Mediação neural na hipotensão pós-exercício em ratos hipertensos

Detalhes bibliográficos
Autor(a) principal: Barreto, André Sales
Data de Publicação: 2014
Tipo de documento: Tese
Idioma: por
Título da fonte: Repositório Institucional da UFS
Texto Completo: https://ri.ufs.br/handle/riufs/3565
Resumo: The sustained reduction in blood pressure after a single bout of aerobic or resistance exercise (RE) has gained significant clinical relevance in hypertensive individuals. This phenomenon is known as post-exercise hypotension (PEH). However, the neural mechanisms that lead to HPE still need to be better understood, particularly arising from the ER. In this sense, the present study sought to review the neural mechanisms involved in HPE and evaluate the hemodynamic and autonomic control changes induced by ER in hypertensive rats induced by Nω-nitro-Larginine methyl ester (L-NAME). The thesis consists of two chapters, which are systematic review and an original article. Initially was elaborated a systematic review "A systematic review of neural mechanisms involved on post-exercise hypotension in hypertensive animals", with search for articles in LILACS, EMBASE and PUBMED database, which describes an overview of the neural mechanisms involved in HPE in studies of hypertensive animals. These studies demonstrated the presence of cardiovascular afferents, afferent skeletal muscle stimulation during exercise and bulbar or suprabulbar modulations are fundamental to the expression of HPE. After completion of the experimental protocols the article: "Arterial Baroreflex participates in the post-resistance exercise hypotension in L-NAME-induced hypertensive rats", was presented. This paper demonstrated that the increased baroreflex arterial sensitibity REinduced plays a crucial role in PEH followed by bradycardia, probably through cardiac and vascular sympathetic inhibition. Together, these findings show that the involvement of neural mechanisms are important for the manifestation of PEH induced by both aerobic and resistance exercise in hypertensive rats.
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spelling Barreto, André Saleshttp://lattes.cnpq.br/9692770802439503Santos, Márcio Roberto Viana doshttp://lattes.cnpq.br/73690504338063102017-09-26T12:07:07Z2017-09-26T12:07:07Z2014-03-24BARRETO, André Sales. Neural mediation in post-exercise hypotension in hypertensive rats. 2014. 122 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Sergipe, Aracaju, 2014.https://ri.ufs.br/handle/riufs/3565The sustained reduction in blood pressure after a single bout of aerobic or resistance exercise (RE) has gained significant clinical relevance in hypertensive individuals. This phenomenon is known as post-exercise hypotension (PEH). However, the neural mechanisms that lead to HPE still need to be better understood, particularly arising from the ER. In this sense, the present study sought to review the neural mechanisms involved in HPE and evaluate the hemodynamic and autonomic control changes induced by ER in hypertensive rats induced by Nω-nitro-Larginine methyl ester (L-NAME). The thesis consists of two chapters, which are systematic review and an original article. Initially was elaborated a systematic review "A systematic review of neural mechanisms involved on post-exercise hypotension in hypertensive animals", with search for articles in LILACS, EMBASE and PUBMED database, which describes an overview of the neural mechanisms involved in HPE in studies of hypertensive animals. These studies demonstrated the presence of cardiovascular afferents, afferent skeletal muscle stimulation during exercise and bulbar or suprabulbar modulations are fundamental to the expression of HPE. After completion of the experimental protocols the article: "Arterial Baroreflex participates in the post-resistance exercise hypotension in L-NAME-induced hypertensive rats", was presented. This paper demonstrated that the increased baroreflex arterial sensitibity REinduced plays a crucial role in PEH followed by bradycardia, probably through cardiac and