Differential effects of lead and zinc on inhibitory avoidance learning in mice

Detalhes bibliográficos
Autor(a) principal: Oliveira, Fábio S. de
Data de Publicação: 2002
Outros Autores: Santos, Márcio Roberto Viana dos, Antoniolli, Ângelo Roberto, Marchioro, Murilo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFS
Texto Completo: https://ri.ufs.br/handle/riufs/1168
Resumo: We studied the effects of chronic intoxication with the heavy metals lead (Pb2+) and zinc (Zn2+) on memory formation in mice. Animals were intoxicated through drinking water during the pre- and postnatal periods and then tested in the step-through inhibitory avoidance memory task. Chronic postnatal intoxication with Pb2+ did not change the step-through latency values recorded during the 4 weeks of the test (ANOVA, P>0.05). In contrast, mice intoxicated during the prenatal period showed significantly reduced latency values when compared to the control group (day 1: q = 4.62, P<0.05; day 7: q = 4.42, P<0.05; day 14: q = 5.65, P<0.05; day 21: q = 3.96, P<0.05, and day 28: q = 6.09, P<0.05). Although chronic postnatal intoxication with Zn2+ did not alter a memory retention test performed 24 h after training, we noticed a gradual decrease in latency at subsequent 4-week intervals (F = 3.07, P<0.05), an effect that was not observed in the control or in the Pb2+-treated groups. These results suggest an impairment of memory formation by Pb2+ when the animals are exposed during the critical period of neurogenesis, while Zn2+ appears to facilitate learning extinction.
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spelling Oliveira, Fábio S. deSantos, Márcio Roberto Viana dosAntoniolli, Ângelo RobertoMarchioro, Murilo2014-09-09T16:45:23Z2014-09-09T16:45:23Z2002-01OLIVEIRA F. S. et al. Differential effects of lead and zinc on inhibitory avoidance learning in mice. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 34, n. 1, jan. 2001. Disponível em: <http://dx.doi.org/10.1590/S0100-879X2001000100014>. Acesso em: 08 de set. 2014.1414-431Xhttps://ri.ufs.br/handle/riufs/1168Creative Commons Attribution LicenseWe studied the effects of chronic intoxication with the heavy metals lead (Pb2+) and zinc (Zn2+) on memory formation in mice. Animals were intoxicated through drinking water during the pre- and postnatal periods and then tested in the step-through inhibitory avoidance memory task. Chronic postnatal intoxication with Pb2+ did not change the step-through latency values recorded during the 4 weeks of the test (ANOVA, P>0.05). In contrast, mice intoxicated during the prenatal period showed significantly reduced latency values when compared to the control group (day 1: q = 4.62, P<0.05; day 7: q = 4.42, P<0.05; day 14: q = 5.65, P<0.05; day 21: q = 3.96, P<0.05, and day 28: q = 6.09, P<0.05). Although chronic postnatal intoxication with Zn2+ did not alter a memory retention test performed 24 h after training, we noticed a gradual decrease in latency at subsequent 4-week intervals (F = 3.07, P<0.05), an effect that was not observed in the control or in the Pb2+-treated groups. These results suggest an impairment of memory formation by Pb2+ when the animals are exposed during the critical period of neurogenesis, while Zn2+ appears to facilitate learning extinction.Brazilian Journal of Medical and Biological ResearchChumboZincoEsquiva inibitóriaMemóriaDifferential effects of lead and zinc on inhibitory avoidance learning in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTHUMBNAILDifferentialEffects.pdf.jpgDifferentialEffects.pdf.jpgGenerated Thumbnailimage/jpeg1618https://ri.ufs.br/jspui/bitstream/riufs/1168/4/DifferentialEffects.pdf.jpg8ff1af8748a236f8d6d846dcebdd7454MD54ORIGINALDifferentialEffects.pdfDifferentialEffects.pdfapplication/pdf158446https://ri.ufs.br/jspui/bitstream/riufs/1168/1/DifferentialEffects.pdfba0dc1f89bed91e2622fd07502fefe24MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://ri.ufs.br/jspui/bitstream/riufs/1168/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTDifferentialEffects.pdf.txtDifferentialEffects.pdf.txtExtracted texttext/plain15027https://ri.ufs.br/jspui/bitstream/riufs/1168/3/DifferentialEffects.pdf.txt5757b1696aeb3e6307ae150317351e4bMD53riufs/11682014-09-16 14:33:13.868oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2014-09-16T17:33:13Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false
