Detecção precoce de recidivas em pacientes com mieloma múltiplo através da análise de imunoglobulinas monoclonais
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional Manancial UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/6002 |
Resumo: | Multiple myeloma (MM) is an incurable progressive hematologic malignancy with heterogeneous evolution. It is a disease characterized by abnormal clonal proliferation of plasma cells in the bone marrow producing monoclonal immunoglobulins and causing a number of organ dysfunctions. Most patients relapse after treatment. Therefore, the use of methods of analysis of serum and urinary samples in order to detect as early as possible the presence of monoclonal immunoglobulins, before the occurrence of relapses, may aid in the treatment of patients with MM, improving its quality and prolonging survival. In this study we compared the effectiveness of the techniques of immunofixation (IF) and electrophoresis (EP) in the detection of MM relapses. For this, 52 patients under treatment in the University Hospital of Santa Maria (HUSM) were monitored, being detected the relapse of the disease in nine of these patients. A retrospective analysis of serum proteins of the nine patients, between January 2012 and July 2014, showed that IF was more effective than EP in early detection of relapse, regardless of the present class of immunoglobulins. The precocity of IF in relation to EP in detecting MM relapses in the nine patients studied, ranged from 2.0 to 18.8 months, with a mean of 6.6 months. Thus, we suggest the implementation of IF in the Clinical Analysis Laboratory (CAL) of HUSM to help onco-hematology physicians in the diagnosis and supportive care for patients with MM. |
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2015-05-112015-05-112014-12-15AITA, Marta Helena Carlesso. EARLY DETECTION OF RELAPSES IN PATIENTS WITH MULTIPLE MYELOMA BY ANALYSIS OF MONOCLONAL IMMUNOGLOBULINS. 2014. 85 f. Dissertação (Mestrado em Farmacologia) - Universidade Federal de Santa Maria, Santa Maria, 2014.http://repositorio.ufsm.br/handle/1/6002Multiple myeloma (MM) is an incurable progressive hematologic malignancy with heterogeneous evolution. It is a disease characterized by abnormal clonal proliferation of plasma cells in the bone marrow producing monoclonal immunoglobulins and causing a number of organ dysfunctions. Most patients relapse after treatment. Therefore, the use of methods of analysis of serum and urinary samples in order to detect as early as possible the presence of monoclonal immunoglobulins, before the occurrence of relapses, may aid in the treatment of patients with MM, improving its quality and prolonging survival. In this study we compared the effectiveness of the techniques of immunofixation (IF) and electrophoresis (EP) in the detection of MM relapses. For this, 52 patients under treatment in the University Hospital of Santa Maria (HUSM) were monitored, being detected the relapse of the disease in nine of these patients. A retrospective analysis of serum proteins of the nine patients, between January 2012 and July 2014, showed that IF was more effective than EP in early detection of relapse, regardless of the present class of immunoglobulins. The precocity of IF in relation to EP in detecting MM relapses in the nine patients studied, ranged from 2.0 to 18.8 months, with a mean of 6.6 months. Thus, we suggest the implementation of IF in the Clinical Analysis Laboratory (CAL) of HUSM to help onco-hematology physicians in the diagnosis and supportive care for patients with MM.O mieloma múltiplo (MM) é uma neoplasia hematológica progressiva, com evolução heterogênea e ainda incurável. É uma doença caracterizada pela proliferação clonal anormal de plasmócitos na medula óssea produzindo imunoglobulinas monoclonais e ocasionando uma série de disfunções orgânicas. A maioria dos pacientes recidivam após o tratamento. Portanto, a utilização de métodos de análise de amostras séricas e urinárias, que permitam detectar o mais precocemente possível a presença de imunoglobulinas monoclonais, antes da ocorrência das