Endocannabinoid system as a potential target for neurodegenerative diseases

Detalhes bibliográficos
Autor(a) principal: Paes, Rodrigo Sebben
Data de Publicação: 2022
Outros Autores: Baldasso, Gabriela Mantovani
Tipo de documento: Trabalho de conclusão de curso
Idioma: eng
Título da fonte: Repositório Institucional da UFSC
Texto Completo: https://repositorio.ufsc.br/handle/123456789/237603
Resumo: TCC(graduação) - Universidade Federal de Santa Catarina. Araranguá. Fisioterapia.
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spelling Endocannabinoid system as a potential target for neurodegenerative diseasesPrakinson's diseaseAlzheimer's diseaseHuntington’s diseaseneuroinflammationNeurodegenerationNeurogenerative diseasesTCC(graduação) - Universidade Federal de Santa Catarina. Araranguá. Fisioterapia.Neurodegenerative diseases (ND) represent a critical social and economic problem worldwide and are becoming highly prevalent because of the increasing average age of the population. ND is characterized by exacerbated neural death which leads to motor, cognitive or behavioural diss representing an important cause of disability and mortality. Both its development and maintenance have been investigated over the last decades. In most of them, there is a chronic neuroinflammatory state establishment commonly associated with pathological protein aggregation, as evidenced in AD, PD and HD. This neuroinflammatory state is recognized by microglial hyperactivation, inflammatory cytokines storm and neural death, compromising the neurological environment. Accordingly, in the last decades, intensive efforts have been put into investigating the main pathways involved in its development and new pharmacological approaches to management it. Since the ’80s, when cannabinoid receptors (CB1R and CB2R) were discovered, the endocannabinoid system modulation has been investigated in many diseases context in order to the millenary medicinal use of cannabis. Nowadays, have already been described the different roles played by components that make up it, such as antitumoral, regulation of neurotransmission in different brain regions, inflammatory modulation, and regulation of glial cells. In this context, this work aimed to provide a summarized translational review of the most recent studies about the involvement of the ECS in NDs development and maintenance, as well as a therapeutic target.Araranguá, SCDellaAcqua, Melissa NegroUniversidade Federal de Santa CatarinaPaes, Rodrigo SebbenBaldasso, Gabriela Mantovani2022-08-02T19:27:57Z2022-08-02T19:27:57Z2022-07-13info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesis39 páginasapplication/pdfhttps://repositorio.ufsc.br/handle/123456789/237603info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFSCinstname:Universidade Federal de Santa Catarina (UFSC)instacron:UFSC2022-08-02T19:27:57Zoai:repositorio.ufsc.br:123456789/237603Repositório InstitucionalPUBhttp://150.162.242.35/oai/requestopendoar:23732022-08-02T19:27:57Repositório Institucional da UFSC - Universidade Federal de Santa Catarina (UFSC)false
dc.title.none.fl_str_mv Endocannabinoid system as a potential target for neurodegenerative diseases
title Endocannabinoid system as a potential target for neurodegenerative diseases
spellingShingle Endocannabinoid system as a potential target for neurodegenerative diseases
Paes, Rodrigo Sebben
Prakinson's disease
Alzheimer's disease
Huntington’s disease
neuroinflammation
Neurodegeneration
Neurogenerative diseases
title_short Endocannabinoid system as a potential target for neurodegenerative diseases
title_full Endocannabinoid system as a potential target for neurodegenerative diseases
title_fullStr Endocannabinoid system as a potential target for neurodegenerative diseases
title_full_unstemmed Endocannabinoid system as a potential target for neurodegenerative diseases
title_sort Endocannabinoid system as a potential target for neurodegenerative diseases
author Paes, Rodrigo Sebben
author_facet Paes, Rodrigo Sebben
Baldasso, Gabriela Mantovani
author_role author
author2 Baldasso, Gabriela Mantovani
author2_role author
dc.contributor.none.fl_str_mv DellaAcqua, Melissa Negro
Universidade Federal de Santa Catarina
dc.contributor.author.fl_str_mv Paes, Rodrigo Sebben
Baldasso, Gabriela Mantovani
dc.subject.por.fl_str_mv Prakinson's disease
Alzheimer's disease
Huntington’s disease
neuroinflammation
Neurodegeneration
Neurogenerative diseases
topic Prakinson's disease
Alzheimer's disease
Huntington’s disease
neuroinflammation
Neurodegeneration
Neurogenerative diseases
description TCC(graduação) - Universidade Federal de Santa Catarina. Araranguá. Fisioterapia.
publishDate 2022
dc.date.none.fl_str_mv 2022-08-02T19:27:57Z
2022-08-02T19:27:57Z
2022-07-13
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bachelorThesis
format bachelorThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio.ufsc.br/handle/123456789/237603
url https://repositorio.ufsc.br/handle/123456789/237603
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 39 páginas
application/pdf
dc.publisher.none.fl_str_mv Araranguá, SC
publisher.none.fl_str_mv Araranguá, SC
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFSC
instname:Universidade Federal de Santa Catarina (UFSC)
instacron:UFSC
instname_str Universidade Federal de Santa Catarina (UFSC)
instacron_str UFSC
institution UFSC
reponame_str Repositório Institucional da UFSC
collection Repositório Institucional da UFSC
repository.name.fl_str_mv Repositório Institucional da UFSC - Universidade Federal de Santa Catarina (UFSC)
repository.mail.fl_str_mv
_version_ 1808652088526241792

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