Investigação da atividade antioxidante in vitro e da composição química de diferentes extratos de plantas medicinais
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Manancial - Repositório Digital da UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/4427 |
Resumo: | Oxidative stress (OS) is involved in the development of several disorders involving the central nervous system, such as Alzheimer s disease (AD). Considering the limitations of current therapeutics for AD, there is still a great demand for discovery of new medical alternatives. In the first part of the present study it was investigated the antioxidant capacity and the chemical composition of three plants popularly used to treat neurological disorders: Melissa officinalis, Matricaria recutita and Cymbopogon citratus. The antioxidant effect of some phenolic compounds was also examined for comparative purposes. All plant extracts were effective in to combat OS, but Melissa officinalis presented the highest antioxidant effect. Among the purified compounds, quercetin had the highest antioxidant activity followed by gallic acid, quercitrin and rutin. In this work, we have demonstrated that the plant extracts could protect against OS induced by various pro-oxidant agents that induce lipid peroxidation by different process. Based on this study, which indicates that Melissa officinalis could be an effective agent in the prevention of various neurological diseases associated with OS. In the second part of this study, it was investigated the chemical composition and antioxidant activity of different fractions from Melissa officinalis extract. Furthermore, it was verified the effect of the most antioxidant fraction on acethylcholinesterase (AChE) activity and the effect of gallic acid on the matrix metalloproteinase-2 (MMP-2) activity. Ethyl acetate fraction presented the highest flavonoids content as well as antioxidant activity when compared with other tested fractions and also it caused AChE inhibition. Moreover, gallic acid inhibited MMP-2 activity. In conclusion, M. officinalis ethyl acetate fraction is suggested to be further investigated for its possible use in the treatment of AD, due its antioxidant, anticholinesterase activities and the MMP-2 inhibitory capacity of their phenolic compound, gallic acid. |
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2017-04-262017-04-262011-03-18PEREIRA, Romaiana Picada. Investigation about in vitro antioxidant activity and chemical composition of different extracts from medicinal. 2011. 125 f. Tese (Doutorado em Bioquímica) - Universidade Federal de Santa Maria, Santa Maria, 2011.http://repositorio.ufsm.br/handle/1/4427Oxidative stress (OS) is involved in the development of several disorders involving the central nervous system, such as Alzheimer s disease (AD). Considering the limitations of current therapeutics for AD, there is still a great demand for discovery of new medical alternatives. In the first part of the present study it was investigated the antioxidant capacity and the chemical composition of three plants popularly used to treat neurological disorders: Melissa officinalis, Matricaria recutita and Cymbopogon citratus. The antioxidant effect of some phenolic compounds was also examined for comparative purposes. All plant extracts were effective in to combat OS, but Melissa officinalis presented the highest antioxidant effect. Among the purified compounds, quercetin had the highest antioxidant activity followed by gallic acid, quercitrin and rutin. In this work, we have demonstrated that the plant extracts could protect against OS induced by various pro-oxidant agents that induce lipid peroxidation by different process. Based on this study, which indicates that Melissa officinalis could be an effective agent in the prevention of various neurological diseases associated with OS. In the second part of this study, it was investigated the chemical composition and antioxidant activity of different fractions from Melissa officinalis extract. Furthermore, it was verified the effect of the most antioxidant fraction on acethylcholinesterase (AChE) activity and the effect of gallic acid on the matrix metalloproteinase-2 (MMP-2) activity. Ethyl acetate fraction presented the highest flavonoids content as well as antioxidant activity when compared with other tested fractions and also it caused AChE inhibition. Moreover, gallic acid inhibited MMP-2 activity. In conclusion, M. officinalis ethyl acetate fraction is suggested to be further investigated for its possible use in the treatment of AD, due its antioxidant, anticholinesterase activities and the MMP-2 inhibitory capacity of their phenolic compound, gallic acid.O estresse oxidativo (EO) está envolvido no desenvolvimento de várias doenças relacionadas ao sistema nervoso central, tal como a Doença de Alzheimer (DA). Considerando as limitações da terapia existente para a DA, existe ainda a necessidade de novas alternativas médicas. Na primeira parte deste estudo, foi investigada a capacidade antioxidante e a composição química de três plantas usadas popularmente para tratar desordens neurológicas: Melissa officinalis, Matricaria recutita e Cymbopogon citratus. O efeito antioxidante de alguns compostos fenólicos também foi examinado para fins comparativos. Todos os extratos de plantas foram efetivos no combate ao EO induzido por diferentes agentes, mas o extrato aquoso da Melissa officinalis apresentou o maior efeito antioxidante. Dentre os compostos purificados, a quercetina teve a maior