Anisotropias ópticas e morfometria das fibras colágenas da matriz extracelular em pele de indivíduos portadores de hanseníase
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Tipo de documento: | Trabalho de conclusão de curso |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFS |
Texto Completo: | http://ri.ufs.br/jspui/handle/riufs/8258 |
Resumo: | Background: Hansen's disease is a chronic disease caused by Mycobacterium leprae, which progressively affects the skin and peripheral nerves. The host inflammatory response against the presence of bacilli responsible for alterations in the extracellular matrix. Objective: To study the molecular organization of the fibrous components of the extracellular matrix in skin of patients with leprosy. Methods: This was a descriptive study conducted from August 2011 to July 2012, which were analyzed 20 biopsies from the forearm skin lesions of patients with leprosy. Results: The skin appendages were often compromised by inflammatory infiltrate and showed a partial or total destruction. There wall thickening of blood vessels in all types of leprosy. The morphometric analysis showed a higher level of collagen in patients with multibacillary leprosy. Conclusions: For all types of leprosy there was a disorganization of collagen fibers. |
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Gomes, Mariana Araújo BezerraFeitosa, Vera Lucia Correa2018-05-23T18:05:54Z2018-05-23T18:05:54Z2013-08-31GOMES, Mariana Araújo Bezerra. Anisotropias ópticas e morfometria das fibras colágenas da matriz extracelular em pele de indivíduos portadores de hanseníase. Aracaju, SE, 2013. TCC (Graduação em Medicina) - Departamento de Medicina, Aracaju, 2013.http://ri.ufs.br/jspui/handle/riufs/8258Background: Hansen's disease is a chronic disease caused by Mycobacterium leprae, which progressively affects the skin and peripheral nerves. The host inflammatory response against the presence of bacilli responsible for alterations in the extracellular matrix. Objective: To study the molecular organization of the fibrous components of the extracellular matrix in skin of patients with leprosy. Methods: This was a descriptive study conducted from August 2011 to July 2012, which were analyzed 20 biopsies from the forearm skin lesions of patients with leprosy. Results: The skin appendages were often compromised by inflammatory infiltrate and showed a partial or total destruction. There wall thickening of blood vessels in all types of leprosy. The morphometric analysis showed a higher level of collagen in patients with multibacillary leprosy. Conclusions: For all types of leprosy there was a disorganization of collagen fibers.Introdução: A doença de Hansen é uma doença crônica causada pelo Mycobacterium leprae, que afeta progressivamente a pele e os nervos periféricos. A resposta inflamatória do hospedeiro frente à presença do bacilo é responsável por alterações na matriz extracelular. Objetivos: Estudar a organização molecular dos componentes fibrosos da matriz extracelular em pele de indivíduos portadores de hanseníase. Materiais e Métodos: Trata-se de um estudo descritivo, realizado no período de agosto de 2011 a julho de 2012, onde foram analisadas 20 biópsias de lesões cutâneas do antebraço de pacientes com hanseníase. Resultados: Os anexos cutâneos geralmente estavam comprometidos por infiltrado inflamatório e apresentaram uma destruição parcial ou total. Ocorreu espessamento na parede de vasos sanguíneos em todos os tipos de hanseníase. A análise morfométrica demonstrou um maior nível de colagenização em pacientes com as formas multibacilares da hanseníase. Conclusões: Para todos os tipos de hanseníase houve uma desorganização das fibras colágenas.Aracaju-(SE)porMedicinaSaúdeHanseníaseColágenoAnisotropiaMedicineLeprosyCollagenAnisotropyCIENCIAS DA SAUDE::MEDICINAAnisotropias ópticas e morfometria das fibras colágenas da matriz extracelular em pele de indivíduos portadores de hanseníaseOptical anisotropies and morphometry of extracellular matrix collagen fibers in the skin of individuals with leprosyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisUniversidade Federal de SergipeDME - Departamento de Medicina – Aracaju - Presencialreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain; charset=utf-81475https://ri.ufs.br/jspui/bitstream/riufs/8258/1/license.txt098cbbf65c2c15e1fb2e49c5d306a44cMD51ORIGINALMariana_Araujo_Bezerra_Gomes.pdfMariana_Araujo_Bezerra_Gomes.pdfapplication/pdf1638528https://ri.ufs.br/jspui/bitstream/riufs/8258/2/Mariana_Araujo_Bezerra_Gomes.pdfc238c6ac342e74b87e8a6bf79ed544f2MD52TEXTMariana_Araujo_Bezerra_Gomes.pdf.txtMariana_Araujo_Bezerra_Gomes.pdf.txtExtracted texttext/plain93151https://ri.ufs.br/jspui/bitstream/riufs/8258/3/Mariana_Araujo_Bezerra_Gomes.pdf.txt203969dedb38a29269561b38b82b7eebMD53THUMBNAILMariana_Araujo_Bezerra_Gomes.pdf.jpgMariana_Araujo_Bezerra_Gomes.pdf.jpgGenerated Thumbnailimage/jpeg1342https://ri.ufs.br/jspui/bitstream/riufs/8258/4/Mariana_Araujo_Bezerra_Gomes.pdf.jpg38c26834d2c805f955c9ea749479b7d0MD54riufs/82582018-05-23 15:05:55.247oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2018-05-23T18:05:55Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
