Análise da atividade da enzima delta-aminolevulinato desidratase (d-ALA-D) no diabetes mellitus e no hipotireoidismo
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional Manancial UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/11159 |
Resumo: | The activity of Delta-Aminolevulinate Dehydratase (d-ALA-D) was analyzed in patients suffering from diabetes mellitus and primary hypothyroidism. Five groups of patients were studied: compensated diabetes mellitus, non-compensated diabetes mellitus, compensated hypothyroidism, non-compensated hypothyroidism and control group. The analysis of d-ALA-D in these groups showed the following results: the activity of d-ALA-D on non-compensated diabetes mellitus decreased comparing to the control group, to the compensated diabetes mellitus group. The activity of d-ALA-D on non-compensated hypothyroidism increased compared to the control group and also to non-compensated hypothyroidism. In vitro analyses of the drugs used by the patients suffering diabetes mellitus (metformin, chlorpropamide, glibenclamide, glimepiride) and the drug used by the patients suffering primary hypothyroidism (thyroxine) were fulfilled to verify some change in the activity of d-ALA-D, and the findings showed that there was not any changes on d-ALA-D activity. Metals may interfere in the action of d-ALA-D. Consequently,the quantity of metals (lead, zinc, copper) present in the patients blood was measured. One observed that the amount of those metals was not different, from a statistical, among the groups. Therefore, we can conclude that the activity of d-ALA-D increased in the group of non-compensated hipothyroidism and decreased in the non-compensated diabetes, and may be it could be related to the complications observed in such pathologies |
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2017-04-242017-04-242004-07-27SOUZA, João Baptista D'andrea. Analyses of Delta -aminolevulinate Dehydratase in the diabetes mellitus and hypothyroidism. 2004. 139 f. Dissertação (Mestrado em Bioquímica) - Universidade Federal de Santa Maria, Santa Maria, 2004.http://repositorio.ufsm.br/handle/1/11159The activity of Delta-Aminolevulinate Dehydratase (d-ALA-D) was analyzed in patients suffering from diabetes mellitus and primary hypothyroidism. Five groups of patients were studied: compensated diabetes mellitus, non-compensated diabetes mellitus, compensated hypothyroidism, non-compensated hypothyroidism and control group. The analysis of d-ALA-D in these groups showed the following results: the activity of d-ALA-D on non-compensated diabetes mellitus decreased comparing to the control group, to the compensated diabetes mellitus group. The activity of d-ALA-D on non-compensated hypothyroidism increased compared to the control group and also to non-compensated hypothyroidism. In vitro analyses of the drugs used by the patients suffering diabetes mellitus (metformin, chlorpropamide, glibenclamide, glimepiride) and the drug used by the patients suffering primary hypothyroidism (thyroxine) were fulfilled to verify some change in the activity of d-ALA-D, and the findings showed that there was not any changes on d-ALA-D activity. Metals may interfere in the action of d-ALA-D. Consequently,the quantity of metals (lead, zinc, copper) present in the patients blood was measured. One observed that the amount of those metals was not different, from a statistical, among the groups. Therefore, we can conclude that the activity of d-ALA-D increased in the group of non-compensated hipothyroidism and decreased in the non-compensated diabetes, and may be it could be related to the complications observed in such pathologiesA atividade da delta-aminolevulinato desidratase (d-ALA-D) foi analisada em pacientes com diabetes mellitus e pacientes com hipotireoidismo primário. Foram estudados cinco grupos de pacientes: diabetes mellitus compensado, diabetes mellitus descompensado, hipotireoidismo compensado, hipotireoidismo descompensado e grupo controle. A análise da d-ALA-D nesses grupos mostrou os seguintes resultados: a atividade da d-ALA-D nos pacientes com diabetes mellitus descompensados encontrava-se diminuída em relação ao grupo controle, ao