Autologous bone marrow transplantation in a dog with lymphoma: a clinical study
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Ciência Rural |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782009000200045 |
Resumo: | The objective of this study is to provide the first report of bone marrow transplantation (BMT) in dogs in Brazil. A Rottweiler with cutaneous lymphoma was submitted to a twelve-week Madison-Wisconsin chemotherapy protocol followed by autologous bone marrow transplantation. For this, 10mL kg-1 of bone marrow was collected simultaneously from both iliac crests and cryopreserved in a freezer at -80°C. The conditioning step was performed by administering cyclophosphamide by intravenous route at 400mg m-2. Bone marrow was reinfused after defrosting in a water bath at 37°C. Bone marrow nucleated cell counts before and after freezing, showed a small relative loss of nucleated cells (35.10 and 31.80x10³µL-1 , respectively). Cyclophosphamide induced neutropenia which was reverted by a granulocyte colony-stimulating factor (G-CSF) capable of stimulating hematopoetic reconstitution. On the day 360 after transplant the patient was found to be in complete remission. This study indicates that autologous BMT in a dog with lymphoma submitted to myelosuppressive chemotherapy was potentially safe and effective. |
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Autologous bone marrow transplantation in a dog with lymphoma: a clinical studycaninecutaneous lymphomaautologous bone marrow transplantchemotherapyThe objective of this study is to provide the first report of bone marrow transplantation (BMT) in dogs in Brazil. A Rottweiler with cutaneous lymphoma was submitted to a twelve-week Madison-Wisconsin chemotherapy protocol followed by autologous bone marrow transplantation. For this, 10mL kg-1 of bone marrow was collected simultaneously from both iliac crests and cryopreserved in a freezer at -80°C. The conditioning step was performed by administering cyclophosphamide by intravenous route at 400mg m-2. Bone marrow was reinfused after defrosting in a water bath at 37°C. Bone marrow nucleated cell counts before and after freezing, showed a small relative loss of nucleated cells (35.10 and 31.80x10³µL-1 , respectively). Cyclophosphamide induced neutropenia which was reverted by a granulocyte colony-stimulating factor (G-CSF) capable of stimulating hematopoetic reconstitution. On the day 360 after transplant the patient was found to be in complete remission. This study indicates that autologous BMT in a dog with lymphoma submitted to myelosuppressive chemotherapy was potentially safe and effective.Universidade Federal de Santa Maria2009-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782009000200045Ciência Rural v.39 n.2 2009reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/S0103-84782008005000087info:eu-repo/semantics/openAccessCápua,Maria Luísa Buffo deColeta,Flávia Eiras DelaMiotto,Mariana RodriguesCalazans,Sabryna GouveiaGodoy,Aline VieiraNakage,Ana Paula MassaeLisbão,Carolina Bonduki SalesDaleck,Carlos RobertoSantana,Aureo Evangelistaeng2009-03-13T00:00:00ZRevista |
dc.title.none.fl_str_mv |
Autologous bone marrow transplantation in a dog with lymphoma: a clinical study |
title |
Autologous bone marrow transplantation in a dog with lymphoma: a clinical study |
spellingShingle |
Autologous bone marrow transplantation in a dog with lymphoma: a clinical study Cápua,Maria Luísa Buffo de canine cutaneous lymphoma autologous bone marrow transplant chemotherapy |
title_short |
Autologous bone marrow transplantation in a dog with lymphoma: a clinical study |
title_full |
Autologous bone marrow transplantation in a dog with lymphoma: a clinical study |
title_fullStr |
Autologous bone marrow transplantation in a dog with lymphoma: a clinical study |
title_full_unstemmed |
Autologous bone marrow transplantation in a dog with lymphoma: a clinical study |
title_sort |
Autologous bone marrow transplantation in a dog with lymphoma: a clinical study |
author |
Cápua,Maria Luísa Buffo de |
author_facet |
Cápua,Maria Luísa Buffo de Coleta,Flávia Eiras Dela Miotto,Mariana Rodrigues Calazans,Sabryna Gouveia Godoy,Aline Vieira Nakage,Ana Paula Massae Lisbão,Carolina Bonduki Sales Daleck,Carlos Roberto Santana,Aureo Evangelista |
author_role |
author |
author2 |
Coleta,Flávia Eiras Dela Miotto,Mariana Rodrigues Calazans,Sabryna Gouveia Godoy,Aline Vieira Nakage,Ana Paula Massae Lisbão,Carolina Bonduki Sales Daleck,Carlos Roberto Santana,Aureo Evangelista |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Cápua,Maria Luísa Buffo de Coleta,Flávia Eiras Dela Miotto,Mariana Rodrigues Calazans,Sabryna Gouveia Godoy,Aline Vieira Nakage,Ana Paula Massae Lisbão,Carolina Bonduki Sales Daleck,Carlos Roberto Santana,Aureo Evangelista |
dc.subject.por.fl_str_mv |
canine cutaneous lymphoma autologous bone marrow transplant chemotherapy |
topic |
canine cutaneous lymphoma autologous bone marrow transplant chemotherapy |
description |
The objective of this study is to provide the first report of bone marrow transplantation (BMT) in dogs in Brazil. A Rottweiler with cutaneous lymphoma was submitted to a twelve-week Madison-Wisconsin chemotherapy protocol followed by autologous bone marrow transplantation. For this, 10mL kg-1 of bone marrow was collected simultaneously from both iliac crests and cryopreserved in a freezer at -80°C. The conditioning step was performed by administering cyclophosphamide by intravenous route at 400mg m-2. Bone marrow was reinfused after defrosting in a water bath at 37°C. Bone marrow nucleated cell counts before and after freezing, showed a small relative loss of nucleated cells (35.10 and 31.80x10³µL-1 , respectively). Cyclophosphamide induced neutropenia which was reverted by a granulocyte colony-stimulating factor (G-CSF) capable of stimulating hematopoetic reconstitution. On the day 360 after transplant the patient was found to be in complete remission. This study indicates that autologous BMT in a dog with lymphoma submitted to myelosuppressive chemotherapy was potentially safe and effective. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782009000200045 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782009000200045 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-84782008005000087 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.source.none.fl_str_mv |
Ciência Rural v.39 n.2 2009 reponame:Ciência Rural instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Ciência Rural |
collection |
Ciência Rural |
repository.name.fl_str_mv |
|
repository.mail.fl_str_mv |
|
_version_ |
1749140532568784896 |