Efeitos do ácido gálico na sinalização purinérgica em linfócitos e plaquetas de ratos submetidos a um modelo experimental de diabetes
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Manancial - Repositório Digital da UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/18417 |
Resumo: | Diabetes mellitus (DM) is a chronic metabolic disease associated with hyperglycemia, systemic inflammatory changes and vascular endothelial dysfunction. NTPDase, 5'-nucleotidase and adenosine deaminase (ADA) are important enzymes involved in the regulation of inflammatory, immune and platelet responses and thus may are the suitable therapeutic targets in DM. Gallic acid has many biological properties such as antihyperglycemic, antioxidant, anti-inflammatory and antiaggregant actions. Thus, the objective of this study was to evaluate the effect of gallic acid on hematological parameters and on the ectonucleotidases activities in platelets, lymphocytes and serum of diabetic rats. Male Wistar rats were divided into four groups: I - control, II - gallic acid, III - diabetic and IV - diabetic / gallic acid. DM was induced in the animals by injection of streptozotocin (65 mg / kg i.p.). Gallic acid was administered orally seven days after induction of DM, at a dose of 30 mg/kg during to time of 21 days. The results demonstrated that administration of gallic acid was not able to revert to hyperglycemia in diabetic rats. In relation to the hematological parameters, the mean corpuscular hemoglobin concentration was decreased while the red blood cell distribution was increased in the diabetic group, and gallic acid was able to reverse these alterations. Gallic acid also reversed the diabetes-induced increase in NTPDase activity in lymphocytes and platelets and ADA activity in lymphocytes. On the other hand, in animals of group IV was observed a in the activity of the ADA in the platelets. A decrease in ATP hydrolysis and an increase in ADP and AMP hydrolysis in diabetic rats were observed in serum and gallic acid treatment was capable to revert only changes in ATP hydrolysis. Our results suggest that gallic acid has beneficial effects on immune and thromboregulatory responses in DM, and that these effects may be related to the modulation of purinergic signaling in lymphocytes, platelets and serum. |
id |
UFSM-20_2156c06eafcda550452bef5c8f15dd61 |
---|---|
oai_identifier_str |
oai:repositorio.ufsm.br:1/18417 |
network_acronym_str |
UFSM-20 |
network_name_str |
Manancial - Repositório Digital da UFSM |
repository_id_str |
3913 |
spelling |
2019-09-24T21:55:31Z2019-09-24T21:55:31Z2017-03-21http://repositorio.ufsm.br/handle/1/18417Diabetes mellitus (DM) is a chronic metabolic disease associated with hyperglycemia, systemic inflammatory changes and vascular endothelial dysfunction. NTPDase, 5'-nucleotidase and adenosine deaminase (ADA) are important enzymes involved in the regulation of inflammatory, immune and platelet responses and thus may are the suitable therapeutic targets in DM. Gallic acid has many biological properties such as antihyperglycemic, antioxidant, anti-inflammatory and antiaggregant actions. Thus, the objective of this study was to evaluate the effect of gallic acid on hematological parameters and on the ectonucleotidases activities in platelets, lymphocytes and serum of diabetic rats. Male Wistar rats were divided into four groups: I - control, II - gallic acid, III - diabetic and IV - diabetic / gallic acid. DM was induced in the animals by injection of streptozotocin (65 mg / kg i.p.). Gallic acid was administered orally seven days after induction of DM, at a dose of 30 mg/kg during to time of 21 days. The results demonstrated that administration of gallic acid was not able to revert to hyperglycemia in diabetic rats. In relation to the hematological parameters, the mean corpuscular hemoglobin concentration was decreased while the red blood cell distribution was increased