Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis

Detalhes bibliográficos
Autor(a) principal: Silva,Ariana de Castro Tavares da
Data de Publicação: 2021
Outros Autores: Santos,José Rômulo Soares dos, Silva,Rosangela Maria Nunes da, Santana,Vanessa Lira de, Martins,Francisco Sávio de Moura, Falcão,Brunna Muniz Rodrigues, Tanikawa,Atticcus, Almeida,Talles Monte de, Vaz,Antônio Fernando de Melo, Souza,Almir Pereira de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Ciência Rural
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000300601
Resumo: ABSTRACT: The objective of the present study was to assess the treatment of dogs with ehrlichiosis (tropical canine pancytopenia (TCP)) with doxycycline hydrochloride associated or not with prednisolone on the hematological profile and serum proteins. Ten dogs with TCP were selected in the Small Animal Medical Clinic Veterinary Hospital, Federal University of Campina Grande-UFCG-PB, Brazil. The diagnosis was obtained by clinical examination, hemogram and immunochromatographic test (with anti Ehrlichia canis antibodies). Samples were distributed randomly in two experimental groups of five animals each (n = 5), named GD and GDP. The GD group was treated with doxycycline (5 mg/kg, VO, BID for 28 days) and the GDP group was treated with doxycycline at the same dose and duration and prednisolone (2 mg/kg, VO, BID, for five days). Four blood collections were made during the treatment period: a base collection (M0), one at 10 days (M10), a second at 21 days (M21) and another at the end of the treatment (M28). These samples were used for the tests erythrogram, leucogram, plateletgram and proteinogram (dose of total proteins, pre-albumin, albumin, albumin, α-1 globulin, α-2 globulin, ß-globulin, ɣ-globulin and C- reactive protein) in the Clinical Pathology Laboratory, Veterinary Hospital-UFCG-PB. Results, that presented normal distribution, was submitted to the Tukey test (P<0.05). Comparison of treatments GD and GDP showed that both promoted discreet and similar response in the hematological parameters at different times. Results obtained allowed the conclusion that both therapeutic protocols resulted in clinical, hematological parameter and proteinogram improvement, but the use of prednisolone at the dose administered during the first five days of treatment did not show more beneficial effects than isolated administration of doxycycline.
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spelling Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosistickhemoparasitosesimmunoglobulinsproteinABSTRACT: The objective of the present study was to assess the treatment of dogs with ehrlichiosis (tropical canine pancytopenia (TCP)) with doxycycline hydrochloride associated or not with prednisolone on the hematological profile and serum proteins. Ten dogs with TCP were selected in the Small Animal Medical Clinic Veterinary Hospital, Federal University of Campina Grande-UFCG-PB, Brazil. The diagnosis was obtained by clinical examination, hemogram and immunochromatographic test (with anti Ehrlichia canis antibodies). Samples were distributed randomly in two experimental groups of five animals each (n = 5), named GD and GDP. The GD group was treated with doxycycline (5 mg/kg, VO, BID for 28 days) and the GDP group was treated with doxycycline at the same dose and duration and prednisolone (2 mg/kg, VO, BID, for five days). Four blood collections were made during the treatment period: a base collection (M0), one at 10 days (M10), a second at 21 days (M21) and another at the end of the treatment (M28). These samples were used for the tests erythrogram, leucogram, plateletgram and proteinogram (dose of total proteins, pre-albumin, albumin, albumin, α-1 globulin, α-2 globulin, ß-globulin, ɣ-globulin and C- reactive protein) in the Clinical Pathology Laboratory, Veterinary Hospital-UFCG-PB. Results, that presented normal distribution, was submitted to the Tukey test (P<0.05). Comparison of treatments GD and GDP showed that both promoted discreet and similar response in the hematological parameters at different times. Results obtained allowed the conclusion that both therapeutic protocols resulted in clinical, hematological parameter and proteinogram improvement, but the use of prednisolone at the dose administered during the first five days of treatment did not show more beneficial effects than isolated administration of doxycycline.Universidade Federal de Santa Maria2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000300601Ciência Rural v.51 n.3 2021reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/0103-8478cr20200335info:eu-repo/semantics/openAccessSilva,Ariana de Castro Tavares daSantos,José Rômulo Soares dosSilva,Rosangela Maria Nunes daSantana,Vanessa Lira deMartins,Francisco Sávio de MouraFalcão,Brunna Muniz RodriguesTanikawa,AtticcusAlmeida,Talles Monte deVaz,Antônio Fernando de MeloSouza,Almir Pereira deeng2021-01-27T00:00:00ZRevista
