Desenvolvimento de formulações de interesse farmacêutico e cosmético a partir de óleos vegetais derivados de plantas cultivadas no RS
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional Manancial UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/27334 |
Resumo: | This work aimed to use the rice bran, soybean or sunflower seed oil as alternative raw materials for the development of pharmaceutical and cosmetic dosage forms. In the first chapter sunscreen cosmetic formulations were prepared from gel-cream containing rice bran or soybean oil at different concentrations, using an organic sunscreen (benzophenone-3). The influence of these oils on the following characteristics was assessed: pH, spreadability, rheological behavior, and in vitro sun protection factor. The formulations showed suitable physical and chemical characteristics, non-Newtonian rheological behavior, and spreadability dependent on the concentration of the oil. The sun protection factor was around 10 regardless of the type and concentration of oil used. In the second chapter, lipid-core nanocapsules were prepared by interfacial deposition of preformed polymer containing rice bran, soybean or sunflower seed oil. The physicochemical parameters analyzed were pH, particle size, polydispersity index, zeta potential, morphological characteristics, and stability. The type of vegetable oil did not have influence on the physicochemical characteristics of the formulations, which remained adequate and stable during the 3 months of storage. Moreover, based on the genotoxicity and proliferative activity studies we can suggest that none of the formulations present risks to the environment. In the third chapter, nanocapsule formulations containing the three vegetable oils and a model drug (0.5 mg/mL) were prepared to evaluate the effect of the oils on the in vitro drug release. The drug was successfully encapsulated in all nanocapsule formulations with total drug close to the theoretical value. The in vitro drug release study from nanocapsules showed that the controlled release follows a biexponential regardless of the type of vegetable oil. The nanocapsule formulations containing the sunflower seed oil provided higher drug release control, followed by the nanocapsule formulations containing soybean and rice bran oil, showing that the type of the vegetable oil influences the drug release profile. Through these works the technological feasibility to use the rice bran, soybean or sunflower seed oil was demonstrated as an alternative source of viable raw material for obtaining pharmaceutical formulations of pharmaceutical and cosmetic interest. |
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2022-12-13T20:06:39Z2022-12-13T20:06:39Z2011-03-14http://repositorio.ufsm.br/handle/1/27334This work aimed to use the rice bran, soybean or sunflower seed oil as alternative raw materials for the development of pharmaceutical and cosmetic dosage forms. In the first chapter sunscreen cosmetic formulations were prepared from gel-cream containing rice bran or soybean oil at different concentrations, using an organic sunscreen (benzophenone-3). The influence of these oils on the following characteristics was assessed: pH, spreadability, rheological behavior, and in vitro sun protection factor. The formulations showed suitable physical and chemical characteristics, non-Newtonian rheological behavior, and spreadability dependent on the concentration of the oil. The sun protection factor was around 10 regardless of the type and concentration of oil used. In the second chapter, lipid-core nanocapsules were prepared by interfacial deposition of preformed polymer containing rice bran, soybean or sunflower seed oil. The physicochemical parameters analyzed were pH, particle size, polydispersity index, zeta potential, morphological characteristics, and stability. The type of vegetable oil did not have influence on the physicochemical characteristics of the formulations, which remained adequate and stable during the 3 months of storage. Moreover, based on the genotoxicity and proliferative activity studies we can suggest that none of the formulations present risks to the environment. In the third chapter, nanocapsule formulations containing the three vegetable oils and a model drug (0.5 mg/mL) were prepared to evaluate the effect of the oils on the in vitro drug release. The drug was successfully encapsulated in all nanocapsule formulations with total drug close to the theoretical value. The in vitro drug release study from nanocapsules showed that the controlled release follows a biexponential regardless of the type of vegetable oil. The nanocapsule formulations containing the sunflower seed oil provided higher drug release control, followed by the nanocapsule formulations containing soybean and rice bran oil, showing that the type of the vegetable oil influences the drug release profile. Through these works the technological feasibility to use the rice bran, soybean or sunflower seed oil was demonstrated as an alternative source of viable raw material for obtaining pharmaceutical formulations of pharmaceutical and cosmetic interest.Este trabalho teve como objetivo utilizar os óleos de arroz, soja e girassol como matérias-primas alternativas