recidivas, pode auxiliar no tratamento de pacientes com MM, melhorando a qualidade e ampliando o tempo de sobrevida dos mesmos. No presente estudo foram comparadas as técnicas de imunofixação (IF) e eletroforese (EF) quanto a sua eficácia na detecção das recidivas do MM. Para isso, foram monitorados 52 pacientes em tratamento junto ao Hospital Universitário de Santa Maria (HUSM), sendo detectada a recidiva da doença em nove destes pacientes. A análise retrospectiva de proteínas séricas dos nove pacientes, no período entre janeiro de 2012 e julho de 2014, mostrou que a IF foi mais eficaz do que a EF em detectar precocemente as recidivas, independentemente da classe de imunoglobulinas presente. Nos nove pacientes recidivados, a precocidade da IF, em relação à EF, na detecção das recidivas do MM variou de 2,0 a 18,8 meses, com um tempo médio de 6,6 meses.application/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em Ciências FarmacêuticasUFSMBRAnálises Clínicas e ToxicológicasImunofixaçãoEletroforeseRecidivasMieloma múltiploImmunofixationElectrophoresisRelapsesMultiple myelomaCNPQ::CIENCIAS DA SAUDE::FARMACIADetecção precoce de recidivas em pacientes com mieloma múltiplo através da análise de imunoglobulinas monoclonaisEarly detection of relapses in patients with multiple myeloma by analysis of monoclonal immunoglobulinsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisSilva, José Edson Paz dahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4799809H4Arantes, Luiz Claudiohttp://lattes.cnpq.br/1152754896611268Beck, Sandra Trevisanhttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4701157Y7Moreira, Cleci Menezeshttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4798637U7http://lattes.cnpq.br/8556606177259458Aita, Marta Helena Carlesso201000000000400300300300500300e7eceac5-be97-49f0-9619-62a17927bd1a5036fcfc-1d37-469a-8eb3-332081e5a84f1b77d552-e37b-40e8-8ae5-dcb5170533dcefc1f94d-0b34-46d2-9c0a-6edf5440f89071f0bad9-5821-43f5-9c15-6a4d86944a83info:eu-repo/semantics/openAccessreponame:Repositório Institucional Manancial UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALAITA, MARTA HELENA CARLESSO.pdfapplication/pdf4315309http://repositorio.ufsm.br/bitstream/1/6002/1/AITA%2c%20MARTA%20HELENA%20CARLESSO.pdf35dd876137f8a86eba1802052d272e15MD51TEXTAITA, MARTA HELENA CARLESSO.pdf.txtAITA, MARTA HELENA CARLESSO.pdf.txtExtracted texttext/plain159017http://repositorio.ufsm.br/bitstream/1/6002/2/AITA%2c%20MARTA%20HELENA%20CARLESSO.pdf.txt411a34d55640be14406dbd15fd507d80MD52THUMBNAILAITA, MARTA HELENA CARLESSO.pdf.jpgAITA, MARTA HELENA CARLESSO.pdf.jpgIM Thumbnailimage/jpeg5060http://repositorio.ufsm.br/bitstream/1/6002/3/AITA%2c%20MARTA%20HELENA%20CARLESSO.pdf.jpg2a79a2548f08e7946fdd752e93d5eb08MD531/60022022-10-10 12:00:12.865oai:repositorio.ufsm.br:1/6002Repositório Institucionalhttp://repositorio.ufsm.br/PUBhttp://repositorio.ufsm.br/oai/requestouvidoria@ufsm.bropendoar:39132022-10-10T15:00:12Repositório Institucional Manancial UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Detecção precoce de recidivas em pacientes com mieloma múltiplo através da análise de imunoglobulinas monoclonais |
dc.title.alternative.eng.fl_str_mv |
Early detection of relapses in patients with multiple myeloma by analysis of monoclonal immunoglobulins |
title |
Detecção precoce de recidivas em pacientes com mieloma múltiplo através da análise de imunoglobulinas monoclonais |
spellingShingle |
Detecção precoce de recidivas em pacientes com mieloma múltiplo através da análise de imunoglobulinas monoclonais Aita, Marta Helena Carlesso Imunofixação Eletroforese Recidivas Mieloma múltiplo Immunofixation Electrophoresis Relapses Multiple myeloma CNPQ::CIENCIAS DA SAUDE::FARMACIA |
title_short |
Detecção precoce de recidivas em pacientes com mieloma múltiplo através da análise de imunoglobulinas monoclonais |
title_full |
Detecção precoce de recidivas em pacientes com mieloma múltiplo através da análise de imunoglobulinas monoclonais |
title_fullStr |
Detecção precoce de recidivas em pacientes com mieloma múltiplo através da análise de imunoglobulinas monoclonais |
