Avaliação do efeito cardioprotetor do nerol em modelo de hipertrofia cardíaca induzida por isoproterenol

Detalhes bibliográficos
Autor(a) principal: Santos, Vinícius Cisneiros de Oliveira
Data de Publicação: 2019
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFS
Texto Completo: http://ri.ufs.br/jspui/handle/riufs/12593
Resumo: The nerol is a monoterpene present in several plants such as Cymbopogon flexuosos (lemon grass), Wisteria brachybotrys (wisteria) and Rosa damascaena (rose tea) with antioxidant, anti-inflammatory, antibacterial, antifungal and antiarrhythmic effects. The objective of the present study was to investigate the cardioprotective activity of the nerol on isoproterenol-induced cardiac hypertrophy (ISO) model. Wistar rats (200-250 g, CEPA: 29/18) were distributed in 5 groups and treated for 7 days ip: 1) Control group (CTR; n = 6), animals receiving saline + DMSO 0 ,1%; 2) Nerol group (n = 6), animals treated with 50 mg / kg nerol + 0.1% DMSO; 3) Group hypertrophy (ISO, n = 6), animals receiving ISO (4.5 mg / kg), 4) Group hypertrophy + nerol (ISO + nerol, n = 6), animals received ISO + nerol, Group hypertrophy + N-acetylcysteine (ISO + NAC, n = 6), animals treated with ISO + NAC (50 mg / kg). The morphometric results showed an increase in the heart weight / body weight ratio (4.89 ± 0.13 mg / g) and heart weight / tibia size (350 ± 8.64 mg / cm) in the ISO group, which were in the ISO + nerol group (3.77 ± 0.16 mg / cm and 211.6 ± 3.29 mg / cm, respectively, p <0.05). Enzyme markers were elevated in hypertrophic animals (LDH: 126.8 ± 11.23 U / L, CPK: 235.6 ± 29.9 U / L and CPK-MB 49.5 ± 5.5 U / L ). However, treatment with the nerol was able to prevent these changes (LDH: 78.5 ± 11.29 U / L, CPK: 48.2 ± 9.7 U / L, CPK-MB: 12.9 ± 2, 5 U / L, p <0.05). The treatment with the nerol was able to reduce the duration of the QRS (43.46 ± 0.63 ms to 23.04 ± 0.6 ms, p <0.05) and abolish the T wave inversion characteristic of cardiac hypertrophy and of QTc (from 114.2 ± 0.2 ms to 56.6 ± 5.7 ms, p <0.05). An improvement in ventricular contractility (47.2 ± 3.0 mmHg, p <0.05) was also observed in relation to the hypertrophy group (12.36 ± 4.42 mmHg). No alteration of PRi and heart rate was observed in the experimental groups evaluated. At coronary pressure, we observed a reduction in the hypertrophy group (44.6 ± 1.6 cmH2O, p <0.05) in relation to the control group (90.6 ± 1.7 cmH2O, p <0.05) which was attenuated in the ISO + nerol group (77.6 ± 1.4 cmH2O, p <0.05). The NAC, used as a positive control, was also able to attenuate the morphometric, enzymatic, electrocardiographic and contractile alterations observed in hypertrophic animals. In addition, histopathology (Mansson's Tricycle) revealed significant improvement of tissue fibrosis, inflammatory infiltrate and edema of hypertrophic hearts with nerol treatment. The area of fibrosis and the left ventricular cross-sectional area were reduced by 58% and 36% (n = 6), respectively, in the hypertrophic hearts treated with the nerol. We conclude that the nerol has a cardioprotective effect in a model of isoproterenol-induced cardiac hypertrophy.