in the diabetic group, and gallic acid was able to reverse these alterations. Gallic acid also reversed the diabetes-induced increase in NTPDase activity in lymphocytes and platelets and ADA activity in lymphocytes. On the other hand, in animals of group IV was observed a in the activity of the ADA in the platelets. A decrease in ATP hydrolysis and an increase in ADP and AMP hydrolysis in diabetic rats were observed in serum and gallic acid treatment was capable to revert only changes in ATP hydrolysis. Our results suggest that gallic acid has beneficial effects on immune and thromboregulatory responses in DM, and that these effects may be related to the modulation of purinergic signaling in lymphocytes, platelets and serum.O Diabetes mellitus (DM), é uma doença metabólica crônica associada a um quadro de hiperglicemia, alterações inflamatórias sistêmicas e disfunções no endotélio vascular. A NTPDase, 5'- nucleotidase e a adenosina desaminase (ADA) são importantes enzimas envolvidas na regulação das respostas inflamatórias, imunes e plaquetárias e desta forma, podem ser potenciais alvos terapêuticos no DM. O ácido gálico possui muitas propriedades biológicas como ação anti-hiperglicêmica, antioxidante, anti-inflamatória e antiagregante. Sendo assim, o objetivo deste estudo foi avaliar o efeito do ácido gálico sobre parâmetros hematológicos e na atividade de ectonucleotidases em plaquetas, linfócitos e soro de ratos diabéticos. Foram utilizados ratos machos Wistar, os quais foram divididos em quatro grupos: I - controle, II - ácido gálico, III - diabético e IV - diabético/ ácido gálico. O DM foi induzido nos animais por injeção intraperitoneal de estreptozotocina (65 mg/kg). O ácido gálico foi administrado por via oral sete dias após a indução do DM, na dose de 30 mg/kg, durante um período de 21 dias. Os resultados demonstraram que a administração de ácido gálico não foi capaz de reverter à hiperglicemia dos ratos diabéticos. Em relação aos parâmetros hematológicos, a concentração de hemoglobina corpuscular média foi diminuída enquanto que a distribuição de glóbulos vermelhos foi aumentada no grupo diabético, sendo que o ácido gálico foi capaz de reverter essas alterações. O ácido gálico também reverteu o aumento induzido pelo diabetes da atividade da NTPDase em linfócitos e plaquetas e da atividade da ADA em linfócitos. Por outro lado, em animais do grupo IV ocorreu uma diminuição na atividade da enzima ADA nas plaquetas. Em soro foi observado uma diminuição na hidrólise de ATP e um aumento na hidrólise de ADP e AMP em ratos diabéticos, sendo que o tratamento com ácido gálico reverteu somente às alterações na hidrólise de ATP. Nossos resultados sugerem que o ácido gálico possui efeitos benéficos nas respostas imunes e tromboregulatórias no DM, e que estes efeitos podem estar relacionados à modulação da sinalização purinérgica em linfócitos, plaquetas e soro.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESporUniversidade Federal de Santa MariaCentro de Ciências Naturais e ExatasPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaUFSMBrasilBioquímicaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessEctonucleotidasesDiabetes mellitusÁcido gálicoLinfócitosPlaquetasSoroGallic acidLymphocytesPlateletsCNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICAEfeitos do ácido gálico na sinalização purinérgica em linfócitos e plaquetas de ratos submetidos a um modelo experimental de diabetesEffects of galic acid in purinergic signaling in lymphocytes and platelets of rats submitted to an experimental diabetes modelinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisSpanevello, Roselia Mariahttp://lattes.cnpq.br/3446031341157893Cardoso, Andréia Machadohttp://lattes.cnpq.br/0690875690674360Stefanello, Francieli Morohttp://lattes.cnpq.br/8828875564145245http://lattes.cnpq.br/0361314637758080Pereira, Aline da