atividade antioxidante seguida pelo ácido gálico, quercitrina e rutina. Neste trabalho, foi mostrado que os extratos de plantas protegeram contra o EO induzido por vários agentes pró-oxidantes que induzem peroxidação lipídica por diferentes processos. Baseado nestes resultados, que indicam que a Melissa officinalis poderia ser um agente efetivo na prevenção de várias doenças neurológicas associadas ao EO, na segunda parte deste estudo, foram investigadas a composição química e a atividade antioxidante de diferentes frações do extrato de Melissa officinalis. Além disso, investigou-se o efeito da fração com maior potencial antioxidante na atividade da acetilcolinesterase (AChE) e o efeito do ácido gálico na atividade da metaloproteinase-2 da matriz (MMP-2). A fração acetato de etila apresentou maior conteúdo de flavonóides associada a uma maior atividade antioxidante quando comparado com as outras frações testadas e causou inibição da AChE. Além disso, o ácido gálico inibiu a atividade da MMP-2. Desta forma, sugere-se que a fração acetato de etila da M. officinalis poderia ser melhor investigada para o seu possível uso no tratamento da DA, devido às suas atividades antioxidante e anticolinesterase e a capacidade do ácido gálico, composto fenólico presente em sua composição, inibir a MMP-2.Conselho Nacional de Desenvolvimento Científico e Tecnológicoapplication/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaUFSMBRBioquímicaMelissa officinalisMatricaria recutitaCymbopogon citratusEstresse oxidativoQuercetinaÁcido gálicoDoença de AlzheimerMelissa officinalisMatricaria recutitaCymbopogon citratusOxidative stressTBARSDPPHHPLCQuercetinGallic acidCNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICAInvestigação da atividade antioxidante in vitro e da composição química de diferentes extratos de plantas medicinaisInvestigation about in vitro antioxidant activity and chemical composition of different extracts from medicinalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisRocha, João Batista Teixeira dahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4782281H2Farina, Marcelohttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4706271Y7Bem, Andreza Fabro dehttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4767637D2Wagner, Carolinehttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4745160D1Pereira, Luciane Belmontehttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4762396A4http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4711676H5Pereira, Romaiana Picada20080000000240050030030030030030027186f63-94dd-4f0f-8181-7ce1b0835009b31ec08e-9391-48ac-aa6b-cebc34aa55e65dd23b6c-62c2-4151-9273-82b3c73a45199f3ecc6f-2c96-4fbf-8f4f-9d1590061398d7dc21db-e508-4e38-b2e9-c73d2ec6592763e6b832-62fa-4023-8372-b7ff77816d93info:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALPEREIRA, ROMAIANA PICADA.pdfapplication/pdf5350916http://repositorio.ufsm.br/bitstream/1/4427/1/PEREIRA%2c%20ROMAIANA%20%20PICADA.pdfea2b073be33c4b682c0e6d2facb09ceeMD51TEXTPEREIRA, ROMAIANA PICADA.pdf.txtPEREIRA, ROMAIANA PICADA.pdf.txtExtracted texttext/plain138440http://repositorio.ufsm.br/bitstream/1/4427/2/PEREIRA%2c%20ROMAIANA%20%20PICADA.pdf.txt5327905077724d0a0615a6c934f9d311MD52THUMBNAILPEREIRA, ROMAIANA PICADA.pdf.jpgPEREIRA, ROMAIANA PICADA.pdf.jpgIM Thumbnailimage/jpeg5687http://repositorio.ufsm.br/bitstream/1/4427/3/PEREIRA%2c%20ROMAIANA%20%20PICADA.pdf.jpg6bb484722b64a4ec81047bebdd09b03cMD531/44272017-07-25 11:06:36.152oai:repositorio.ufsm.br:1/4427Repositório Institucionalhttp://repositorio.ufsm.br/PUBhttp://repositorio.ufsm.br/oai/requestopendoar:39132017-07-25T14:06:36Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Investigação da atividade antioxidante in vitro e da composição química de diferentes extratos de plantas medicinais |
dc.title.alternative.eng.fl_str_mv |
Investigation about in vitro antioxidant activity and chemical composition of different extracts from medicinal |
title |
Investigação da atividade antioxidante in vitro e da composição química de diferentes extratos de plantas medicinais |
spellingShingle |
Investigação da atividade antioxidante in vitro e da composição química de diferentes extratos de plantas medicinais Pereira, Romaiana Picada Melissa officinalis Matricaria recutita Cymbopogon citratus Estresse oxidativo Quercetina Ácido gálico Doença de Alzheimer Melissa officinalis Matricaria recutita Cymbopogon citratus Oxidative stress TBARS DPPH HPLC Quercetin Gallic acid CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
title_short |
Investigação da atividade antioxidante in vitro e da composição química de diferentes extratos de plantas medicinais |
title_full |
Investigação da atividade antioxidante in vitro e da composição química de diferentes extratos de plantas medicinais |
title_fullStr |
Investigação da atividade antioxidante in vitro e da composição química de diferentes extratos de plantas medicinais |
title_full_unstemmed |
Investigação da atividade antioxidante in vitro e da composição química de diferentes extratos de plantas medicinais |
title_sort |
Investigação da atividade antioxidante in vitro e da composição química de diferentes extratos de plantas medicinais |
author |
Pereira, Romaiana Picada |
author_facet |
Pereira, Romaiana Picada |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Rocha, João Batista Teixeira da |
dc.contributor.advisor1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4782281H2 |
dc.contributor.referee1.fl_str_mv |
Farina, Marcelo |