title_full_unstemmed |
Detecção precoce de recidivas em pacientes com mieloma múltiplo através da análise de imunoglobulinas monoclonais |
title_sort |
Detecção precoce de recidivas em pacientes com mieloma múltiplo através da análise de imunoglobulinas monoclonais |
author |
Aita, Marta Helena Carlesso |
author_facet |
Aita, Marta Helena Carlesso |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Silva, José Edson Paz da |
dc.contributor.advisor1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4799809H4 |
dc.contributor.advisor-co1.fl_str_mv |
Arantes, Luiz Claudio |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/1152754896611268 |
dc.contributor.referee1.fl_str_mv |
Beck, Sandra Trevisan |
dc.contributor.referee1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4701157Y7 |
dc.contributor.referee2.fl_str_mv |
Moreira, Cleci Menezes |
dc.contributor.referee2Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4798637U7 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/8556606177259458 |
dc.contributor.author.fl_str_mv |
Aita, Marta Helena Carlesso |
contributor_str_mv |
Silva, José Edson Paz da Arantes, Luiz Claudio Beck, Sandra Trevisan Moreira, Cleci Menezes |
dc.subject.por.fl_str_mv |
Imunofixação Eletroforese Recidivas Mieloma múltiplo |
topic |
Imunofixação Eletroforese Recidivas Mieloma múltiplo Immunofixation Electrophoresis Relapses Multiple myeloma CNPQ::CIENCIAS DA SAUDE::FARMACIA |
dc.subject.eng.fl_str_mv |
Immunofixation Electrophoresis Relapses Multiple myeloma |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS DA SAUDE::FARMACIA |
description |
Multiple myeloma (MM) is an incurable progressive hematologic malignancy with heterogeneous evolution. It is a disease characterized by abnormal clonal proliferation of plasma cells in the bone marrow producing monoclonal immunoglobulins and causing a number of organ dysfunctions. Most patients relapse after treatment. Therefore, the use of methods of analysis of serum and urinary samples in order to detect as early as possible the presence of monoclonal immunoglobulins, before the occurrence of relapses, may aid in the treatment of patients with MM, improving its quality and prolonging survival. In this study we compared the effectiveness of the techniques of immunofixation (IF) and electrophoresis (EP) in the detection of MM relapses. For this, 52 patients under treatment in the University Hospital of Santa Maria (HUSM) were monitored, being detected the relapse of the disease in nine of these patients. A retrospective analysis of serum proteins of the nine patients, between January 2012 and July 2014, showed that IF was more effective than EP in early detection of relapse, regardless of the present class of immunoglobulins. The precocity of IF in relation to EP in detecting MM relapses in the nine patients studied, ranged from 2.0 to 18.8 months, with a mean of 6.6 months. Thus, we suggest the implementation of IF in the Clinical Analysis Laboratory (CAL) of HUSM to help onco-hematology physicians in the diagnosis and supportive care for patients with MM. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-12-15 |
dc.date.accessioned.fl_str_mv |
2015-05-11 |
dc.date.available.fl_str_mv |
2015-05-11 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
AITA, Marta Helena Carlesso. EARLY DETECTION OF RELAPSES IN PATIENTS WITH MULTIPLE MYELOMA BY ANALYSIS OF MONOCLONAL IMMUNOGLOBULINS. 2014. 85 f. Dissertação (Mestrado em Farmacologia) - Universidade Federal de Santa Maria, Santa Maria, 2014. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/6002 |
identifier_str_mv |
AITA, Marta Helena Carlesso. EARLY DETECTION OF RELAPSES IN PATIENTS WITH MULTIPLE MYELOMA BY ANALYSIS OF MONOCLONAL IMMUNOGLOBULINS. 2014. 85 f. Dissertação (Mestrado em Farmacologia) - Universidade Federal de Santa Maria, Santa Maria, 2014. |
url |
http://repositorio.ufsm.br/handle/1/6002 |
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por |
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Análises Clínicas e Toxicológicas |
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