Avaliação do efeito antinociceptivo orofacial da Sida cordifolia L. (Malvaceae) em roedores

• Autor(a) principal: Silva, Adailton Martins
• Data de Publicação: 2011
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UFS
• Texto Completo: https://ri.ufs.br/handle/riufs/3703
• topic: Plantas medicinais; Sida cordifolia; Dor orofacial; Medicinal plant; Sida cordifolia; Orofacial pain; CNPQ::CIENCIAS DA SAUDE

Sida cordifolia from Malvaceae family (Sida L.) with about 250 species around the world, has been used in folk medicine as anti-inflammatory, antirheumatic and antipyretic, laxative, diuretic, analgesic and hypoglycemic, antiviral, bactericide and antifungal. In this study, we attempted to identify the possible antinociceptive action of the ethanol extract (EE), chloroform (CF) and methanol (MF) fractions obtained of Sida cordifolia, known in Brazil as malva branca or malva branca sedosa . Leaves of S. cordifolia were used to produce the crude ethanol extract and after CF and MF. Experiments were conducted on Swiss mice using the glutamate and formalin-induced orofacial nociception. In the formalin test, all doses of EE, CF and MF significantly reduced the orofacial nociception in the first (p < 0.001) and second phase (p < 0.001), which was also naloxone-sensitive. The percentage reduction average for the first phase of the formalin test was 79,6% (EE), 78,4% (CF) e 65,6% (MF) and for the second phase 77,9% (EE), 69,7% (CF) e 81,1% (MF). In the glutamate-induced nociception test, only CF and MF significantly reduced the orofacial nociceptive behavior with inhibition percentage values of 48.1% (100 mg/kg, CF), 56.1% (200 mg/kg, CF), 66.4% (400 mg/kg, CF), 48.2 (200 mg/kg, MF) and 60.1 (400 mg/kg, MF). Furthermore, treatment of the animals with EE, CF and MF was not able to promote motor activity changes. These data demonstrate that S. cordifolia has a pronounced antinociceptive activity against orofacial nociception. However, pharmacological and chemical studies are continuing in order to characterize the mechanism(s) responsible for this antinociceptive action and also to identify other active substances present in S. cordifolia.