Avaliação do efeito anticonvulsivante do geraniol e do complexo de inclusão geraniol:β-ciclodextrina em camundongos
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFS |
Texto Completo: | https://ri.ufs.br/handle/riufs/3840 |
Resumo: | Geraniol (GR) is an acyclic monoterpene alcohol component of essential oils of several aromatic plants used by Brazilian folk medicine for the treatment of epilepsy. However, there are no studies in literature that report effects of GR on Central Nervous System, specifically its potential anticonvulsant effect. The aim of this study was to investigate the anticonvulsant effect of GR and of inclusion complex GR: β-cyclodextrin (GR: β-CD) in animal models of epilepsy induced by Pentilenotetrazole (PTZ) or Strychnine (STR). Initially, mice Swiss male were pretreated, acutely, with GR or GR: β-CD at doses of 50, 100 or 200mg/kg, i. p., 30 minutes before of PTZ administration. The latency of first convulsion and the frequency of convulsion and death were observed for a period of 15 minutes after the administration of convulsant stimuli. The results showed that pre-treatment with GR at dose of 200mg/kg and with GR: β-CD at doses of 100 and 200mg/kg significantly increased the latency of first convulsion and reduced the frequency of animals that convulsed. The procedures were repeated in STR-induced convulsion model, however only the effects of pretreatment with GR were evaluated and no significant effect of GR were observed in this model. The results indicate that GR has an anticonvulsant effect, possibly mediated by GABAergic mechanisms, and the encapsulation of GR in β-CD improved this effect, probably by increase of bioavailability of GR. |
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Lins, Lívia Cristina Rodrigues Ferreirahttp://lattes.cnpq.br/0236515445675827Marchioro, Murilohttp://lattes.cnpq.br/35658516641960892017-09-26T12:17:56Z2017-09-26T12:17:56Z2013-02-21LINS, Lívia Cristina Rodrigues Ferreira. Evaluation of anticonvulsant effect of geraniol and inclusion complex geraniol: β-cyclodextrin in mice. 2013. 57 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Sergipe, Aracaju, 2013.https://ri.ufs.br/handle/riufs/3840Geraniol (GR) is an acyclic monoterpene alcohol component of essential oils of several aromatic plants used by Brazilian folk medicine for the treatment of epilepsy. However, there are no studies in literature that report effects of GR on Central Nervous System, specifically its potential anticonvulsant effect. The aim of this study was to investigate the anticonvulsant effect of GR and of inclusion complex GR: β-cyclodextrin (GR: β-CD) in animal models of epilepsy induced by Pentilenotetrazole (PTZ) or Strychnine (STR). Initially, mice Swiss male were pretreated, acutely, with GR or GR: β-CD at doses of 50, 100 or 200mg/kg, i. p., 30 minutes before of PTZ administration. The latency of first convulsion and the frequency of convulsion and death were observed for a period of 15 minutes after the administration of convulsant stimuli. The results showed that pre-treatment with GR at dose of 200mg/kg and with GR: β-CD at doses of 100 and 200mg/kg significantly increased the latency of first convulsion and reduced the frequency of animals that convulsed. The procedures were repeated in STR-induced convulsion model, however only the effects of pretreatment with GR were evaluated and no significant effect of GR were observed in this model. The results indicate that GR has an anticonvulsant effect, possibly mediated by GABAergic mechanisms, and the encapsulation of GR in β-CD improved this effect, probably by increase of bioavailability of GR.O Geraniol (GR) é um álcool monoterpeno acíclico encontrado em óleos essenciais de várias plantas aromáticas utilizadas pela medicina popular brasileira para o tratamento da epilepsia. Contudo não há estudos na literatura abordando os