Manipulação ambiental e farmacológica induz respostas comportamentais e endócrinas similares em peixe-zebra
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Manancial - Repositório Digital da UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/3857 |
Resumo: | The physiological and behavioral responses can vary with the form of housing of the fish and the presence of anxiolytic drugs. The aim of this study was to evaluate the response to acute stress in isolated and grouped fish and the effect of fluoxetine, diazepam and environmental enrichment on behavioral and endocrine parameters. Six experiments were performed: 1. Acute stress test in isolated and groups zebrafish; 2. Transfer of isolated or group zebrafish to a new environment; 3. Effect of introducing grouped stressed fish in a resident zebrafish shoal; 4. Effect of introducing one stressed fish in a resident zebrafish shoal; 5. Effect of acute exposure to fluoxetine and diazepam on behavioral responses after acute stress protocol; 6. Response to acute stress in isolated and grouped fish and the modulation by fluoxetine, diazepam and environmental enrichment. Based on the results we concluded that the group is able to potentiate stress response, however, that response is reduced by exposure to fluoxetine and diazepam in water and environmental enrichment; acute exposure to fluoxetine and diazepam modulates behavior in zebrafish after acute stress. |
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Manipulação ambiental e farmacológica induz respostas comportamentais e endócrinas similares em peixe-zebraEnvironmental and drug manipulation induces similar behavioral and endocrine responses in zebrafishCortisolComportamentoPsicofármacosEnriquecimento ambientalCortisolBehaviorPsychoactive drugsEnvironmental enrichmentCNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIAThe physiological and behavioral responses can vary with the form of housing of the fish and the presence of anxiolytic drugs. The aim of this study was to evaluate the response to acute stress in isolated and grouped fish and the effect of fluoxetine, diazepam and environmental enrichment on behavioral and endocrine parameters. Six experiments were performed: 1. Acute stress test in isolated and groups zebrafish; 2. Transfer of isolated or group zebrafish to a new environment; 3. Effect of introducing grouped stressed fish in a resident zebrafish shoal; 4. Effect of introducing one stressed fish in a resident zebrafish shoal; 5. Effect of acute exposure to fluoxetine and diazepam on behavioral responses after acute stress protocol; 6. Response to acute stress in isolated and grouped fish and the modulation by fluoxetine, diazepam and environmental enrichment. Based on the results we concluded that the group is able to potentiate stress response, however, that response is reduced by exposure to fluoxetine and diazepam in water and environmental enrichment; acute exposure to fluoxetine and diazepam modulates behavior in zebrafish after acute stress.As respostas fisiológicas e comportamentais podem variar de acordo com a forma de alojamento dos peixes e pela presença de fármacos ansiolíticos. O objetivo do estudo foi avaliar a resposta ao estresse agudo em peixes isolados e agrupados e o efeito da fluoxetina, diazepam e enriquecimento ambiental sobre parâmetros comportamentais e endócrino. Foram realizados 6 experimentos: 1. Teste de estresse agudo em peixes-zebra isolados e em grupos; 2. Transferência de peixes-zebra isolados ou em grupo para um ambiente novo; 3. Efeito da introdução de peixes agrupados estressados em um cardume de peixe-zebra residente; 4. Efeito da introdução de um peixe estressado em um cardume de peixe-zebra residente; 5. Efeito da exposição aguda à fluoxetina e diazepam sobre as respostas comportamentais após o protocolo de estresse agudo; 6. Resposta ao estresse agudo em peixes isolados, agrupados e a modulação por fluoxetina, diazepam e enriquecimento ambiental. Com base nos resultados concluímos que grupo é capaz de potencializar a resposta ao estresse, porém, essa resposta é reduzida pela exposição à fluoxetina e diazepam na água e pelo enriquecimento ambiental; a exposição aguda à fluoxetina e diazepam modula comportamentos em peixes-zebra após estresse agudo.Universidade Federal de Santa MariaBRFarmacologiaUFSMPrograma de Pós-Graduação em FarmacologiaBarcellos, Leonardo Jose Gilhttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4763175J2Mello, Carlos Fernando dehttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4782674D2Bonan, Carla Denisehttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4799528J3Rosemberg, Denis Broockhttp://lattes.cnpq.br/7713953979203056Emanuelli, Tatianahttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4797080Z5Giacomini, Ana Cristina Vendrametto Varrone2016-08-152016-08-152016-04-26info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisapplication/pdfapplication/pdfGIACOMINI, Ana Cristina Vendrametto Varrone. ENVIRONMENTAL AND DRUG MANIPULATION INDUCES SIMILAR BEHAVIORAL AND ENDOCRINE RESPONSES IN ZEBRAFISH. 2016. 83 f. Tese (Doutorado em Farmácia) - Universidade Federal de Santa Maria, Santa Maria, 2016.http://repositorio.ufsm.br/handle/1/3857porinfo:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM2021-02-04T12:18:30Zoai:repositorio.ufsm.br:1/3857Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2021-02-04T12:18:30Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.none.fl_str_mv |
