Tablet splitting: implications in clonazepam dose adjustment?
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Saúde (Santa Maria) |
Texto Completo: | https://periodicos.ufsm.br/revistasaude/article/view/28841 |
Resumo: | Tablet splitting is particularly interesting for dose tapering and slow dose titration, especially in psychiatric and geriatric communities. The objective of this study was to investigate the accuracy and precision of splitting clonazepam tablets using a kitchen knife and a commercially available tablet splitter. Whole tablets and split portions were individually weighed to determine weight variation and weight loss. Despite an accurate splitting (mean percentage close to 100%), precision analysis indicated a high variability in half-tablets weight (RSD>6%), ranging around ± 25% for tablet splitter and ± 18% for kitchen knife. There was no significant difference between the splitting techniques used to divide the tablets for both accuracy and weight loss. These preliminary findings indicate that splitting clonazepam tablets either by tablet splitter or kitchen knife might result in an apparent accurate splitting, in spite of the lack of precision between split portions. Future research is needed to investigate if such variations in clonazepam daily drug doses would result in clinical outcomes compromising dose adjustment schedules. |
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Saúde (Santa Maria) |
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Tablet splitting: implications in clonazepam dose adjustment?tabletsclonazepamdosagecomprimidosclonazepamdosagemTablet splitting is particularly interesting for dose tapering and slow dose titration, especially in psychiatric and geriatric communities. The objective of this study was to investigate the accuracy and precision of splitting clonazepam tablets using a kitchen knife and a commercially available tablet splitter. Whole tablets and split portions were individually weighed to determine weight variation and weight loss. Despite an accurate splitting (mean percentage close to 100%), precision analysis indicated a high variability in half-tablets weight (RSD>6%), ranging around ± 25% for tablet splitter and ± 18% for kitchen knife. There was no significant difference between the splitting techniques used to divide the tablets for both accuracy and weight loss. These preliminary findings indicate that splitting clonazepam tablets either by tablet splitter or kitchen knife might result in an apparent accurate splitting, in spite of the lack of precision between split portions. Future research is needed to investigate if such variations in clonazepam daily drug doses would result in clinical outcomes compromising dose adjustment schedules. A divisão de comprimidos permite o ajuste de dose e retirada gradual de medicamentos, principalmente para pacientes psiquiátricos e geriátricos. O objetivo deste estudo foi investigar a exatidão e precisão de doses das porções provenientes da divisão de comprimidos de clonazepam utilizando-se faca e cortador de comprimidos. Comprimidos inteiros e porções foram pesados individualmente para determinação da variação de peso e perda de peso. Apesar de uma divisão exata (próxima a 100%), a análise da precisão indicou alta variabilidade entre o peso das porções (DPR>6%), variando em torno de ± 25% para o cortador de comprimidos e ± 18% para a faca. Não houve diferença significativa entre as técnicas utilizadas quanto à exatidão e perda de peso. Esses dados preliminares indicam que dividir comprimidos de clonazepam tanto com o cortador de comprimidos quanto com a faca pode resultar em uma divisão aparentemente exata, apesar da falta de precisão entre as porções obtidas. Estudos são necessários para investigar se tais variações nas doses diárias de clonazepam resultariam em um desfecho clínico comprometendo esquemas de ajuste de doses.Universidade Federal de Santa Maria2018-01-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.ufsm.br/revistasaude/article/view/2884110.5902/2236583428841Saúde (Santa Maria); Revista Saúde (Santa Maria), Vol.43, n.3, Set./Dez. 2017Saúde (Santa Maria); Revista Saúde (Santa Maria), Vol.43, n.3, Set./Dez. 20172236-58340103-4499reponame:Saúde (Santa Maria)instname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMenghttps://periodicos.ufsm.br/revistasaude/article/view/28841/pdfCopyright (c) 2018 Saúde (Santa Maria)info:eu-repo/semantics/openAccessEserian, Jaqueline KalleianLombardo, Márcia2019-12-02T15:05:40Zoai:ojs.pkp.sfu.ca:article/28841Revistahttps://periodicos.ufsm.br/revistasaudePUBhttps://periodicos.ufsm.br/revistasaude/oairevistasaude.ufsm@gmail.com || amanda.revsaude@gmail.com || beatriz.revsaude@gmail.com2236-58342236-5834opendoar:2019-12-02T15:05:40Saúde (Santa Maria) - Universidade Federal de Santa Maria (UFSM)false |
dc.title.none.fl_str_mv |
Tablet splitting: implications in clonazepam dose adjustment? |
title |
Tablet splitting: implications in clonazepam dose adjustment? |
spellingShingle |
Tablet splitting: implications in clonazepam dose adjustment? Eserian, Jaqueline Kalleian tablets clonazepam dosage comprimidos clonazepam dosagem |
title_short |
Tablet splitting: implications in clonazepam dose adjustment? |
title_full |
Tablet splitting: implications in clonazepam dose adjustment? |
title_fullStr |
Tablet splitting: implications in clonazepam dose adjustment? |
title_full_unstemmed |
Tablet splitting: implications in clonazepam dose adjustment? |
title_sort |
Tablet splitting: implications in clonazepam dose adjustment? |
author |
Eserian, Jaqueline Kalleian |
author_facet |
Eserian, Jaqueline Kalleian Lombardo, Márcia |
author_role |
author |
author2 |
Lombardo, Márcia |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Eserian, Jaqueline Kalleian Lombardo, Márcia |
dc.subject.por.fl_str_mv |
tablets clonazepam dosage comprimidos clonazepam dosagem |
topic |
tablets clonazepam dosage comprimidos clonazepam dosagem |
description |
Tablet splitting is particularly interesting for dose tapering and slow dose titration, especially in psychiatric and geriatric communities. The objective of this study was to investigate the accuracy and precision of splitting clonazepam tablets using a kitchen knife and a commercially available tablet splitter. Whole tablets and split portions were individually weighed to determine weight variation and weight loss. Despite an accurate splitting (mean percentage close to 100%), precision analysis indicated a high variability in half-tablets weight (RSD>6%), ranging around ± 25% for tablet splitter and ± 18% for kitchen knife. There was no significant difference between the splitting techniques used to divide the tablets for both accuracy and weight loss. These preliminary findings indicate that splitting clonazepam tablets either by tablet splitter or kitchen knife might result in an apparent accurate splitting, in spite of the lack of precision between split portions. Future research is needed to investigate if such variations in clonazepam daily drug doses would result in clinical outcomes compromising dose adjustment schedules. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-24 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.ufsm.br/revistasaude/article/view/28841 10.5902/2236583428841 |
url |
https://periodicos.ufsm.br/revistasaude/article/view/28841 |
identifier_str_mv |
10.5902/2236583428841 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://periodicos.ufsm.br/revistasaude/article/view/28841/pdf |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Saúde (Santa Maria) info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Saúde (Santa Maria) |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.source.none.fl_str_mv |
Saúde (Santa Maria); Revista Saúde (Santa Maria), Vol.43, n.3, Set./Dez. 2017 Saúde (Santa Maria); Revista Saúde (Santa Maria), Vol.43, n.3, Set./Dez. 2017 2236-5834 0103-4499 reponame:Saúde (Santa Maria) instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Saúde (Santa Maria) |
collection |
Saúde (Santa Maria) |
repository.name.fl_str_mv |
Saúde (Santa Maria) - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
revistasaude.ufsm@gmail.com || amanda.revsaude@gmail.com || beatriz.revsaude@gmail.com |
_version_ |
1799944000661094400 |