Correção de ruptura de ligamento cruzado em cães com implante de polipropileno associado a fração total de células mononucleares
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Manancial - Repositório Digital da UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/4071 |
Resumo: | The ligament rupture (LC) is lesion diagnosed in most dogs with joint problems, and the most common cause is degenerative joint disease of the knee joint. This study aimed to evaluate the action of the total fraction of mononuclear cells from autologous bone marrow (FCMO) applied intra-articular by after surgical repair of ruptured cruciate ligament. It is proposed a new technique for surgical correction of this disease, evaluating clinically the action of a polypropylene mesh as the only substitute for cranial cruciate ligament and flow of dogs. Twenty dogs underwent unilateral desmotomy cranial and caudal LC. Twenty-one days after the break, all were treated surgically by the technique of open reduction, with implantation of polypropylene replacing only the cranial cruciate ligament (CCL). Ten animals received FCMO at the time of correction. The assessments were by X-ray study, clinical examinations and biopsies at 50 and 90 days postoperatively. The surgical technique has shown rapid implementation and low soft tissue dissection, early return to ambulation and adequate strength of the implant. The group that received FCMO grew intra-articular bone at the X-ray study, however, the twenty animals showed CD34 positive in their biopsy samples, indicating a presence of stem cells in both groups. It was concluded that there was no clinical difference between the two groups until 90 days of evaluation. |
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2017-06-012017-06-012010-04-09MÜLLER, Daniel Curvello de Mendonça. Correction of ligament rupture in dogs with polypropylene implants linked to total fraction of mononuclear cells. 2010. 120 f. Tese (Doutorado em Medicina Veterinária) - Universidade Federal de Santa Maria, Santa Maria, 2010.http://repositorio.ufsm.br/handle/1/4071The ligament rupture (LC) is lesion diagnosed in most dogs with joint problems, and the most common cause is degenerative joint disease of the knee joint. This study aimed to evaluate the action of the total fraction of mononuclear cells from autologous bone marrow (FCMO) applied intra-articular by after surgical repair of ruptured cruciate ligament. It is proposed a new technique for surgical correction of this disease, evaluating clinically the action of a polypropylene mesh as the only substitute for cranial cruciate ligament and flow of dogs. Twenty dogs underwent unilateral desmotomy cranial and caudal LC. Twenty-one days after the break, all were treated surgically by the technique of open reduction, with implantation of polypropylene replacing only the cranial cruciate ligament (CCL). Ten animals received FCMO at the time of correction. The assessments were by X-ray study, clinical examinations and biopsies at 50 and 90 days postoperatively. The surgical technique has shown rapid implementation and low soft tissue dissection, early return to ambulation and adequate strength of the implant. The group that received FCMO grew intra-articular bone at the X-ray study, however, the twenty animals showed CD34 positive in their biopsy samples, indicating a presence of stem cells in both groups. It was concluded that there was no clinical difference between the two groups until 90 days of evaluation.A ruptura do ligamento cruzado (LC) é uma lesão diagnosticada em grande parte dos cães com problemas articulares, sendo a causa mais comum de afecção articular degenerativa da articulação do joelho. Este trabalho teve por objetivo, avaliar a ação da fração total de células mononucleares autógenas da medula óssea (FCMO) de aplicação intra-articular, após a correção cirúrgica dos ligamentos cruzados rompidos. Foi proposta uma nova técnica de correção cirúrgica desta afecção, avaliando-se clinicamente a ação da malha de polipropileno como único substituto do ligamento cruzado cranial e caudal de cães. Foram utilizados 20 cães, submetidos à desmotomia unilateral dos LC cranial e caudal. Vinte e um dias após a ruptura, todos foram tratados cirurgicamente pela técnica de redução aberta, com o implante de polipropileno, substituindo apenas o ligamento cruzado cranial (LCC). Dez