Efeitos do extrato aquoso de abajeru (Crhysobalanus icaco) sobre o peso corporal, adiposidade e sensibilidade à insulina de camundongos obesos

Detalhes bibliográficos
Autor(a) principal: White, Pollyanna Alves Secundo
Data de Publicação: 2011
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFS
Texto Completo: https://ri.ufs.br/handle/riufs/3742
Resumo: Obesity is characterized by excessive accumulation of fat in the body. The anatomical location of the tissue, more specifically its abdominal (visceral) distribution, plays a major role in the development of insulin resistance, which acts as a key point linking obesity to the development of several other chronicle diseases. Thus, research on new therapies that may positively affect the development and treatment of obesity and its co morbidities are needed. This study aimed at investigating the potential of aqueous extract of Chrysobalanus icaco leaves (EACI) on the loss of weight and adipose tissue, and assessing its effects on insulin sensitivity in obese mice. Therefore, we used 34 Swiss mice divided into four groups which received a standard diet (SD), standard diet plus EACI (DPE), high-fat diet (HFD) and high-fat diet plus EACI (DHE), which was mixed to the drinking water of animals during the last 4 weeks of a total of 14weeks in which they received their diets. At the end of the experiment consumption, body weight, weight of fat pads, blood glucose, serum lipids, insulin sensitivity and glucose tolerance were evaluated. The results showed that the HC group had significant higher body mass (p < 0,001), fat pads (p < 0,0001), feed efficiency (p < 0,0001) and blood glucose levels (p< 0,05), besides higher area under curve (p < 0,05) on the insulin tolerance test. After the 4th week of treatment, in the HAD group, the EACI promoted less weight gain (p < 0,05), blood glucose (p <0.05) and insulin sensitivity (p <0.05) normalization, despite the high-fat diet intake. Regarding the adipose tissue there was little effect caused by the extract and no effect on the serum lipids and glucose tolerance. Thus, the data indicates that a model of high-fat induced obesity associated with insulin resistance was validated and that the extract was capable of normalizing the blood glucose levels and insulin sensitivity and still prevented the weight gain in the obese animals.
id UFS-2_cc62ec5a22a75d1dce03e517806d26b4
oai_identifier_str oai:ufs.br:riufs/3742
network_acronym_str UFS-2
network_name_str Repositório Institucional da UFS
repository_id_str
spelling White, Pollyanna Alves Secundohttp://lattes.cnpq.br/9692770802439503Santos, Márcio Roberto Viana doshttp://lattes.cnpq.br/14337281216914952017-09-26T12:17:03Z2017-09-26T12:17:03Z2011-02-03https://ri.ufs.br/handle/riufs/3742Obesity is characterized by excessive accumulation of fat in the body. The anatomical location of the tissue, more specifically its abdominal (visceral) distribution, plays a major role in the development of insulin resistance, which acts as a key point linking obesity to the development of several other chronicle diseases. Thus, research on new therapies that may positively affect the development and treatment of obesity and its co morbidities are needed. This study aimed at investigating the potential of aqueous extract of Chrysobalanus icaco leaves (EACI) on the loss of weight and adipose tissue, and assessing its effects on insulin sensitivity in obese mice. Therefore, we used 34 Swiss mice divided into four groups which received a standard diet (SD), standard diet plus EACI (DPE), high-fat diet (HFD) and high-fat diet plus EACI (DHE), which was mixed to the drinking water of animals during the last 4 weeks of a total of 14weeks in which they received their diets. At the end of the experiment consumption, body weight, weight of fat pads, blood glucose, serum lipids, insulin sensitivity and glucose tolerance were evaluated. The results showed that the HC group had significant higher body mass (p < 0,001), fat pads (p < 0,0001), feed efficiency (p < 0,0001) and blood glucose levels (p< 0,05), besides higher area under curve (p < 0,05) on the insulin tolerance test. After the 4th week of treatment, in the HAD group, the EACI promoted less weight gain (p < 0,05), blood glucose (p <0.05) and insulin sensitivity (p <0.05) normalization, despite the high-fat diet intake. Regarding