vascular reactivity analysis. The utilized drugs were: Acetilcholine (ACh): 10-9 10-4 M; Nù-nitro-L-arginine methyl ester hydrochloride (L-NAME): 100ìM. The variabilities of pulse interval, blood pressure and spontaneous baroreflex sensitivity (BRS) were also analyzed. TR animals showed an significantly reduction in mean arterial pressure (CO 117.04 ± 2.68 vs GT 105.5 ± 4.28, p=0.045), diastolic arterial pressure (CO 107.71 ± 2.95 vs GT 97 ± 3.42, p=0.001) and heart rate (CO 395 ± 7.1 vs GT 344 ± 13.25, p=0.007) when compared to CO animals. In addition, it was seen in trained animals an increase in cardiac vagal modulation (LF/HF: CO 0.35 ± 0.08 vs GT 0.14 ± 0.03, p=0.034), BRS (CO 0.77 ± 0.01 vs GT 1.05 ± 0.1, p=0.019) and percentage of ACh-induced relaxation of mesenteric arterial rings (pD2: CO 6.2 ± 0.1 vs GT 7.1 ± 0.1, p<0.001) when compared to the CO animals. Furthermore, the addition of L-NAME reduced the ACh-induced relaxation (CO 52 ± 3.2% vs GT 35.8 ± 3.7%, p<0.01). In conclusion, we observed that low intensity TR apparently was able to promote beneficial cardiovascular adaptations mediated by neurohumoral adjustments, being able to be a possible instrument on maintenance and treatment for a healthy life.
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spelling Macedo, Fabrício Nuneshttp://lattes.cnpq.br/3659358368327255Santana Filho, Valter Joviniano dehttp://lattes.cnpq.br/53018988297901002017-09-26T12:31:19Z2017-09-26T12:31:19Z2014-02-21https://ri.ufs.br/handle/riufs/3987Low intensity aerobic training increases cardiac vagal modulation and reduces sympathetic activity. These adaptations are factors to prediction of healthy. Resistance training (TR) is am usual component of fitness programs, however the effects on autonomic regulation are not totally clear. Our hypothesis is low intensity resistance training promotes beneficial adaptations in cardiac autonomic modulation, as aerobic exercise. Therefore, the aim was to evaluate the effects of low intensity TR on blood pressure, cardiovascular autonomic balance and vascular reactivity. One group of animals were submitted to TR, trained group (GT). Control animals (CO) were fictitious trained (no exercise). After 8 weeks of TR with 40% of 1RM (1 Maximal Repetition) or fictitious exercise, blood pressure and pulse interval were recorded and mesenteric artery was removed and sliced in rings for vascular reactivity analysis. The utilized drugs were: Acetilcholine (ACh): 10-9 10-4 M; Nù-nitro-L-arginine methyl ester hydrochloride (L-NAME): 100ìM. The variabilities of pulse interval, blood pressure and spontaneous baroreflex sensitivity (BRS) were also analyzed. TR animals showed an significantly reduction in mean arterial pressure (CO 117.04 ± 2.68 vs GT 105.5 ± 4.28, p=0.045), diastolic arterial pressure (CO 107.71 ± 2.95 vs GT 97 ± 3.42, p=0.001) and heart rate (CO 395 ± 7.1 vs GT 344 ± 13.25, p=0.007) when compared to CO animals. In addition, it was seen in trained animals an increase in cardiac vagal modulation (LF/HF: CO 0.35 ± 0.08 vs GT 0.14 ± 0.03, p=0.034), BRS (CO 0.77 ± 0.01 vs GT 1.05 ± 0.1, p=0.019) and percentage of ACh-induced relaxation of mesenteric arterial rings (pD2: CO 6.2 ± 0.1 vs GT 7.1 ± 0.1, p<0.001) when compared to the CO animals. Furthermore, the addition of L-NAME reduced the ACh-induced relaxation (CO 52 ± 3.2% vs GT 35.8 ± 3.7%, p<0.01). In conclusion, we observed that low intensity TR apparently was able to promote beneficial cardiovascular adaptations mediated by neurohumoral adjustments, being able to be a possible instrument on maintenance and treatment for a healthy life.Treinamento aerobico de baixa intensidade aumenta modulacao parassimpatica e reduz atividade simpatica. Estas adaptacoes sao fatores para predicao de saude. O treinamento resistido (TR) e um importante componente de programas de condicionamento fisico, porem seus efeitos na