Photocatalytic oxidation of clozapine using TiO2 immobilized in polystyrene: effect of operation parameters and artificial neural network modeling

Detalhes bibliográficos
Autor(a) principal: Santana, Rayany Magali da Rocha
Data de Publicação: 2019
Outros Autores: Moura, Thalita Cristhina de Lima, Nascimento, Graziele Elisandra do, Charamba, Lívia Vieira Carlini, Duarte, Marta Maria Menezes Bezerra, Napoleão, Daniella Carla
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Eletrônica em Gestão Educação e Tecnologia Ambiental (REGET)
Texto Completo: https://periodicos.ufsm.br/reget/article/view/38236
Resumo: In recent years, heterogeneous photocatalysis using semiconductors has proved to be efficient for the treatment of wastewater containing organic pollutants, such as drugs. Among some photocatalysts, titanium dioxide (TiO2) has been studied and applied for this purpose. Therefore, this work investigated the photocatalytic degradation of the antipsychotic clozapine under ultraviolet irradiation, using suspended and supported TiO2 in polystyrene material. Some experimental parameters were evaluated through a factorial design 23; a higher degradation rate of the compound was verified using 0.15 g of the immobilized catalyst, [H2O2] of 340 mg L-1 and pH 9, after 6 h of treatment. It was possible to obtain degradations above 93.48% and a two-stage model was proposed to describe the reaction kinetics. An artificial neural network was used to model the photocatalytic process and to determine the importance of the operational variables. It was also established that the use of this treatment resulted in 78.30% removal of chemical oxygen demand (COD) under optimized conditions. In addition, the stability of TiO2 support after five consecutive cycles was verified from reuse tests. However, by means of toxicological tests with Escherichia coli and Salmonella enteritidis, it was observed that the products generated by the reaction were more toxic than the original compound.
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spelling Photocatalytic oxidation of clozapine using TiO2 immobilized in polystyrene: effect of operation parameters and artificial neural network modelingOxidação fotocatalítica da clozapina empregando TiO2 imobilizado em poliestireno: efeito dos parâmetros operacionais e modelagem via redes neuraisDrugEcotoxicityHeterogeneous photocatalysisPsychotropicUltraviolet radiationEcotoxicidadeFármacoFotocatálise heterogêneaPsicotrópicoRadiação ultravioletaIn recent years, heterogeneous photocatalysis using semiconductors has proved to be efficient for the treatment of wastewater containing organic pollutants, such as drugs. Among some photocatalysts, titanium dioxide (TiO2) has been studied and applied for this purpose. Therefore, this work investigated the photocatalytic degradation of the antipsychotic clozapine under ultraviolet irradiation, using suspended and supported TiO2 in polystyrene material. Some experimental parameters were evaluated through a factorial design 23; a higher degradation rate of the compound was verified using 0.15 g of the immobilized catalyst, [H2O2] of 340 mg L-1 and pH 9, after 6 h of treatment. It was possible to obtain degradations above 93.48% and a two-stage model was proposed to describe the reaction kinetics. An artificial neural network was used to model the photocatalytic process and to determine the importance of the operational variables. It was also established that the use of this treatment resulted in 78.30% removal of chemical oxygen demand (COD) under optimized conditions. In addition, the stability of TiO2 support after five consecutive cycles was verified from reuse tests. However, by means of toxicological tests with Escherichia coli and Salmonella enteritidis, it was observed that the products generated by the reaction were more toxic than the original compound.Nos últimos anos, a fotocatálise heterogênea através de semicondutores demonstrou ser eficiente para o tratamento de águas residuárias contendo poluentes orgânicos, como os fármacos. Dentre alguns fotocatalisadores, o