Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFS |
Texto Completo: | https://ri.ufs.br/handle/riufs/1470 |
Resumo: | Medicinal plants are an important source of treatment for many ailments, although little is known of the potential genotoxic effects of most species. In the present study, two species from diverse and medicinally important genera - Maytenus rigida Mart., Celastraceae, and Aristolochia birostris Ducht, Aristolochiaceae - were analyzed to identify potentially significant secondary metabolites and the possible effects of their aqueous and alcoholic extracts on cell division in the onion root stem (genotoxicity test). The phytochemical testing revealed the presence of a number of potentially important secondary compounds in both species, including phenols, flavonoids, triterpenoids, steroids, and saponins. In the genotoxicity tests, no chromosomal abnormalities of any kind were observed in either species. In the case of M. rigida, a significant increase in mitotic activity was observed at the highest concentration. No significant tendency was recorded in A. birostris, although a considerable increase in the prophase was observed at all concentrations of the alcoholic extract. The triterpenoid content of both species may be especially important from a medicinal viewpoint, although recent findings on the carcinogenic potential of Aristolochia extracts demands caution in the interpretation of the results, and the need for further research. |
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Mendes, Sandra SantosAndrade, Josivaldo Almeida deXavier, Maria AldireneSecundo Júnior, José AlvesPantaleao, Silmara de MoraesEstevam, Charles dos SantosGarcia, Carlos Alexandre BorgesFerrari, Stephen Francis2015-02-09T20:16:51Z2015-02-09T20:16:51Z2012-02MENDES, S. S. et al. Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa. Revista Brasileira de Farmacognosia, Curitiba, v. 22, n. 1, jan./fev. 2012. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000100011>. Acesso em: 9 fev. 2015.0102-695Xhttps://ri.ufs.br/handle/riufs/1470Creative Commons Attribution LicenseMedicinal plants are an important source of treatment for many ailments, although little is known of the potential genotoxic effects of most species. In the present study, two species from diverse and medicinally important genera - Maytenus rigida Mart., Celastraceae, and Aristolochia birostris Ducht, Aristolochiaceae - were analyzed to identify potentially significant secondary metabolites and the possible effects of their aqueous and alcoholic extracts on cell division in the onion root stem (genotoxicity test). The phytochemical testing revealed the presence of a number of potentially important secondary compounds in both species, including phenols, flavonoids, triterpenoids, steroids, and saponins. In the genotoxicity tests, no chromosomal abnormalities of any kind were observed in either species. In the case of M. rigida, a significant increase in mitotic activity was observed at the highest concentration. No significant tendency was recorded in A. birostris, although a considerable increase in the prophase was observed at all concentrations of the alcoholic extract. The triterpenoid content of both species may be especially important from a medicinal viewpoint, although recent findings on the carcinogenic potential of Aristolochia extracts demands caution in the interpretation of the results, and the need for further research.Sociedade Brasileira de FarmacognosiaAllium cepaExtratos vegetaisGenotoxicidadePlantas medicinaisAnálise fitoquímicaGenotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTHUMBNAILGenotoxicityTestMaytenus.pdf.jpgGenotoxicityTestMaytenus.pdf.jpgGenerated Thumbnailimage/jpeg1701https://ri.ufs.br/jspui/bitstream/riufs/1470/4/GenotoxicityTestMaytenus.pdf.jpg032f74512a31f808c957e258b3a45082MD54ORIGINALGenotoxicityTestMaytenus.pdfGenotoxicityTestMaytenus.pdfapplication/pdf699505https://ri.ufs.br/jspui/bitstream/riufs/1470/1/GenotoxicityTestMaytenus.pdfd2a464375385c103ff854169c4edad9aMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://ri.ufs.br/jspui/bitstream/riufs/1470/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTGenotoxicityTestMaytenus.pdf.txtGenotoxicityTestMaytenus.pdf.txtExtracted texttext/plain24367https://ri.ufs.br/jspui/bitstream/riufs/1470/3/GenotoxicityTestMaytenus.pdf.txt389219e870e1c0d4bff8f262aac666feMD53riufs/14702016-07-29 20:43:06.62oai:ufs.br:riufs/1470Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2016-07-29T23:43:06Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
dc.title.pt_BR.fl_str_mv |
Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa |
