Etiological and antimicrobial susceptibility profile of isolated blood cultures in a university hospital

• Autor(a) principal: Foletto, Vitória Segabinazzi
• Data de Publicação: 2019
• Outros Autores: Bottega, Angelita, Serafin, Marissa Bolson, Rosa, Taciéli Fagundes da, Mainardi, Amanda, Franco, Laísa Nunes, Hörner, Rosmari
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Saúde (Santa Maria)
• Texto Completo: https://periodicos.ufsm.br/revistasaude/article/view/40016
• topic: Bacteremia; Nosocomial infection; Sepsis; Antibacterials; Staphylococcus epidermidis; Klebsiella pneumoniae; Hemocultura; Bacteremia; Infecção hospitalar; Sepse; Antibacterianos.

Objective: To evaluate the etiological and antimicrobial susceptibility profile of positive blood cultures from a university hospital in southern Brazil over a period of one year. Methods: All positive blood cultures collected from January to December 2018 were retrospectively analyzed, and information regarding gender and age, type of collection (peripheral/catheter), hospital sectors, isolated microorganisms, mean positivity time and antimicrobial resistance profile. Results: Of the 870 positive blood cultures, there was preponderance in males (53,0%), in adults (33,9%), in peripheral blood (65,7%) and in the Adult Intensive Care Unit (19,8%). Staphylococcus epidermidis (38,1%) and Klebsiella pneumoniae (26,3%) were the prevalent microorganisms. Mean bacterial positivity time was less than 24 hours (18h 39min and 17h, Gram positive and Gram negative, respectively), and for fungi (4,7% of the total), over 48 hours (52h 26min). Staphylococcus showed significant resistance to oxacillin (S. epidermidis – 82,3% and S. hominis – 85,5%). The resistance of K. pneumoniae to carbapenems was 56,5%, to 23,2% to colistin and to 53,6% to cephalosporins. Conclusions: Resistance to methicillin/oxacillin in staphylococci coagulase, as well as that of carbapenemics, colistin, and broad spectrum cephalosporins in K. pneumoniae are of concern, as bloodstream infection is still a major source of mortality. Immediate correct antibiotic therapy impacts financially and clinical outcome, which makes epidemiological studies such as this important aid in the initiation of effective therapy and significantly increase the likelihood of patient survival, especially in this hospita