grupo dos diabéticos compensados. Observamos que nos pacientes com hipotireoidismo descompensado, a atividade da d-ALA-D encontrava-se aumentada em relação ao controle e também em relação ao grupo dos hipotireoideos compensados. Foram realizadas análises in vitro das medicações utilizadas pelos pacientes diabéticos (metformina, glibenclamida, clorpropamida, glimepirida) e hipotireoideos (tiroxina), com o objetivo de verificar se havia alteração na atividade da d-ALA-D e como resultados obtivemos que as medicações não alteraram a atividade da referida enzima. Os metais podem interferir na atividade da d-ALA-D. Por isso foi medida a quantidade de metais (chumbo, zinco, cobre) presentes no sangue destes pacientes. Observamos que a quantidade dos referidos metais não foi diferente, do ponto de vista estatístico, entre os grupos. Desta forma, concluímos que a atividade da d-ALA-D estava aumentada no grupo de pacientes hipotireoideos descompensados e diminuída no dos diabéticos descompensados, podendo este fato ter relação com o desenvolvimento das complicações nestas doençasapplication/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaUFSMBRBioquímicaDelta-aminolevulinato desidrataseDiabetes mellitusHipotireoidismoDelta-aminolevulinate dehydratase (d-ALA-D)Diabetes mellitusHipothyroidismCNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICAAnálise da atividade da enzima delta-aminolevulinato desidratase (d-ALA-D) no diabetes mellitus e no hipotireoidismoAnalyses of Delta -aminolevulinate Dehydratase in the diabetes mellitus and hypothyroidisminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisSchetinger, Maria Rosa Chitolinahttp://lattes.cnpq.br/4401319386725357Pereira, Maria Esterhttp://lattes.cnpq.br/9299114496157799Perry, Marcos Luiz Santoshttp://lattes.cnpq.br/5583113475404099http://lattes.cnpq.br/9602237964043728Souza, João Baptista D'andrea200800000002400500300500500f2c5f39c-089e-4825-bfba-cc66b90989815db36588-daef-4327-8d02-f6a5fae0b5906f6ff1fa-1a27-4584-8864-3e18f46fe2e73cd76448-fb79-4eef-964a-72648182483cinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional Manancial UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALjoao.pdfapplication/pdf354484http://repositorio.ufsm.br/bitstream/1/11159/1/joao.pdf0b81271c5d0a74ab3e45a54e7f3f0a61MD51TEXTjoao.pdf.txtjoao.pdf.txtExtracted texttext/plain171832http://repositorio.ufsm.br/bitstream/1/11159/2/joao.pdf.txtad0df0326b8258216a8cf5b38a1a5138MD52THUMBNAILjoao.pdf.jpgjoao.pdf.jpgIM Thumbnailimage/jpeg4995http://repositorio.ufsm.br/bitstream/1/11159/3/joao.pdf.jpgb41edcfd6dba9b0b850f8931fd2f3a0eMD531/111592022-04-11 09:42:26.265oai:repositorio.ufsm.br:1/11159Repositório Institucionalhttp://repositorio.ufsm.br/PUBhttp://repositorio.ufsm.br/oai/requestouvidoria@ufsm.bropendoar:39132022-04-11T12:42:26Repositório Institucional Manancial UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Análise da atividade da enzima delta-aminolevulinato desidratase (d-ALA-D) no diabetes mellitus e no hipotireoidismo |
dc.title.alternative.eng.fl_str_mv |
Analyses of Delta -aminolevulinate Dehydratase in the diabetes mellitus and hypothyroidism |
title |
Análise da atividade da enzima delta-aminolevulinato desidratase (d-ALA-D) no diabetes mellitus e no hipotireoidismo |
spellingShingle |
Análise da atividade da enzima delta-aminolevulinato desidratase (d-ALA-D) no diabetes mellitus e no hipotireoidismo Souza, João Baptista D'andrea Delta-aminolevulinato desidratase Diabetes mellitus Hipotireoidismo Delta-aminolevulinate dehydratase (d-ALA-D) Diabetes mellitus Hipothyroidism CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
title_short |
Análise da atividade da enzima delta-aminolevulinato desidratase (d-ALA-D) no diabetes mellitus e no hipotireoidismo |
title_full |
Análise da atividade da enzima delta-aminolevulinato desidratase (d-ALA-D) no diabetes mellitus e no hipotireoidismo |
title_fullStr |
Análise da atividade da enzima delta-aminolevulinato desidratase (d-ALA-D) no diabetes mellitus e no hipotireoidismo |
title_full_unstemmed |
Análise da atividade da enzima delta-aminolevulinato desidratase (d-ALA-D) no diabetes mellitus e no hipotireoidismo |
title_sort |