dc.title.pt_BR.fl_str_mv Differential effects of lead and zinc on inhibitory avoidance learning in mice
title Differential effects of lead and zinc on inhibitory avoidance learning in mice
spellingShingle Differential effects of lead and zinc on inhibitory avoidance learning in mice
Oliveira, Fábio S. de
Chumbo
Zinco
Esquiva inibitória
Memória
title_short Differential effects of lead and zinc on inhibitory avoidance learning in mice
title_full Differential effects of lead and zinc on inhibitory avoidance learning in mice
title_fullStr Differential effects of lead and zinc on inhibitory avoidance learning in mice
title_full_unstemmed Differential effects of lead and zinc on inhibitory avoidance learning in mice
title_sort Differential effects of lead and zinc on inhibitory avoidance learning in mice
author Oliveira, Fábio S. de
author_facet Oliveira, Fábio S. de
Santos, Márcio Roberto Viana dos
Antoniolli, Ângelo Roberto
Marchioro, Murilo
author_role author
author2 Santos, Márcio Roberto Viana dos
Antoniolli, Ângelo Roberto
Marchioro, Murilo
author2_role author
author
author
dc.contributor.author.fl_str_mv Oliveira, Fábio S. de
Santos, Márcio Roberto Viana dos
Antoniolli, Ângelo Roberto
Marchioro, Murilo
dc.subject.por.fl_str_mv Chumbo
Zinco
Esquiva inibitória
Memória
topic Chumbo
Zinco
Esquiva inibitória
Memória
description We studied the effects of chronic intoxication with the heavy metals lead (Pb2+) and zinc (Zn2+) on memory formation in mice. Animals were intoxicated through drinking water during the pre- and postnatal periods and then tested in the step-through inhibitory avoidance memory task. Chronic postnatal intoxication with Pb2+ did not change the step-through latency values recorded during the 4 weeks of the test (ANOVA, P>0.05). In contrast, mice intoxicated during the prenatal period showed significantly reduced latency values when compared to the control group (day 1: q = 4.62, P<0.05; day 7: q = 4.42, P<0.05; day 14: q = 5.65, P<0.05; day 21: q = 3.96, P<0.05, and day 28: q = 6.09, P<0.05). Although chronic postnatal intoxication with Zn2+ did not alter a memory retention test performed 24 h after training, we noticed a gradual decrease in latency at subsequent 4-week intervals (F = 3.07, P<0.05), an effect that was not observed in the control or in the Pb2+-treated groups. These results suggest an impairment of memory formation by Pb2+ when the animals are exposed during the critical period of neurogenesis, while Zn2+ appears to facilitate learning extinction.
publishDate 2002
dc.date.issued.fl_str_mv 2002-01
dc.date.accessioned.fl_str_mv 2014-09-09T16:45:23Z
dc.date.available.fl_str_mv 2014-09-09T16:45:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv OLIVEIRA F. S. et al. Differential effects of lead and zinc on inhibitory avoidance learning in mice. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 34, n. 1, jan. 2001. Disponível em: <http://dx.doi.org/10.1590/S0100-879X2001000100014>. Acesso em: 08 de set. 2014.
dc.identifier.uri.fl_str_mv https://ri.ufs.br/handle/riufs/1168
dc.identifier.issn.none.fl_str_mv 1414-431X
dc.identifier.license.pt_BR.fl_str_mv Creative Commons Attribution License
identifier_str_mv OLIVEIRA F. S. et al. Differential effects of lead and zinc on inhibitory avoidance learning in mice. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 34, n. 1, jan. 2001. Disponível em: <http://dx.doi.org/10.1590/S0100-879X2001000100014>. Acesso em: 08 de set. 2014.
1414-431X
Creative Commons Attribution License
url https://ri.ufs.br/handle/riufs/1168
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Brazilian Journal of Medical and Biological Research
publisher.none.fl_str_mv Brazilian Journal of Medical and Biological Research
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFS
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reponame_str Repositório Institucional da UFS
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