Pharmacological validation of the free-exploratory paradigm in Wistar rats : a proposed test of trait anxiety

Detalhes bibliográficos
Autor(a) principal: Souza, Thiago Henrique Almeida
Data de Publicação: 2014
Tipo de documento: Trabalho de conclusão de curso
Idioma: por
Título da fonte: Repositório Institucional da UFS
Texto Completo: https://ri.ufs.br/handle/riufs/6857
Resumo: São Cristóvão, SE
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spelling Souza, Thiago Henrique AlmeidaSilva, Flávia Teixeira2017-11-06T12:43:17Z2017-11-06T12:43:17Z2014-09-22SOUZA, Thiago Henrique Almeida. Pharmacological validation of the free-exploratory paradigm in Wistar rats : a proposed test of trait anxiety. 2015. 1 CD-ROM Monografia (Bacharelado em Farmácia) - Departamento de Farmácia, Centro de Ciências Biológicas e da saúde, Universidade Federal de Sergipe, São Cristóvão, SE, 2015.https://ri.ufs.br/handle/riufs/6857porFarmáciaEnsino de farmáciaPharmacological validation of the free-exploratory paradigm in Wistar rats : a proposed test of trait anxietyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisSão Cristóvão, SEThe free-exploratory paradigm (FEP) has been proposed as a model of trait anxiety for both mice and rats. However, its pharmacological validation has only been carried out for mice. Thus, the aim of the present study was to pharmacologically validate FEP for Wistar rats, by testing the effects of clinically established anxiolytic and anxiogenic drugs, in four different experiments. In all experiments, male Wistar rats were first tested in FEP to be categorized according to their levels of trait anxiety (high, medium and low). Then, only medium trait anxiety rats were selected to be tested again in FEP, two weeks later, after being pharmacologically treated, according to each experiment as follows: Experiment I: 0.5 mg/kg of diazepam (DZP) or vehicle; Experiment II: 20 mg/kg of pentylenetetrazole (PTZ) or vehicle; Experiment III: 5 mg/kg of fluoxetine (FLX5) or vehicle: and Experiment IV: 0.5 mg/kg of fluoxetine (FLX0.5) or vehicle. As a group, the results showed that PTZ and FLX5 increased levels of trait anxiety and reduced locomotor activity, whereas DZP and FLX0.5 decreased levels of trait anxiety, without impairing locomotor activity. These results demonstrate that FEP for rats is able to predict clinical anxiolytic and anxiogenic activities of different drugs, including fluoxetine, which is believed to present a dual effect on anxiety. Therefore, this paradigm can be proposed as an effective method for testing potential trait anxiety-reducing drugs, in rats.Universidade Federal de SergipeDFA - Departamento de Farmácia – São Cristóvão - Presencialreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain; charset=utf-81475https://ri.ufs.br/jspui/bitstream/riufs/6857/1/license.txt098cbbf65c2c15e1fb2e49c5d306a44cMD51ORIGINALThiago Henrique Almeida Souza.pdfThiago Henrique Almeida Souza.pdfapplication/pdf297856https://ri.ufs.br/jspui/bitstream/riufs/6857/2/Thiago%20Henrique%20Almeida%20Souza.pdf4bf38ffd07063e0e8bb363a7d5eda0cfMD52TEXTThiago Henrique Almeida Souza.pdf.txtThiago Henrique Almeida Souza.pdf.txtExtracted texttext/plain33866https://ri.ufs.br/jspui/bitstream/riufs/6857/3/Thiago%20Henrique%20Almeida%20Souza.pdf.txtab43266ab0700e59fe9404350dfb0fedMD53THUMBNAILThiago Henrique Almeida Souza.pdf.jpgThiago Henrique Almeida Souza.pdf.jpgGenerated Thumbnailimage/jpeg1270https://ri.ufs.br/jspui/bitstream/riufs/6857/4/Thiago%20Henrique%20Almeida%20Souza.pdf.jpg4f118d1e318afa998d431106ac7b60c0MD54riufs/68572017-11-06 09:43:17.904oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2017-11-06T12:43:17Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false
dc.title.pt_BR.fl_str_mv Pharmacological validation of the free-exploratory paradigm in Wistar rats : a proposed test of trait anxiety
title Pharmacological validation of the free-exploratory paradigm in Wistar rats : a proposed test of trait anxiety
spellingShingle Pharmacological validation of the free-exploratory paradigm in Wistar rats : a proposed test of trait anxiety
Souza, Thiago Henrique Almeida
Farmácia
Ensino de farmácia
title_short Pharmacological validation of the free-exploratory paradigm in Wistar rats : a proposed test of trait anxiety
title_full Pharmacological validation of the free-exploratory paradigm in Wistar rats : a proposed test of trait anxiety
title_fullStr Pharmacological validation of the free-exploratory paradigm in Wistar rats : a proposed test of trait anxiety
title_full_unstemmed Pharmacological validation of the free-exploratory paradigm in Wistar rats : a proposed test of trait anxiety
title_sort Pharmacological validation of the free-exploratory paradigm in Wistar rats : a proposed test of trait anxiety
author Souza, Thiago Henrique Almeida
author_facet Souza, Thiago Henrique Almeida
author_role author
dc.contributor.author.fl_str_mv Souza, Thiago Henrique Almeida
dc.contributor.advisor1.fl_str_mv Silva, Flávia Teixeira
contributor_str_mv Silva, Flávia Teixeira
dc.subject.por.fl_str_mv Farmácia
Ensino de farmácia
topic Farmácia
Ensino de farmácia
description São Cristóvão, SE
publishDate 2014
dc.date.issued.fl_str_mv 2014-09-22
dc.date.accessioned.fl_str_mv 2017-11-06T12:43:17Z
dc.date.available.fl_str_mv 2017-11-06T12:43:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bachelorThesis
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status_str publishedVersion
dc.identifier.citation.fl_str_mv SOUZA, Thiago Henrique Almeida. Pharmacological validation of the free-exploratory paradigm in Wistar rats : a proposed test of trait anxiety. 2015. 1 CD-ROM Monografia (Bacharelado em Farmácia) - Departamento de Farmácia, Centro de Ciências Biológicas e da saúde, Universidade Federal de Sergipe, São Cristóvão, SE, 2015.
dc.identifier.uri.fl_str_mv https://ri.ufs.br/handle/riufs/6857
identifier_str_mv SOUZA, Thiago Henrique Almeida. Pharmacological validation of the free-exploratory paradigm in Wistar rats : a proposed test of trait anxiety. 2015. 1 CD-ROM Monografia (Bacharelado em Farmácia) - Departamento de Farmácia, Centro de Ciências Biológicas e da saúde, Universidade Federal de Sergipe, São Cristóvão, SE, 2015.
url https://ri.ufs.br/handle/riufs/6857
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.initials.fl_str_mv Universidade Federal de Sergipe
dc.publisher.department.fl_str_mv DFA - Departamento de Farmácia – São Cristóvão - Presencial
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFS
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