the adipose tissue there was little effect caused by the extract and no effect on the serum lipids and glucose tolerance. Thus, the data indicates that a model of high-fat induced obesity associated with insulin resistance was validated and that the extract was capable of normalizing the blood glucose levels and insulin sensitivity and still prevented the weight gain in the obese animals.A obesidade é caracterizada pelo acúmulo excessivo de tecido adiposo no organismo. A localização anatômica desse tecido, mais especificamente sua distribuição abdominal (visceral), tem papel primordial no desenvolvimento da resistência à insulina, que atua como um ponto chave ligando a obesidade ao desenvolvimento de diversas outras doenças crônico-degenerativas. Dessa forma, pesquisas acerca de novas terapêuticas que possam promover benefícios sobre o desenvolvimento e tratamento da obesidade e de suas comorbidades se fazem necessárias. Este estudo teve como propósito verificar o potencial do extrato aquoso das folhas do Chrysobalanus icaco (EACI) sobre a redução de peso e tecido adiposo, bem como avaliar seu efeito sobre a sensibilidade à insulina em camundongos obesos. Para tanto, foram utilizados 34 camundongos Swiss divididos em 4 grupos que receberam dieta padrão (DP), dieta padrão e EACI (DPE), dieta hiperlipídica (DH) e dieta hiperlipídica associada ao EACI (DHE), o qual foi colocado na água de beber dos animais durante as 4 últimas semanas de um período total de 14 semanas em que eles receberam as respectivas dietas. Ao final do experimento foram avaliados consumo, peso corporal, peso dos coxins adiposos, glicemia, lipídios séricos, sensibilidade à insulina e tolerância à glicose. Os resultados obtidos mostram que o grupo DH apresentou aumento significativo de massa corpórea (p < 0,001), dos coxins adiposos (P < 0 0001), da eficiência energética (p < 0,0001) e da glicemia (p < 0,05), além de maior área sob a curva obtido no teste de tolerância à insulina (p < 0,05). Após tratamento por 4 semanas, no grupo DHE, o EACI possibilitou menor ganho de peso (p < 0,05), normalização da glicemia (p < 0,05) e da sensibilidade à insulina (p < 0,05), apesar do consumo de dieta hiperlipídica. Com relação ao tecido adiposo houve pouca influência do extrato e nenhum efeito sobre os lipídios séricos e tolerância à glicose. Dessa forma, os dados indicam que foi validado um modelo de obesidade induzido por dieta hiperlipídica associado à resistência insulínica e que o extrato foi capaz de normalizar a glicemia, sensibilidade à insulina e ainda promover menor ganho de peso nos animais obesos.Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorapplication/pdfporUniversidade Federal de SergipePós-Graduação em Ciências da SaúdeUFSBRCamundongosChrysobalanus icacoObesidadeResistência à insulinaMiceChrysobalanus icacoObesityInsulin resistanceCNPQ::CIENCIAS DA SAUDE::MEDICINAEfeitos do extrato aquoso de abajeru (Crhysobalanus icaco) sobre o peso corporal, adiposidade e sensibilidade à insulina de camundongos obesosEFFECTS OF AQUEOUS EXTRACT OF ABAJERU (Crhysobalanus icaco) ON BODY WEIGHT, ADIPOSITY AND INSULIN SENSITIVITY IN OBESE MICE.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSTEXTPOLLYANNA_ALVES_SECUNDO_WHITE.pdf.txtPOLLYANNA_ALVES_SECUNDO_WHITE.pdf.txtExtracted texttext/plain108793https://ri.ufs.br/jspui/bitstream/riufs/3742/2/POLLYANNA_ALVES_SECUNDO_WHITE.pdf.txtae2a728618a30b9d2b1fe51cdd418536MD52THUMBNAILPOLLYANNA_ALVES_SECUNDO_WHITE.pdf.jpgPOLLYANNA_ALVES_SECUNDO_WHITE.pdf.jpgGenerated Thumbnailimage/jpeg1383https://ri.ufs.br/jspui/bitstream/riufs/3742/3/POLLYANNA_ALVES_SECUNDO_WHITE.pdf.jpgae41814d240a67262e0b9c0d3ee88f1eMD53ORIGINALPOLLYANNA_ALVES_SECUNDO_WHITE.pdfapplication/pdf721007https://ri.ufs.br/jspui/bitstream/riufs/3742/1/POLLYANNA_ALVES_SECUNDO_WHITE.pdfa153156eac334ad3a78bf7301ef3c061MD51riufs/37422017-11-28 16:37:30.301oai:ufs.br:riufs/3742Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2017-11-28T19:37:30Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false
dc.title.por.fl_str_mv Efeitos do extrato aquoso de abajeru (Crhysobalanus icaco) sobre o peso corporal, adiposidade e sensibilidade à insulina de camundongos obesos
dc.title.alternative.eng.fl_str_mv EFFECTS OF AQUEOUS EXTRACT OF ABAJERU (Crhysobalanus icaco) ON BODY WEIGHT, ADIPOSITY AND INSULIN SENSITIVITY IN OBESE MICE.
