Mediação neural na hipotensão pós-exercício em ratos hipertensos
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFS |
Texto Completo: | https://ri.ufs.br/handle/riufs/3565 |
Resumo: | The sustained reduction in blood pressure after a single bout of aerobic or resistance exercise (RE) has gained significant clinical relevance in hypertensive individuals. This phenomenon is known as post-exercise hypotension (PEH). However, the neural mechanisms that lead to HPE still need to be better understood, particularly arising from the ER. In this sense, the present study sought to review the neural mechanisms involved in HPE and evaluate the hemodynamic and autonomic control changes induced by ER in hypertensive rats induced by Nω-nitro-Larginine methyl ester (L-NAME). The thesis consists of two chapters, which are systematic review and an original article. Initially was elaborated a systematic review "A systematic review of neural mechanisms involved on post-exercise hypotension in hypertensive animals", with search for articles in LILACS, EMBASE and PUBMED database, which describes an overview of the neural mechanisms involved in HPE in studies of hypertensive animals. These studies demonstrated the presence of cardiovascular afferents, afferent skeletal muscle stimulation during exercise and bulbar or suprabulbar modulations are fundamental to the expression of HPE. After completion of the experimental protocols the article: "Arterial Baroreflex participates in the post-resistance exercise hypotension in L-NAME-induced hypertensive rats", was presented. This paper demonstrated that the increased baroreflex arterial sensitibity REinduced plays a crucial role in PEH followed by bradycardia, probably through cardiac and vascular sympathetic inhibition. Together, these findings show that the involvement of neural mechanisms are important for the manifestation of PEH induced by both aerobic and resistance exercise in hypertensive rats. |
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Barreto, André Saleshttp://lattes.cnpq.br/9692770802439503Santos, Márcio Roberto Viana doshttp://lattes.cnpq.br/73690504338063102017-09-26T12:07:07Z2017-09-26T12:07:07Z2014-03-24BARRETO, André Sales. Neural mediation in post-exercise hypotension in hypertensive rats. 2014. 122 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Sergipe, Aracaju, 2014.https://ri.ufs.br/handle/riufs/3565The sustained reduction in blood pressure after a single bout of aerobic or resistance exercise (RE) has gained significant clinical relevance in hypertensive individuals. This phenomenon is known as post-exercise hypotension (PEH). However, the neural mechanisms that lead to HPE still need to be better understood, particularly arising from the ER. In this sense, the present study sought to review the neural mechanisms involved in HPE and evaluate the hemodynamic and autonomic control changes induced by ER in hypertensive rats induced by Nω-nitro-Larginine methyl ester (L-NAME). The thesis consists of two chapters, which are systematic review and an original article. Initially was elaborated a systematic review "A systematic review of neural mechanisms involved on post-exercise hypotension in hypertensive animals", with search for articles in LILACS, EMBASE and PUBMED database, which describes an overview of the neural mechanisms involved in HPE in studies of hypertensive animals. These studies demonstrated the presence of cardiovascular afferents, afferent skeletal muscle stimulation during exercise and bulbar or suprabulbar modulations are fundamental to the expression of HPE. After completion of the experimental protocols the article: "Arterial Baroreflex participates in the post-resistance exercise hypotension in L-NAME-induced hypertensive rats", was presented. This paper demonstrated that the increased baroreflex arterial sensitibity REinduced plays a crucial role in PEH followed by bradycardia, probably through cardiac and vascular sympathetic inhibition. Together, these findings show that the involvement of neural mechanisms are important for the manifestation of PEH induced by both aerobic and resistance exercise in hypertensive rats.A redução