Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Ciência Rural |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000300601 |
Resumo: | ABSTRACT: The objective of the present study was to assess the treatment of dogs with ehrlichiosis (tropical canine pancytopenia (TCP)) with doxycycline hydrochloride associated or not with prednisolone on the hematological profile and serum proteins. Ten dogs with TCP were selected in the Small Animal Medical Clinic Veterinary Hospital, Federal University of Campina Grande-UFCG-PB, Brazil. The diagnosis was obtained by clinical examination, hemogram and immunochromatographic test (with anti Ehrlichia canis antibodies). Samples were distributed randomly in two experimental groups of five animals each (n = 5), named GD and GDP. The GD group was treated with doxycycline (5 mg/kg, VO, BID for 28 days) and the GDP group was treated with doxycycline at the same dose and duration and prednisolone (2 mg/kg, VO, BID, for five days). Four blood collections were made during the treatment period: a base collection (M0), one at 10 days (M10), a second at 21 days (M21) and another at the end of the treatment (M28). These samples were used for the tests erythrogram, leucogram, plateletgram and proteinogram (dose of total proteins, pre-albumin, albumin, albumin, α-1 globulin, α-2 globulin, ß-globulin, ɣ-globulin and C- reactive protein) in the Clinical Pathology Laboratory, Veterinary Hospital-UFCG-PB. Results, that presented normal distribution, was submitted to the Tukey test (P<0.05). Comparison of treatments GD and GDP showed that both promoted discreet and similar response in the hematological parameters at different times. Results obtained allowed the conclusion that both therapeutic protocols resulted in clinical, hematological parameter and proteinogram improvement, but the use of prednisolone at the dose administered during the first five days of treatment did not show more beneficial effects than isolated administration of doxycycline. |
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Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosistickhemoparasitosesimmunoglobulinsproteinABSTRACT: The objective of the present study was to assess the treatment of dogs with ehrlichiosis (tropical canine pancytopenia (TCP)) with doxycycline hydrochloride associated or not with prednisolone on the hematological profile and serum proteins. Ten dogs with TCP were selected in the Small Animal Medical Clinic Veterinary Hospital, Federal University of Campina Grande-UFCG-PB, Brazil. The diagnosis was obtained by clinical examination, hemogram and immunochromatographic test (with anti Ehrlichia canis antibodies). Samples were distributed randomly in two experimental groups of five animals each (n = 5), named GD and GDP. The GD group was treated with doxycycline (5 mg/kg, VO, BID for 28 days) and the GDP group was treated with doxycycline at the same dose and duration and prednisolone (2 mg/kg, VO, BID, for five days). Four blood collections were made during the treatment period: a base collection (M0), one at 10 days (M10), a second at 21 days (M21) and another at the end of the treatment (M28). These samples were used for the tests erythrogram, leucogram, plateletgram and proteinogram (dose of total proteins, pre-albumin, albumin, albumin, α-1 globulin, α-2 globulin, ß-globulin, ɣ-globulin and C- reactive protein) in the Clinical Pathology Laboratory, Veterinary Hospital-UFCG-PB. Results, that presented normal distribution, was submitted to the Tukey test (P<0.05). Comparison of treatments GD and GDP showed that both promoted discreet and similar response in the hematological parameters at different times. Results obtained allowed the conclusion that both therapeutic protocols resulted in clinical, hematological parameter and proteinogram improvement, but the use of prednisolone at the dose administered during the first five days of treatment did not show more beneficial effects than isolated administration of doxycycline.Universidade Federal de Santa Maria2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000300601Ciência Rural v.51 n.3 2021reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/0103-8478cr20200335info:eu-repo/semantics/openAccessSilva,Ariana de Castro Tavares daSantos,José Rômulo Soares dosSilva,Rosangela Maria Nunes daSantana,Vanessa Lira deMartins,Francisco Sávio de MouraFalcão,Brunna Muniz RodriguesTanikawa,AtticcusAlmeida,Talles Monte deVaz,Antônio Fernando de MeloSouza,Almir Pereira deeng2021-01-27T00:00:00ZRevista |