dc.title.none.fl_str_mv Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis
title Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis
spellingShingle Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis
Silva,Ariana de Castro Tavares da
tick
hemoparasitoses
immunoglobulins
protein
title_short Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis
title_full Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis
title_fullStr Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis
title_full_unstemmed Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis
title_sort Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis
author Silva,Ariana de Castro Tavares da
author_facet Silva,Ariana de Castro Tavares da
Santos,José Rômulo Soares dos
Silva,Rosangela Maria Nunes da
Santana,Vanessa Lira de
Martins,Francisco Sávio de Moura
Falcão,Brunna Muniz Rodrigues
Tanikawa,Atticcus
Almeida,Talles Monte de
Vaz,Antônio Fernando de Melo
Souza,Almir Pereira de
author_role author
author2 Santos,José Rômulo Soares dos
Silva,Rosangela Maria Nunes da
Santana,Vanessa Lira de
Martins,Francisco Sávio de Moura
Falcão,Brunna Muniz Rodrigues
Tanikawa,Atticcus
Almeida,Talles Monte de
Vaz,Antônio Fernando de Melo
Souza,Almir Pereira de
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva,Ariana de Castro Tavares da
Santos,José Rômulo Soares dos
Silva,Rosangela Maria Nunes da
Santana,Vanessa Lira de
Martins,Francisco Sávio de Moura
Falcão,Brunna Muniz Rodrigues
Tanikawa,Atticcus
Almeida,Talles Monte de
Vaz,Antônio Fernando de Melo
Souza,Almir Pereira de
dc.subject.por.fl_str_mv tick
hemoparasitoses
immunoglobulins
protein
topic tick
hemoparasitoses
immunoglobulins
protein
description ABSTRACT: The objective of the present study was to assess the treatment of dogs with ehrlichiosis (tropical canine pancytopenia (TCP)) with doxycycline hydrochloride associated or not with prednisolone on the hematological profile and serum proteins. Ten dogs with TCP were selected in the Small Animal Medical Clinic Veterinary Hospital, Federal University of Campina Grande-UFCG-PB, Brazil. The diagnosis was obtained by clinical examination, hemogram and immunochromatographic test (with anti Ehrlichia canis antibodies). Samples were distributed randomly in two experimental groups of five animals each (n = 5), named GD and GDP. The GD group was treated with doxycycline (5 mg/kg, VO, BID for 28 days) and the GDP group was treated with doxycycline at the same dose and duration and prednisolone (2 mg/kg, VO, BID, for five days). Four blood collections were made during the treatment period: a base collection (M0), one at 10 days (M10), a second at 21 days (M21) and another at the end of the treatment (M28). These samples were used for the tests erythrogram, leucogram, plateletgram and proteinogram (dose of total proteins, pre-albumin, albumin, albumin, α-1 globulin, α-2 globulin, ß-globulin, ɣ-globulin and C- reactive protein) in the Clinical Pathology Laboratory, Veterinary Hospital-UFCG-PB. Results, that presented normal distribution, was submitted to the Tukey test (P<0.05). Comparison of treatments GD and GDP showed that both promoted discreet and similar response in the hematological parameters at different times. Results obtained allowed the conclusion that both therapeutic protocols resulted in clinical, hematological parameter and proteinogram improvement, but the use of prednisolone at the dose administered during the first five days of treatment did not show more beneficial effects than isolated administration of doxycycline.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000300601
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000300601
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0103-8478cr20200335
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
publisher.none.fl_str_mv Universidade Federal de Santa Maria
dc.source.none.fl_str_mv Ciência Rural v.51 n.3 2021
reponame:Ciência Rural
instname:Universidade Federal de Santa Maria (UFSM)
instacron:UFSM
instname_str Universidade Federal de Santa Maria (UFSM)
instacron_str UFSM
institution UFSM
reponame_str Ciência Rural
collection Ciência Rural
repository.name.fl_str_mv
repository.mail.fl_str_mv
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