Manipulação ambiental e farmacológica induz respostas comportamentais e endócrinas similares em peixe-zebra Environmental and drug manipulation induces similar behavioral and endocrine responses in zebrafish |
title |
Manipulação ambiental e farmacológica induz respostas comportamentais e endócrinas similares em peixe-zebra |
spellingShingle |
Manipulação ambiental e farmacológica induz respostas comportamentais e endócrinas similares em peixe-zebra Giacomini, Ana Cristina Vendrametto Varrone Cortisol Comportamento Psicofármacos Enriquecimento ambiental Cortisol Behavior Psychoactive drugs Environmental enrichment CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA |
title_short |
Manipulação ambiental e farmacológica induz respostas comportamentais e endócrinas similares em peixe-zebra |
title_full |
Manipulação ambiental e farmacológica induz respostas comportamentais e endócrinas similares em peixe-zebra |
title_fullStr |
Manipulação ambiental e farmacológica induz respostas comportamentais e endócrinas similares em peixe-zebra |
title_full_unstemmed |
Manipulação ambiental e farmacológica induz respostas comportamentais e endócrinas similares em peixe-zebra |
title_sort |
Manipulação ambiental e farmacológica induz respostas comportamentais e endócrinas similares em peixe-zebra |
author |
Giacomini, Ana Cristina Vendrametto Varrone |
author_facet |
Giacomini, Ana Cristina Vendrametto Varrone |
author_role |
author |
dc.contributor.none.fl_str_mv |
Barcellos, Leonardo Jose Gil http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4763175J2 Mello, Carlos Fernando de http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4782674D2 Bonan, Carla Denise http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4799528J3 Rosemberg, Denis Broock http://lattes.cnpq.br/7713953979203056 Emanuelli, Tatiana http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4797080Z5 |
dc.contributor.author.fl_str_mv |
Giacomini, Ana Cristina Vendrametto Varrone |
dc.subject.por.fl_str_mv |
Cortisol Comportamento Psicofármacos Enriquecimento ambiental Cortisol Behavior Psychoactive drugs Environmental enrichment CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA |
topic |
Cortisol Comportamento Psicofármacos Enriquecimento ambiental Cortisol Behavior Psychoactive drugs Environmental enrichment CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA |
description |
The physiological and behavioral responses can vary with the form of housing of the fish and the presence of anxiolytic drugs. The aim of this study was to evaluate the response to acute stress in isolated and grouped fish and the effect of fluoxetine, diazepam and environmental enrichment on behavioral and endocrine parameters. Six experiments were performed: 1. Acute stress test in isolated and groups zebrafish; 2. Transfer of isolated or group zebrafish to a new environment; 3. Effect of introducing grouped stressed fish in a resident zebrafish shoal; 4. Effect of introducing one stressed fish in a resident zebrafish shoal; 5. Effect of acute exposure to fluoxetine and diazepam on behavioral responses after acute stress protocol; 6. Response to acute stress in isolated and grouped fish and the modulation by fluoxetine, diazepam and environmental enrichment. Based on the results we concluded that the group is able to potentiate stress response, however, that response is reduced by exposure to fluoxetine and diazepam in water and environmental enrichment; acute exposure to fluoxetine and diazepam modulates behavior in zebrafish after acute stress. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-08-15 2016-08-15 2016-04-26 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
GIACOMINI, Ana Cristina Vendrametto Varrone. ENVIRONMENTAL AND DRUG MANIPULATION INDUCES SIMILAR BEHAVIORAL AND ENDOCRINE RESPONSES IN ZEBRAFISH. 2016. 83 f. Tese (Doutorado em Farmácia) - Universidade Federal de Santa Maria, Santa Maria, 2016. http://repositorio.ufsm.br/handle/1/3857 |
identifier_str_mv |
GIACOMINI, Ana Cristina Vendrametto Varrone. ENVIRONMENTAL AND DRUG MANIPULATION INDUCES SIMILAR BEHAVIORAL AND ENDOCRINE RESPONSES IN ZEBRAFISH. 2016. 83 f. Tese (Doutorado em Farmácia) - Universidade Federal de Santa Maria, Santa Maria, 2016. |
url |
http://repositorio.ufsm.br/handle/1/3857 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria BR Farmacologia UFSM Programa de Pós-Graduação em Farmacologia |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria BR Farmacologia UFSM Programa de Pós-Graduação em Farmacologia |
dc.source.none.fl_str_mv |
reponame:Manancial - Repositório Digital da UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Manancial - Repositório Digital da UFSM |
collection |
Manancial - Repositório Digital da UFSM |
repository.name.fl_str_mv |
Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
atendimento.sib@ufsm.br||tedebc@gmail.com |
_version_ |
1805922030383529984 |