Obtenção de membranas à base de farinha de babaçu com adição de vitamina C e La0,4Sr0,6MnO3 para aplicação como curativo de feridas

• Autor(a) principal: Carvalho, Emanuella de Araújo
• Data de Publicação: 2024
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UFS
• Texto Completo: https://ri.ufs.br/jspui/handle/riufs/19566
• topic: Ferimentos e lesões (tratamento); Babaçu; Manganita; Vitamina C; Curativos; Feridas crônicas; La0,4Sr0,6MnO3; Chronic wounds; Babassu; Vitamin C; Dressing; ENGENHARIAS::ENGENHARIA DE MATERIAIS E METALURGICA

The treatment of chronic wounds is increasingly becoming a public health problem, mainly due to the long period until healing, resulting in more costs for materials and medicines, in addition to increasing the possibility of these infections arising. For this reason, tissue engineering has been seeking ways to accelerate wound healing through the production of polymeric dressings. Therefore, the babassu coconut, the fruit of a palm tree found on a large scale in the North and Northeast of Brazil, has mesocarp in its “between-shell” zone, a natural polymeric source, from which its flour is produced. This one has already been used in biomedical applications as it has antimicrobial, anti-inflammatory, and healing properties. Furthermore, substances with active ingredients can be associated with the polymeric matrix, such as vitamin C, which helps in the production of skin collagen, and the particles with magnetic and antibacterial properties, such as La0.4Sr0.6MnO3, which can favor the wound healing process. Based on this problem, the objectives of this study were: i) to produce manganites: La0.4Sr0.6MnO3, LaMnO3, and SrMnO3, to evaluate antibacterial susceptibility against S. aureus and E. Coli strains; ii) develop membranes from babassu flour, with the addition of glycerol as a plasticizer at concentrations of 20, 30, 40 and 60% to evaluate the effect of this variation in relation to hydrophilicity, degree of swelling (G.I.) and mechanical properties to define the ideal concentration; iii) produce membranes with a defined glycerol concentration, combining vitamin C and different concentrations of La0.4Sr0.6MnO3. Regarding the results of antibacterial susceptibility, it was shown that LaMnO3 and SrMnO3 manganites present antimicrobial activity against strains of S. aureus and E. Coli, with La0.4Sr0.6MnO3 being more effective, indicating a possible synergistic effect between lanthanum and strontium. To define the plasticizer concentration, from the contact angle and GI tests it was identified that, as the glycerol concentration increased, there was a reduction in the interaction of the membrane with the liquid medium due to the polarity of the plasticizer, which in turn, it interacted with the polar part of the polymer and reduced binding sites available for water. With the results of the tensile test, the effectiveness of the plasticizer in promoting plastic deformation was observed, making the membranes more flexible. With a concentration of 30% glycerol selected, it meets both elongation and tensile strength. Membranes with the association of vitamin C and La0.4Sr0.6MnO3 showed a reduction in degradation, permeability, and release of vitamin C with the increase in powder concentration, in addition to increasing hydrophilicity, GI, and elongation. Therefore, as a permeable, hydrophilic, biodegradable membrane is desirable, capable of retaining liquid and releasing vitamin C more slowly into the medium, the concentration of 10 % of La0.4Sr0.6MnO3 presented results more consistent with what is desirable, being a possible promise of application as a wound dressing.