sustentada da pressão arterial após uma única sessão de exercício aeróbico ou resistido (ER) tem ganhado significativa relevância clínica em indivíduos hipertensos. Esse fenômeno é conhecido como hipotensão pós-exercício (HPE). No entanto, os mecanismos neurais que levam a HPE ainda necessitam serem melhor compreendidos, especialmente decorrentes do ER. Neste sentido, o presente trabalho buscou revisar os mecanismos neurais envolvidos na HPE e avaliar as alterações hemodinâmicas e controle autonômico provocadas pelo ER em ratos hipertensos induzidos por Nω-Nitro-L-arginina metil éster (L-NAME). A tese é composta por dois capítulos, constituídos de uma revisão sistemática e um artigo original. Inicialmente foi elaborada a revisão sistemática A systematic review of neural mechanisms involved on post-exercise hypotension in hypertensive animals , com busca dos artigos nos bancos de dados LILACS, PUBMED e EMBASE, a qual descreve uma visão geral dos mecanismos neurais envolvidos na HPE em estudos realizados com animais hipertensos. Esses estudos demonstraram que a presença de aferência cardiovascular, estímulo da aferência muscular esquelética durante o exercício e modulações suprabulbares são fundamentais para a expressão da HPE. Após a realização dos protocolos experimentais foi elaborado o artigo Arterial Baroreflex participates in the post-resistance exercise hypotension in L-NAMEinduced hypertensive rats . Este artigo demonstrou que o aumento da sensibilidade do barorreflexo arterial induzido pelo ER desempenha um papel crucial na HPE seguida de bradicardia, provavelmente através da inibição simpática cardíaca e vascular. Juntos, esses achados permitem concluir que a participação de mecanismos neurais são importantes para a manifestação da HPE induzido por ambos os tipos de exercício aeróbico e resistido em ratos hipertensos.application/pdfporUniversidade Federal de SergipePós-Graduação em Ciências da SaúdeUFSBRHipertensãoExercícios físicosAptidão cardiovascularAptidão físicaCircuito de treinamentoExperiência com animaisHipotensão pós-exercícioCondicionamento físico animalSistema nervoso autônomoHypertensionPost-exercise hypotensionExercisePhysical conditioningAutonomic nervous systemCNPQ::CIENCIAS DA SAUDEMediação neural na hipotensão pós-exercício em ratos hipertensosNeural mediation in post-exercise hypotension in hypertensive ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSTEXTANDRE_SALES_BARRETO.pdf.txtANDRE_SALES_BARRETO.pdf.txtExtracted texttext/plain186103https://ri.ufs.br/jspui/bitstream/riufs/3565/2/ANDRE_SALES_BARRETO.pdf.txt3ffe9c02315ee9ea829a23439a6ca2d5MD52THUMBNAILANDRE_SALES_BARRETO.pdf.jpgANDRE_SALES_BARRETO.pdf.jpgGenerated Thumbnailimage/jpeg1365https://ri.ufs.br/jspui/bitstream/riufs/3565/3/ANDRE_SALES_BARRETO.pdf.jpg61d7287bdd82f0974461a5b99dc448c3MD53ORIGINALANDRE_SALES_BARRETO.pdfapplication/pdf4991585https://ri.ufs.br/jspui/bitstream/riufs/3565/1/ANDRE_SALES_BARRETO.pdf77903d9a76e0805eb5f04b0826b1ab51MD51riufs/35652017-11-28 16:51:10.13oai:ufs.br:riufs/3565Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2017-11-28T19:51:10Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
dc.title.por.fl_str_mv |
Mediação neural na hipotensão pós-exercício em ratos hipertensos |
dc.title.alternative.eng.fl_str_mv |
Neural mediation in post-exercise hypotension in hypertensive rats |
title |
Mediação neural na hipotensão pós-exercício em ratos hipertensos |
spellingShingle |
Mediação neural na hipotensão pós-exercício em ratos hipertensos Barreto, André Sales Hipertensão Exercícios físicos Aptidão cardiovascular Aptidão física Circuito de treinamento Experiência com animais Hipotensão pós-exercício Condicionamento físico animal Sistema nervoso autônomo Hypertension Post-exercise hypotension Exercise Physical conditioning Autonomic nervous system CNPQ::CIENCIAS DA SAUDE |
title_short |
Mediação neural na hipotensão pós-exercício em ratos hipertensos |
title_full |
Mediação neural na hipotensão pós-exercício em ratos hipertensos |
title_fullStr |
Mediação neural na hipotensão pós-exercício em ratos hipertensos |
title_full_unstemmed |
Mediação neural na hipotensão pós-exercício em ratos hipertensos |
