Avaliação clínica de diferentes protocolos de laser de baixa potência em mucosite bucal induzida por 5-fluouracil em hamsters
Autor(a) principal: | |
---|---|
Data de Publicação: | 2012 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional Manancial UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/17523 |
Resumo: | Aims: The purpose of this study was to investigate the effects of different of low level laser (LLL) protocols on induced-oral mucositis by 5-fluoracil (5-FU) in hamsters. Introduction: The oral mucositis is a ordinary side effect from antineoplasic therapy. Development of effective interventions to its prevention and treatment are priory on caring of the oncology patients. Metodologia: In the present study 96 hamsters were used and randomly allocated into 4 groups: Control (without treatment), Preventive (laser from day -5 to day +5), Therapeutic (laser from day +5 to day +15) and Combined (laser from day -5 to day +15). Mucositis was induced in hamsters by intraperitoneal injection of 5- fluorouracil (5-FU) at days 0 and 2 and superficial scratching in cheek pouch mucosa. The irradiation was carried out using diode LLL, 660 nm, 40mW of power, 6,0J/cm2 during 6seconds/point. At days 0, 5, 10 and 15, six animals from each group were sacrificed, weighted and the cheek pouch mucosa was clinically analyzed. Statistical analysis was made considering the time x treatment interaction through the SPSS Statistics 18.0® software. The multiple comparison was made by the Generalized Estimation Equation test and adjusted by the Bonferroni test. Results: The animals from the Control group had significant lose of weight at the 10th day of the experiment. The laser treatment at preventive, therapeutic and combined form presented mucosits scratching reduction in comparison to the control group. However there was no statistic difference between the mucositis scores at the groups that received treatment. Conclusion: The low level laser, independent of the used protocol, is efficient to clinical reducing oral-inducted mucositis by 5-FU in hamsters. |
id |
UFSM-20_b498a413edae0b8b793f6c240d22fea8 |
---|---|
oai_identifier_str |
oai:repositorio.ufsm.br:1/17523 |
network_acronym_str |
UFSM-20 |
network_name_str |
Repositório Institucional Manancial UFSM |
repository_id_str |
3913 |
spelling |
2019-07-22T19:36:22Z2019-07-22T19:36:22Z2012-08-29http://repositorio.ufsm.br/handle/1/17523Aims: The purpose of this study was to investigate the effects of different of low level laser (LLL) protocols on induced-oral mucositis by 5-fluoracil (5-FU) in hamsters. Introduction: The oral mucositis is a ordinary side effect from antineoplasic therapy. Development of effective interventions to its prevention and treatment are priory on caring of the oncology patients. Metodologia: In the present study 96 hamsters were used and randomly allocated into 4 groups: Control (without treatment), Preventive (laser from day -5 to day +5), Therapeutic (laser from day +5 to day +15) and Combined (laser from day -5 to day +15). Mucositis was induced in hamsters by intraperitoneal injection of 5- fluorouracil (5-FU) at days 0 and 2 and superficial scratching in cheek pouch mucosa. The irradiation was carried out using diode LLL, 660 nm, 40mW of power, 6,0J/cm2 during 6seconds/point. At days 0, 5, 10 and 15, six animals from each group were sacrificed, weighted and the cheek pouch mucosa was clinically analyzed. Statistical analysis was made considering the time x treatment interaction through the SPSS Statistics 18.0® software. The multiple comparison was made by the Generalized Estimation Equation test and adjusted by the Bonferroni test. Results: The animals from the Control group had significant lose of weight at the 10th day of the experiment. The laser treatment at preventive, therapeutic and combined form presented mucosits scratching reduction in comparison to the control group. However there was no statistic difference between the mucositis scores at the groups that received treatment. Conclusion: The low level laser, independent of the used protocol, is efficient to clinical reducing oral-inducted mucositis by 5-FU in hamsters.Objetivos: O objetivo do presente estudo foi investigar o efeito de diferentes protocolos de laser de baixa potência (LBP) na mucosite bucal induzida por 5-fluouracil (5-FU) em hamsters. Introdução: A mucosite bucal é uma complicação comum da terapia antineoplásica. O desenvolvimento de intervenções efetivas para sua prevenção e tratamento é visto como prioridade nos cuidados de suporte ao paciente oncológico. Metodologia: Foram utilizados 96 hamsters divididos aleatoriamente em 4 grupos: Controle (sem tratamento), Preventivo (laser do Dia -7 ao Dia +5); Terapêutico (laser do Dia +5 ao Dia +15) e Conjugado (laser do Dia -7 ao Dia +15). Os animais receberam injeção