vascular sympathetic inhibition. Together, these findings show that the involvement of neural mechanisms are important for the manifestation of PEH induced by both aerobic and resistance exercise in hypertensive rats.A redução sustentada da pressão arterial após uma única sessão de exercício aeróbico ou resistido (ER) tem ganhado significativa relevância clínica em indivíduos hipertensos. Esse fenômeno é conhecido como hipotensão pós-exercício (HPE). No entanto, os mecanismos neurais que levam a HPE ainda necessitam serem melhor compreendidos, especialmente decorrentes do ER. Neste sentido, o presente trabalho buscou revisar os mecanismos neurais envolvidos na HPE e avaliar as alterações hemodinâmicas e controle autonômico provocadas pelo ER em ratos hipertensos induzidos por Nω-Nitro-L-arginina metil éster (L-NAME). A tese é composta por dois capítulos, constituídos de uma revisão sistemática e um artigo original. Inicialmente foi elaborada a revisão sistemática A systematic review of neural mechanisms involved on post-exercise hypotension in hypertensive animals , com busca dos artigos nos bancos de dados LILACS, PUBMED e EMBASE, a qual descreve uma visão geral dos mecanismos neurais envolvidos na HPE em estudos realizados com animais hipertensos. Esses estudos demonstraram que a presença de aferência cardiovascular, estímulo da aferência muscular esquelética durante o exercício e modulações suprabulbares são fundamentais para a expressão da HPE. Após a realização dos protocolos experimentais foi elaborado o artigo Arterial Baroreflex participates in the post-resistance exercise hypotension in L-NAMEinduced hypertensive rats . Este artigo demonstrou que o aumento da sensibilidade do barorreflexo arterial induzido pelo ER desempenha um papel crucial na HPE seguida de bradicardia, provavelmente através da inibição simpática cardíaca e vascular. Juntos, esses achados permitem concluir que a participação de mecanismos neurais são importantes para a manifestação da HPE induzido por ambos os tipos de exercício aeróbico e resistido em ratos hipertensos.application/pdfporUniversidade Federal de SergipePós-Graduação em Ciências da SaúdeUFSBRHipertensãoExercícios físicosAptidão cardiovascularAptidão físicaCircuito de treinamentoExperiência com animaisHipotensão pós-exercícioCondicionamento físico animalSistema nervoso autônomoHypertensionPost-exercise hypotensionExercisePhysical conditioningAutonomic nervous systemCNPQ::CIENCIAS DA SAUDEMediação neural na hipotensão pós-exercício em ratos hipertensosNeural mediation in post-exercise hypotension in hypertensive ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSTEXTANDRE_SALES_BARRETO.pdf.txtANDRE_SALES_BARRETO.pdf.txtExtracted texttext/plain186103https://ri.ufs.br/jspui/bitstream/riufs/3565/2/ANDRE_SALES_BARRETO.pdf.txt3ffe9c02315ee9ea829a23439a6ca2d5MD52THUMBNAILANDRE_SALES_BARRETO.pdf.jpgANDRE_SALES_BARRETO.pdf.jpgGenerated Thumbnailimage/jpeg1365https://ri.ufs.br/jspui/bitstream/riufs/3565/3/ANDRE_SALES_BARRETO.pdf.jpg61d7287bdd82f0974461a5b99dc448c3MD53ORIGINALANDRE_SALES_BARRETO.pdfapplication/pdf4991585https://ri.ufs.br/jspui/bitstream/riufs/3565/1/ANDRE_SALES_BARRETO.pdf77903d9a76e0805eb5f04b0826b1ab51MD51riufs/35652017-11-28 16:51:10.13oai:ufs.br:riufs/3565Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2017-11-28T19:51:10Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false
dc.title.por.fl_str_mv Mediação neural na hipotensão pós-exercício em ratos hipertensos
dc.title.alternative.eng.fl_str_mv Neural mediation in post-exercise hypotension in hypertensive rats
title Mediação neural na hipotensão pós-exercício em ratos hipertensos
spellingShingle Mediação neural na hipotensão pós-exercício em ratos hipertensos
Barreto, André Sales
Hipertensão
Exercícios físicos
Aptidão cardiovascular
Aptidão física
Circuito de treinamento
Experiência com animais
Hipotensão pós-exercício
Condicionamento físico animal
Sistema nervoso autônomo
Hypertension
Post-exercise hypotension
Exercise
Physical conditioning
Autonomic nervous system
CNPQ::CIENCIAS DA SAUDE
