Brazilian adult individuals with untreated isolated GH deficiency do not have accelerated subclinical atherosclerosis

Detalhes bibliográficos
Autor(a) principal: Burgos, Ursula Maria Moreira Costa
Data de Publicação: 2016
Outros Autores: Oliveira, Carla Raquel Pereira, Salvatori, Roberto, Barreto Filho, José Augusto Soares, Campos, Viviane Correia, Oliveira, Francielle Temer de, Rocha, Ivina Elaine dos Santos, Oliveira, Joselina Luzia Menezes, Silva, Wersley Araújo, Oliveira, Manuel Herminio de Aguiar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFS
Texto Completo: https://ri.ufs.br/handle/riufs/1751
Resumo: GH and its principal mediator IGF1 have important effects on metabolic and cardiovascular (CV) status. While acquired GH deficiency (GHD) is often associated with increased CV risk, the consequences of congenital GHD are not known. We have described a large group of patients with isolated GHD (IGHD) due to a homozygous mutation (c.57C1GOA) in the GH releasing hormone receptor gene, and shown that adult GH-naı¨ve individuals have no evidence of clinically evident premature atherosclerosis. To test whether subclinical atherosclerosis is anticipated in untreated IGHD, we performed a cross-sectional study of 25 IGHD and 27 adult controls matched for age and gender. A comprehensive clinical and biochemical panel and coronary artery calcium scores were evaluated by multi-detector tomography. Height, weight, IGF1, homeostasis model assessment of insulin resistance, creatinine and creatininekinase were lower in the IGHD group. Median and interquartile range of calcium scores distribution was similar in the two groups: IGHD 0(0) and control 0(4.9). The vast majority of the calcium scores (20 of 25 IGHD (80%) and 18 of 27 controls (66.6%)) were equal to zero (difference not significant). There was no difference in the calcium scores classification. None of IGHD subjects had minimal calcification, which were present in four controls. Three IGHD and four controls had mild calcification. There were two IGHD individuals with moderate calcification and one control with severe calcification. Our study provides evidence that subjects with congenital isolated lifetime and untreated severe IGHD do not have accelerated subclinical coronary atherosclerosis.
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spelling Burgos, Ursula Maria Moreira CostaOliveira, Carla Raquel PereiraSalvatori, RobertoBarreto Filho, José Augusto SoaresCampos, Viviane CorreiaOliveira, Francielle Temer deRocha, Ivina Elaine dos SantosOliveira, Joselina Luzia MenezesSilva, Wersley AraújoOliveira, Manuel Herminio de Aguiar2016-04-11T11:02:54Z2016-04-11T11:02:54Z2016-01BURGOS, U. M. M. C. et al. Brazilian adult individuals with untreated isolated GH deficiency do not have accelerated subclinical atherosclerosis. Endocrine Connections, v. 5, n. 1, jan. 2016. Disponível em: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738236/>. Acesso em: 11 abr. 2016.2049-3614https://ri.ufs.br/handle/riufs/1751Creative Commons Attribution-NonCommercial 4.0 International LicenseGH and its principal mediator IGF1 have important effects on metabolic and cardiovascular (CV) status. While acquired GH deficiency (GHD) is often associated with increased CV risk, the consequences of congenital GHD are not known. We have described a large group of patients with isolated GHD (IGHD) due to a homozygous mutation (c.57C1GOA) in the GH releasing hormone receptor gene, and shown that adult GH-naı¨ve individuals have no evidence of clinically evident premature atherosclerosis. To test whether subclinical atherosclerosis is anticipated in untreated IGHD, we performed a cross-sectional study of 25 IGHD and 27 adult controls matched for age and gender. A comprehensive clinical and biochemical panel and coronary artery calcium scores were evaluated by multi-detector tomography. Height, weight, IGF1, homeostasis model assessment of insulin resistance, creatinine and creatininekinase were lower in the IGHD group. Median and interquartile range of calcium scores distribution was similar in the two groups: IGHD 0(0) and control 0(4.9). The vast majority of the calcium scores (20 of 25 IGHD (80%) and 18 of 27 controls (66.6%)) were equal to zero (difference not significant). There was no difference in the calcium scores classification. None of IGHD subjects had minimal calcification, which were present in four controls. Three IGHD and four controls had mild calcification. There were two IGHD individuals with moderate calcification and one control with severe calcification. Our study provides evidence that subjects with congenital isolated lifetime and untreated severe IGHD do not have accelerated subclinical coronary atherosclerosis.BioscientificaCoronary atherosclerosisAterosclerose coronáriaIsolated growth hormone deficiencyCalcium scoreMulti-detector CTBrazilian adult individuals with untreated isolated GH deficiency do not have accelerated subclinical atherosclerosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTHUMBNAILGHDeficiencyAtherosclerosis.pdf.jpgGHDeficiencyAtherosclerosis.pdf.jpgGenerated Thumbnailimage/jpeg1796https://ri.ufs.br/jspui/bitstream/riufs/1751/4/GHDeficiencyAtherosclerosis.pdf.jpg35971cbbb976d806a42dab5b375d8c20MD54ORIGINALGHDeficiencyAtherosclerosis.pdfGHDeficiencyAtherosclerosis.pdfapplication/pdf228469https://ri.ufs.br/jspui/bitstream/riufs/1751/1/GHDeficiencyAtherosclerosis.pdffbe97b44e9f08eb11eccbc08e7ebc154MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://ri.ufs.br/jspui/bitstream/riufs/1751/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTGHDeficiencyAtherosclerosis.pdf.txtGHDeficiencyAtherosclerosis.pdf.txtExtracted texttext/plain31566https://ri.ufs.br/jspui/bitstream/riufs/1751/3/GHDeficiencyAtherosclerosis.pdf.txt3981e43b4c4b0765e8dc3be0b6d7fb0bMD53riufs/17512016-04-12 02:00:11.512oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2016-04-12T05:00:11Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false
