Distúrbios ventilatórios em portadores de Anemia Falciforme

• Autor(a) principal: Rocha, Neuly Almeida Figueirêdo
• Data de Publicação: 2011
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UFS
• Texto Completo: https://ri.ufs.br/handle/riufs/3691
• topic: Anemia falciforme; Doença pulmonar crônica; Espirometria; Sickle cell anemia; Chronic pulmonary disease and spirometria; CNPQ::CIENCIAS DA SAUDE

The Sickle Cell Anemia (SCA) is the most common hematologic inherit disease in the world and, according to the Health World s Organization (HWO) estimative, about 2.500 children with the sickle cell disease are born each year in Brazil. The characteristic vaso-occlusive phenomenon can occur in any organ, as for the lung one are among the main causes of the morbidity. With the aim of analyzing the pulmonary commitment of the children, teenagers and young adults with the SCA and identify the possible risk factors to the aerobics disturbance, a transversal study was made through a clinical and spirometric evaluation. The study involved 125 patients with the SCA, at ages between 14,3 +/- 4,9 years old (six and twenty-seven years), being 52% of the male gender. It was observed that 57,6% of the patients showed some alterations from aerobics to espirometric (44,8% had a restrictive pattern, 10,4% obstructive and 2,4% mixed). When the groups with spirometric alteration were compared according to the variations: genders, family background, acute chest syndrome, personal allergies background, lung noise, bronchodilator (BD) medication, home smokers, internship and vaccine calendar, there wasn t any alteration related to none of them. However, when the relation of hemotransfusion with the espirometric patterns was analyzed, the statistic difference (p=0,06) was not found, therefore a comparative analyses between the the frequency of the hemotransfusion and the normal patterns versus the restrictive was made, observing a significant difference in the restrictive group in relation to the normal with p=0,045. It was observed that the annual average of the hemoglobin of the group of patients without spirometric alterations was significantly smaller when comparing to the group with restrictive profile (p<0,004), as for the chronological age average (p=0,04). No other variation was associated with the espirometric profile. It is possible to concluded that the disturbance in the pulmonary function in the patients with SCA, many times appearing in childhood and adolescence. Among them, there is a greater number of the restrictive disturbance. Beyond that, low hemoglobin, transfusion profile and the age of the patient related to endangerment of the pulmonary function.