Expression of EGF receptors in canine prostate with proliferative inflammatory atrophy and carcinoma

• Autor(a) principal: Faleiro,Mariana Batista Rodrigues
• Data de Publicação: 2017
• Outros Autores: Cintra,Lorena Cardoso, Jesuino,Rosália Santos Amorim, Araújo,Eugênio Gonçalves de, Rocha,Rafael Malagoli, Moura,Veridiana Maria Brianezi Dignani de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Ciência Rural
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017001200553
• topic: growth factor receptor; Her1; c-erbB-2; PIA; RT-PCR

ABSTRACT: Gene expression of ErbB1 and ErbB2, and immunostaining of EGFR (Her1) and Her2 (c-erbB-2) were evaluated in this study to ascertain whether these receptors are involved in the evolution of canine premalignant and malignant prostatic lesions, as proliferative inflammatory atrophy (PIA) and prostatic carcinoma (PC). With regards to the intensity of EGFR immunostaining, there was no difference between normal prostatic tissue and tissues with PIA or PC. In relation to Her2 immunostaining, there were differences between normal prostatic tissue and those with PIA and PC, as also differences between prostates with PIA and PC. There was no correlation between EGFR and Her2 immunostaining. ErbB1 gene product was detected in two normal tissue samples, in one with PIA, and in all samples with PC. ErbB2 mRNA was recorded in two canine samples with PIA, in all with PC, but was not detected in normal prostatic tissue. It was concluded that EGFR and Her2 play roles in canine PIA and PC, suggesting that those receptors may be involved in canine prostatic carcinogenesis.