Photocatalytic oxidation of clozapine using TiO2 immobilized in polystyrene: effect of operation parameters and artificial neural network modeling
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Eletrônica em Gestão Educação e Tecnologia Ambiental (REGET) |
Texto Completo: | https://periodicos.ufsm.br/reget/article/view/38236 |
Resumo: | In recent years, heterogeneous photocatalysis using semiconductors has proved to be efficient for the treatment of wastewater containing organic pollutants, such as drugs. Among some photocatalysts, titanium dioxide (TiO2) has been studied and applied for this purpose. Therefore, this work investigated the photocatalytic degradation of the antipsychotic clozapine under ultraviolet irradiation, using suspended and supported TiO2 in polystyrene material. Some experimental parameters were evaluated through a factorial design 23; a higher degradation rate of the compound was verified using 0.15 g of the immobilized catalyst, [H2O2] of 340 mg L-1 and pH 9, after 6 h of treatment. It was possible to obtain degradations above 93.48% and a two-stage model was proposed to describe the reaction kinetics. An artificial neural network was used to model the photocatalytic process and to determine the importance of the operational variables. It was also established that the use of this treatment resulted in 78.30% removal of chemical oxygen demand (COD) under optimized conditions. In addition, the stability of TiO2 support after five consecutive cycles was verified from reuse tests. However, by means of toxicological tests with Escherichia coli and Salmonella enteritidis, it was observed that the products generated by the reaction were more toxic than the original compound. |
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Photocatalytic oxidation of clozapine using TiO2 immobilized in polystyrene: effect of operation parameters and artificial neural network modelingOxidação fotocatalítica da clozapina empregando TiO2 imobilizado em poliestireno: efeito dos parâmetros operacionais e modelagem via redes neuraisDrugEcotoxicityHeterogeneous photocatalysisPsychotropicUltraviolet radiationEcotoxicidadeFármacoFotocatálise heterogêneaPsicotrópicoRadiação ultravioletaIn recent years, heterogeneous photocatalysis using semiconductors has proved to be efficient for the treatment of wastewater containing organic pollutants, such as drugs. Among some photocatalysts, titanium dioxide (TiO2) has been studied and applied for this purpose. Therefore, this work investigated the photocatalytic degradation of the antipsychotic clozapine under ultraviolet irradiation, using suspended and supported TiO2 in polystyrene material. Some experimental parameters were evaluated through a factorial design 23; a higher degradation rate of the compound was verified using 0.15 g of the immobilized catalyst, [H2O2] of 340 mg L-1 and pH 9, after 6 h of treatment. It was possible to obtain degradations above 93.48% and a two-stage model was proposed to describe the reaction kinetics. An artificial neural network was used to model the photocatalytic process and to determine the importance of the operational variables. It was also established that the use of this treatment resulted in 78.30% removal of chemical oxygen demand (COD) under optimized conditions. In addition, the stability of TiO2 support after five consecutive cycles was verified from reuse tests. However, by means of toxicological tests with Escherichia coli and Salmonella enteritidis, it was observed that the products generated by the reaction were more toxic than the original compound.Nos últimos anos, a fotocatálise heterogênea através de semicondutores demonstrou ser eficiente para o tratamento de águas residuárias contendo poluentes orgânicos, como os fármacos. Dentre alguns fotocatalisadores, o dióxido de titânio (TiO2) tem sido estudado e aplicado para esta finalidade. À vista disso, neste trabalho investigou-se a degradação fotocatalítica do antipsicótico clozapina sob irradiação ultravioleta, mediante emprego de TiO2 suspenso e suportado em material de poliestireno. Alguns parâmetros experimentais foram avaliados através de um planejamento fatorial 23; verificando-se uma maior taxa de degradação do composto ao utilizar 0,15 g do catalisador imobilizado, [H2O2] de 340 mg L-1 e pH 9, após 6 h de tratamento. Para tal obteve-se degradações superiores a 93,48% e um modelo de dois estágios foi proposto para descrever a cinética reacional. Uma rede neural artificial foi utilizada para modelar o processo fotocatalítico e determinar a importância das variáveis operacionais. Também ficou estabelecido que o emprego deste tratamento resultou em 78,30% de remoção da demanda química de oxigênio (DQO) nas condições otimizadas. Além disso, a partir de testes de reutilização foi verificada a estabilidade do suporte de TiO2 após 5 ciclos consecutivos. No entanto, por meio de ensaios toxicológicos com Escherichia coli e Salmonella enteritidis observou-se que os produtos gerados através da reação geram produtos mais tóxicos que o composto original.Universidade Federal de Santa Maria2019-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.ufsm.br/reget/article/view/3823610.5902/2236117038236Revista Eletrônica em Gestão, Educação e Tecnologia Ambiental; REGET, V. 23, 2019; e31Revista Eletrônica em Gestão, Educação e Tecnologia Ambiental; REGET, V. 23, 2019; e312236-11702236-1170reponame:Revista Eletrônica em Gestão Educação e Tecnologia Ambiental (REGET)instname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMenghttps://periodicos.ufsm.br/reget/article/view/38236/pdfCopyright (c) 2019 Revista Eletrônica em Gestão, Educação e Tecnologia Ambientalhttp://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessSantana, Rayany Magali da RochaMoura, Thalita Cristhina de LimaNascimento, Graziele Elisandra doCharamba, Lívia Vieira CarliniDuarte, Marta Maria Menezes BezerraNapoleão, Daniella Carla2022-08-09T12:09:27Zoai:ojs.pkp.sfu.ca:article/38236Revistahttps://periodicos.ufsm.br/regetPUBhttps://periodicos.ufsm.br/reget/oaimarcelobdarosa@gmail.com||reget.ufsm@gmail.com2236-11702236-1170opendoar:2022-08-09T12:09:27Revista Eletrônica em Gestão Educação e Tecnologia Ambiental (REGET) - Universidade Federal de Santa Maria (UFSM)false |