dióxido de titânio (TiO2) tem sido estudado e aplicado para esta finalidade. À vista disso, neste trabalho investigou-se a degradação fotocatalítica do antipsicótico clozapina sob irradiação ultravioleta, mediante emprego de TiO2 suspenso e suportado em material de poliestireno. Alguns parâmetros experimentais foram avaliados através de um planejamento fatorial 23; verificando-se uma maior taxa de degradação do composto ao utilizar 0,15 g do catalisador imobilizado, [H2O2] de 340 mg L-1 e pH 9, após 6 h de tratamento. Para tal obteve-se degradações superiores a 93,48% e um modelo de dois estágios foi proposto para descrever a cinética reacional. Uma rede neural artificial foi utilizada para modelar o processo fotocatalítico e determinar a importância das variáveis operacionais. Também ficou estabelecido que o emprego deste tratamento resultou em 78,30% de remoção da demanda química de oxigênio (DQO) nas condições otimizadas. Além disso, a partir de testes de reutilização foi verificada a estabilidade do suporte de TiO2 após 5 ciclos consecutivos. No entanto, por meio de ensaios toxicológicos com Escherichia coli e Salmonella enteritidis observou-se que os produtos gerados através da reação geram produtos mais tóxicos que o composto original.Universidade Federal de Santa Maria2019-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.ufsm.br/reget/article/view/3823610.5902/2236117038236Revista Eletrônica em Gestão, Educação e Tecnologia Ambiental; REGET, V. 23, 2019; e31Revista Eletrônica em Gestão, Educação e Tecnologia Ambiental; REGET, V. 23, 2019; e312236-11702236-1170reponame:Revista Eletrônica em Gestão Educação e Tecnologia Ambiental (REGET)instname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMenghttps://periodicos.ufsm.br/reget/article/view/38236/pdfCopyright (c) 2019 Revista Eletrônica em Gestão, Educação e Tecnologia Ambientalhttp://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessSantana, Rayany Magali da RochaMoura, Thalita Cristhina de LimaNascimento, Graziele Elisandra doCharamba, Lívia Vieira CarliniDuarte, Marta Maria Menezes BezerraNapoleão, Daniella Carla2022-08-09T12:09:27Zoai:ojs.pkp.sfu.ca:article/38236Revistahttps://periodicos.ufsm.br/regetPUBhttps://periodicos.ufsm.br/reget/oaimarcelobdarosa@gmail.com||reget.ufsm@gmail.com2236-11702236-1170opendoar:2022-08-09T12:09:27Revista Eletrônica em Gestão Educação e Tecnologia Ambiental (REGET) - Universidade Federal de Santa Maria (UFSM)false
dc.title.none.fl_str_mv Photocatalytic oxidation of clozapine using TiO2 immobilized in polystyrene: effect of operation parameters and artificial neural network modeling
Oxidação fotocatalítica da clozapina empregando TiO2 imobilizado em poliestireno: efeito dos parâmetros operacionais e modelagem via redes neurais
title Photocatalytic oxidation of clozapine using TiO2 immobilized in polystyrene: effect of operation parameters and artificial neural network modeling
spellingShingle Photocatalytic oxidation of clozapine using TiO2 immobilized in polystyrene: effect of operation parameters and artificial neural network modeling
Santana, Rayany Magali da Rocha
Drug
Ecotoxicity
Heterogeneous photocatalysis
Psychotropic
Ultraviolet radiation
Ecotoxicidade
Fármaco
Fotocatálise heterogênea
Psicotrópico
Radiação ultravioleta
title_short Photocatalytic oxidation of clozapine using TiO2 immobilized in polystyrene: effect of operation parameters and artificial neural network modeling
title_full Photocatalytic oxidation of clozapine using TiO2 immobilized in polystyrene: effect of operation parameters and artificial neural network modeling
title_fullStr Photocatalytic oxidation of clozapine using TiO2 immobilized in polystyrene: effect of operation parameters and artificial neural network modeling
title_full_unstemmed Photocatalytic oxidation of clozapine using TiO2 immobilized in polystyrene: effect of operation parameters and artificial neural network modeling
title_sort Photocatalytic oxidation of clozapine using TiO2 immobilized in polystyrene: effect of operation parameters and artificial neural network modeling