Silva200800000002600600da3a26e6-eccb-4d3e-80b7-f283ae768b94b7f93d9c-211e-4f59-bbad-99e598c186cd79fe0b9c-bac0-4cdf-a37d-1e3ef32c538d7aef3378-52c9-45bc-9ead-061d26c0199creponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALDIS_PPGBT_2017_PEREIRA_ALINE.pdfDIS_PPGBT_2017_PEREIRA_ALINE.pdfDissertação de Mestradoapplication/pdf926128http://repositorio.ufsm.br/bitstream/1/18417/1/DIS_PPGBT_2017_PEREIRA_ALINE.pdf8c05d4c95e605207dfb1f1a04474b477MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805http://repositorio.ufsm.br/bitstream/1/18417/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81956http://repositorio.ufsm.br/bitstream/1/18417/3/license.txt2f0571ecee68693bd5cd3f17c1e075dfMD53TEXTDIS_PPGBT_2017_PEREIRA_ALINE.pdf.txtDIS_PPGBT_2017_PEREIRA_ALINE.pdf.txtExtracted texttext/plain92031http://repositorio.ufsm.br/bitstream/1/18417/4/DIS_PPGBT_2017_PEREIRA_ALINE.pdf.txtb882f0f5bb99a70d51481cb82a5b0924MD54THUMBNAILDIS_PPGBT_2017_PEREIRA_ALINE.pdf.jpgDIS_PPGBT_2017_PEREIRA_ALINE.pdf.jpgIM Thumbnailimage/jpeg5638http://repositorio.ufsm.br/bitstream/1/18417/5/DIS_PPGBT_2017_PEREIRA_ALINE.pdf.jpg36d29837b7ee80b95aa7f79478673236MD551/184172019-09-25 03:00:40.513oai:repositorio.ufsm.br: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ório Institucionalhttp://repositorio.ufsm.br/PUBhttp://repositorio.ufsm.br/oai/requestopendoar:39132019-09-25T06:00:40Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Efeitos do ácido gálico na sinalização purinérgica em linfócitos e plaquetas de ratos submetidos a um modelo experimental de diabetes |
dc.title.alternative.eng.fl_str_mv |
Effects of galic acid in purinergic signaling in lymphocytes and platelets of rats submitted to an experimental diabetes model |
title |
Efeitos do ácido gálico na sinalização purinérgica em linfócitos e plaquetas de ratos submetidos a um modelo experimental de diabetes |
spellingShingle |
Efeitos do ácido gálico na sinalização purinérgica em linfócitos e plaquetas de ratos submetidos a um modelo experimental de diabetes Pereira, Aline da Silva Ectonucleotidases Diabetes mellitus Ácido gálico Linfócitos Plaquetas Soro Gallic acid Lymphocytes Platelets CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
title_short |
Efeitos do ácido gálico na sinalização purinérgica em linfócitos e plaquetas de ratos submetidos a um modelo experimental de diabetes |
title_full |
Efeitos do ácido gálico na sinalização purinérgica em linfócitos e plaquetas de ratos submetidos a um modelo experimental de diabetes |
title_fullStr |
Efeitos do ácido gálico na sinalização purinérgica em linfócitos e plaquetas de ratos submetidos a um modelo experimental de diabetes |
title_full_unstemmed |
Efeitos do ácido gálico na sinalização purinérgica em linfócitos e plaquetas de ratos submetidos a um modelo experimental de diabetes |
title_sort |
Efeitos do ácido gálico na sinalização purinérgica em linfócitos e plaquetas de ratos submetidos a um modelo experimental de diabetes |
author |
Pereira, Aline da Silva |
author_facet |
Pereira, Aline da Silva |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Spanevello, Roselia Maria |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/3446031341157893 |
dc.contributor.referee1.fl_str_mv |
Cardoso, Andréia Machado |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/0690875690674360 |
dc.contributor.referee2.fl_str_mv |
Stefanello, Francieli Moro |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/8828875564145245 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/0361314637758080 |
dc.contributor.author.fl_str_mv |
Pereira, Aline da Silva |
contributor_str_mv |
Spanevello, Roselia Maria Cardoso, Andréia Machado Stefanello, Francieli Moro |
dc.subject.por.fl_str_mv |
Ectonucleotidases Diabetes mellitus Ácido gálico Linfócitos Plaquetas Soro |
topic |
Ectonucleotidases Diabetes mellitus Ácido gálico Linfócitos Plaquetas Soro Gallic acid Lymphocytes Platelets CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
