Respostas bioquímicas de mulheres com síndrome metabólica submetidas ao treinamento aeróbico
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Manancial - Repositório Digital da UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/6712 |
Resumo: | The sedentary lifestyle and a high fat diet are related with the emergence of metabolic syndrome (MS), which is represented by the cluster of risk factors such abdominal obesity, insulin resistance, dyslipidemia and hypertension. Nowadays, it is well known that both obesity and metabolic syndrome-related cardiovascular diseases are associated with oxidative stress and chronic low-grade inflammation. Considering that regular physical exercise may be considered one of the best non-pharmacological ways to MS prevention and treatment, few studies assessed the effects of moderate aerobic training (AT) alone on oxidative, inflammatory, anthropometric and functional parameters and quality of life in women with MS. Thus, it was investigated the effects of 15 weeks of AT on functional, anthropometric, biochemical profiles and the health-related quality of life (HRQOL) (manuscript 1) and the impact of 12 weeks of AT on body composition and systemic biomarkers of oxidative stress and inflammation in middle-aged women with MS (manuscript 2). Both inverventions comprised three weekly sessions of brisk walking and/or jogging in treadmills, with the training intensity being controlled by heart rate monitors. The 15-week AT decreased waist and hip circumferences, total cholesterol, low-density lipoprotein (LDL), thiobarbituric acid-reactive substances levels (TBARS) and myeloperoxidase and lactate dehydrogenase activities. Furthermore, it was observed an increasing in estimated maximal oxygen uptake and flexibility, albumin and high-density lipoprotein (HDL) levels and higher scores in physical functioning, role-physical, bodily pain, general health and social functioning domains in the HRQOL questionnaire. However, it was not found a simultaneous weight loss (manuscript 1). The 12-week AT provoked reductions in total body fat mass, interleukin-1 beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), interferom-gamma (INF-γ), advanced oxidation protein products (AOPP) and TBARS levels. In this context, AT resulted in increased total body lean mass, interleukin-10 (IL-10) and total thiol groups content levels, even with the maintenance of nitrite and nitrate (NOx) levels (manuscript 2). Therefore, it was concluded that biochemical, anthropometric and quality of life improved-exercise related parameters are independent of weight loss and that the moderate aerobic training positively modulates inflammation and oxidative stress biomarkers and body composition in middle-aged women with MS. |
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Respostas bioquímicas de mulheres com síndrome metabólica submetidas ao treinamento aeróbicoBiochemical responses to aerobic training in women with metabolic syndromeTreinamento aeróbicoSíndrome metabólicaObesidadeInflamaçãoEstresse oxidativoAerobic trainingMetabolic syndromeObesityInflammationOxidative stressCNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICAThe sedentary lifestyle and a high fat diet are related with the emergence of metabolic syndrome (MS), which is represented by the cluster of risk factors such abdominal obesity, insulin resistance, dyslipidemia and hypertension. Nowadays, it is well known that both obesity and metabolic syndrome-related cardiovascular diseases are associated with oxidative stress and chronic low-grade inflammation. Considering that regular physical exercise may be considered one of the best non-pharmacological ways to MS prevention and treatment, few studies assessed the effects of moderate aerobic training (AT) alone on oxidative, inflammatory, anthropometric and functional parameters and quality of life in women with MS. Thus, it was investigated the effects of 15 weeks of AT on functional, anthropometric, biochemical profiles and the health-related quality of life (HRQOL) (manuscript 1) and the impact of 12 weeks of AT on body composition and systemic biomarkers of oxidative stress and inflammation in middle-aged women with MS (manuscript 2). Both inverventions comprised three weekly sessions of brisk walking and/or jogging in treadmills, with the training intensity being controlled by heart rate monitors. The 15-week AT decreased waist and hip circumferences, total cholesterol, low-density lipoprotein (LDL), thiobarbituric acid-reactive substances levels (TBARS) and myeloperoxidase and lactate dehydrogenase activities. Furthermore, it was observed an increasing in estimated maximal oxygen uptake and flexibility, albumin and high-density lipoprotein (HDL) levels and higher scores in physical functioning, role-physical, bodily pain, general health and social functioning domains in the HRQOL questionnaire. However, it was not found a simultaneous weight loss (manuscript 1). The 12-week AT provoked reductions in total body fat mass, interleukin-1 beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), interferom-gamma (INF-γ), advanced oxidation protein products (AOPP) and TBARS levels. In this context, AT resulted in increased total body lean mass, interleukin-10 (IL-10) and total thiol groups content levels, even with the maintenance of nitrite and nitrate (NOx) levels (manuscript 2). Therefore, it was concluded that biochemical, anthropometric and quality of life improved-exercise related parameters are independent of weight loss and that the moderate aerobic training positively modulates inflammation and oxidative stress biomarkers and body composition in middle-aged women with MS.Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorO sedentarismo e as dietas hiperlipídicas estão relacionados com o surgimento da síndrome metabólica (SM), representada pela junção de fatores de risco, como obesidade abdominal, resistência insulínica, dislipidemia e hipertensão arterial. Atualmente, sabe-se que tanto a obesidade quanto as doenças cardiovasculares relacionadas com a presença da SM estão intimamente associadas ao estresse oxidativo e à inflamação crônica de baixo grau. Apesar de a prática regular de exercícios físicos ser considerada uma das melhores intervenções não farmacológicas para a prevenção e o tratamento da SM, poucos estudos analisaram os efeitos do treinamento aeróbico moderado (TA) isolado sobre parâmetros oxidativos, inflamatórios, antropométricos, funcionais e da qualidade de vida de mulheres com SM. Dessa forma, investigamos os efeitos de 15 semanas de TA sobre o perfil funcional, antropométrico, bioquímico e a percepção subjetiva da qualidade de vida (PSQV) (manuscrito 1) e o impacto de 12 semanas de TA sobre a composição corporal e marcadores sistêmicos de inflamação e de estresse oxidativo de mulheres de meia-idade com SM (manuscrito 2). Ambas as intervenções foram compostas por três sessões semanais de caminhadas rápidas e/ou corridas leves em esteiras, sendo que a intensidade prescrita do treinamento foi controlada através de monitores cardíacos. O TA de 15 semanas foi efetivo na diminuição das circunferências da cintura e do quadril, dos níveis de colesterol total, lipoproteínas de baixa densidade (LDL), de substâncias reativas ao ácido tiobarbitúrico (TBARS) e da atividade das enzimas mieloperoxidase e lactato desidrogenase. Além disso, observou-se um aumento da estimativa do consumo máximo de oxigênio e da flexibilidade, dos níveis de albumina e lipoproteínas de alta densidade (HDL) e maiores pontuações nos domínios de capacidade funcional, limitação por aspectos físicos, dor, estado geral de saúde e aspectos sociais do questionário relacionado à PSQV. Entretanto, não foi constatada uma concomitante redução ponderal (manuscrito 1). Doze semanas de TA provocaram redução da quantidade total de tecido adiposo, bem como dos níveis de interleucina-1 beta (IL-1β), interleucina-6 (IL-6), fator de necrose tumoral alfa (TNF-α), interferon-gama (INF-γ), produtos avançados de oxidação proteica (AOPP) e TBARS. Nesse contexto, ele causou aumento do conteúdo total de massa magra, dos níveis de interleucina-10 (IL-10) e tióis totais, apesar da manutenção dos níveis de nitritos e nitratos (NOx) (manuscrito 2). Assim, conclui-se que os benefícios sobre variáveis bioquímicas, antropométricas e a qualidade de vida oportunizados pela prática regular de exercícios aeróbicos não são dependentes da perda ponderal e que o treinamento aeróbico moderado modula positivamente marcadores de inflamação e estresse oxidativo e a composição corporal em mulheres de meia-idade com SM.Universidade Federal de Santa MariaBREducação FísicaUFSMPrograma de Pós-Graduação em Educação FísicaSoares, Félix Alexandre Antuneshttp://lattes.cnpq.br/8752453650114092Oliveira, álvaro Reischak dehttp://lattes.cnpq.br/0641735531407998Puntel, Gustavo Orionehttp://lattes.cnpq.br/0319301096075015Royes, Luiz Fernando Freirehttp://lattes.cnpq.br/0543081555633400Farinha, Juliano Boufleur2014-10-062014-10-062014-02-19info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfapplication/pdfFARINHA, Juliano Boufleur. Biochemical responses to aerobic training in women with metabolic syndrome. 2014. 72 f. Dissertação (Mestrado em Educação Física) - Universidade Federal de Santa Maria, Santa Maria, 2014.http://repositorio.ufsm.br/handle/1/6712porinfo:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM2023-05-24T11:51:14Zoai:repositorio.ufsm.br:1/6712Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2023-05-24T11:51:14Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.none.fl_str_mv |
Respostas bioquímicas de mulheres com síndrome metabólica submetidas ao treinamento aeróbico Biochemical responses to aerobic training in women with metabolic syndrome |
title |
Respostas bioquímicas de mulheres com síndrome metabólica submetidas ao treinamento aeróbico |
spellingShingle |
Respostas bioquímicas de mulheres com síndrome metabólica submetidas ao treinamento aeróbico Farinha, Juliano Boufleur Treinamento aeróbico Síndrome metabólica Obesidade Inflamação Estresse oxidativo Aerobic training Metabolic syndrome Obesity Inflammation Oxidative stress CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA |
title_short |
Respostas bioquímicas de mulheres com síndrome metabólica submetidas ao treinamento aeróbico |
title_full |