dc.contributor.referee1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4706271Y7 |
dc.contributor.referee2.fl_str_mv |
Bem, Andreza Fabro de |
dc.contributor.referee2Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4767637D2 |
dc.contributor.referee3.fl_str_mv |
Wagner, Caroline |
dc.contributor.referee3Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4745160D1 |
dc.contributor.referee4.fl_str_mv |
Pereira, Luciane Belmonte |
dc.contributor.referee4Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4762396A4 |
dc.contributor.authorLattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4711676H5 |
dc.contributor.author.fl_str_mv |
Pereira, Romaiana Picada |
contributor_str_mv |
Rocha, João Batista Teixeira da Farina, Marcelo Bem, Andreza Fabro de Wagner, Caroline Pereira, Luciane Belmonte |
dc.subject.por.fl_str_mv |
Melissa officinalis Matricaria recutita Cymbopogon citratus Estresse oxidativo Quercetina Ácido gálico Doença de Alzheimer |
topic |
Melissa officinalis Matricaria recutita Cymbopogon citratus Estresse oxidativo Quercetina Ácido gálico Doença de Alzheimer Melissa officinalis Matricaria recutita Cymbopogon citratus Oxidative stress TBARS DPPH HPLC Quercetin Gallic acid CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
dc.subject.eng.fl_str_mv |
Melissa officinalis Matricaria recutita Cymbopogon citratus Oxidative stress TBARS DPPH HPLC Quercetin Gallic acid |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
description |
Oxidative stress (OS) is involved in the development of several disorders involving the central nervous system, such as Alzheimer s disease (AD). Considering the limitations of current therapeutics for AD, there is still a great demand for discovery of new medical alternatives. In the first part of the present study it was investigated the antioxidant capacity and the chemical composition of three plants popularly used to treat neurological disorders: Melissa officinalis, Matricaria recutita and Cymbopogon citratus. The antioxidant effect of some phenolic compounds was also examined for comparative purposes. All plant extracts were effective in to combat OS, but Melissa officinalis presented the highest antioxidant effect. Among the purified compounds, quercetin had the highest antioxidant activity followed by gallic acid, quercitrin and rutin. In this work, we have demonstrated that the plant extracts could protect against OS induced by various pro-oxidant agents that induce lipid peroxidation by different process. Based on this study, which indicates that Melissa officinalis could be an effective agent in the prevention of various neurological diseases associated with OS. In the second part of this study, it was investigated the chemical composition and antioxidant activity of different fractions from Melissa officinalis extract. Furthermore, it was verified the effect of the most antioxidant fraction on acethylcholinesterase (AChE) activity and the effect of gallic acid on the matrix metalloproteinase-2 (MMP-2) activity. Ethyl acetate fraction presented the highest flavonoids content as well as antioxidant activity when compared with other tested fractions and also it caused AChE inhibition. Moreover, gallic acid inhibited MMP-2 activity. In conclusion, M. officinalis ethyl acetate fraction is suggested to be further investigated for its possible use in the treatment of AD, due its antioxidant, anticholinesterase activities and the MMP-2 inhibitory capacity of their phenolic compound, gallic acid. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-03-18 |
dc.date.accessioned.fl_str_mv |
2017-04-26 |
dc.date.available.fl_str_mv |
2017-04-26 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
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doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PEREIRA, Romaiana Picada. Investigation about in vitro antioxidant activity and chemical composition of different extracts from medicinal. 2011. 125 f. Tese (Doutorado em Bioquímica) - Universidade Federal de Santa Maria, Santa Maria, 2011. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/4427 |
identifier_str_mv |
PEREIRA, Romaiana Picada. Investigation about in vitro antioxidant activity and chemical composition of different extracts from medicinal. 2011. 125 f. Tese (Doutorado em Bioquímica) - Universidade Federal de Santa Maria, Santa Maria, 2011. |
url |
http://repositorio.ufsm.br/handle/1/4427 |
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por |
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por |
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200800000002 |
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400 500 300 300 300 300 300 |
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27186f63-94dd-4f0f-8181-7ce1b0835009 b31ec08e-9391-48ac-aa6b-cebc34aa55e6 5dd23b6c-62c2-4151-9273-82b3c73a4519 9f3ecc6f-2c96-4fbf-8f4f-9d1590061398 d7dc21db-e508-4e38-b2e9-c73d2ec65927 63e6b832-62fa-4023-8372-b7ff77816d93 |
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openAccess |
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Universidade Federal de Santa Maria |
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Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica |
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UFSM |
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BR |
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Bioquímica |
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Universidade Federal de Santa Maria |
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