dc.subject.eng.fl_str_mv |
Gallic acid Lymphocytes Platelets |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
description |
Diabetes mellitus (DM) is a chronic metabolic disease associated with hyperglycemia, systemic inflammatory changes and vascular endothelial dysfunction. NTPDase, 5'-nucleotidase and adenosine deaminase (ADA) are important enzymes involved in the regulation of inflammatory, immune and platelet responses and thus may are the suitable therapeutic targets in DM. Gallic acid has many biological properties such as antihyperglycemic, antioxidant, anti-inflammatory and antiaggregant actions. Thus, the objective of this study was to evaluate the effect of gallic acid on hematological parameters and on the ectonucleotidases activities in platelets, lymphocytes and serum of diabetic rats. Male Wistar rats were divided into four groups: I - control, II - gallic acid, III - diabetic and IV - diabetic / gallic acid. DM was induced in the animals by injection of streptozotocin (65 mg / kg i.p.). Gallic acid was administered orally seven days after induction of DM, at a dose of 30 mg/kg during to time of 21 days. The results demonstrated that administration of gallic acid was not able to revert to hyperglycemia in diabetic rats. In relation to the hematological parameters, the mean corpuscular hemoglobin concentration was decreased while the red blood cell distribution was increased in the diabetic group, and gallic acid was able to reverse these alterations. Gallic acid also reversed the diabetes-induced increase in NTPDase activity in lymphocytes and platelets and ADA activity in lymphocytes. On the other hand, in animals of group IV was observed a in the activity of the ADA in the platelets. A decrease in ATP hydrolysis and an increase in ADP and AMP hydrolysis in diabetic rats were observed in serum and gallic acid treatment was capable to revert only changes in ATP hydrolysis. Our results suggest that gallic acid has beneficial effects on immune and thromboregulatory responses in DM, and that these effects may be related to the modulation of purinergic signaling in lymphocytes, platelets and serum. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017-03-21 |
dc.date.accessioned.fl_str_mv |
2019-09-24T21:55:31Z |
dc.date.available.fl_str_mv |
2019-09-24T21:55:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/18417 |
url |
http://repositorio.ufsm.br/handle/1/18417 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
200800000002 |
dc.relation.confidence.fl_str_mv |
600 600 |
dc.relation.authority.fl_str_mv |
da3a26e6-eccb-4d3e-80b7-f283ae768b94 b7f93d9c-211e-4f59-bbad-99e598c186cd 79fe0b9c-bac0-4cdf-a37d-1e3ef32c538d 7aef3378-52c9-45bc-9ead-061d26c0199c |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências Naturais e Exatas |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica |
dc.publisher.initials.fl_str_mv |
UFSM |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Bioquímica |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências Naturais e Exatas |
dc.source.none.fl_str_mv |
reponame:Manancial - Repositório Digital da UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Manancial - Repositório Digital da UFSM |
collection |
Manancial - Repositório Digital da UFSM |
bitstream.url.fl_str_mv |
http://repositorio.ufsm.br/bitstream/1/18417/1/DIS_PPGBT_2017_PEREIRA_ALINE.pdf http://repositorio.ufsm.br/bitstream/1/18417/2/license_rdf http://repositorio.ufsm.br/bitstream/1/18417/3/license.txt http://repositorio.ufsm.br/bitstream/1/18417/4/DIS_PPGBT_2017_PEREIRA_ALINE.pdf.txt http://repositorio.ufsm.br/bitstream/1/18417/5/DIS_PPGBT_2017_PEREIRA_ALINE.pdf.jpg |
bitstream.checksum.fl_str_mv |
8c05d4c95e605207dfb1f1a04474b477 4460e5956bc1d1639be9ae6146a50347 2f0571ecee68693bd5cd3f17c1e075df b882f0f5bb99a70d51481cb82a5b0924 36d29837b7ee80b95aa7f79478673236 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
|
_version_ |
1801223760716496896 |