efeitos do GR sobre o Sistema Nervoso Central(SNC), especialmente seu potencial efeito anticonvulsivante. Este estudo buscou investigar o efeito anticonvulsivante do GR e do complexo de inclusão GR:β-ciclodextrina (GR:β-CD) em modelos animais de convulsão induzidos por pentilenotetrazol(PTZ) ou estricnina(EST). Inicialmente, camundongos Swiss machos foram pré-tratados, agudamente, com GR ou GR:β-CD nas doses de 50, 100 e 200mg/kg, i.p., 30 minutos antes da aministração do PTZ. A latência para a primeira convulsão e a frequência de convulsões e morte foram observados durante 15 minutos após o estímulo convulsivante. Os resultados mostraram que o pré-tratamento com GR na dose de 200mg/kg e com GR:β-ciclodextrina nas doses de 100 e 200mg/kg aumentaram significativamente a latência para a primeira convulsão e reduziram a porcentagem dos animais que convulsionaram. Os procedimentos foram repetidos no modelo de convulsão induzido por EST, porém apenas os efeitos do pré-tratamento com GR foram avaliados e não foram observados efeitos significativos do GR neste modelo. Os resultados demonstram que o GR possui um efeito anticonvulsivante, possivelmente mediado por mecanismos gabaérgicos, e que a encapsulação do GR em β-CD potencializou este efeito, provavelmente pelo aumento da biodisponibilidade do GR.Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorapplication/pdfporUniversidade Federal de SergipePós-Graduação em Ciências da SaúdeUFSBRCiclodextrinasEfeito anticonvulsivanteEpilepsiaGeraniolMonoterpenoAnticonvulsant effectCyclodextrinEpilepsyGeraniolMonoterpeneCNPQ::CIENCIAS DA SAUDEAvaliação do efeito anticonvulsivante do geraniol e do complexo de inclusão geraniol:β-ciclodextrina em camundongosEvaluation of anticonvulsant effect of geraniol and inclusion complex geraniol: β-cyclodextrin in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSTEXTLIVIA_FERREIRA_LINS.pdf.txtLIVIA_FERREIRA_LINS.pdf.txtExtracted texttext/plain90665https://ri.ufs.br/jspui/bitstream/riufs/3840/2/LIVIA_FERREIRA_LINS.pdf.txt9b516cbe8aa70eddb216458d460956c5MD52THUMBNAILLIVIA_FERREIRA_LINS.pdf.jpgLIVIA_FERREIRA_LINS.pdf.jpgGenerated Thumbnailimage/jpeg1417https://ri.ufs.br/jspui/bitstream/riufs/3840/3/LIVIA_FERREIRA_LINS.pdf.jpg1974d821d662bf03b817b21ae06057dcMD53ORIGINALLIVIA_FERREIRA_LINS.pdfapplication/pdf751079https://ri.ufs.br/jspui/bitstream/riufs/3840/1/LIVIA_FERREIRA_LINS.pdf78ddbda93f0a766230d979c0ffd1e87cMD51riufs/38402018-01-17 21:43:12.782oai:ufs.br:riufs/3840Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2018-01-18T00:43:12Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
dc.title.por.fl_str_mv |
Avaliação do efeito anticonvulsivante do geraniol e do complexo de inclusão geraniol:β-ciclodextrina em camundongos |
dc.title.alternative.eng.fl_str_mv |
Evaluation of anticonvulsant effect of geraniol and inclusion complex geraniol: β-cyclodextrin in mice |
title |
Avaliação do efeito anticonvulsivante do geraniol e do complexo de inclusão geraniol:β-ciclodextrina em camundongos |
spellingShingle |
Avaliação do efeito anticonvulsivante do geraniol e do complexo de inclusão geraniol:β-ciclodextrina em camundongos Lins, Lívia Cristina Rodrigues Ferreira Ciclodextrinas Efeito anticonvulsivante Epilepsia Geraniol Monoterpeno Anticonvulsant effect Cyclodextrin Epilepsy Geraniol Monoterpene CNPQ::CIENCIAS DA SAUDE |
title_short |
Avaliação do efeito anticonvulsivante do geraniol e do complexo de inclusão geraniol:β-ciclodextrina em camundongos |
title_full |
Avaliação do efeito anticonvulsivante do geraniol e do complexo de inclusão geraniol:β-ciclodextrina em camundongos |
title_fullStr |
Avaliação do efeito anticonvulsivante do geraniol e do complexo de inclusão geraniol:β-ciclodextrina em camundongos |
title_full_unstemmed |
Avaliação do efeito anticonvulsivante do geraniol e do complexo de inclusão geraniol:β-ciclodextrina em camundongos |
