Neutrophils response in dairy cows during early pregnancy
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Manancial - Repositório Digital da UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/22080 |
Resumo: | Studies highlighted the role of the immune system during the establishment of pregnancy. Maternal immune response has to find a balance to avoid any damage to the conceptus and maintain its function in combating microbes. When pregnancy cannot achieve this balance, losses might occur. Intercommunication between mother and conceptus is fundamental during early pregnancy to dictate the outcome of pregnancy. During pregnancy, the embryo signals to the maternal system its presence mainly locally via interferon tau (IFNT), and any stress factor can disrupt the signaling. The maternal immune response can alter between anti- and pro-inflammatory type, but usually, in the first few days (e.g., day 7), anti-inflammatory responses are established. IFNT concentration begins to be detected in circulation around day 12 of pregnancy in low concentrations, suggesting that maternal immune modulation does not occur by the direct effect of IFNT during this time. However, it’s unclear how amplification of IFNT signal in circulation occurs. Based on that, the present study focuses on determining IFNT effects in polymorphonuclear (PMN) cells and if immune cells can amplify embryonic signals to other immune cells in vitro. And if the signaling in PMN can be disrupted by stressor factor, i.e., heat stress in vivo. The first study demonstrated that IFNT could generate anti-inflammatory responses and upregulation of ISGs expressions in PMNs, subsequently amplifying and transferring IFNT signals to a new cell population via a cell-to-cell communication mechanism possibly mediated by IFNA. The second study demonstrated that heat stress modulates PMN responses with greater anti- and pro-inflammatory cytokines expressions in different early pregnancy days. These findings might provide a better understanding of the modulation of innate immune responses during maternal recognition of pregnancy. |
id |
UFSM_7b09e8c48db8e89ba422630564bca15d |
---|---|
oai_identifier_str |
oai:repositorio.ufsm.br:1/22080 |
network_acronym_str |
UFSM |
network_name_str |
Manancial - Repositório Digital da UFSM |
repository_id_str |
|
spelling |
Neutrophils response in dairy cows during early pregnancyNeutrophilsInterferon tauToleranceHyperthermiaInflammationCNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIAStudies highlighted the role of the immune system during the establishment of pregnancy. Maternal immune response has to find a balance to avoid any damage to the conceptus and maintain its function in combating microbes. When pregnancy cannot achieve this balance, losses might occur. Intercommunication between mother and conceptus is fundamental during early pregnancy to dictate the outcome of pregnancy. During pregnancy, the embryo signals to the maternal system its presence mainly locally via interferon tau (IFNT), and any stress factor can disrupt the signaling. The maternal immune response can alter between anti- and pro-inflammatory type, but usually, in the first few days (e.g., day 7), anti-inflammatory responses are established. IFNT concentration begins to be detected in circulation around day 12 of pregnancy in low concentrations, suggesting that maternal immune modulation does not occur by the direct effect of IFNT during this time. However, it’s unclear how amplification of IFNT signal in circulation occurs. Based on that, the present study focuses on determining IFNT effects in polymorphonuclear (PMN) cells and if immune cells can amplify embryonic signals to other immune cells in vitro. And if the signaling in PMN can be disrupted by stressor factor, i.e., heat stress in vivo. The first study demonstrated that IFNT could generate anti-inflammatory responses and upregulation of ISGs expressions in PMNs, subsequently amplifying and transferring IFNT signals to a new cell population via a cell-to-cell communication mechanism possibly mediated by IFNA. The second study demonstrated that heat stress modulates PMN responses with greater anti- and pro-inflammatory cytokines expressions in different early pregnancy days. These findings might provide a better understanding of the modulation of innate immune responses during maternal recognition of pregnancy.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESNão possui resumo em português.Universidade Federal de Santa MariaBrasilMedicina VeterináriaUFSMPrograma de Pós-Graduação em Medicina VeterináriaCentro de Ciências RuraisFiorenza, Mariani Fariashttp://lattes.cnpq.br/7258679373419746Miyamoto, AkioComim, Fabio VasconcellosSilveira, Juliano Coelho daEmanuelli, Mauren PicadaFiorenza, Mariani Farias2021-08-26T19:05:02Z2021-08-26T19:05:02Z2021-02-26info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisapplication/pdfhttp://repositorio.ufsm.br/handle/1/22080porAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM2021-08-27T06:04:26Zoai:repositorio.ufsm.br:1/22080Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2021-08-27T06:04:26Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.none.fl_str_mv |