Análise da atividade da enzima delta-aminolevulinato desidratase (d-ALA-D) no diabetes mellitus e no hipotireoidismo |
author |
Souza, João Baptista D'andrea |
author_facet |
Souza, João Baptista D'andrea |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Schetinger, Maria Rosa Chitolina |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/4401319386725357 |
dc.contributor.referee1.fl_str_mv |
Pereira, Maria Ester |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/9299114496157799 |
dc.contributor.referee2.fl_str_mv |
Perry, Marcos Luiz Santos |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/5583113475404099 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9602237964043728 |
dc.contributor.author.fl_str_mv |
Souza, João Baptista D'andrea |
contributor_str_mv |
Schetinger, Maria Rosa Chitolina Pereira, Maria Ester Perry, Marcos Luiz Santos |
dc.subject.por.fl_str_mv |
Delta-aminolevulinato desidratase Diabetes mellitus Hipotireoidismo |
topic |
Delta-aminolevulinato desidratase Diabetes mellitus Hipotireoidismo Delta-aminolevulinate dehydratase (d-ALA-D) Diabetes mellitus Hipothyroidism CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
dc.subject.eng.fl_str_mv |
Delta-aminolevulinate dehydratase (d-ALA-D) Diabetes mellitus Hipothyroidism |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
description |
The activity of Delta-Aminolevulinate Dehydratase (d-ALA-D) was analyzed in patients suffering from diabetes mellitus and primary hypothyroidism. Five groups of patients were studied: compensated diabetes mellitus, non-compensated diabetes mellitus, compensated hypothyroidism, non-compensated hypothyroidism and control group. The analysis of d-ALA-D in these groups showed the following results: the activity of d-ALA-D on non-compensated diabetes mellitus decreased comparing to the control group, to the compensated diabetes mellitus group. The activity of d-ALA-D on non-compensated hypothyroidism increased compared to the control group and also to non-compensated hypothyroidism. In vitro analyses of the drugs used by the patients suffering diabetes mellitus (metformin, chlorpropamide, glibenclamide, glimepiride) and the drug used by the patients suffering primary hypothyroidism (thyroxine) were fulfilled to verify some change in the activity of d-ALA-D, and the findings showed that there was not any changes on d-ALA-D activity. Metals may interfere in the action of d-ALA-D. Consequently,the quantity of metals (lead, zinc, copper) present in the patients blood was measured. One observed that the amount of those metals was not different, from a statistical, among the groups. Therefore, we can conclude that the activity of d-ALA-D increased in the group of non-compensated hipothyroidism and decreased in the non-compensated diabetes, and may be it could be related to the complications observed in such pathologies |
publishDate |
2004 |
dc.date.issued.fl_str_mv |
2004-07-27 |
dc.date.accessioned.fl_str_mv |
2017-04-24 |
dc.date.available.fl_str_mv |
2017-04-24 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SOUZA, João Baptista D'andrea. Analyses of Delta -aminolevulinate Dehydratase in the diabetes mellitus and hypothyroidism. 2004. 139 f. Dissertação (Mestrado em Bioquímica) - Universidade Federal de Santa Maria, Santa Maria, 2004. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/11159 |
identifier_str_mv |
SOUZA, João Baptista D'andrea. Analyses of Delta -aminolevulinate Dehydratase in the diabetes mellitus and hypothyroidism. 2004. 139 f. Dissertação (Mestrado em Bioquímica) - Universidade Federal de Santa Maria, Santa Maria, 2004. |
url |
http://repositorio.ufsm.br/handle/1/11159 |
dc.language.iso.fl_str_mv |
por |
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por |
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200800000002 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica |
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UFSM |
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BR |
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Bioquímica |
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Universidade Federal de Santa Maria |
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