Efeito da mobilização articular na nocicepção e na atividade motora em modelo animal de dor musculoesquelética inflamatória

• Autor(a) principal: Sousa, Thiago Abner dos Santos
• Data de Publicação: 2015
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UFS
• Texto Completo: https://ri.ufs.br/handle/riufs/3860
• topic: Mobilização articular; Hiperalgesia; Atividade motora; Ansiedade; Joint mobilization; Hyperalgesia; Motor activity; Anxiety; CNPQ::CIENCIAS DA SAUDE

Introduction: Musculoskeletal pain can be known consequence of repetitive strain, overuse and musculoskeletal disorders related to work. These injuries include a variety of disorders that cause pain in bones, joints, muscles, or surrounding structures, often promoting decreased range of motion and loss of function. The therapeutic management of musculoskeletal pain involves pharmacological treatment and physical therapy. However, the effects of joint mobilization (JM) between the grades of small and large amplitude in the peripheral joints in nociception and locomotor activity are still not well understood scientifically. Objective: To investigate the effects of joint mobilization in peripheral nociception, motor activity and axient in animal models of inflammatory musculoskeletal pain. Methods: Eighteen male Wistar rats (250 to 300 g) received carrageenan and kaolin (0.1 mL) injection solution into the left knee joint to induce inflammation. Joint mobilization grade I (n=6) and grade III (n=6) were held diferentiated by the grade of range. Control animals (n = 6) were kept within a glove during the same time of the animals that were submitted to therapy intervention. All tests were performed with the investigator blinded to the type of treatment performed. Treatment with JM occurred for three days interspersed from the third post-induction day. Were measured the secondary mechanical hyperalgesia (Von Frey digital), spontaneous displacement motor (Open field) and locomotor activity by mean speed, time activity and frequency of rearing (Monitor de Atividades- IR). These measurements are performed before and 24 hours after induction and before and after each treatment day. Data were expressed as mean ± SEM. Differences between groups were analyzed by ANOVA one-way followed by Tukey test and intra-group differences were analyzed by paired t test. Results: After induction of musculoskeletal joint inflammation, decreased paw withdrawal threshold in all groups (p <0.001). The groups JM I and JM III demonstrated significantly increased paw withdrawal threshold (p=0.05) 48 hours after the intervention days D5 and D7, showing no immediate analgesic effect MA. Significant reduction of the mean speed (p <0.001) in groups JM I and JM III on day D1, 24 hours after induction. A significant increase in speed (p=0.02) in the group JM III 48 hours after therapeutic intervention in the days D5 and D7. Immediately after application of therapy in group JM III, mean speed was reduced (p <0.03) on days and D3 and D7 (p <0.03) at day D5 after application JM I and JM III. A significant increase in rearing time (p <0.03) in the group JM III 48 hours after intervention on D7, showing no immediate effect of the JM grade III in the exploratory motor activity. The activity was significantly reduced in time (p <0.002) in the groups JM I and JM III compared to the time before the induction of musculoskeletal inflammation. The data showed increased activity time (p <0.01) 48 hours after the intervention JM III at days D5 and D7. In spontaneous movement, there was an increase in the number of quadrants (p <0.04) in the groups JM I and JM III 48 hours after intervention on days D5 and D7, suggesting there by reducing the levels of anxiety. There was no significant difference between the groups treated in any variable. Conclusion: It is concluded that the joint mobilization carried out in grades I and III had no immediate effect, but did not present adverse effects on reduction of hyperalgesia and levels of anxiet and improving motor activity in acute experimental model of inflammatory musculoskeletal pain