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spelling Santos, Vinícius Cisneiros de OliveiraVasconcelos, Carla Maria Lins de2020-01-20T21:06:39Z2020-01-20T21:06:39Z2019-07-22SANTOS, Vinícius Cisneiros de Oliveira. Avaliação do efeito cardioprotetor do nerol em modelo de hipertrofia cardíaca induzida por isoproterenol. 2019. 69 f. Dissertação (Mestrado em Ciências Fisiológicas) - Universidade Federal de Sergipe, São Cristóvão, SE, 2019.http://ri.ufs.br/jspui/handle/riufs/12593The nerol is a monoterpene present in several plants such as Cymbopogon flexuosos (lemon grass), Wisteria brachybotrys (wisteria) and Rosa damascaena (rose tea) with antioxidant, anti-inflammatory, antibacterial, antifungal and antiarrhythmic effects. The objective of the present study was to investigate the cardioprotective activity of the nerol on isoproterenol-induced cardiac hypertrophy (ISO) model. Wistar rats (200-250 g, CEPA: 29/18) were distributed in 5 groups and treated for 7 days ip: 1) Control group (CTR; n = 6), animals receiving saline + DMSO 0 ,1%; 2) Nerol group (n = 6), animals treated with 50 mg / kg nerol + 0.1% DMSO; 3) Group hypertrophy (ISO, n = 6), animals receiving ISO (4.5 mg / kg), 4) Group hypertrophy + nerol (ISO + nerol, n = 6), animals received ISO + nerol, Group hypertrophy + N-acetylcysteine (ISO + NAC, n = 6), animals treated with ISO + NAC (50 mg / kg). The morphometric results showed an increase in the heart weight / body weight ratio (4.89 ± 0.13 mg / g) and heart weight / tibia size (350 ± 8.64 mg / cm) in the ISO group, which were in the ISO + nerol group (3.77 ± 0.16 mg / cm and 211.6 ± 3.29 mg / cm, respectively, p <0.05). Enzyme markers were elevated in hypertrophic animals (LDH: 126.8 ± 11.23 U / L, CPK: 235.6 ± 29.9 U / L and CPK-MB 49.5 ± 5.5 U / L ). However, treatment with the nerol was able to prevent these changes (LDH: 78.5 ± 11.29 U / L, CPK: 48.2 ± 9.7 U / L, CPK-MB: 12.9 ± 2, 5 U / L, p <0.05). The treatment with the nerol was able to reduce the duration of the QRS (43.46 ± 0.63 ms to 23.04 ± 0.6 ms, p <0.05) and abolish the T wave inversion characteristic of cardiac hypertrophy and of QTc (from 114.2 ± 0.2 ms to 56.6 ± 5.7 ms, p <0.05). An improvement in ventricular contractility (47.2 ± 3.0 mmHg, p <0.05) was also observed in relation to the hypertrophy group (12.36 ± 4.42 mmHg). No alteration of PRi and heart rate was observed in the experimental groups evaluated. At coronary pressure, we observed a reduction in the hypertrophy group (44.6 ± 1.6 cmH2O, p <0.05) in relation to the control group (90.6 ± 1.7 cmH2O, p <0.05) which was attenuated in the ISO + nerol group (77.6 ± 1.4 cmH2O, p <0.05). The NAC, used as a positive control, was also able to attenuate the morphometric, enzymatic, electrocardiographic and contractile alterations observed in hypertrophic animals. In addition, histopathology (Mansson's Tricycle) revealed significant improvement of tissue fibrosis, inflammatory infiltrate and edema of hypertrophic hearts with nerol treatment. The area of fibrosis and the left ventricular cross-sectional area were reduced by 58% and 36% (n = 6), respectively, in the hypertrophic hearts treated with the nerol. We conclude that the nerol has a cardioprotective effect in a model of isoproterenol-induced cardiac hypertrophy.O nerol é um monoterpeno presente em várias plantas como Cymbopogon flexuosos (capim-limão), Wisteria brachybotrys (glicínia) e Rosa damascaena (rosa-chá) com efeitos