title_sort |
Avaliação do efeito anticonvulsivante do geraniol e do complexo de inclusão geraniol:β-ciclodextrina em camundongos |
author |
Lins, Lívia Cristina Rodrigues Ferreira |
author_facet |
Lins, Lívia Cristina Rodrigues Ferreira |
author_role |
author |
dc.contributor.author.fl_str_mv |
Lins, Lívia Cristina Rodrigues Ferreira |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/0236515445675827 |
dc.contributor.advisor1.fl_str_mv |
Marchioro, Murilo |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/3565851664196089 |
contributor_str_mv |
Marchioro, Murilo |
dc.subject.por.fl_str_mv |
Ciclodextrinas Efeito anticonvulsivante Epilepsia Geraniol Monoterpeno |
topic |
Ciclodextrinas Efeito anticonvulsivante Epilepsia Geraniol Monoterpeno Anticonvulsant effect Cyclodextrin Epilepsy Geraniol Monoterpene CNPQ::CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
Anticonvulsant effect Cyclodextrin Epilepsy Geraniol Monoterpene |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS DA SAUDE |
description |
Geraniol (GR) is an acyclic monoterpene alcohol component of essential oils of several aromatic plants used by Brazilian folk medicine for the treatment of epilepsy. However, there are no studies in literature that report effects of GR on Central Nervous System, specifically its potential anticonvulsant effect. The aim of this study was to investigate the anticonvulsant effect of GR and of inclusion complex GR: β-cyclodextrin (GR: β-CD) in animal models of epilepsy induced by Pentilenotetrazole (PTZ) or Strychnine (STR). Initially, mice Swiss male were pretreated, acutely, with GR or GR: β-CD at doses of 50, 100 or 200mg/kg, i. p., 30 minutes before of PTZ administration. The latency of first convulsion and the frequency of convulsion and death were observed for a period of 15 minutes after the administration of convulsant stimuli. The results showed that pre-treatment with GR at dose of 200mg/kg and with GR: β-CD at doses of 100 and 200mg/kg significantly increased the latency of first convulsion and reduced the frequency of animals that convulsed. The procedures were repeated in STR-induced convulsion model, however only the effects of pretreatment with GR were evaluated and no significant effect of GR were observed in this model. The results indicate that GR has an anticonvulsant effect, possibly mediated by GABAergic mechanisms, and the encapsulation of GR in β-CD improved this effect, probably by increase of bioavailability of GR. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-02-21 |
dc.date.accessioned.fl_str_mv |
2017-09-26T12:17:56Z |
dc.date.available.fl_str_mv |
2017-09-26T12:17:56Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
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masterThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
LINS, Lívia Cristina Rodrigues Ferreira. Evaluation of anticonvulsant effect of geraniol and inclusion complex geraniol: β-cyclodextrin in mice. 2013. 57 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Sergipe, Aracaju, 2013. |
dc.identifier.uri.fl_str_mv |
https://ri.ufs.br/handle/riufs/3840 |
identifier_str_mv |
LINS, Lívia Cristina Rodrigues Ferreira. Evaluation of anticonvulsant effect of geraniol and inclusion complex geraniol: β-cyclodextrin in mice. 2013. 57 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Sergipe, Aracaju, 2013. |
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https://ri.ufs.br/handle/riufs/3840 |
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Universidade Federal de Sergipe |
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Pós-Graduação em Ciências da Saúde |
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UFS |
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BR |
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Universidade Federal de Sergipe |
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