dc.title.none.fl_str_mv |
Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis |
title |
Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis |
spellingShingle |
Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis Silva,Ariana de Castro Tavares da tick hemoparasitoses immunoglobulins protein |
title_short |
Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis |
title_full |
Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis |
title_fullStr |
Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis |
title_full_unstemmed |
Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis |
title_sort |
Prednisolone associated with doxycycline on the hematological parameters and serum proteinogram of dogs with ehrlichiosis |
author |
Silva,Ariana de Castro Tavares da |
author_facet |
Silva,Ariana de Castro Tavares da Santos,José Rômulo Soares dos Silva,Rosangela Maria Nunes da Santana,Vanessa Lira de Martins,Francisco Sávio de Moura Falcão,Brunna Muniz Rodrigues Tanikawa,Atticcus Almeida,Talles Monte de Vaz,Antônio Fernando de Melo Souza,Almir Pereira de |
author_role |
author |
author2 |
Santos,José Rômulo Soares dos Silva,Rosangela Maria Nunes da Santana,Vanessa Lira de Martins,Francisco Sávio de Moura Falcão,Brunna Muniz Rodrigues Tanikawa,Atticcus Almeida,Talles Monte de Vaz,Antônio Fernando de Melo Souza,Almir Pereira de |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva,Ariana de Castro Tavares da Santos,José Rômulo Soares dos Silva,Rosangela Maria Nunes da Santana,Vanessa Lira de Martins,Francisco Sávio de Moura Falcão,Brunna Muniz Rodrigues Tanikawa,Atticcus Almeida,Talles Monte de Vaz,Antônio Fernando de Melo Souza,Almir Pereira de |
dc.subject.por.fl_str_mv |
tick hemoparasitoses immunoglobulins protein |
topic |
tick hemoparasitoses immunoglobulins protein |
description |
ABSTRACT: The objective of the present study was to assess the treatment of dogs with ehrlichiosis (tropical canine pancytopenia (TCP)) with doxycycline hydrochloride associated or not with prednisolone on the hematological profile and serum proteins. Ten dogs with TCP were selected in the Small Animal Medical Clinic Veterinary Hospital, Federal University of Campina Grande-UFCG-PB, Brazil. The diagnosis was obtained by clinical examination, hemogram and immunochromatographic test (with anti Ehrlichia canis antibodies). Samples were distributed randomly in two experimental groups of five animals each (n = 5), named GD and GDP. The GD group was treated with doxycycline (5 mg/kg, VO, BID for 28 days) and the GDP group was treated with doxycycline at the same dose and duration and prednisolone (2 mg/kg, VO, BID, for five days). Four blood collections were made during the treatment period: a base collection (M0), one at 10 days (M10), a second at 21 days (M21) and another at the end of the treatment (M28). These samples were used for the tests erythrogram, leucogram, plateletgram and proteinogram (dose of total proteins, pre-albumin, albumin, albumin, α-1 globulin, α-2 globulin, ß-globulin, ɣ-globulin and C- reactive protein) in the Clinical Pathology Laboratory, Veterinary Hospital-UFCG-PB. Results, that presented normal distribution, was submitted to the Tukey test (P<0.05). Comparison of treatments GD and GDP showed that both promoted discreet and similar response in the hematological parameters at different times. Results obtained allowed the conclusion that both therapeutic protocols resulted in clinical, hematological parameter and proteinogram improvement, but the use of prednisolone at the dose administered during the first five days of treatment did not show more beneficial effects than isolated administration of doxycycline. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000300601 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000300601 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0103-8478cr20200335 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.source.none.fl_str_mv |
Ciência Rural v.51 n.3 2021 reponame:Ciência Rural instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Ciência Rural |
collection |
Ciência Rural |
repository.name.fl_str_mv |
|
repository.mail.fl_str_mv |
|
_version_ |
1749140555657379840 |