regulacao autonomica nao estao totalmente claros. Nossa hipotese e que o treinamento resistido de baixa intensidade promova, assim como o exercicio aerobico, adaptacoes beneficas na modulacao autonomica cardiaca. Sendo assim, os objetivos deste estudo foram avaliar os efeitos do treinamento resistido de baixa intensidade na pressao arterial, no balanco autonomico cardiovascular e reatividade vascular. Um grupo de animais (n=8) foi submetido a treinamento resistido (GT), os animais controle (CO) foram treinados ficticiamente (sem exercicio). Apos 8 semanas de treinamento com 40% de 1RM (1 Repeticao Maxima) ou periodo ficticio de treinamento, a pressao arterial e o intervalo de pulso foram gravados e a arteria mesenterica foi removida e seccionada em aneis para analise da reatividade vascular. As drogas utilizadas foram: Acetilcolina (ACh): 10-9 . 10-4 M; hidrocloreto de N Ö-nitro-L-arginina metil ester (L-NAME): 100 ÊM. A sensibilidade espontanea do barorreflexo (SBR) e variabilidade do intervalo de pulso e da pressao arterial foram analisadas. Os animais que foram submetidos ao periodo de treinamento em baixa intensidade apresentaram reducao significativa da pressao arterial media (CO 117,04 } 2,68 vs GT 105,5 } 4,28, p=0,045), pressao arterial diastolica (CO 107,71 } 2.95 vs GT 97 } 3,42, p=0,001) e frequencia cardiaca (CO 395 } 7,1 vs GT 344 } 13,25, p=0,007) quando comparados ao CO. Em adicao, foi observado no GT um aumento da modulacao vagal cardiaca (LF/HF: CO 0,35 } 0,08 vs GT 0,14 } 0,03, p=0,034), SBR (CO 0,77 } 0,01 vs GT 1,05 } 0,1, p=0,019) e percentual de relaxamento induzido pela ACh nos aneis de arteria mesenterica (pD2: CO 6,2 } 0,1 vs GT 7,1 } 0,1, p<0,001) quando comparados ao CO. Alem disso, adicao de L-NAME reduziu o relaxamento induzido pela ACh (CO 52 } 3,2% vs GT 35,8 } 3,7%, p<0,01). Em conclusao, foi observado que o TR em baixa intensidade aparentemente tem um grande potencial em promover adaptacoes cardiovasculares beneficas mediadas por ajustes neuro-humorais, podendo assim ser uma possivel ferramenta na manutencao e tratamento para uma vida saudavel.application/pdfporFisiologiaNeurociênciasTreinamento (Atletismo)Sistema cardiovascularExercícios físicosCardiovascular systemCoaching (Athletics)ExerciseNeurosciencesPhysiologyCNPQ::CIENCIAS BIOLOGICAS::FISIOLOGIAEfeitos do treinamento resistido de baixa intensidade em variáveis cardiovasculares e reatividade vascular de ratosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisPós-Graduação em Ciências Fisiológicasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSTEXTFABRICIO_NUNES_MACEDO.pdf.txtFABRICIO_NUNES_MACEDO.pdf.txtExtracted texttext/plain85988https://ri.ufs.br/jspui/bitstream/riufs/3987/2/FABRICIO_NUNES_MACEDO.pdf.txtb379d996f912cfdeb6b05947cc3f1618MD52THUMBNAILFABRICIO_NUNES_MACEDO.pdf.jpgFABRICIO_NUNES_MACEDO.pdf.jpgGenerated Thumbnailimage/jpeg1313https://ri.ufs.br/jspui/bitstream/riufs/3987/3/FABRICIO_NUNES_MACEDO.pdf.jpg75bc28d3d097c70d48fd1d26f914a3aeMD53ORIGINALFABRICIO_NUNES_MACEDO.pdfapplication/pdf666986https://ri.ufs.br/jspui/bitstream/riufs/3987/1/FABRICIO_NUNES_MACEDO.pdf68116e4eeda0838f01ba45a4975741e7MD51riufs/39872017-11-24 21:46:20.622oai:ufs.br:riufs/3987Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2017-11-25T00:46:20Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false
dc.title.por.fl_str_mv Efeitos do treinamento resistido de baixa intensidade em variáveis cardiovasculares e reatividade vascular de ratos
title Efeitos do treinamento resistido de baixa intensidade em variáveis cardiovasculares e reatividade vascular de ratos
spellingShingle Efeitos do treinamento resistido de baixa intensidade em variáveis cardiovasculares e reatividade vascular de ratos
Macedo, Fabrício Nunes
Fisiologia
Neurociências
Treinamento (Atletismo)
Sistema cardiovascular
Exercícios físicos
Cardiovascular system
Coaching (Athletics)
Exercise
