Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa

Detalhes bibliográficos
Autor(a) principal: Mendes, Sandra Santos
Data de Publicação: 2012
Outros Autores: Andrade, Josivaldo Almeida de, Xavier, Maria Aldirene, Secundo Júnior, José Alves, Pantaleao, Silmara de Moraes, Estevam, Charles dos Santos, Garcia, Carlos Alexandre Borges, Ferrari, Stephen Francis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFS
Texto Completo: https://ri.ufs.br/handle/riufs/1470
Resumo: Medicinal plants are an important source of treatment for many ailments, although little is known of the potential genotoxic effects of most species. In the present study, two species from diverse and medicinally important genera - Maytenus rigida Mart., Celastraceae, and Aristolochia birostris Ducht, Aristolochiaceae - were analyzed to identify potentially significant secondary metabolites and the possible effects of their aqueous and alcoholic extracts on cell division in the onion root stem (genotoxicity test). The phytochemical testing revealed the presence of a number of potentially important secondary compounds in both species, including phenols, flavonoids, triterpenoids, steroids, and saponins. In the genotoxicity tests, no chromosomal abnormalities of any kind were observed in either species. In the case of M. rigida, a significant increase in mitotic activity was observed at the highest concentration. No significant tendency was recorded in A. birostris, although a considerable increase in the prophase was observed at all concentrations of the alcoholic extract. The triterpenoid content of both species may be especially important from a medicinal viewpoint, although recent findings on the carcinogenic potential of Aristolochia extracts demands caution in the interpretation of the results, and the need for further research.
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spelling Mendes, Sandra SantosAndrade, Josivaldo Almeida deXavier, Maria AldireneSecundo Júnior, José AlvesPantaleao, Silmara de MoraesEstevam, Charles dos SantosGarcia, Carlos Alexandre BorgesFerrari, Stephen Francis2015-02-09T20:16:51Z2015-02-09T20:16:51Z2012-02MENDES, S. S. et al. Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa. Revista Brasileira de Farmacognosia, Curitiba, v. 22, n. 1, jan./fev. 2012. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000100011>. Acesso em: 9 fev. 2015.0102-695Xhttps://ri.ufs.br/handle/riufs/1470Creative Commons Attribution LicenseMedicinal plants are an important source of treatment for many ailments, although little is known of the potential genotoxic effects of most species. In the present study, two species from diverse and medicinally important genera - Maytenus rigida Mart., Celastraceae, and Aristolochia birostris Ducht, Aristolochiaceae - were analyzed to identify potentially significant secondary metabolites and the possible effects of their aqueous and alcoholic extracts on cell division in the onion root stem (genotoxicity test). The phytochemical testing revealed the presence of a number of potentially important secondary compounds in both species, including phenols, flavonoids, triterpenoids, steroids, and saponins. In the genotoxicity tests, no chromosomal abnormalities of any kind were observed in either species. In the case of M. rigida, a significant increase in mitotic activity was observed at the highest concentration. No significant tendency was recorded in A. birostris, although a considerable increase in the prophase was observed at all concentrations of the alcoholic extract. The triterpenoid content of both species may be especially important from a medicinal viewpoint, although recent findings on the carcinogenic potential of Aristolochia extracts demands caution in the interpretation of the results, and the need for further research.Sociedade Brasileira de FarmacognosiaAllium cepaExtratos vegetaisGenotoxicidadePlantas medicinaisAnálise fitoquímicaGenotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTHUMBNAILGenotoxicityTestMaytenus.pdf.jpgGenotoxicityTestMaytenus.pdf.jpgGenerated Thumbnailimage/jpeg1701https://ri.ufs.br/jspui/bitstream/riufs/1470/4/GenotoxicityTestMaytenus.pdf.jpg032f74512a31f808c957e258b3a45082MD54ORIGINALGenotoxicityTestMaytenus.pdfGenotoxicityTestMaytenus.pdfapplication/pdf699505https://ri.ufs.br/jspui/bitstream/riufs/1470/1/GenotoxicityTestMaytenus.pdfd2a464375385c103ff854169c4edad9aMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://ri.ufs.br/jspui/bitstream/riufs/1470/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTGenotoxicityTestMaytenus.pdf.txtGenotoxicityTestMaytenus.pdf.txtExtracted texttext/plain24367https://ri.ufs.br/jspui/bitstream/riufs/1470/3/GenotoxicityTestMaytenus.pdf.txt389219e870e1c0d4bff8f262aac666feMD53riufs/14702016-07-29 20:43:06.62oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2016-07-29T23:43:06Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false