title_sort |
Mediação neural na hipotensão pós-exercício em ratos hipertensos |
author |
Barreto, André Sales |
author_facet |
Barreto, André Sales |
author_role |
author |
dc.contributor.author.fl_str_mv |
Barreto, André Sales |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/9692770802439503 |
dc.contributor.advisor1.fl_str_mv |
Santos, Márcio Roberto Viana dos |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/7369050433806310 |
contributor_str_mv |
Santos, Márcio Roberto Viana dos |
dc.subject.por.fl_str_mv |
Hipertensão Exercícios físicos Aptidão cardiovascular Aptidão física Circuito de treinamento Experiência com animais Hipotensão pós-exercício Condicionamento físico animal Sistema nervoso autônomo |
topic |
Hipertensão Exercícios físicos Aptidão cardiovascular Aptidão física Circuito de treinamento Experiência com animais Hipotensão pós-exercício Condicionamento físico animal Sistema nervoso autônomo Hypertension Post-exercise hypotension Exercise Physical conditioning Autonomic nervous system CNPQ::CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
Hypertension Post-exercise hypotension Exercise Physical conditioning Autonomic nervous system |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS DA SAUDE |
description |
The sustained reduction in blood pressure after a single bout of aerobic or resistance exercise (RE) has gained significant clinical relevance in hypertensive individuals. This phenomenon is known as post-exercise hypotension (PEH). However, the neural mechanisms that lead to HPE still need to be better understood, particularly arising from the ER. In this sense, the present study sought to review the neural mechanisms involved in HPE and evaluate the hemodynamic and autonomic control changes induced by ER in hypertensive rats induced by Nω-nitro-Larginine methyl ester (L-NAME). The thesis consists of two chapters, which are systematic review and an original article. Initially was elaborated a systematic review "A systematic review of neural mechanisms involved on post-exercise hypotension in hypertensive animals", with search for articles in LILACS, EMBASE and PUBMED database, which describes an overview of the neural mechanisms involved in HPE in studies of hypertensive animals. These studies demonstrated the presence of cardiovascular afferents, afferent skeletal muscle stimulation during exercise and bulbar or suprabulbar modulations are fundamental to the expression of HPE. After completion of the experimental protocols the article: "Arterial Baroreflex participates in the post-resistance exercise hypotension in L-NAME-induced hypertensive rats", was presented. This paper demonstrated that the increased baroreflex arterial sensitibity REinduced plays a crucial role in PEH followed by bradycardia, probably through cardiac and vascular sympathetic inhibition. Together, these findings show that the involvement of neural mechanisms are important for the manifestation of PEH induced by both aerobic and resistance exercise in hypertensive rats. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-03-24 |
dc.date.accessioned.fl_str_mv |
2017-09-26T12:07:07Z |
dc.date.available.fl_str_mv |
2017-09-26T12:07:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BARRETO, André Sales. Neural mediation in post-exercise hypotension in hypertensive rats. 2014. 122 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Sergipe, Aracaju, 2014. |
dc.identifier.uri.fl_str_mv |
https://ri.ufs.br/handle/riufs/3565 |
identifier_str_mv |
BARRETO, André Sales. Neural mediation in post-exercise hypotension in hypertensive rats. 2014. 122 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Sergipe, Aracaju, 2014. |
url |
https://ri.ufs.br/handle/riufs/3565 |
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Universidade Federal de Sergipe |
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Pós-Graduação em Ciências da Saúde |
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UFS |
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BR |
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Universidade Federal de Sergipe |
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