animais receberam a FCMO no momento da correção. As avaliações se deram por estudo radiográfico, exames clínicos e biópsias aos 50 e 90 dias pós-operatórios. A técnica cirúrgica proposta demonstrou ser de rápida execução e pouca dissecação de tecidos moles, retorno precoce à deambulação e resistência adequada do implante. O grupo que recebeu a FCMO apresentou crescimento ósseo intra-articular ao estudo radiológico, contudo, os vinte animais apresentaram células CD34 positivas em suas amostras biopsiadas, indicando haver presença de células-tronco em ambos os grupos. Concluiu-se que não houve diferença clínica entre os dois grupos até os 90 dias de avaliação.Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorapplication/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em Medicina VeterináriaUFSMBRMedicina VeterináriaDesmotomia do ligamento cruzadoImplante sintéticoCélulas-troncoDesmotomia cruciate ligamentSynthetic implantsStem cellsCNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIACorreção de ruptura de ligamento cruzado em cães com implante de polipropileno associado a fração total de células mononuclearesCorrection of ligament rupture in dogs with polypropylene implants linked to total fraction of mononuclear cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisPippi, Ney Luishttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4783382P7Schossler, Joao Eduardo Wallauhttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4784154D8Graça, Dominguita Luhershttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4783904A3Aguiar, Eduardo Santiago Ventura dehttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4761469D6Alievi, Marcelo Mellerhttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4767491D6http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4130963H9Müller, Daniel Curvello de Mendonça500500000007400300300300300300300e7d62db5-d9ba-4842-bf91-8dd7b40e28b143b985ce-8c23-4008-88ff-60db479cb23ee542c387-4b52-4cf8-8201-feeccb5cc0598dd6a8b4-e3eb-40b3-a215-5b0fecb189d9a98bfac0-b6db-467f-a787-76d6ff3720f93b1e946f-524e-4077-b5c4-5ac3abcbaf66info:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALMULLER, DANIEL CURVELLO DE MENDONCA.pdfapplication/pdf2244996http://repositorio.ufsm.br/bitstream/1/4071/1/MULLER%2c%20DANIEL%20CURVELLO%20DE%20MENDONCA.pdf0814807409e37b2b6049e8064a7b58eaMD51TEXTMULLER, DANIEL CURVELLO DE MENDONCA.pdf.txtMULLER, DANIEL CURVELLO DE MENDONCA.pdf.txtExtracted texttext/plain197886http://repositorio.ufsm.br/bitstream/1/4071/2/MULLER%2c%20DANIEL%20CURVELLO%20DE%20MENDONCA.pdf.txtb69c3e73526b221cc1902ae1834dbd54MD52THUMBNAILMULLER, DANIEL CURVELLO DE MENDONCA.pdf.jpgMULLER, DANIEL CURVELLO DE MENDONCA.pdf.jpgIM Thumbnailimage/jpeg5190http://repositorio.ufsm.br/bitstream/1/4071/3/MULLER%2c%20DANIEL%20CURVELLO%20DE%20MENDONCA.pdf.jpg8f9d2a4a94be21bbae43956f67599a2fMD531/40712017-07-25 11:03:28.008oai:repositorio.ufsm.br:1/4071Repositório Institucionalhttp://repositorio.ufsm.br/PUBhttp://repositorio.ufsm.br/oai/requestopendoar:39132017-07-25T14:03:28Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Correção de ruptura de ligamento cruzado em cães com implante de polipropileno associado a fração total de células mononucleares |
dc.title.alternative.eng.fl_str_mv |
Correction of ligament rupture in dogs with polypropylene implants linked to total fraction of mononuclear cells |
title |
Correção de ruptura de ligamento cruzado em cães com implante de polipropileno associado a fração total de células mononucleares |
spellingShingle |
Correção de ruptura de ligamento cruzado em cães com implante de polipropileno associado a fração total de células mononucleares Müller, Daniel Curvello de Mendonça Desmotomia do ligamento cruzado Implante sintético Células-tronco Desmotomia cruciate ligament Synthetic implants Stem cells CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
title_short |
Correção de ruptura de ligamento cruzado em cães com implante de polipropileno associado a fração total de células mononucleares |
title_full |
Correção de ruptura de ligamento cruzado em cães com implante de polipropileno associado a fração total de células mononucleares |
title_fullStr |
Correção de ruptura de ligamento cruzado em cães com implante de polipropileno associado a fração total de células mononucleares |
title_full_unstemmed |