antioxidante, anti-inflamatório, antibacteriano, antifúngico e antiarrítmico. O objetivo do presente trabalho foi investigar a atividade cardioprotetora do nerol sobre modelo de hipertrofia cardíaca induzida pelo isoproterenol (ISO). Foram usados ratos Wistar (200-250 g, CEPA: 29/18), distribuídos em 5 grupos e tratados por 7 dias por via i.p.: 1) Grupo controle (CTR; n = 6), animais que receberam solução salina + DMSO 0,1%; 2) Grupo nerol (n = 6), animais tratados com 50 mg/kg de nerol + DMSO 0,1%; 3) Grupo hipertrofia (ISO; n = 6), animais que receberam ISO (4,5 mg/kg), 4) Grupo hipertrofia + nerol (ISO + nerol, n = 6), animais receberam ISO + nerol, e 5) Grupo hipertrofia + N-acetilcisteína (ISO + NAC, n = 6), animais tratados com ISO + NAC (50 mg/kg). Os resultados morfométricos evidenciaram um aumento na relação peso do coração/peso corporal (4,89 ± 0,13 mg/g) e peso do coração/tamanho da tíbia (350 ± 8,64 mg/cm) no grupo ISO, que foram prevenidos no grupo ISO + nerol (3,77 ± 0,16 mg/cm e 211,6 ± 3,29 mg/cm, respectivamente, p<0,05). Os marcadores enzimáticos mostraram-se elevados nos animais hipertróficos (LDH: 126,8 ±11,23 U/L, CPK: 235,6 ± 29,9 U/L e CPK-MB 49,5 ± 5,5 U/L). Entretanto, o tratamento com o nerol foi capaz de prevenir essas alterações (LDH: 78,5 ± 11,29 U/L, CPK: 48,2 ± 9,7 U/L, CPK-MB: 12,9 ± 2,5 U/L, p<0,05). O tratamento com o nerol foi capaz de reduzir a duração do QRS (43,46 ± 0,63 ms para 23,04 ± 0,6 ms, p<0,05) e abolir a inversão da onda T característico da hipertrofia cardíaca e do QTc (de 114,2 ± 0,2 ms para 56,6 ± 5,7 ms, p< 0,05). Também foi observado melhora na contratilidade ventricular (47,2 ± 3,0 mmHg, p<0,05) em relação ao grupo hipertrofia (12,36 ± 4,42 mmHg). Não foi observado alteração de PRi e frequência cardíaca nos grupos experimentais avaliados. Na pressão coronariana podemos observar que houve redução no grupo hipertrofia (44,6 ± 1,6 cmH2O, p < 0,05) em relação ao grupo controle (90,6 ± 1,7 cmH2O, p < 0,05), o qual foi atenuado no grupo ISO + nerol (77,6 ± 1,4 cmH2O, p < 0,05). O NAC, usado como controle positivo, também foi capaz de atenuar as alterações morfométricas, enzimáticas, eletrocardiográficas e contráteis observadas nos animais hipertróficos. Além disso, a histopatologia (Tricomo de mansson) revelou melhora significativa da fibrose tecidual, infiltrado inflamatório e edema dos corações hipertróficos com o tratamento com nerol. A área de fibrose e a área da secção transversa do ventrículo esquerdo foram reduzidas em 58% e 36% (n = 6), respectivamente, nos corações hipertróficos tratados com o nerol. Concluímos que o nerol possui efeito cardioprotetor em modelo de hipertrofia cardíaca induzida por isoproterenol.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESSão Cristóvão, SEporCoraçãoVentrículo esquerdoHipertrofiaTerpenosContração do coraçãoIsoproterenolHipertrofia ventricular esquerdaContração miocárdicaLeft ventricular hypertrophyTerpenMyocardial contractionCIENCIAS BIOLOGICAS::FISIOLOGIAAvaliação do efeito cardioprotetor do nerol em modelo de hipertrofia cardíaca induzida por isoproterenolNerol cardioprotector effect in isoproterenol-induced heart hypertrophy modelinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisPós-Graduação em Ciências FisiológicasUniversidade Federal de Sergipereponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessORIGINALVINICIUS_CISNEIROS_OLIVEIRA_SANTOS.pdfVINICIUS_CISNEIROS_OLIVEIRA_SANTOS.pdfapplication/pdf2245681https://ri.ufs.br/jspui/bitstream/riufs/12593/2/VINICIUS_CISNEIROS_OLIVEIRA_SANTOS.pdf26b262846c45971349f2e4b025d270e9MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81475https://ri.ufs.br/jspui/bitstream/riufs/12593/1/license.txt098cbbf65c2c15e1fb2e49c5d306a44cMD51TEXTVINICIUS_CISNEIROS_OLIVEIRA_SANTOS.pdf.txtVINICIUS_CISNEIROS_OLIVEIRA_SANTOS.pdf.txtExtracted texttext/plain129361https://ri.ufs.br/jspui/bitstream/riufs/12593/3/VINICIUS_CISNEIROS_OLIVEIRA_SANTOS.pdf.txt4a8f58a5bf93e8915e491bc7218e133fMD53THUMBNAILVINICIUS_CISNEIROS_OLIVEIRA_SANTOS.pdf.jpgVINICIUS_CISNEIROS_OLIVEIRA_SANTOS.pdf.jpgGenerated Thumbnailimage/jpeg1314https://ri.ufs.br/jspui/bitstream/riufs/12593/4/VINICIUS_CISNEIROS_OLIVEIRA_SANTOS.pdf.jpg327da5afa9e07f9af0b194637bef2598MD54riufs/125932020-01-20 18:06:39.389oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2020-01-20T21:06:39Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false
dc.title.pt_BR.fl_str_mv Avaliação do efeito cardioprotetor do nerol em modelo de hipertrofia cardíaca induzida por isoproterenol
dc.title.alternative.eng.fl_str_mv Nerol cardioprotector effect in isoproterenol-induced heart hypertrophy model
title Avaliação do efeito cardioprotetor do nerol em modelo de hipertrofia cardíaca induzida por isoproterenol
spellingShingle Avaliação do efeito cardioprotetor do nerol em modelo de hipertrofia cardíaca induzida por isoproterenol
Santos, Vinícius Cisneiros de Oliveira
Coração
Ventrículo esquerdo
Hipertrofia
Terpenos
Contração do coração
Isoproterenol
Hipertrofia ventricular esquerda
Contração miocárdica
Left ventricular hypertrophy
Terpen
Myocardial contraction
CIENCIAS BIOLOGICAS::FISIOLOGIA
title_short Avaliação do efeito cardioprotetor do nerol em modelo de hipertrofia cardíaca induzida por isoproterenol
title_full Avaliação do efeito cardioprotetor do nerol em modelo de hipertrofia cardíaca induzida por isoproterenol
title_fullStr Avaliação do efeito cardioprotetor do nerol em modelo de hipertrofia cardíaca induzida por isoproterenol
title_full_unstemmed Avaliação do efeito cardioprotetor do nerol em modelo de hipertrofia cardíaca induzida por isoproterenol
title_sort Avaliação do efeito cardioprotetor do nerol em modelo de hipertrofia cardíaca induzida por isoproterenol
author Santos, Vinícius Cisneiros de Oliveira
author_facet Santos, Vinícius Cisneiros de Oliveira
author_role author
dc.contributor.author.fl_str_mv Santos, Vinícius Cisneiros de Oliveira
dc.contributor.advisor1.fl_str_mv Vasconcelos, Carla Maria Lins de
contributor_str_mv Vasconcelos, Carla Maria Lins de
dc.subject.por.fl_str_mv Coração
Ventrículo esquerdo
Hipertrofia
Terpenos
Contração do coração
Isoproterenol
Hipertrofia ventricular esquerda
Contração miocárdica
topic Coração
Ventrículo esquerdo
Hipertrofia
Terpenos
Contração do coração
Isoproterenol
Hipertrofia ventricular esquerda
Contração miocárdica
Left ventricular hypertrophy
Terpen
Myocardial contraction
CIENCIAS BIOLOGICAS::FISIOLOGIA
dc.subject.eng.fl_str_mv Left ventricular hypertrophy
Terpen
Myocardial contraction
dc.subject.cnpq.fl_str_mv CIENCIAS BIOLOGICAS::FISIOLOGIA