para o desenvolvimento de formas farmacêuticas e cosméticas. No primeiro capítulo foram preparadas formulações cosméticas fotoprotetoras do tipo gelcreme contendo os óleos de arroz ou de soja em diferentes concentrações, utilizando um filtro solar orgânico (benzofenona-3). Foi avaliada a influência que estes óleos exercem sobre as seguintes características: pH, espalhabilidade, comportamento reológico e fator de proteção solar in vitro. As formulações apresentaram características físico-químicas adequadas, comportamento reológico não-Newtoniano e espalhabilidade dependente da concentração de óleo. O fator de proteção solar ficou em torno de 10, independente do tipo e da concentração de óleo utilizados. No segundo capítulo, foram preparadas formulações de nanocápsulas de núcleo lipídico pelo método da deposição interfacial do polímero pré-formado contendo os óleos de arroz, soja ou de girassol. Os parâmetros físico-químicos avaliados foram pH, diâmetro de partícula, índice de polidispersão, potencial zeta, características morfológicas e estabilidade frente ao armazenamento das diferentes formulações. O tipo de óleo vegetal não influenciou nas características físico-químicas das formulações, sendo estas adequadas e estáveis durante o armazenamento por três meses. Além disso, a partir da avaliação da atividade antiproliferativa e genotóxica, pode-se sugerir que nenhuma das formulações apresentou riscos ao meio ambiente. No terceiro capítulo, foram preparadas as formulações de nanocápsulas contendo os três óleos vegetais e um fármaco modelo (0,5 mg/mL) para se avaliar o efeito dos óleos na liberação in vitro do fármaco. O fármaco foi encapsulado com sucesso em todas as nanocápsulas com um teor total próximo ao teórico. O estudo de liberação in vitro a partir das nanocápsulas demonstrou uma liberação controlada seguindo um modelo biexponencial, independente do tipo de óleo. A formulação de nanocápsulas contendo o óleo de girassol proporcionou um maior controle da liberação, seguido da formulação de nanocápsulas contendo o óleo de soja e arroz, demonstrando que o tipo de óleo influencia no perfil de liberação do fármaco. As interações entre os óleos vegetais e o lipídio sólido presentes no núcleo das nanocápsulas foram as responsáveis por controlar a velocidade da liberação. Através dos trabalhos realizados ficou demonstrada a viabilidade tecnológica da utilização dos óleos de arroz, soja e de girassol como fonte alternativa de matéria-prima viável para a obtenção de formulações farmacêuticas de interesse farmacêutico e cosmético.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESporUniversidade Federal de Santa MariaCentro de Ciências da SaúdePrograma de Pós-Graduação em Ciências FarmacêuticasUFSMBrasilFarmáciaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessFotoprotetoresNanocápsulasÓleos vegetaisÓleo de arrozÓleo de sojaÓleo de girassolNanocapsulesSunscreenVegetable oilsRice bran oilSoybean oilSunflower seed oilCNPQ::CIENCIAS DA SAUDE::FARMACIADesenvolvimento de formulações de interesse farmacêutico e cosmético a partir de óleos vegetais derivados de plantas cultivadas no RSDevelopment of cosmetic or pharmaceutical formulations from vegetable oil derivates of plants cultivated in RSinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisBeck, Ruy Carlos Ruverhttp://lattes.cnpq.br/5548361916821654Raffin, Renata PlatchekAthayde, Margareth Lindehttp://lattes.cnpq.br/5962160122200514Rigo, Lucas Almeida4003000000056006006006006004669665b-c6fd-4342-8e09-dcac7d48215138ff9d53-dcf3-48aa-a988-cf9f59ec00fb8d63e0ed-89a9-4617-a29c-30ee5ab5e3039ca77fbe-34f8-47ec-bb3e-1ec571a64a1creponame:Repositório Institucional Manancial UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALDIS_PPGCF_2011_RIGO_LUCAS.pdfDIS_PPGCF_2011_RIGO_LUCAS.pdfDissertação de mestradoapplication/pdf6966204http://repositorio.ufsm.br/bitstream/1/27334/1/DIS_PPGCF_2011_RIGO_LUCAS.pdfa9cc5985f060a553fa82f504d1d8bd0bMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805http://repositorio.ufsm.br/bitstream/1/27334/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81956http://repositorio.ufsm.br/bitstream/1/27334/3/license.txt2f0571ecee68693bd5cd3f17c1e075dfMD531/273342022-12-13 17:06:39.968oai:repositorio.ufsm.br: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ório Institucionalhttp://repositorio.ufsm.br/PUBhttp://repositorio.ufsm.br/oai/requestouvidoria@ufsm.bropendoar:39132022-12-13T20:06:39Repositório Institucional Manancial UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Desenvolvimento de formulações de interesse farmacêutico e cosmético a partir de óleos vegetais derivados de plantas cultivadas no RS |
dc.title.alternative.eng.fl_str_mv |
Development of cosmetic or pharmaceutical formulations from vegetable oil derivates of plants cultivated in RS |
title |
Desenvolvimento de formulações de interesse farmacêutico e cosmético a partir de óleos vegetais derivados de plantas cultivadas no RS |
spellingShingle |
Desenvolvimento de formulações de interesse farmacêutico e cosmético a partir de óleos vegetais derivados de plantas cultivadas no RS Rigo, Lucas Almeida Fotoprotetores Nanocápsulas Óleos vegetais Óleo de arroz Óleo de soja Óleo de girassol Nanocapsules Sunscreen Vegetable oils Rice bran oil Soybean oil Sunflower seed oil CNPQ::CIENCIAS DA SAUDE::FARMACIA |
