Aumento gengival associado à ciclosporina em transplantados renais no HUSM
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Manancial - Repositório Digital da UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/6061 |
Resumo: | Background: Gingival enlargement (GE) is a frequent finding in cyclosporin users. The mechanisms of this association are not totally known and point out to a multifactorial model, with dose and associations with calcium channel blockers. Novel immunosuppression protocols are adjusting for drugs and dosages. Aim: This study aimed at investigating the prevalence and severity of gingival enlargement in renal transplanted individuals under cyclosporin and possible associations with clinical and pharmacological findings. Methods: With a cross- sectional design, 63 renal transplanted patients under cyclosporin therapy from the University Hospital of the Santa Maria Federal University were examined. Demographic, pharmacological and periodontal variables were assessed. Data analysis, independent sample t test and chi square were used to compare means values of different variables, comparing groups with or without gingival enlargement. Results: A response rate of 86,30% was achieved. In total, 40% of the patients presented some degree of GE. Eleven presented scores >10% and only 5 presented scores of 30%. Mean value for GE was low (6,79±15,83). Patients under nifedipine presented higher prevalence of GE, without reaching statistical significance. Mean values for serum levels of CsA were 3,20±0,94 mg/kg/day and 156,12±162,75 ng/ml, respectively. No statistically significant differences among individuals with or without GE was obtained relating to the use of nifedipine and/or none/verapamil. Conclusion: A lower prevalence and severity of GE was found in relation to previous studies, independent to the drug association. |
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Aumento gengival associado à ciclosporina em transplantados renais no HUSMAumento gengivalCiclosporinaBloqueador de canal de cálcioGingival enlargementCyclosporinCalcium channel blockerCNPQ::CIENCIAS DA SAUDE::ODONTOLOGIABackground: Gingival enlargement (GE) is a frequent finding in cyclosporin users. The mechanisms of this association are not totally known and point out to a multifactorial model, with dose and associations with calcium channel blockers. Novel immunosuppression protocols are adjusting for drugs and dosages. Aim: This study aimed at investigating the prevalence and severity of gingival enlargement in renal transplanted individuals under cyclosporin and possible associations with clinical and pharmacological findings. Methods: With a cross- sectional design, 63 renal transplanted patients under cyclosporin therapy from the University Hospital of the Santa Maria Federal University were examined. Demographic, pharmacological and periodontal variables were assessed. Data analysis, independent sample t test and chi square were used to compare means values of different variables, comparing groups with or without gingival enlargement. Results: A response rate of 86,30% was achieved. In total, 40% of the patients presented some degree of GE. Eleven presented scores >10% and only 5 presented scores of 30%. Mean value for GE was low (6,79±15,83). Patients under nifedipine presented higher prevalence of GE, without reaching statistical significance. Mean values for serum levels of CsA were 3,20±0,94 mg/kg/day and 156,12±162,75 ng/ml, respectively. No statistically significant differences among individuals with or without GE was obtained relating to the use of nifedipine and/or none/verapamil. Conclusion: A lower prevalence and severity of GE was found in relation to previous studies, independent to the drug association.Justificativa: Aumento gengival (AG) é um achado freqüente em pacientes que utilizam Ciclosporina (CsA). Os mecanismos dessa associação não são totalmente conhecidos e apontam para um modelo multifatorial, com doses e associações com outras drogas, como bloqueadores de canais de cálcio (BCC). Novos protocolos de imunossupressão vêm ajustando fármacos e doses visando obter melhores resultados na terapia, diminuindo também os efeitos adversos. Objetivo: Este estudo tem por objetivo investigar a prevalência e a gravidade de aumento gengival em transplantados renais medicados com CsA, e possíveis associações com fatores farmacológicos e clínicos. Metodologia: Utilizando um delineamento transversal, foram examinados 63 transplantados renais em terapia com CsA no Hospital Universitário de Santa Maria (HUSM). Dados demográficos, farmacológicos e periodontais foram coletados. Para a análise dos dados, foram utilizados o teste t não-pareado e qui-quadrado a fim de comparar as médias das variáveis para os grupos com e sem aumento gengival. Resultados: Uma taxa de resposta de 86,3% foi obtida. Ao todo 40% dos pacientes apresentaram algum grau de AG. Onze apresentaram escores acima de 10% e apenas 5 com 30%. A média de AG foi baixa (6,79). Pacientes que utilizam nifedipina apresentaram maior prevalência de AG, sem significância estatística. As médias de dosagem e níveis séricos de CsA foram 3,20 mg/kg/dia e 156,12 ng/ml, respectivamente. Não houve diferença estatística dessas variáveis entre os indivíduos com e sem aumento gengival e entre os gruposnifedipina e sem BCC ou verapamil. Conclusão: No presente estudo, o AG associado à CsA apresentou valores de prevalência e gravidade reduzidos , independentemente das interações medicamentosas.Universidade Federal de Santa MariaBROdontologiaUFSMPrograma de Pós-Graduação em Ciências OdontológicasRosing, Cassiano Kuchenbeckerhttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4791476T8Moreira, Carlos Heitor Cunhahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4702944T7Fernandes, Marilene Issahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4702959A7Ardenghi, Thiago Machadohttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4779009Z1Wentz, Luiz Augusto2010-05-132010-05-132010-03-16info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfapplication/pdfWENTZ, Luiz Augusto. AUMENTO GENGIVAL ASSOCIADO À CICLOSPORINA EM TRANSPLANTADOS RENAIS NO HUSM. 2010. 