description The nerol is a monoterpene present in several plants such as Cymbopogon flexuosos (lemon grass), Wisteria brachybotrys (wisteria) and Rosa damascaena (rose tea) with antioxidant, anti-inflammatory, antibacterial, antifungal and antiarrhythmic effects. The objective of the present study was to investigate the cardioprotective activity of the nerol on isoproterenol-induced cardiac hypertrophy (ISO) model. Wistar rats (200-250 g, CEPA: 29/18) were distributed in 5 groups and treated for 7 days ip: 1) Control group (CTR; n = 6), animals receiving saline + DMSO 0 ,1%; 2) Nerol group (n = 6), animals treated with 50 mg / kg nerol + 0.1% DMSO; 3) Group hypertrophy (ISO, n = 6), animals receiving ISO (4.5 mg / kg), 4) Group hypertrophy + nerol (ISO + nerol, n = 6), animals received ISO + nerol, Group hypertrophy + N-acetylcysteine (ISO + NAC, n = 6), animals treated with ISO + NAC (50 mg / kg). The morphometric results showed an increase in the heart weight / body weight ratio (4.89 ± 0.13 mg / g) and heart weight / tibia size (350 ± 8.64 mg / cm) in the ISO group, which were in the ISO + nerol group (3.77 ± 0.16 mg / cm and 211.6 ± 3.29 mg / cm, respectively, p <0.05). Enzyme markers were elevated in hypertrophic animals (LDH: 126.8 ± 11.23 U / L, CPK: 235.6 ± 29.9 U / L and CPK-MB 49.5 ± 5.5 U / L ). However, treatment with the nerol was able to prevent these changes (LDH: 78.5 ± 11.29 U / L, CPK: 48.2 ± 9.7 U / L, CPK-MB: 12.9 ± 2, 5 U / L, p <0.05). The treatment with the nerol was able to reduce the duration of the QRS (43.46 ± 0.63 ms to 23.04 ± 0.6 ms, p <0.05) and abolish the T wave inversion characteristic of cardiac hypertrophy and of QTc (from 114.2 ± 0.2 ms to 56.6 ± 5.7 ms, p <0.05). An improvement in ventricular contractility (47.2 ± 3.0 mmHg, p <0.05) was also observed in relation to the hypertrophy group (12.36 ± 4.42 mmHg). No alteration of PRi and heart rate was observed in the experimental groups evaluated. At coronary pressure, we observed a reduction in the hypertrophy group (44.6 ± 1.6 cmH2O, p <0.05) in relation to the control group (90.6 ± 1.7 cmH2O, p <0.05) which was attenuated in the ISO + nerol group (77.6 ± 1.4 cmH2O, p <0.05). The NAC, used as a positive control, was also able to attenuate the morphometric, enzymatic, electrocardiographic and contractile alterations observed in hypertrophic animals. In addition, histopathology (Mansson's Tricycle) revealed significant improvement of tissue fibrosis, inflammatory infiltrate and edema of hypertrophic hearts with nerol treatment. The area of fibrosis and the left ventricular cross-sectional area were reduced by 58% and 36% (n = 6), respectively, in the hypertrophic hearts treated with the nerol. We conclude that the nerol has a cardioprotective effect in a model of isoproterenol-induced cardiac hypertrophy.
publishDate 2019
dc.date.issued.fl_str_mv 2019-07-22
dc.date.accessioned.fl_str_mv 2020-01-20T21:06:39Z
dc.date.available.fl_str_mv 2020-01-20T21:06:39Z
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dc.identifier.citation.fl_str_mv SANTOS, Vinícius Cisneiros de Oliveira. Avaliação do efeito cardioprotetor do nerol em modelo de hipertrofia cardíaca induzida por isoproterenol. 2019. 69 f. Dissertação (Mestrado em Ciências Fisiológicas) - Universidade Federal de Sergipe, São Cristóvão, SE, 2019.
dc.identifier.uri.fl_str_mv http://ri.ufs.br/jspui/handle/riufs/12593
identifier_str_mv SANTOS, Vinícius Cisneiros de Oliveira. Avaliação do efeito cardioprotetor do nerol em modelo de hipertrofia cardíaca induzida por isoproterenol. 2019. 69 f. Dissertação (Mestrado em Ciências Fisiológicas) - Universidade Federal de Sergipe, São Cristóvão, SE, 2019.
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dc.publisher.initials.fl_str_mv Universidade Federal de Sergipe
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