Identification of multi-drug resistance gene (MDR1) in equine ileum

Detalhes bibliográficos
Autor(a) principal: Natalini,Cláudio Corrêa
Data de Publicação: 2006
Outros Autores: Linardi,Renata Lehn
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Ciência Rural
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782006000100048
Resumo: P-glycoprotein (P-gp) is a membrane transporter encoded in the Multi-drug Resistance (MDR1) gene expressed in several normal tissues and over expressed in tumor cells. P-gp was already identified in different species but not yet in equine. MDR1 gene and P-gp are able to interfere with bioavailability and disposition of several drugs, altering pharmacokinetic and pharmacodinamic of drugs. The presence of the MDR1 and P-gp in the central nervous system blocks the entry of certain drugs in this tissue and reduces drug absorption and enhances drug elimination when P-gp and MDR1 are presented in the gastrointestinal tract. This study showed that the MDR1 gene is present in equine ileum. Future studies on the impact of the P-glycoprotein encoded gene MDR1 on drugs pharmacologic effects in horses are granted.
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spelling Identification of multi-drug resistance gene (MDR1) in equine ileummolecular biologyopioidsequinegeneMDR1ABCB1P-glycoprotein (P-gp) is a membrane transporter encoded in the Multi-drug Resistance (MDR1) gene expressed in several normal tissues and over expressed in tumor cells. P-gp was already identified in different species but not yet in equine. MDR1 gene and P-gp are able to interfere with bioavailability and disposition of several drugs, altering pharmacokinetic and pharmacodinamic of drugs. The presence of the MDR1 and P-gp in the central nervous system blocks the entry of certain drugs in this tissue and reduces drug absorption and enhances drug elimination when P-gp and MDR1 are presented in the gastrointestinal tract. This study showed that the MDR1 gene is present in equine ileum. Future studies on the impact of the P-glycoprotein encoded gene MDR1 on drugs pharmacologic effects in horses are granted.Universidade Federal de Santa Maria2006-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782006000100048Ciência Rural v.36 n.1 2006reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/S0103-84782006000100048info:eu-repo/semantics/openAccessNatalini,Cláudio CorrêaLinardi,Renata Lehneng2006-01-13T00:00:00ZRevista
dc.title.none.fl_str_mv Identification of multi-drug resistance gene (MDR1) in equine ileum
title Identification of multi-drug resistance gene (MDR1) in equine ileum
spellingShingle Identification of multi-drug resistance gene (MDR1) in equine ileum
Natalini,Cláudio Corrêa
molecular biology
opioids
equine
gene
MDR1
ABCB1
title_short Identification of multi-drug resistance gene (MDR1) in equine ileum
title_full Identification of multi-drug resistance gene (MDR1) in equine ileum
title_fullStr Identification of multi-drug resistance gene (MDR1) in equine ileum
title_full_unstemmed Identification of multi-drug resistance gene (MDR1) in equine ileum
title_sort Identification of multi-drug resistance gene (MDR1) in equine ileum
author Natalini,Cláudio Corrêa
author_facet Natalini,Cláudio Corrêa
Linardi,Renata Lehn
author_role author
author2 Linardi,Renata Lehn
author2_role author
dc.contributor.author.fl_str_mv Natalini,Cláudio Corrêa
Linardi,Renata Lehn
dc.subject.por.fl_str_mv molecular biology
opioids
equine
gene
MDR1
ABCB1
topic molecular biology
opioids
equine
gene
MDR1
ABCB1
description P-glycoprotein (P-gp) is a membrane transporter encoded in the Multi-drug Resistance (MDR1) gene expressed in several normal tissues and over expressed in tumor cells. P-gp was already identified in different species but not yet in equine. MDR1 gene and P-gp are able to interfere with bioavailability and disposition of several drugs, altering pharmacokinetic and pharmacodinamic of drugs. The presence of the MDR1 and P-gp in the central nervous system blocks the entry of certain drugs in this tissue and reduces drug absorption and enhances drug elimination when P-gp and MDR1 are presented in the gastrointestinal tract. This study showed that the MDR1 gene is present in equine ileum. Future studies on the impact of the P-glycoprotein encoded gene MDR1 on drugs pharmacologic effects in horses are granted.
publishDate 2006
dc.date.none.fl_str_mv 2006-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782006000100048
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782006000100048
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-84782006000100048
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
publisher.none.fl_str_mv Universidade Federal de Santa Maria
dc.source.none.fl_str_mv Ciência Rural v.36 n.1 2006
reponame:Ciência Rural
instname:Universidade Federal de Santa Maria (UFSM)
instacron:UFSM
instname_str Universidade Federal de Santa Maria (UFSM)
instacron_str UFSM
institution UFSM
reponame_str Ciência Rural
collection Ciência Rural
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1749140527144501248

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