dc.title.pt_BR.fl_str_mv Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa
title Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa
spellingShingle Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa
Mendes, Sandra Santos
Allium cepa
Extratos vegetais
Genotoxicidade
Plantas medicinais
Análise fitoquímica
title_short Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa
title_full Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa
title_fullStr Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa
title_full_unstemmed Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa
title_sort Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa
author Mendes, Sandra Santos
author_facet Mendes, Sandra Santos
Andrade, Josivaldo Almeida de
Xavier, Maria Aldirene
Secundo Júnior, José Alves
Pantaleao, Silmara de Moraes
Estevam, Charles dos Santos
Garcia, Carlos Alexandre Borges
Ferrari, Stephen Francis
author_role author
author2 Andrade, Josivaldo Almeida de
Xavier, Maria Aldirene
Secundo Júnior, José Alves
Pantaleao, Silmara de Moraes
Estevam, Charles dos Santos
Garcia, Carlos Alexandre Borges
Ferrari, Stephen Francis
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mendes, Sandra Santos
Andrade, Josivaldo Almeida de
Xavier, Maria Aldirene
Secundo Júnior, José Alves
Pantaleao, Silmara de Moraes
Estevam, Charles dos Santos
Garcia, Carlos Alexandre Borges
Ferrari, Stephen Francis
dc.subject.por.fl_str_mv Allium cepa
Extratos vegetais
Genotoxicidade
Plantas medicinais
Análise fitoquímica
topic Allium cepa
Extratos vegetais
Genotoxicidade
Plantas medicinais
Análise fitoquímica
description Medicinal plants are an important source of treatment for many ailments, although little is known of the potential genotoxic effects of most species. In the present study, two species from diverse and medicinally important genera - Maytenus rigida Mart., Celastraceae, and Aristolochia birostris Ducht, Aristolochiaceae - were analyzed to identify potentially significant secondary metabolites and the possible effects of their aqueous and alcoholic extracts on cell division in the onion root stem (genotoxicity test). The phytochemical testing revealed the presence of a number of potentially important secondary compounds in both species, including phenols, flavonoids, triterpenoids, steroids, and saponins. In the genotoxicity tests, no chromosomal abnormalities of any kind were observed in either species. In the case of M. rigida, a significant increase in mitotic activity was observed at the highest concentration. No significant tendency was recorded in A. birostris, although a considerable increase in the prophase was observed at all concentrations of the alcoholic extract. The triterpenoid content of both species may be especially important from a medicinal viewpoint, although recent findings on the carcinogenic potential of Aristolochia extracts demands caution in the interpretation of the results, and the need for further research.
publishDate 2012
dc.date.issued.fl_str_mv 2012-02
dc.date.accessioned.fl_str_mv 2015-02-09T20:16:51Z
dc.date.available.fl_str_mv 2015-02-09T20:16:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv MENDES, S. S. et al. Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa. Revista Brasileira de Farmacognosia, Curitiba, v. 22, n. 1, jan./fev. 2012. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000100011>. Acesso em: 9 fev. 2015.
dc.identifier.uri.fl_str_mv https://ri.ufs.br/handle/riufs/1470
dc.identifier.issn.none.fl_str_mv 0102-695X
dc.identifier.license.pt_BR.fl_str_mv Creative Commons Attribution License
identifier_str_mv MENDES, S. S. et al. Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa. Revista Brasileira de Farmacognosia, Curitiba, v. 22, n. 1, jan./fev. 2012. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000100011>. Acesso em: 9 fev. 2015.
0102-695X
Creative Commons Attribution License
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publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
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