dc.title.none.fl_str_mv |
Photocatalytic oxidation of clozapine using TiO2 immobilized in polystyrene: effect of operation parameters and artificial neural network modeling Oxidação fotocatalítica da clozapina empregando TiO2 imobilizado em poliestireno: efeito dos parâmetros operacionais e modelagem via redes neurais |
title |
Photocatalytic oxidation of clozapine using TiO2 immobilized in polystyrene: effect of operation parameters and artificial neural network modeling |
spellingShingle |
Photocatalytic oxidation of clozapine using TiO2 immobilized in polystyrene: effect of operation parameters and artificial neural network modeling Santana, Rayany Magali da Rocha Drug Ecotoxicity Heterogeneous photocatalysis Psychotropic Ultraviolet radiation Ecotoxicidade Fármaco Fotocatálise heterogênea Psicotrópico Radiação ultravioleta |
title_short |
Photocatalytic oxidation of clozapine using TiO2 immobilized in polystyrene: effect of operation parameters and artificial neural network modeling |
title_full |
Photocatalytic oxidation of clozapine using TiO2 immobilized in polystyrene: effect of operation parameters and artificial neural network modeling |
title_fullStr |
Photocatalytic oxidation of clozapine using TiO2 immobilized in polystyrene: effect of operation parameters and artificial neural network modeling |
title_full_unstemmed |
Photocatalytic oxidation of clozapine using TiO2 immobilized in polystyrene: effect of operation parameters and artificial neural network modeling |
title_sort |
Photocatalytic oxidation of clozapine using TiO2 immobilized in polystyrene: effect of operation parameters and artificial neural network modeling |
author |
Santana, Rayany Magali da Rocha |
author_facet |
Santana, Rayany Magali da Rocha Moura, Thalita Cristhina de Lima Nascimento, Graziele Elisandra do Charamba, Lívia Vieira Carlini Duarte, Marta Maria Menezes Bezerra Napoleão, Daniella Carla |
author_role |
author |
author2 |
Moura, Thalita Cristhina de Lima Nascimento, Graziele Elisandra do Charamba, Lívia Vieira Carlini Duarte, Marta Maria Menezes Bezerra Napoleão, Daniella Carla |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Santana, Rayany Magali da Rocha Moura, Thalita Cristhina de Lima Nascimento, Graziele Elisandra do Charamba, Lívia Vieira Carlini Duarte, Marta Maria Menezes Bezerra Napoleão, Daniella Carla |
dc.subject.por.fl_str_mv |
Drug Ecotoxicity Heterogeneous photocatalysis Psychotropic Ultraviolet radiation Ecotoxicidade Fármaco Fotocatálise heterogênea Psicotrópico Radiação ultravioleta |
topic |
Drug Ecotoxicity Heterogeneous photocatalysis Psychotropic Ultraviolet radiation Ecotoxicidade Fármaco Fotocatálise heterogênea Psicotrópico Radiação ultravioleta |
description |
In recent years, heterogeneous photocatalysis using semiconductors has proved to be efficient for the treatment of wastewater containing organic pollutants, such as drugs. Among some photocatalysts, titanium dioxide (TiO2) has been studied and applied for this purpose. Therefore, this work investigated the photocatalytic degradation of the antipsychotic clozapine under ultraviolet irradiation, using suspended and supported TiO2 in polystyrene material. Some experimental parameters were evaluated through a factorial design 23; a higher degradation rate of the compound was verified using 0.15 g of the immobilized catalyst, [H2O2] of 340 mg L-1 and pH 9, after 6 h of treatment. It was possible to obtain degradations above 93.48% and a two-stage model was proposed to describe the reaction kinetics. An artificial neural network was used to model the photocatalytic process and to determine the importance of the operational variables. It was also established that the use of this treatment resulted in 78.30% removal of chemical oxygen demand (COD) under optimized conditions. In addition, the stability of TiO2 support after five consecutive cycles was verified from reuse tests. However, by means of toxicological tests with Escherichia coli and Salmonella enteritidis, it was observed that the products generated by the reaction were more toxic than the original compound. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.ufsm.br/reget/article/view/38236 10.5902/2236117038236 |
url |
https://periodicos.ufsm.br/reget/article/view/38236 |
identifier_str_mv |
10.5902/2236117038236 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://periodicos.ufsm.br/reget/article/view/38236/pdf |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Revista Eletrônica em Gestão, Educação e Tecnologia Ambiental http://creativecommons.org/licenses/by-nc-sa/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Revista Eletrônica em Gestão, Educação e Tecnologia Ambiental http://creativecommons.org/licenses/by-nc-sa/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.source.none.fl_str_mv |
Revista Eletrônica em Gestão, Educação e Tecnologia Ambiental; REGET, V. 23, 2019; e31 Revista Eletrônica em Gestão, Educação e Tecnologia Ambiental; REGET, V. 23, 2019; e31 2236-1170 2236-1170 reponame:Revista Eletrônica em Gestão Educação e Tecnologia Ambiental (REGET) instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Revista Eletrônica em Gestão Educação e Tecnologia Ambiental (REGET) |
collection |
Revista Eletrônica em Gestão Educação e Tecnologia Ambiental (REGET) |
repository.name.fl_str_mv |
Revista Eletrônica em Gestão Educação e Tecnologia Ambiental (REGET) - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
marcelobdarosa@gmail.com||reget.ufsm@gmail.com |
_version_ |
1799950577431478272 |