dc.title.pt_BR.fl_str_mv |
Anisotropias ópticas e morfometria das fibras colágenas da matriz extracelular em pele de indivíduos portadores de hanseníase |
dc.title.alternative.eng.fl_str_mv |
Optical anisotropies and morphometry of extracellular matrix collagen fibers in the skin of individuals with leprosy |
title |
Anisotropias ópticas e morfometria das fibras colágenas da matriz extracelular em pele de indivíduos portadores de hanseníase |
spellingShingle |
Anisotropias ópticas e morfometria das fibras colágenas da matriz extracelular em pele de indivíduos portadores de hanseníase Gomes, Mariana Araújo Bezerra Medicina Saúde Hanseníase Colágeno Anisotropia Medicine Leprosy Collagen Anisotropy CIENCIAS DA SAUDE::MEDICINA |
title_short |
Anisotropias ópticas e morfometria das fibras colágenas da matriz extracelular em pele de indivíduos portadores de hanseníase |
title_full |
Anisotropias ópticas e morfometria das fibras colágenas da matriz extracelular em pele de indivíduos portadores de hanseníase |
title_fullStr |
Anisotropias ópticas e morfometria das fibras colágenas da matriz extracelular em pele de indivíduos portadores de hanseníase |
title_full_unstemmed |
Anisotropias ópticas e morfometria das fibras colágenas da matriz extracelular em pele de indivíduos portadores de hanseníase |
title_sort |
Anisotropias ópticas e morfometria das fibras colágenas da matriz extracelular em pele de indivíduos portadores de hanseníase |
author |
Gomes, Mariana Araújo Bezerra |
author_facet |
Gomes, Mariana Araújo Bezerra |
author_role |
author |
dc.contributor.author.fl_str_mv |
Gomes, Mariana Araújo Bezerra |
dc.contributor.advisor1.fl_str_mv |
Feitosa, Vera Lucia Correa |
contributor_str_mv |
Feitosa, Vera Lucia Correa |
dc.subject.por.fl_str_mv |
Medicina Saúde Hanseníase Colágeno Anisotropia |
topic |
Medicina Saúde Hanseníase Colágeno Anisotropia Medicine Leprosy Collagen Anisotropy CIENCIAS DA SAUDE::MEDICINA |
dc.subject.eng.fl_str_mv |
Medicine Leprosy Collagen Anisotropy |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::MEDICINA |
description |
Background: Hansen's disease is a chronic disease caused by Mycobacterium leprae, which progressively affects the skin and peripheral nerves. The host inflammatory response against the presence of bacilli responsible for alterations in the extracellular matrix. Objective: To study the molecular organization of the fibrous components of the extracellular matrix in skin of patients with leprosy. Methods: This was a descriptive study conducted from August 2011 to July 2012, which were analyzed 20 biopsies from the forearm skin lesions of patients with leprosy. Results: The skin appendages were often compromised by inflammatory infiltrate and showed a partial or total destruction. There wall thickening of blood vessels in all types of leprosy. The morphometric analysis showed a higher level of collagen in patients with multibacillary leprosy. Conclusions: For all types of leprosy there was a disorganization of collagen fibers. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-08-31 |
dc.date.accessioned.fl_str_mv |
2018-05-23T18:05:54Z |
dc.date.available.fl_str_mv |
2018-05-23T18:05:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
format |
bachelorThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GOMES, Mariana Araújo Bezerra. Anisotropias ópticas e morfometria das fibras colágenas da matriz extracelular em pele de indivíduos portadores de hanseníase. Aracaju, SE, 2013. TCC (Graduação em Medicina) - Departamento de Medicina, Aracaju, 2013. |
dc.identifier.uri.fl_str_mv |
http://ri.ufs.br/jspui/handle/riufs/8258 |
identifier_str_mv |
GOMES, Mariana Araújo Bezerra. Anisotropias ópticas e morfometria das fibras colágenas da matriz extracelular em pele de indivíduos portadores de hanseníase. Aracaju, SE, 2013. TCC (Graduação em Medicina) - Departamento de Medicina, Aracaju, 2013. |
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http://ri.ufs.br/jspui/handle/riufs/8258 |
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por |
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por |
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openAccess |
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Universidade Federal de Sergipe |
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DME - Departamento de Medicina – Aracaju - Presencial |
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