Fecal microbiota transplantation via colonoscopy in a dog with Clostridioides (Clostridium) difficile infection

Detalhes bibliográficos
Autor(a) principal: Diniz,Amanda Nadia
Data de Publicação: 2021
Outros Autores: Souza,Angélica da Costa Ferreira de, Nepomuceno,Anelise Carvalho, Marcelino,Sóstenes Apolo Correia, Pierezan,Felipe, Lobato,Francisco Carlos Faria, Silva,Rodrigo Otávio Silveira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Ciência Rural
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000300452
Resumo: ABSTRACT: In dogs, antimicrobial therapy for Clostridioides (Clostridium) difficile infection (CDI) is based solely on metronidazole, leaving limited treatment options in case of recurrent disease. Fecal microbiota transplantation (FMT) has been successfully used in humans with recurrent CDI, whereas the usefulness of this approach is largely unknown in dogs. In the present study, a dog with a chronic-recurring diarrhea was treated with FMT via colonoscopy. CDI was confirmed by A/B toxin detection and isolation of toxigenic C. difficile from ribotype 106, a strain also commonly associated with nosocomial infection in humans. The dog recovered well after the procedure and C. difficile was no longer isolated from its stool sample. The present research suggested that FMT could be a useful tool to treat recurrent CDI in dogs, corroborating the actual protocol in humans.
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spelling Fecal microbiota transplantation via colonoscopy in a dog with Clostridioides (Clostridium) difficile infectioncanine diarrheaFMTcolitisABSTRACT: In dogs, antimicrobial therapy for Clostridioides (Clostridium) difficile infection (CDI) is based solely on metronidazole, leaving limited treatment options in case of recurrent disease. Fecal microbiota transplantation (FMT) has been successfully used in humans with recurrent CDI, whereas the usefulness of this approach is largely unknown in dogs. In the present study, a dog with a chronic-recurring diarrhea was treated with FMT via colonoscopy. CDI was confirmed by A/B toxin detection and isolation of toxigenic C. difficile from ribotype 106, a strain also commonly associated with nosocomial infection in humans. The dog recovered well after the procedure and C. difficile was no longer isolated from its stool sample. The present research suggested that FMT could be a useful tool to treat recurrent CDI in dogs, corroborating the actual protocol in humans.Universidade Federal de Santa Maria2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000300452Ciência Rural v.51 n.3 2021reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/0103-8478cr20200783info:eu-repo/semantics/openAccessDiniz,Amanda NadiaSouza,Angélica da Costa Ferreira deNepomuceno,Anelise CarvalhoMarcelino,Sóstenes Apolo CorreiaPierezan,FelipeLobato,Francisco Carlos FariaSilva,Rodrigo Otávio Silveiraeng2021-02-10T00:00:00ZRevista
dc.title.none.fl_str_mv Fecal microbiota transplantation via colonoscopy in a dog with Clostridioides (Clostridium) difficile infection
title Fecal microbiota transplantation via colonoscopy in a dog with Clostridioides (Clostridium) difficile infection
spellingShingle Fecal microbiota transplantation via colonoscopy in a dog with Clostridioides (Clostridium) difficile infection
Diniz,Amanda Nadia
canine diarrhea
FMT
colitis
title_short Fecal microbiota transplantation via colonoscopy in a dog with Clostridioides (Clostridium) difficile infection
title_full Fecal microbiota transplantation via colonoscopy in a dog with Clostridioides (Clostridium) difficile infection
title_fullStr Fecal microbiota transplantation via colonoscopy in a dog with Clostridioides (Clostridium) difficile infection
title_full_unstemmed Fecal microbiota transplantation via colonoscopy in a dog with Clostridioides (Clostridium) difficile infection
title_sort Fecal microbiota transplantation via colonoscopy in a dog with Clostridioides (Clostridium) difficile infection
author Diniz,Amanda Nadia
author_facet Diniz,Amanda Nadia
Souza,Angélica da Costa Ferreira de
Nepomuceno,Anelise Carvalho
Marcelino,Sóstenes Apolo Correia
Pierezan,Felipe
Lobato,Francisco Carlos Faria
Silva,Rodrigo Otávio Silveira
author_role author
author2 Souza,Angélica da Costa Ferreira de
Nepomuceno,Anelise Carvalho
Marcelino,Sóstenes Apolo Correia
Pierezan,Felipe
Lobato,Francisco Carlos Faria
Silva,Rodrigo Otávio Silveira
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Diniz,Amanda Nadia
Souza,Angélica da Costa Ferreira de
Nepomuceno,Anelise Carvalho
Marcelino,Sóstenes Apolo Correia
Pierezan,Felipe
Lobato,Francisco Carlos Faria
Silva,Rodrigo Otávio Silveira
dc.subject.por.fl_str_mv canine diarrhea
FMT
colitis
topic canine diarrhea
FMT
colitis
description ABSTRACT: In dogs, antimicrobial therapy for Clostridioides (Clostridium) difficile infection (CDI) is based solely on metronidazole, leaving limited treatment options in case of recurrent disease. Fecal microbiota transplantation (FMT) has been successfully used in humans with recurrent CDI, whereas the usefulness of this approach is largely unknown in dogs. In the present study, a dog with a chronic-recurring diarrhea was treated with FMT via colonoscopy. CDI was confirmed by A/B toxin detection and isolation of toxigenic C. difficile from ribotype 106, a strain also commonly associated with nosocomial infection in humans. The dog recovered well after the procedure and C. difficile was no longer isolated from its stool sample. The present research suggested that FMT could be a useful tool to treat recurrent CDI in dogs, corroborating the actual protocol in humans.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000300452
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000300452
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0103-8478cr20200783
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
publisher.none.fl_str_mv Universidade Federal de Santa Maria
dc.source.none.fl_str_mv Ciência Rural v.51 n.3 2021
reponame:Ciência Rural
instname:Universidade Federal de Santa Maria (UFSM)
instacron:UFSM
instname_str Universidade Federal de Santa Maria (UFSM)
instacron_str UFSM
institution UFSM
reponame_str Ciência Rural
collection Ciência Rural
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1749140555653185536

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