Neutrophils response in dairy cows during early pregnancy |
title |
Neutrophils response in dairy cows during early pregnancy |
spellingShingle |
Neutrophils response in dairy cows during early pregnancy Fiorenza, Mariani Farias Neutrophils Interferon tau Tolerance Hyperthermia Inflammation CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
title_short |
Neutrophils response in dairy cows during early pregnancy |
title_full |
Neutrophils response in dairy cows during early pregnancy |
title_fullStr |
Neutrophils response in dairy cows during early pregnancy |
title_full_unstemmed |
Neutrophils response in dairy cows during early pregnancy |
title_sort |
Neutrophils response in dairy cows during early pregnancy |
author |
Fiorenza, Mariani Farias |
author_facet |
Fiorenza, Mariani Farias |
author_role |
author |
dc.contributor.none.fl_str_mv |
Fiorenza, Mariani Farias http://lattes.cnpq.br/7258679373419746 Miyamoto, Akio Comim, Fabio Vasconcellos Silveira, Juliano Coelho da Emanuelli, Mauren Picada |
dc.contributor.author.fl_str_mv |
Fiorenza, Mariani Farias |
dc.subject.por.fl_str_mv |
Neutrophils Interferon tau Tolerance Hyperthermia Inflammation CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
topic |
Neutrophils Interferon tau Tolerance Hyperthermia Inflammation CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
description |
Studies highlighted the role of the immune system during the establishment of pregnancy. Maternal immune response has to find a balance to avoid any damage to the conceptus and maintain its function in combating microbes. When pregnancy cannot achieve this balance, losses might occur. Intercommunication between mother and conceptus is fundamental during early pregnancy to dictate the outcome of pregnancy. During pregnancy, the embryo signals to the maternal system its presence mainly locally via interferon tau (IFNT), and any stress factor can disrupt the signaling. The maternal immune response can alter between anti- and pro-inflammatory type, but usually, in the first few days (e.g., day 7), anti-inflammatory responses are established. IFNT concentration begins to be detected in circulation around day 12 of pregnancy in low concentrations, suggesting that maternal immune modulation does not occur by the direct effect of IFNT during this time. However, it’s unclear how amplification of IFNT signal in circulation occurs. Based on that, the present study focuses on determining IFNT effects in polymorphonuclear (PMN) cells and if immune cells can amplify embryonic signals to other immune cells in vitro. And if the signaling in PMN can be disrupted by stressor factor, i.e., heat stress in vivo. The first study demonstrated that IFNT could generate anti-inflammatory responses and upregulation of ISGs expressions in PMNs, subsequently amplifying and transferring IFNT signals to a new cell population via a cell-to-cell communication mechanism possibly mediated by IFNA. The second study demonstrated that heat stress modulates PMN responses with greater anti- and pro-inflammatory cytokines expressions in different early pregnancy days. These findings might provide a better understanding of the modulation of innate immune responses during maternal recognition of pregnancy. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-26T19:05:02Z 2021-08-26T19:05:02Z 2021-02-26 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/22080 |
url |
http://repositorio.ufsm.br/handle/1/22080 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Brasil Medicina Veterinária UFSM Programa de Pós-Graduação em Medicina Veterinária Centro de Ciências Rurais |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Brasil Medicina Veterinária UFSM Programa de Pós-Graduação em Medicina Veterinária Centro de Ciências Rurais |
dc.source.none.fl_str_mv |
reponame:Manancial - Repositório Digital da UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Manancial - Repositório Digital da UFSM |
collection |
Manancial - Repositório Digital da UFSM |
repository.name.fl_str_mv |
Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
atendimento.sib@ufsm.br||tedebc@gmail.com |
_version_ |
1805922089760194560 |