dc.title.pt_BR.fl_str_mv Brazilian adult individuals with untreated isolated GH deficiency do not have accelerated subclinical atherosclerosis
title Brazilian adult individuals with untreated isolated GH deficiency do not have accelerated subclinical atherosclerosis
spellingShingle Brazilian adult individuals with untreated isolated GH deficiency do not have accelerated subclinical atherosclerosis
Burgos, Ursula Maria Moreira Costa
Coronary atherosclerosis
Aterosclerose coronária
Isolated growth hormone deficiency
Calcium score
Multi-detector CT
title_short Brazilian adult individuals with untreated isolated GH deficiency do not have accelerated subclinical atherosclerosis
title_full Brazilian adult individuals with untreated isolated GH deficiency do not have accelerated subclinical atherosclerosis
title_fullStr Brazilian adult individuals with untreated isolated GH deficiency do not have accelerated subclinical atherosclerosis
title_full_unstemmed Brazilian adult individuals with untreated isolated GH deficiency do not have accelerated subclinical atherosclerosis
title_sort Brazilian adult individuals with untreated isolated GH deficiency do not have accelerated subclinical atherosclerosis
author Burgos, Ursula Maria Moreira Costa
author_facet Burgos, Ursula Maria Moreira Costa
Oliveira, Carla Raquel Pereira
Salvatori, Roberto
Barreto Filho, José Augusto Soares
Campos, Viviane Correia
Oliveira, Francielle Temer de
Rocha, Ivina Elaine dos Santos
Oliveira, Joselina Luzia Menezes
Silva, Wersley Araújo
Oliveira, Manuel Herminio de Aguiar
author_role author
author2 Oliveira, Carla Raquel Pereira
Salvatori, Roberto
Barreto Filho, José Augusto Soares
Campos, Viviane Correia
Oliveira, Francielle Temer de
Rocha, Ivina Elaine dos Santos
Oliveira, Joselina Luzia Menezes
Silva, Wersley Araújo
Oliveira, Manuel Herminio de Aguiar
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Burgos, Ursula Maria Moreira Costa
Oliveira, Carla Raquel Pereira
Salvatori, Roberto
Barreto Filho, José Augusto Soares
Campos, Viviane Correia
Oliveira, Francielle Temer de
Rocha, Ivina Elaine dos Santos
Oliveira, Joselina Luzia Menezes
Silva, Wersley Araújo
Oliveira, Manuel Herminio de Aguiar
dc.subject.por.fl_str_mv Coronary atherosclerosis
Aterosclerose coronária
Isolated growth hormone deficiency
Calcium score
Multi-detector CT
topic Coronary atherosclerosis
Aterosclerose coronária
Isolated growth hormone deficiency
Calcium score
Multi-detector CT
description GH and its principal mediator IGF1 have important effects on metabolic and cardiovascular (CV) status. While acquired GH deficiency (GHD) is often associated with increased CV risk, the consequences of congenital GHD are not known. We have described a large group of patients with isolated GHD (IGHD) due to a homozygous mutation (c.57C1GOA) in the GH releasing hormone receptor gene, and shown that adult GH-naı¨ve individuals have no evidence of clinically evident premature atherosclerosis. To test whether subclinical atherosclerosis is anticipated in untreated IGHD, we performed a cross-sectional study of 25 IGHD and 27 adult controls matched for age and gender. A comprehensive clinical and biochemical panel and coronary artery calcium scores were evaluated by multi-detector tomography. Height, weight, IGF1, homeostasis model assessment of insulin resistance, creatinine and creatininekinase were lower in the IGHD group. Median and interquartile range of calcium scores distribution was similar in the two groups: IGHD 0(0) and control 0(4.9). The vast majority of the calcium scores (20 of 25 IGHD (80%) and 18 of 27 controls (66.6%)) were equal to zero (difference not significant). There was no difference in the calcium scores classification. None of IGHD subjects had minimal calcification, which were present in four controls. Three IGHD and four controls had mild calcification. There were two IGHD individuals with moderate calcification and one control with severe calcification. Our study provides evidence that subjects with congenital isolated lifetime and untreated severe IGHD do not have accelerated subclinical coronary atherosclerosis.
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-04-11T11:02:54Z
dc.date.available.fl_str_mv 2016-04-11T11:02:54Z
dc.date.issued.fl_str_mv 2016-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.fl_str_mv BURGOS, U. M. M. C. et al. Brazilian adult individuals with untreated isolated GH deficiency do not have accelerated subclinical atherosclerosis. Endocrine Connections, v. 5, n. 1, jan. 2016. Disponível em: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738236/>. Acesso em: 11 abr. 2016.
dc.identifier.uri.fl_str_mv https://ri.ufs.br/handle/riufs/1751
dc.identifier.issn.none.fl_str_mv 2049-3614
dc.identifier.license.pt_BR.fl_str_mv Creative Commons Attribution-NonCommercial 4.0 International License
identifier_str_mv BURGOS, U. M. M. C. et al. Brazilian adult individuals with untreated isolated GH deficiency do not have accelerated subclinical atherosclerosis. Endocrine Connections, v. 5, n. 1, jan. 2016. Disponível em: <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738236/>. Acesso em: 11 abr. 2016.
2049-3614
Creative Commons Attribution-NonCommercial 4.0 International License
url https://ri.ufs.br/handle/riufs/1751
dc.language.iso.fl_str_mv eng
language eng
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reponame_str Repositório Institucional da UFS
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