title Efeitos do extrato aquoso de abajeru (Crhysobalanus icaco) sobre o peso corporal, adiposidade e sensibilidade à insulina de camundongos obesos
spellingShingle Efeitos do extrato aquoso de abajeru (Crhysobalanus icaco) sobre o peso corporal, adiposidade e sensibilidade à insulina de camundongos obesos
White, Pollyanna Alves Secundo
Camundongos
Chrysobalanus icaco
Obesidade
Resistência à insulina
Mice
Chrysobalanus icaco
Obesity
Insulin resistance
CNPQ::CIENCIAS DA SAUDE::MEDICINA
title_short Efeitos do extrato aquoso de abajeru (Crhysobalanus icaco) sobre o peso corporal, adiposidade e sensibilidade à insulina de camundongos obesos
title_full Efeitos do extrato aquoso de abajeru (Crhysobalanus icaco) sobre o peso corporal, adiposidade e sensibilidade à insulina de camundongos obesos
title_fullStr Efeitos do extrato aquoso de abajeru (Crhysobalanus icaco) sobre o peso corporal, adiposidade e sensibilidade à insulina de camundongos obesos
title_full_unstemmed Efeitos do extrato aquoso de abajeru (Crhysobalanus icaco) sobre o peso corporal, adiposidade e sensibilidade à insulina de camundongos obesos
title_sort Efeitos do extrato aquoso de abajeru (Crhysobalanus icaco) sobre o peso corporal, adiposidade e sensibilidade à insulina de camundongos obesos
author White, Pollyanna Alves Secundo
author_facet White, Pollyanna Alves Secundo
author_role author
dc.contributor.author.fl_str_mv White, Pollyanna Alves Secundo
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/9692770802439503
dc.contributor.advisor1.fl_str_mv Santos, Márcio Roberto Viana dos
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/1433728121691495
contributor_str_mv Santos, Márcio Roberto Viana dos
dc.subject.por.fl_str_mv Camundongos
Chrysobalanus icaco
Obesidade
Resistência à insulina
topic Camundongos
Chrysobalanus icaco
Obesidade
Resistência à insulina
Mice
Chrysobalanus icaco
Obesity
Insulin resistance
CNPQ::CIENCIAS DA SAUDE::MEDICINA
dc.subject.eng.fl_str_mv Mice
Chrysobalanus icaco
Obesity
Insulin resistance
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS DA SAUDE::MEDICINA
description Obesity is characterized by excessive accumulation of fat in the body. The anatomical location of the tissue, more specifically its abdominal (visceral) distribution, plays a major role in the development of insulin resistance, which acts as a key point linking obesity to the development of several other chronicle diseases. Thus, research on new therapies that may positively affect the development and treatment of obesity and its co morbidities are needed. This study aimed at investigating the potential of aqueous extract of Chrysobalanus icaco leaves (EACI) on the loss of weight and adipose tissue, and assessing its effects on insulin sensitivity in obese mice. Therefore, we used 34 Swiss mice divided into four groups which received a standard diet (SD), standard diet plus EACI (DPE), high-fat diet (HFD) and high-fat diet plus EACI (DHE), which was mixed to the drinking water of animals during the last 4 weeks of a total of 14weeks in which they received their diets. At the end of the experiment consumption, body weight, weight of fat pads, blood glucose, serum lipids, insulin sensitivity and glucose tolerance were evaluated. The results showed that the HC group had significant higher body mass (p < 0,001), fat pads (p < 0,0001), feed efficiency (p < 0,0001) and blood glucose levels (p< 0,05), besides higher area under curve (p < 0,05) on the insulin tolerance test. After the 4th week of treatment, in the HAD group, the EACI promoted less weight gain (p < 0,05), blood glucose (p <0.05) and insulin sensitivity (p <0.05) normalization, despite the high-fat diet intake. Regarding the adipose tissue there was little effect caused by the extract and no effect on the serum lipids and glucose tolerance. Thus, the data indicates that a model of high-fat induced obesity associated with insulin resistance was validated and that the extract was capable of normalizing the blood glucose levels and insulin sensitivity and still prevented the weight gain in the obese animals.
publishDate 2011
dc.date.issued.fl_str_mv 2011-02-03
dc.date.accessioned.fl_str_mv 2017-09-26T12:17:03Z
dc.date.available.fl_str_mv 2017-09-26T12:17:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ri.ufs.br/handle/riufs/3742
url https://ri.ufs.br/handle/riufs/3742
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Sergipe
dc.publisher.program.fl_str_mv Pós-Graduação em Ciências da Saúde
dc.publisher.initials.fl_str_mv UFS
dc.publisher.country.fl_str_mv BR
publisher.none.fl_str_mv Universidade Federal de Sergipe
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFS
instname:Universidade Federal de Sergipe (UFS)
instacron:UFS
instname_str Universidade Federal de Sergipe (UFS)
instacron_str UFS
institution UFS
reponame_str Repositório Institucional da UFS
collection Repositório Institucional da UFS
bitstream.url.fl_str_mv https://ri.ufs.br/jspui/bitstream/riufs/3742/2/POLLYANNA_ALVES_SECUNDO_WHITE.pdf.txt
https://ri.ufs.br/jspui/bitstream/riufs/3742/3/POLLYANNA_ALVES_SECUNDO_WHITE.pdf.jpg
https://ri.ufs.br/jspui/bitstream/riufs/3742/1/POLLYANNA_ALVES_SECUNDO_WHITE.pdf
bitstream.checksum.fl_str_mv ae2a728618a30b9d2b1fe51cdd418536
ae41814d240a67262e0b9c0d3ee88f1e
a153156eac334ad3a78bf7301ef3c061
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)
repository.mail.fl_str_mv repositorio@academico.ufs.br
_version_ 1802110661620137984