title_short |
Desenvolvimento de formulações de interesse farmacêutico e cosmético a partir de óleos vegetais derivados de plantas cultivadas no RS |
title_full |
Desenvolvimento de formulações de interesse farmacêutico e cosmético a partir de óleos vegetais derivados de plantas cultivadas no RS |
title_fullStr |
Desenvolvimento de formulações de interesse farmacêutico e cosmético a partir de óleos vegetais derivados de plantas cultivadas no RS |
title_full_unstemmed |
Desenvolvimento de formulações de interesse farmacêutico e cosmético a partir de óleos vegetais derivados de plantas cultivadas no RS |
title_sort |
Desenvolvimento de formulações de interesse farmacêutico e cosmético a partir de óleos vegetais derivados de plantas cultivadas no RS |
author |
Rigo, Lucas Almeida |
author_facet |
Rigo, Lucas Almeida |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Beck, Ruy Carlos Ruver |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/5548361916821654 |
dc.contributor.referee1.fl_str_mv |
Raffin, Renata Platchek |
dc.contributor.referee2.fl_str_mv |
Athayde, Margareth Linde |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/5962160122200514 |
dc.contributor.author.fl_str_mv |
Rigo, Lucas Almeida |
contributor_str_mv |
Beck, Ruy Carlos Ruver Raffin, Renata Platchek Athayde, Margareth Linde |
dc.subject.por.fl_str_mv |
Fotoprotetores Nanocápsulas Óleos vegetais Óleo de arroz Óleo de soja Óleo de girassol Nanocapsules |
topic |
Fotoprotetores Nanocápsulas Óleos vegetais Óleo de arroz Óleo de soja Óleo de girassol Nanocapsules Sunscreen Vegetable oils Rice bran oil Soybean oil Sunflower seed oil CNPQ::CIENCIAS DA SAUDE::FARMACIA |
dc.subject.eng.fl_str_mv |
Sunscreen Vegetable oils Rice bran oil Soybean oil Sunflower seed oil |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS DA SAUDE::FARMACIA |
description |
This work aimed to use the rice bran, soybean or sunflower seed oil as alternative raw materials for the development of pharmaceutical and cosmetic dosage forms. In the first chapter sunscreen cosmetic formulations were prepared from gel-cream containing rice bran or soybean oil at different concentrations, using an organic sunscreen (benzophenone-3). The influence of these oils on the following characteristics was assessed: pH, spreadability, rheological behavior, and in vitro sun protection factor. The formulations showed suitable physical and chemical characteristics, non-Newtonian rheological behavior, and spreadability dependent on the concentration of the oil. The sun protection factor was around 10 regardless of the type and concentration of oil used. In the second chapter, lipid-core nanocapsules were prepared by interfacial deposition of preformed polymer containing rice bran, soybean or sunflower seed oil. The physicochemical parameters analyzed were pH, particle size, polydispersity index, zeta potential, morphological characteristics, and stability. The type of vegetable oil did not have influence on the physicochemical characteristics of the formulations, which remained adequate and stable during the 3 months of storage. Moreover, based on the genotoxicity and proliferative activity studies we can suggest that none of the formulations present risks to the environment. In the third chapter, nanocapsule formulations containing the three vegetable oils and a model drug (0.5 mg/mL) were prepared to evaluate the effect of the oils on the in vitro drug release. The drug was successfully encapsulated in all nanocapsule formulations with total drug close to the theoretical value. The in vitro drug release study from nanocapsules showed that the controlled release follows a biexponential regardless of the type of vegetable oil. The nanocapsule formulations containing the sunflower seed oil provided higher drug release control, followed by the nanocapsule formulations containing soybean and rice bran oil, showing that the type of the vegetable oil influences the drug release profile. Through these works the technological feasibility to use the rice bran, soybean or sunflower seed oil was demonstrated as an alternative source of viable raw material for obtaining pharmaceutical formulations of pharmaceutical and cosmetic interest. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-03-14 |
dc.date.accessioned.fl_str_mv |
2022-12-13T20:06:39Z |
dc.date.available.fl_str_mv |
2022-12-13T20:06:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/27334 |
url |
http://repositorio.ufsm.br/handle/1/27334 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
400300000005 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 600 |
dc.relation.authority.fl_str_mv |
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dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências da Saúde |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Ciências Farmacêuticas |
dc.publisher.initials.fl_str_mv |
UFSM |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Farmácia |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências da Saúde |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional Manancial UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
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