Respostas bioquímicas de mulheres com síndrome metabólica submetidas ao treinamento aeróbico |
title_fullStr |
Respostas bioquímicas de mulheres com síndrome metabólica submetidas ao treinamento aeróbico |
title_full_unstemmed |
Respostas bioquímicas de mulheres com síndrome metabólica submetidas ao treinamento aeróbico |
title_sort |
Respostas bioquímicas de mulheres com síndrome metabólica submetidas ao treinamento aeróbico |
author |
Farinha, Juliano Boufleur |
author_facet |
Farinha, Juliano Boufleur |
author_role |
author |
dc.contributor.none.fl_str_mv |
Soares, Félix Alexandre Antunes http://lattes.cnpq.br/8752453650114092 Oliveira, álvaro Reischak de http://lattes.cnpq.br/0641735531407998 Puntel, Gustavo Orione http://lattes.cnpq.br/0319301096075015 Royes, Luiz Fernando Freire http://lattes.cnpq.br/0543081555633400 |
dc.contributor.author.fl_str_mv |
Farinha, Juliano Boufleur |
dc.subject.por.fl_str_mv |
Treinamento aeróbico Síndrome metabólica Obesidade Inflamação Estresse oxidativo Aerobic training Metabolic syndrome Obesity Inflammation Oxidative stress CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA |
topic |
Treinamento aeróbico Síndrome metabólica Obesidade Inflamação Estresse oxidativo Aerobic training Metabolic syndrome Obesity Inflammation Oxidative stress CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA |
description |
The sedentary lifestyle and a high fat diet are related with the emergence of metabolic syndrome (MS), which is represented by the cluster of risk factors such abdominal obesity, insulin resistance, dyslipidemia and hypertension. Nowadays, it is well known that both obesity and metabolic syndrome-related cardiovascular diseases are associated with oxidative stress and chronic low-grade inflammation. Considering that regular physical exercise may be considered one of the best non-pharmacological ways to MS prevention and treatment, few studies assessed the effects of moderate aerobic training (AT) alone on oxidative, inflammatory, anthropometric and functional parameters and quality of life in women with MS. Thus, it was investigated the effects of 15 weeks of AT on functional, anthropometric, biochemical profiles and the health-related quality of life (HRQOL) (manuscript 1) and the impact of 12 weeks of AT on body composition and systemic biomarkers of oxidative stress and inflammation in middle-aged women with MS (manuscript 2). Both inverventions comprised three weekly sessions of brisk walking and/or jogging in treadmills, with the training intensity being controlled by heart rate monitors. The 15-week AT decreased waist and hip circumferences, total cholesterol, low-density lipoprotein (LDL), thiobarbituric acid-reactive substances levels (TBARS) and myeloperoxidase and lactate dehydrogenase activities. Furthermore, it was observed an increasing in estimated maximal oxygen uptake and flexibility, albumin and high-density lipoprotein (HDL) levels and higher scores in physical functioning, role-physical, bodily pain, general health and social functioning domains in the HRQOL questionnaire. However, it was not found a simultaneous weight loss (manuscript 1). The 12-week AT provoked reductions in total body fat mass, interleukin-1 beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), interferom-gamma (INF-γ), advanced oxidation protein products (AOPP) and TBARS levels. In this context, AT resulted in increased total body lean mass, interleukin-10 (IL-10) and total thiol groups content levels, even with the maintenance of nitrite and nitrate (NOx) levels (manuscript 2). Therefore, it was concluded that biochemical, anthropometric and quality of life improved-exercise related parameters are independent of weight loss and that the moderate aerobic training positively modulates inflammation and oxidative stress biomarkers and body composition in middle-aged women with MS. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-10-06 2014-10-06 2014-02-19 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
FARINHA, Juliano Boufleur. Biochemical responses to aerobic training in women with metabolic syndrome. 2014. 72 f. Dissertação (Mestrado em Educação Física) - Universidade Federal de Santa Maria, Santa Maria, 2014. http://repositorio.ufsm.br/handle/1/6712 |
identifier_str_mv |
FARINHA, Juliano Boufleur. Biochemical responses to aerobic training in women with metabolic syndrome. 2014. 72 f. Dissertação (Mestrado em Educação Física) - Universidade Federal de Santa Maria, Santa Maria, 2014. |
url |
http://repositorio.ufsm.br/handle/1/6712 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria BR Educação Física UFSM Programa de Pós-Graduação em Educação Física |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria BR Educação Física UFSM Programa de Pós-Graduação em Educação Física |
dc.source.none.fl_str_mv |
reponame:Manancial - Repositório Digital da UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Manancial - Repositório Digital da UFSM |
collection |
Manancial - Repositório Digital da UFSM |
repository.name.fl_str_mv |
Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
atendimento.sib@ufsm.br||tedebc@gmail.com |
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1805922065013800960 |