54 f. Dissertação (Mestrado em Odontologia) - Universidade Federal de Santa Maria, Santa Maria, 2010.http://repositorio.ufsm.br/handle/1/6061porinfo:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM2022-02-21T18:25:37Zoai:repositorio.ufsm.br:1/6061Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2022-02-21T18:25:37Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.none.fl_str_mv |
Aumento gengival associado à ciclosporina em transplantados renais no HUSM |
title |
Aumento gengival associado à ciclosporina em transplantados renais no HUSM |
spellingShingle |
Aumento gengival associado à ciclosporina em transplantados renais no HUSM Wentz, Luiz Augusto Aumento gengival Ciclosporina Bloqueador de canal de cálcio Gingival enlargement Cyclosporin Calcium channel blocker CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
title_short |
Aumento gengival associado à ciclosporina em transplantados renais no HUSM |
title_full |
Aumento gengival associado à ciclosporina em transplantados renais no HUSM |
title_fullStr |
Aumento gengival associado à ciclosporina em transplantados renais no HUSM |
title_full_unstemmed |
Aumento gengival associado à ciclosporina em transplantados renais no HUSM |
title_sort |
Aumento gengival associado à ciclosporina em transplantados renais no HUSM |
author |
Wentz, Luiz Augusto |
author_facet |
Wentz, Luiz Augusto |
author_role |
author |
dc.contributor.none.fl_str_mv |
Rosing, Cassiano Kuchenbecker http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4791476T8 Moreira, Carlos Heitor Cunha http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4702944T7 Fernandes, Marilene Issa http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4702959A7 Ardenghi, Thiago Machado http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4779009Z1 |
dc.contributor.author.fl_str_mv |
Wentz, Luiz Augusto |
dc.subject.por.fl_str_mv |
Aumento gengival Ciclosporina Bloqueador de canal de cálcio Gingival enlargement Cyclosporin Calcium channel blocker CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
topic |
Aumento gengival Ciclosporina Bloqueador de canal de cálcio Gingival enlargement Cyclosporin Calcium channel blocker CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
description |
Background: Gingival enlargement (GE) is a frequent finding in cyclosporin users. The mechanisms of this association are not totally known and point out to a multifactorial model, with dose and associations with calcium channel blockers. Novel immunosuppression protocols are adjusting for drugs and dosages. Aim: This study aimed at investigating the prevalence and severity of gingival enlargement in renal transplanted individuals under cyclosporin and possible associations with clinical and pharmacological findings. Methods: With a cross- sectional design, 63 renal transplanted patients under cyclosporin therapy from the University Hospital of the Santa Maria Federal University were examined. Demographic, pharmacological and periodontal variables were assessed. Data analysis, independent sample t test and chi square were used to compare means values of different variables, comparing groups with or without gingival enlargement. Results: A response rate of 86,30% was achieved. In total, 40% of the patients presented some degree of GE. Eleven presented scores >10% and only 5 presented scores of 30%. Mean value for GE was low (6,79±15,83). Patients under nifedipine presented higher prevalence of GE, without reaching statistical significance. Mean values for serum levels of CsA were 3,20±0,94 mg/kg/day and 156,12±162,75 ng/ml, respectively. No statistically significant differences among individuals with or without GE was obtained relating to the use of nifedipine and/or none/verapamil. Conclusion: A lower prevalence and severity of GE was found in relation to previous studies, independent to the drug association. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-05-13 2010-05-13 2010-03-16 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
WENTZ, Luiz Augusto. AUMENTO GENGIVAL ASSOCIADO À CICLOSPORINA EM TRANSPLANTADOS RENAIS NO HUSM. 2010. 54 f. Dissertação (Mestrado em Odontologia) - Universidade Federal de Santa Maria, Santa Maria, 2010. http://repositorio.ufsm.br/handle/1/6061 |
identifier_str_mv |
WENTZ, Luiz Augusto. AUMENTO GENGIVAL ASSOCIADO À CICLOSPORINA EM TRANSPLANTADOS RENAIS NO HUSM. 2010. 54 f. Dissertação (Mestrado em Odontologia) - Universidade Federal de Santa Maria, Santa Maria, 2010. |
url |
http://repositorio.ufsm.br/handle/1/6061 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria BR Odontologia UFSM Programa de Pós-Graduação em Ciências Odontológicas |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria BR Odontologia UFSM Programa de Pós-Graduação em Ciências Odontológicas |
dc.source.none.fl_str_mv |
reponame:Manancial - Repositório Digital da UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Manancial - Repositório Digital da UFSM |
collection |
Manancial - Repositório Digital da UFSM |
repository.name.fl_str_mv |
Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
atendimento.sib@ufsm.br||tedebc@gmail.com |
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1805922133462745088 |