title |
Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa |
spellingShingle |
Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa Mendes, Sandra Santos Allium cepa Extratos vegetais Genotoxicidade Plantas medicinais Análise fitoquímica |
title_short |
Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa |
title_full |
Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa |
title_fullStr |
Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa |
title_full_unstemmed |
Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa |
title_sort |
Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa |
author |
Mendes, Sandra Santos |
author_facet |
Mendes, Sandra Santos Andrade, Josivaldo Almeida de Xavier, Maria Aldirene Secundo Júnior, José Alves Pantaleao, Silmara de Moraes Estevam, Charles dos Santos Garcia, Carlos Alexandre Borges Ferrari, Stephen Francis |
author_role |
author |
author2 |
Andrade, Josivaldo Almeida de Xavier, Maria Aldirene Secundo Júnior, José Alves Pantaleao, Silmara de Moraes Estevam, Charles dos Santos Garcia, Carlos Alexandre Borges Ferrari, Stephen Francis |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Mendes, Sandra Santos Andrade, Josivaldo Almeida de Xavier, Maria Aldirene Secundo Júnior, José Alves Pantaleao, Silmara de Moraes Estevam, Charles dos Santos Garcia, Carlos Alexandre Borges Ferrari, Stephen Francis |
dc.subject.por.fl_str_mv |
Allium cepa Extratos vegetais Genotoxicidade Plantas medicinais Análise fitoquímica |
topic |
Allium cepa Extratos vegetais Genotoxicidade Plantas medicinais Análise fitoquímica |
description |
Medicinal plants are an important source of treatment for many ailments, although little is known of the potential genotoxic effects of most species. In the present study, two species from diverse and medicinally important genera - Maytenus rigida Mart., Celastraceae, and Aristolochia birostris Ducht, Aristolochiaceae - were analyzed to identify potentially significant secondary metabolites and the possible effects of their aqueous and alcoholic extracts on cell division in the onion root stem (genotoxicity test). The phytochemical testing revealed the presence of a number of potentially important secondary compounds in both species, including phenols, flavonoids, triterpenoids, steroids, and saponins. In the genotoxicity tests, no chromosomal abnormalities of any kind were observed in either species. In the case of M. rigida, a significant increase in mitotic activity was observed at the highest concentration. No significant tendency was recorded in A. birostris, although a considerable increase in the prophase was observed at all concentrations of the alcoholic extract. The triterpenoid content of both species may be especially important from a medicinal viewpoint, although recent findings on the carcinogenic potential of Aristolochia extracts demands caution in the interpretation of the results, and the need for further research. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-02 |
dc.date.accessioned.fl_str_mv |
2015-02-09T20:16:51Z |
dc.date.available.fl_str_mv |
2015-02-09T20:16:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MENDES, S. S. et al. Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa. Revista Brasileira de Farmacognosia, Curitiba, v. 22, n. 1, jan./fev. 2012. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000100011>. Acesso em: 9 fev. 2015. |
dc.identifier.uri.fl_str_mv |
https://ri.ufs.br/handle/riufs/1470 |
dc.identifier.issn.none.fl_str_mv |
0102-695X |
dc.identifier.license.pt_BR.fl_str_mv |
Creative Commons Attribution License |
identifier_str_mv |
MENDES, S. S. et al. Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa. Revista Brasileira de Farmacognosia, Curitiba, v. 22, n. 1, jan./fev. 2012. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000100011>. Acesso em: 9 fev. 2015. 0102-695X Creative Commons Attribution License |
url |
https://ri.ufs.br/handle/riufs/1470 |
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eng |
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eng |
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openAccess |
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Sociedade Brasileira de Farmacognosia |
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Sociedade Brasileira de Farmacognosia |
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Universidade Federal de Sergipe (UFS) |
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UFS |
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Repositório Institucional da UFS |
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