author Santana, Rayany Magali da Rocha
author_facet Santana, Rayany Magali da Rocha
Moura, Thalita Cristhina de Lima
Nascimento, Graziele Elisandra do
Charamba, Lívia Vieira Carlini
Duarte, Marta Maria Menezes Bezerra
Napoleão, Daniella Carla
author_role author
author2 Moura, Thalita Cristhina de Lima
Nascimento, Graziele Elisandra do
Charamba, Lívia Vieira Carlini
Duarte, Marta Maria Menezes Bezerra
Napoleão, Daniella Carla
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Santana, Rayany Magali da Rocha
Moura, Thalita Cristhina de Lima
Nascimento, Graziele Elisandra do
Charamba, Lívia Vieira Carlini
Duarte, Marta Maria Menezes Bezerra
Napoleão, Daniella Carla
dc.subject.por.fl_str_mv Drug
Ecotoxicity
Heterogeneous photocatalysis
Psychotropic
Ultraviolet radiation
Ecotoxicidade
Fármaco
Fotocatálise heterogênea
Psicotrópico
Radiação ultravioleta
topic Drug
Ecotoxicity
Heterogeneous photocatalysis
Psychotropic
Ultraviolet radiation
Ecotoxicidade
Fármaco
Fotocatálise heterogênea
Psicotrópico
Radiação ultravioleta
description In recent years, heterogeneous photocatalysis using semiconductors has proved to be efficient for the treatment of wastewater containing organic pollutants, such as drugs. Among some photocatalysts, titanium dioxide (TiO2) has been studied and applied for this purpose. Therefore, this work investigated the photocatalytic degradation of the antipsychotic clozapine under ultraviolet irradiation, using suspended and supported TiO2 in polystyrene material. Some experimental parameters were evaluated through a factorial design 23; a higher degradation rate of the compound was verified using 0.15 g of the immobilized catalyst, [H2O2] of 340 mg L-1 and pH 9, after 6 h of treatment. It was possible to obtain degradations above 93.48% and a two-stage model was proposed to describe the reaction kinetics. An artificial neural network was used to model the photocatalytic process and to determine the importance of the operational variables. It was also established that the use of this treatment resulted in 78.30% removal of chemical oxygen demand (COD) under optimized conditions. In addition, the stability of TiO2 support after five consecutive cycles was verified from reuse tests. However, by means of toxicological tests with Escherichia coli and Salmonella enteritidis, it was observed that the products generated by the reaction were more toxic than the original compound.
publishDate 2019
dc.date.none.fl_str_mv 2019-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.ufsm.br/reget/article/view/38236
10.5902/2236117038236
url https://periodicos.ufsm.br/reget/article/view/38236
identifier_str_mv 10.5902/2236117038236
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://periodicos.ufsm.br/reget/article/view/38236/pdf
dc.rights.driver.fl_str_mv Copyright (c) 2019 Revista Eletrônica em Gestão, Educação e Tecnologia Ambiental
http://creativecommons.org/licenses/by-nc-sa/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2019 Revista Eletrônica em Gestão, Educação e Tecnologia Ambiental
http://creativecommons.org/licenses/by-nc-sa/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
publisher.none.fl_str_mv Universidade Federal de Santa Maria
dc.source.none.fl_str_mv Revista Eletrônica em Gestão, Educação e Tecnologia Ambiental; REGET, V. 23, 2019; e31
Revista Eletrônica em Gestão, Educação e Tecnologia Ambiental; REGET, V. 23, 2019; e31
2236-1170
2236-1170
reponame:Revista Eletrônica em Gestão Educação e Tecnologia Ambiental (REGET)
instname:Universidade Federal de Santa Maria (UFSM)
instacron:UFSM
instname_str Universidade Federal de Santa Maria (UFSM)
instacron_str UFSM
institution UFSM
reponame_str Revista Eletrônica em Gestão Educação e Tecnologia Ambiental (REGET)
collection Revista Eletrônica em Gestão Educação e Tecnologia Ambiental (REGET)
repository.name.fl_str_mv Revista Eletrônica em Gestão Educação e Tecnologia Ambiental (REGET) - Universidade Federal de Santa Maria (UFSM)
repository.mail.fl_str_mv marcelobdarosa@gmail.com||reget.ufsm@gmail.com
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