intraperitoneal de 5-FU nos dias 0 e 2 e escarificação da mucosa jugal nos dias 3 e 4. A irradiação foi realizada com LBP de diodo (InGaAlP), 660 nm, 40 mW de potência, 6,0 J/cm2 por 6 segundos/ponto. Nos dias 0, 5, 10 e 15 foram sacrificados seis animais de cada grupo, pesados e a mucosa jugal foi analisada clinicamente. Foi realizada análise estatística para a interação tempo x tratamento através do programa SPSS Statistics 18.0®. As comparações múltiplas foram feitas pelo teste de Equações de Estimação Generalizada e ajustado pelo teste de Bonferroni. Resultados: Houve significativa perde de peso dos animais do grupo controle no dia 10 do experimento. Os tratamentos com laser tanto na forma preventiva, terapêutica e conjugada exibiram redução dos escores de mucosite de forma estatisticamente significante quando comparados ao grupo controle. Todavia, não houve diferença estatisticamente significativa entre escores de mucosites nos grupos que receberam tratamento laser. Conclusão: O laser de baixa intensidade, independente do protocolo utilizado, é eficaz na redução clínica da mucosite bucal induzida por 5-FU em hamsters.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESporUniversidade Federal de Santa MariaCentro de Ciências da SaúdePrograma de Pós-Graduação em Ciências OdontológicasUFSMBrasilOdontologiaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessLaserterapiaQuimioterapiaEfeito adversoMucosa bucalSide effectLaser therapyChemotherapyOral mucosaCNPQ::CIENCIAS DA SAUDE::ODONTOLOGIAAvaliação clínica de diferentes protocolos de laser de baixa potência em mucosite bucal induzida por 5-fluouracil em hamstersClinical assesment of diferent of low level laser protocols in induced-oral mucositis by 5-fluouracil in hamsterinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisMartins, Manoela Domingueshttp://lattes.cnpq.br/4958184722611235Hildebrand, Laura de Camposhttp://lattes.cnpq.br/9389175033734431Lamers, Marcelo Lazzaronhttp://lattes.cnpq.br/9421062861957581http://lattes.cnpq.br/9972239843316219Kaefer, Thieni40020000000060079073f63-7824-4ef3-b80c-c9965cc66c7871be69f5-9933-480b-8ee1-d3dffb02512d7c055851-276f-4b66-8f06-817887eae8118ccaaf17-1154-4164-9667-18db877dfe54reponame:Repositório Institucional Manancial UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805http://repositorio.ufsm.br/bitstream/1/17523/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81956http://repositorio.ufsm.br/bitstream/1/17523/3/license.txt2f0571ecee68693bd5cd3f17c1e075dfMD53ORIGINALDIS_PPGCO_2012_KAEFER_THIENI.pdfDIS_PPGCO_2012_KAEFER_THIENI.pdfDissertação de Mestradoapplication/pdf1158298http://repositorio.ufsm.br/bitstream/1/17523/1/DIS_PPGCO_2012_KAEFER_THIENI.pdf00b5c4a0f770a9452e13797c9011e31dMD51TEXTDIS_PPGCO_2012_KAEFER_THIENI.pdf.txtDIS_PPGCO_2012_KAEFER_THIENI.pdf.txtExtracted texttext/plain70719http://repositorio.ufsm.br/bitstream/1/17523/4/DIS_PPGCO_2012_KAEFER_THIENI.pdf.txt6a5aafc37b5c9bf331fb474985e6fc94MD54THUMBNAILDIS_PPGCO_2012_KAEFER_THIENI.pdf.jpgDIS_PPGCO_2012_KAEFER_THIENI.pdf.jpgIM Thumbnailimage/jpeg5526http://repositorio.ufsm.br/bitstream/1/17523/5/DIS_PPGCO_2012_KAEFER_THIENI.pdf.jpg4c851c0036fc44715ac16ff09ed63097MD551/175232019-07-23 03:00:56.731oai:repositorio.ufsm.br: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ório Institucionalhttp://repositorio.ufsm.br/PUBhttp://repositorio.ufsm.br/oai/requestouvidoria@ufsm.bropendoar:39132019-07-23T06:00:56Repositório Institucional Manancial UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Avaliação clínica de diferentes protocolos de laser de baixa potência em mucosite bucal induzida por 5-fluouracil em hamsters |
dc.title.alternative.eng.fl_str_mv |
Clinical assesment of diferent of low level laser protocols in induced-oral mucositis by 5-fluouracil in hamster |
title |
Avaliação clínica de diferentes protocolos de laser de baixa potência em mucosite bucal induzida por 5-fluouracil em hamsters |
spellingShingle |
Avaliação clínica de diferentes protocolos de laser de baixa potência em mucosite bucal induzida por 5-fluouracil em hamsters Kaefer, Thieni Laserterapia Quimioterapia Efeito adverso Mucosa bucal Side effect Laser therapy Chemotherapy Oral mucosa CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
title_short |
Avaliação clínica de diferentes protocolos de laser de baixa potência em mucosite bucal induzida por 5-fluouracil em hamsters |
title_full |
Avaliação clínica de diferentes protocolos de laser de baixa potência em mucosite bucal induzida por 5-fluouracil em hamsters |
title_fullStr |
Avaliação clínica de diferentes protocolos de laser de baixa potência em mucosite bucal induzida por 5-fluouracil em hamsters |
title_full_unstemmed |
Avaliação clínica de diferentes protocolos de laser de baixa potência em mucosite bucal induzida por 5-fluouracil em hamsters |
title_sort |
