Creolin® administered by different pathways in rats experimentally poisoned with Bothrops jararaca venom

Detalhes bibliográficos
Autor(a) principal: Carvalho,Lucas Rannier Ribeiro Antonino
Data de Publicação: 2019
Outros Autores: Pereira,Helder Camilo da Silva, Silva,Hugo Thyares Fonseca Nascimento Pereira da, Lucena,Ricardo Barbosa de, Guerra,Ricardo Romão
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Ciência Rural
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000500550
Resumo: ABSTRACT: This study aimed to evaluate the effects of Creolin® when administered by different pathways in rats experimentally poisoned with Bothrops jararaca venom. In female Wistar rats, the Bothropic venom was inoculated intramuscularly, and then the rats were either treated with Creolin® (administered orally, topically, or intramuscularly), or with amixture of venom + Creolin® intramuscularly. Animals that received Creolin®, apart from the venom, by oral, topical, or intramuscular routes developed local symptoms and showed laboratory findings similar to those animals that received only the venom. Conversely, animals inoculated with the venom incubated with Creolin® showed no signs of local venom toxicity (necrosis or hemorrhage) and displayed hematological parameters within the normal range for the species. These results suggest that Creolin® exhibited an antiophidian effect only when it is mixed with the venom and administered intramuscularly.
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spelling Creolin® administered by different pathways in rats experimentally poisoned with Bothrops jararaca venomantivenomfolk medicinebothropic venomABSTRACT: This study aimed to evaluate the effects of Creolin® when administered by different pathways in rats experimentally poisoned with Bothrops jararaca venom. In female Wistar rats, the Bothropic venom was inoculated intramuscularly, and then the rats were either treated with Creolin® (administered orally, topically, or intramuscularly), or with amixture of venom + Creolin® intramuscularly. Animals that received Creolin®, apart from the venom, by oral, topical, or intramuscular routes developed local symptoms and showed laboratory findings similar to those animals that received only the venom. Conversely, animals inoculated with the venom incubated with Creolin® showed no signs of local venom toxicity (necrosis or hemorrhage) and displayed hematological parameters within the normal range for the species. These results suggest that Creolin® exhibited an antiophidian effect only when it is mixed with the venom and administered intramuscularly.Universidade Federal de Santa Maria2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000500550Ciência Rural v.49 n.5 2019reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/0103-8478cr20180699info:eu-repo/semantics/openAccessCarvalho,Lucas Rannier Ribeiro AntoninoPereira,Helder Camilo da SilvaSilva,Hugo Thyares Fonseca Nascimento Pereira daLucena,Ricardo Barbosa deGuerra,Ricardo Romãoeng2019-04-08T00:00:00ZRevista
dc.title.none.fl_str_mv Creolin® administered by different pathways in rats experimentally poisoned with Bothrops jararaca venom
title Creolin® administered by different pathways in rats experimentally poisoned with Bothrops jararaca venom
spellingShingle Creolin® administered by different pathways in rats experimentally poisoned with Bothrops jararaca venom
Carvalho,Lucas Rannier Ribeiro Antonino
antivenom
folk medicine
bothropic venom
title_short Creolin® administered by different pathways in rats experimentally poisoned with Bothrops jararaca venom
title_full Creolin® administered by different pathways in rats experimentally poisoned with Bothrops jararaca venom
title_fullStr Creolin® administered by different pathways in rats experimentally poisoned with Bothrops jararaca venom
title_full_unstemmed Creolin® administered by different pathways in rats experimentally poisoned with Bothrops jararaca venom
title_sort Creolin® administered by different pathways in rats experimentally poisoned with Bothrops jararaca venom
author Carvalho,Lucas Rannier Ribeiro Antonino
author_facet Carvalho,Lucas Rannier Ribeiro Antonino
Pereira,Helder Camilo da Silva
Silva,Hugo Thyares Fonseca Nascimento Pereira da
Lucena,Ricardo Barbosa de
Guerra,Ricardo Romão
author_role author
author2 Pereira,Helder Camilo da Silva
Silva,Hugo Thyares Fonseca Nascimento Pereira da
Lucena,Ricardo Barbosa de
Guerra,Ricardo Romão
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Carvalho,Lucas Rannier Ribeiro Antonino
Pereira,Helder Camilo da Silva
Silva,Hugo Thyares Fonseca Nascimento Pereira da
Lucena,Ricardo Barbosa de
Guerra,Ricardo Romão
dc.subject.por.fl_str_mv antivenom
folk medicine
bothropic venom
topic antivenom
folk medicine
bothropic venom
description ABSTRACT: This study aimed to evaluate the effects of Creolin® when administered by different pathways in rats experimentally poisoned with Bothrops jararaca venom. In female Wistar rats, the Bothropic venom was inoculated intramuscularly, and then the rats were either treated with Creolin® (administered orally, topically, or intramuscularly), or with amixture of venom + Creolin® intramuscularly. Animals that received Creolin®, apart from the venom, by oral, topical, or intramuscular routes developed local symptoms and showed laboratory findings similar to those animals that received only the venom. Conversely, animals inoculated with the venom incubated with Creolin® showed no signs of local venom toxicity (necrosis or hemorrhage) and displayed hematological parameters within the normal range for the species. These results suggest that Creolin® exhibited an antiophidian effect only when it is mixed with the venom and administered intramuscularly.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000500550
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000500550
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0103-8478cr20180699
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
publisher.none.fl_str_mv Universidade Federal de Santa Maria
dc.source.none.fl_str_mv Ciência Rural v.49 n.5 2019
reponame:Ciência Rural
instname:Universidade Federal de Santa Maria (UFSM)
instacron:UFSM
instname_str Universidade Federal de Santa Maria (UFSM)
instacron_str UFSM
institution UFSM
reponame_str Ciência Rural
collection Ciência Rural
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1749140553554984960

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