Neurosciences
Physiology
CNPQ::CIENCIAS BIOLOGICAS::FISIOLOGIA
title_short Efeitos do treinamento resistido de baixa intensidade em variáveis cardiovasculares e reatividade vascular de ratos
title_full Efeitos do treinamento resistido de baixa intensidade em variáveis cardiovasculares e reatividade vascular de ratos
title_fullStr Efeitos do treinamento resistido de baixa intensidade em variáveis cardiovasculares e reatividade vascular de ratos
title_full_unstemmed Efeitos do treinamento resistido de baixa intensidade em variáveis cardiovasculares e reatividade vascular de ratos
title_sort Efeitos do treinamento resistido de baixa intensidade em variáveis cardiovasculares e reatividade vascular de ratos
author Macedo, Fabrício Nunes
author_facet Macedo, Fabrício Nunes
author_role author
dc.contributor.author.fl_str_mv Macedo, Fabrício Nunes
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3659358368327255
dc.contributor.advisor1.fl_str_mv Santana Filho, Valter Joviniano de
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/5301898829790100
contributor_str_mv Santana Filho, Valter Joviniano de
dc.subject.por.fl_str_mv Fisiologia
Neurociências
Treinamento (Atletismo)
Sistema cardiovascular
Exercícios físicos
topic Fisiologia
Neurociências
Treinamento (Atletismo)
Sistema cardiovascular
Exercícios físicos
Cardiovascular system
Coaching (Athletics)
Exercise
Neurosciences
Physiology
CNPQ::CIENCIAS BIOLOGICAS::FISIOLOGIA
dc.subject.eng.fl_str_mv Cardiovascular system
Coaching (Athletics)
Exercise
Neurosciences
Physiology
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS BIOLOGICAS::FISIOLOGIA
description Low intensity aerobic training increases cardiac vagal modulation and reduces sympathetic activity. These adaptations are factors to prediction of healthy. Resistance training (TR) is am usual component of fitness programs, however the effects on autonomic regulation are not totally clear. Our hypothesis is low intensity resistance training promotes beneficial adaptations in cardiac autonomic modulation, as aerobic exercise. Therefore, the aim was to evaluate the effects of low intensity TR on blood pressure, cardiovascular autonomic balance and vascular reactivity. One group of animals were submitted to TR, trained group (GT). Control animals (CO) were fictitious trained (no exercise). After 8 weeks of TR with 40% of 1RM (1 Maximal Repetition) or fictitious exercise, blood pressure and pulse interval were recorded and mesenteric artery was removed and sliced in rings for vascular reactivity analysis. The utilized drugs were: Acetilcholine (ACh): 10-9 10-4 M; Nù-nitro-L-arginine methyl ester hydrochloride (L-NAME): 100ìM. The variabilities of pulse interval, blood pressure and spontaneous baroreflex sensitivity (BRS) were also analyzed. TR animals showed an significantly reduction in mean arterial pressure (CO 117.04 ± 2.68 vs GT 105.5 ± 4.28, p=0.045), diastolic arterial pressure (CO 107.71 ± 2.95 vs GT 97 ± 3.42, p=0.001) and heart rate (CO 395 ± 7.1 vs GT 344 ± 13.25, p=0.007) when compared to CO animals. In addition, it was seen in trained animals an increase in cardiac vagal modulation (LF/HF: CO 0.35 ± 0.08 vs GT 0.14 ± 0.03, p=0.034), BRS (CO 0.77 ± 0.01 vs GT 1.05 ± 0.1, p=0.019) and percentage of ACh-induced relaxation of mesenteric arterial rings (pD2: CO 6.2 ± 0.1 vs GT 7.1 ± 0.1, p<0.001) when compared to the CO animals. Furthermore, the addition of L-NAME reduced the ACh-induced relaxation (CO 52 ± 3.2% vs GT 35.8 ± 3.7%, p<0.01). In conclusion, we observed that low intensity TR apparently was able to promote beneficial cardiovascular adaptations mediated by neurohumoral adjustments, being able to be a possible instrument on maintenance and treatment for a healthy life.
publishDate 2014
dc.date.issued.fl_str_mv 2014-02-21
dc.date.accessioned.fl_str_mv 2017-09-26T12:31:19Z
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