Avaliação clínica de diferentes protocolos de laser de baixa potência em mucosite bucal induzida por 5-fluouracil em hamsters |
author |
Kaefer, Thieni |
author_facet |
Kaefer, Thieni |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Martins, Manoela Domingues |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/4958184722611235 |
dc.contributor.referee1.fl_str_mv |
Hildebrand, Laura de Campos |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/9389175033734431 |
dc.contributor.referee2.fl_str_mv |
Lamers, Marcelo Lazzaron |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/9421062861957581 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9972239843316219 |
dc.contributor.author.fl_str_mv |
Kaefer, Thieni |
contributor_str_mv |
Martins, Manoela Domingues Hildebrand, Laura de Campos Lamers, Marcelo Lazzaron |
dc.subject.por.fl_str_mv |
Laserterapia Quimioterapia Efeito adverso Mucosa bucal Side effect |
topic |
Laserterapia Quimioterapia Efeito adverso Mucosa bucal Side effect Laser therapy Chemotherapy Oral mucosa CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
dc.subject.eng.fl_str_mv |
Laser therapy Chemotherapy Oral mucosa |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
description |
Aims: The purpose of this study was to investigate the effects of different of low level laser (LLL) protocols on induced-oral mucositis by 5-fluoracil (5-FU) in hamsters. Introduction: The oral mucositis is a ordinary side effect from antineoplasic therapy. Development of effective interventions to its prevention and treatment are priory on caring of the oncology patients. Metodologia: In the present study 96 hamsters were used and randomly allocated into 4 groups: Control (without treatment), Preventive (laser from day -5 to day +5), Therapeutic (laser from day +5 to day +15) and Combined (laser from day -5 to day +15). Mucositis was induced in hamsters by intraperitoneal injection of 5- fluorouracil (5-FU) at days 0 and 2 and superficial scratching in cheek pouch mucosa. The irradiation was carried out using diode LLL, 660 nm, 40mW of power, 6,0J/cm2 during 6seconds/point. At days 0, 5, 10 and 15, six animals from each group were sacrificed, weighted and the cheek pouch mucosa was clinically analyzed. Statistical analysis was made considering the time x treatment interaction through the SPSS Statistics 18.0® software. The multiple comparison was made by the Generalized Estimation Equation test and adjusted by the Bonferroni test. Results: The animals from the Control group had significant lose of weight at the 10th day of the experiment. The laser treatment at preventive, therapeutic and combined form presented mucosits scratching reduction in comparison to the control group. However there was no statistic difference between the mucositis scores at the groups that received treatment. Conclusion: The low level laser, independent of the used protocol, is efficient to clinical reducing oral-inducted mucositis by 5-FU in hamsters. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-08-29 |
dc.date.accessioned.fl_str_mv |
2019-07-22T19:36:22Z |
dc.date.available.fl_str_mv |
2019-07-22T19:36:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/17523 |
url |
http://repositorio.ufsm.br/handle/1/17523 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
400200000000 |
dc.relation.confidence.fl_str_mv |
600 |
dc.relation.authority.fl_str_mv |
79073f63-7824-4ef3-b80c-c9965cc66c78 71be69f5-9933-480b-8ee1-d3dffb02512d 7c055851-276f-4b66-8f06-817887eae811 8ccaaf17-1154-4164-9667-18db877dfe54 |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências da Saúde |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Ciências Odontológicas |
dc.publisher.initials.fl_str_mv |
UFSM |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Odontologia |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências da Saúde |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional Manancial UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Repositório Institucional Manancial UFSM |
collection |
Repositório Institucional Manancial UFSM |
bitstream.url.fl_str_mv |
http://repositorio.ufsm.br/bitstream/1/17523/2/license_rdf http://repositorio.ufsm.br/bitstream/1/17523/3/license.txt http://repositorio.ufsm.br/bitstream/1/17523/1/DIS_PPGCO_2012_KAEFER_THIENI.pdf http://repositorio.ufsm.br/bitstream/1/17523/4/DIS_PPGCO_2012_KAEFER_THIENI.pdf.txt http://repositorio.ufsm.br/bitstream/1/17523/5/DIS_PPGCO_2012_KAEFER_THIENI.pdf.jpg |
bitstream.checksum.fl_str_mv |
4460e5956bc1d1639be9ae6146a50347 2f0571ecee68693bd5cd3f17c1e075df 00b5c4a0f770a9452e13797c9011e31d 6a5aafc37b5c9bf331fb474985e6fc94 4c851c0036fc44715ac16ff09ed63097 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional Manancial UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
ouvidoria@ufsm.br |
_version_ |
1808854704500768768 |