Efficacy and safety of bexagliflozin in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Pasqualotto, Eric
Data de Publicação: 2024
Tipo de documento: Trabalho de conclusão de curso
Idioma: eng
Título da fonte: Repositório Institucional da UFSC
Texto Completo: https://repositorio.ufsc.br/handle/123456789/255510
Resumo: TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Medicina.
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spelling Efficacy and safety of bexagliflozin in patients with type 2 diabetes mellitus: a systematic review and meta-analysisSodium-Glucose Transporter 2 InhibitorsDiabetes Mellitus, Type 2Glycated HemoglobinTCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Medicina.Aim: To assess the efficacy of bexagliflozin in reducing glycated hemoglobin (HbA1c) and the occurrence of side effects in patients with type 2 diabetes (T2DM). Methods: We searched PubMed, Embase, Cochrane and ClinicalTrials.gov databases for placebo-controlled, randomized clinical trials until February 15, 2023. The primary outcome was change in HbA1c. We computed weighted mean differences (WMDs) for continuous outcomes and odds ratios (ORs) for binary endpoints, with 95% confidence intervals (CIs). Results: A total of 6 studies and 3,111 patients were included, of whom 1,951 were prescribed bexagliflozin. Compared to placebo, bexagliflozin significantly reduced HbA1c levels (WMD -0.53%; 95% CI -0.75,-0.31), fasting plasma glucose levels (WMD -1.45 mmol/L; 95% CI -2.32,-0.57), systolic blood pressure (WMD -4.66 mmHg; 95% CI -6.41,-2.92), diastolic blood pressure (WMD -2.12 mmHg; 95% CI -3.94,-0.30), body weight (WMD -1.61 Kg; 95% CI -2.14,-1.07), and body weight in patients with a body mass index > 25 kg/m2 (WMD -2.05 Kg; 95% CI -2.78,-1.31). The proportion of patients who achieved HbA1c < 7% was higher in patients who received bexagliflozin as compared with placebo (OR 1.94; 95% CI 1.36-2.78). There were no significant differences between groups regarding side effects as hypoglycemia, genital mycotic infection, urinary tract infection, diarrhea, headache, náusea, polyuria, diabetic ketoacidosis, or all-cause mortality. Conclusions: In this meta-analysis, the use of bexagliflozin was associated with improved clinical and laboratory measures in patients with T2DM compared to placebo, with a similar profile of side effects. These findings support the efficacy of bexagliflozin in the treatment of T2DM.Florianópolis, SC.van de Sande-Lee, SimonePinheiro, Carlos Eduardo AndradeUniversidade Federal de Santa Catarina.Pasqualotto, Eric2024-06-28T16:16:45Z2024-06-28T16:16:45Z2024-03-08info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesis42fapplication/pdfhttps://repositorio.ufsc.br/handle/123456789/255510Open Access.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFSCinstname:Universidade Federal de Santa Catarina (UFSC)instacron:UFSC2024-06-28T16:16:46Zoai:repositorio.ufsc.br:123456789/255510Repositório InstitucionalPUBhttp://150.162.242.35/oai/requestopendoar:23732024-06-28T16:16:46Repositório Institucional da UFSC - Universidade Federal de Santa Catarina (UFSC)false
dc.title.none.fl_str_mv Efficacy and safety of bexagliflozin in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
title Efficacy and safety of bexagliflozin in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
spellingShingle Efficacy and safety of bexagliflozin in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
Pasqualotto, Eric
Sodium-Glucose Transporter 2 Inhibitors
Diabetes Mellitus, Type 2
Glycated Hemoglobin
title_short Efficacy and safety of bexagliflozin in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
title_full Efficacy and safety of bexagliflozin in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
title_fullStr Efficacy and safety of bexagliflozin in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
title_full_unstemmed Efficacy and safety of bexagliflozin in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
title_sort Efficacy and safety of bexagliflozin in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
author Pasqualotto, Eric
author_facet Pasqualotto, Eric
author_role author
dc.contributor.none.fl_str_mv van de Sande-Lee, Simone
Pinheiro, Carlos Eduardo Andrade
Universidade Federal de Santa Catarina.
dc.contributor.author.fl_str_mv Pasqualotto, Eric
dc.subject.por.fl_str_mv Sodium-Glucose Transporter 2 Inhibitors
Diabetes Mellitus, Type 2
Glycated Hemoglobin
topic Sodium-Glucose Transporter 2 Inhibitors
Diabetes Mellitus, Type 2
Glycated Hemoglobin
description TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Medicina.
publishDate 2024
dc.date.none.fl_str_mv 2024-06-28T16:16:45Z
2024-06-28T16:16:45Z
2024-03-08
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bachelorThesis
format bachelorThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio.ufsc.br/handle/123456789/255510
url https://repositorio.ufsc.br/handle/123456789/255510
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv Open Access.
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Open Access.
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 42f
application/pdf
dc.publisher.none.fl_str_mv Florianópolis, SC.
publisher.none.fl_str_mv Florianópolis, SC.
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFSC
instname:Universidade Federal de Santa Catarina (UFSC)
instacron:UFSC
instname_str Universidade Federal de Santa Catarina (UFSC)
instacron_str UFSC
institution UFSC
reponame_str Repositório Institucional da UFSC
collection Repositório Institucional da UFSC
repository.name.fl_str_mv Repositório Institucional da UFSC - Universidade Federal de Santa Catarina (UFSC)
repository.mail.fl_str_mv
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