Correção de ruptura de ligamento cruzado em cães com implante de polipropileno associado a fração total de células mononucleares |
title_sort |
Correção de ruptura de ligamento cruzado em cães com implante de polipropileno associado a fração total de células mononucleares |
author |
Müller, Daniel Curvello de Mendonça |
author_facet |
Müller, Daniel Curvello de Mendonça |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Pippi, Ney Luis |
dc.contributor.advisor1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4783382P7 |
dc.contributor.referee1.fl_str_mv |
Schossler, Joao Eduardo Wallau |
dc.contributor.referee1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4784154D8 |
dc.contributor.referee2.fl_str_mv |
Graça, Dominguita Luhers |
dc.contributor.referee2Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4783904A3 |
dc.contributor.referee3.fl_str_mv |
Aguiar, Eduardo Santiago Ventura de |
dc.contributor.referee3Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4761469D6 |
dc.contributor.referee4.fl_str_mv |
Alievi, Marcelo Meller |
dc.contributor.referee4Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4767491D6 |
dc.contributor.authorLattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4130963H9 |
dc.contributor.author.fl_str_mv |
Müller, Daniel Curvello de Mendonça |
contributor_str_mv |
Pippi, Ney Luis Schossler, Joao Eduardo Wallau Graça, Dominguita Luhers Aguiar, Eduardo Santiago Ventura de Alievi, Marcelo Meller |
dc.subject.por.fl_str_mv |
Desmotomia do ligamento cruzado Implante sintético Células-tronco |
topic |
Desmotomia do ligamento cruzado Implante sintético Células-tronco Desmotomia cruciate ligament Synthetic implants Stem cells CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
dc.subject.eng.fl_str_mv |
Desmotomia cruciate ligament Synthetic implants Stem cells |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
description |
The ligament rupture (LC) is lesion diagnosed in most dogs with joint problems, and the most common cause is degenerative joint disease of the knee joint. This study aimed to evaluate the action of the total fraction of mononuclear cells from autologous bone marrow (FCMO) applied intra-articular by after surgical repair of ruptured cruciate ligament. It is proposed a new technique for surgical correction of this disease, evaluating clinically the action of a polypropylene mesh as the only substitute for cranial cruciate ligament and flow of dogs. Twenty dogs underwent unilateral desmotomy cranial and caudal LC. Twenty-one days after the break, all were treated surgically by the technique of open reduction, with implantation of polypropylene replacing only the cranial cruciate ligament (CCL). Ten animals received FCMO at the time of correction. The assessments were by X-ray study, clinical examinations and biopsies at 50 and 90 days postoperatively. The surgical technique has shown rapid implementation and low soft tissue dissection, early return to ambulation and adequate strength of the implant. The group that received FCMO grew intra-articular bone at the X-ray study, however, the twenty animals showed CD34 positive in their biopsy samples, indicating a presence of stem cells in both groups. It was concluded that there was no clinical difference between the two groups until 90 days of evaluation. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010-04-09 |
dc.date.accessioned.fl_str_mv |
2017-06-01 |
dc.date.available.fl_str_mv |
2017-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MÜLLER, Daniel Curvello de Mendonça. Correction of ligament rupture in dogs with polypropylene implants linked to total fraction of mononuclear cells. 2010. 120 f. Tese (Doutorado em Medicina Veterinária) - Universidade Federal de Santa Maria, Santa Maria, 2010. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/4071 |
identifier_str_mv |
MÜLLER, Daniel Curvello de Mendonça. Correction of ligament rupture in dogs with polypropylene implants linked to total fraction of mononuclear cells. 2010. 120 f. Tese (Doutorado em Medicina Veterinária) - Universidade Federal de Santa Maria, Santa Maria, 2010. |
url |
http://repositorio.ufsm.br/handle/1/4071 |
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por |
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Medicina Veterinária |
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Universidade Federal de Santa Maria |
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