title_short Mediação neural na hipotensão pós-exercício em ratos hipertensos
title_full Mediação neural na hipotensão pós-exercício em ratos hipertensos
title_fullStr Mediação neural na hipotensão pós-exercício em ratos hipertensos
title_full_unstemmed Mediação neural na hipotensão pós-exercício em ratos hipertensos
title_sort Mediação neural na hipotensão pós-exercício em ratos hipertensos
author Barreto, André Sales
author_facet Barreto, André Sales
author_role author
dc.contributor.author.fl_str_mv Barreto, André Sales
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/9692770802439503
dc.contributor.advisor1.fl_str_mv Santos, Márcio Roberto Viana dos
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/7369050433806310
contributor_str_mv Santos, Márcio Roberto Viana dos
dc.subject.por.fl_str_mv Hipertensão
Exercícios físicos
Aptidão cardiovascular
Aptidão física
Circuito de treinamento
Experiência com animais
Hipotensão pós-exercício
Condicionamento físico animal
Sistema nervoso autônomo
topic Hipertensão
Exercícios físicos
Aptidão cardiovascular
Aptidão física
Circuito de treinamento
Experiência com animais
Hipotensão pós-exercício
Condicionamento físico animal
Sistema nervoso autônomo
Hypertension
Post-exercise hypotension
Exercise
Physical conditioning
Autonomic nervous system
CNPQ::CIENCIAS DA SAUDE
dc.subject.eng.fl_str_mv Hypertension
Post-exercise hypotension
Exercise
Physical conditioning
Autonomic nervous system
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS DA SAUDE
description The sustained reduction in blood pressure after a single bout of aerobic or resistance exercise (RE) has gained significant clinical relevance in hypertensive individuals. This phenomenon is known as post-exercise hypotension (PEH). However, the neural mechanisms that lead to HPE still need to be better understood, particularly arising from the ER. In this sense, the present study sought to review the neural mechanisms involved in HPE and evaluate the hemodynamic and autonomic control changes induced by ER in hypertensive rats induced by Nω-nitro-Larginine methyl ester (L-NAME). The thesis consists of two chapters, which are systematic review and an original article. Initially was elaborated a systematic review "A systematic review of neural mechanisms involved on post-exercise hypotension in hypertensive animals", with search for articles in LILACS, EMBASE and PUBMED database, which describes an overview of the neural mechanisms involved in HPE in studies of hypertensive animals. These studies demonstrated the presence of cardiovascular afferents, afferent skeletal muscle stimulation during exercise and bulbar or suprabulbar modulations are fundamental to the expression of HPE. After completion of the experimental protocols the article: "Arterial Baroreflex participates in the post-resistance exercise hypotension in L-NAME-induced hypertensive rats", was presented. This paper demonstrated that the increased baroreflex arterial sensitibity REinduced plays a crucial role in PEH followed by bradycardia, probably through cardiac and vascular sympathetic inhibition. Together, these findings show that the involvement of neural mechanisms are important for the manifestation of PEH induced by both aerobic and resistance exercise in hypertensive rats.
publishDate 2014
dc.date.issued.fl_str_mv 2014-03-24
dc.date.accessioned.fl_str_mv 2017-09-26T12:07:07Z
dc.date.available.fl_str_mv 2017-09-26T12:07:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
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dc.identifier.citation.fl_str_mv BARRETO, André Sales. Neural mediation in post-exercise hypotension in hypertensive rats. 2014. 122 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Sergipe, Aracaju, 2014.
dc.identifier.uri.fl_str_mv https://ri.ufs.br/handle/riufs/3565
identifier_str_mv BARRETO, André Sales. Neural mediation in post-exercise hypotension in hypertensive rats. 2014. 122 f. Tese (Doutorado em Ciências da Saúde) - Universidade Federal de Sergipe, Aracaju, 2014.
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