Síntese, caracterização e avaliação da atividade peroxidase de novos complexos de cobalto com ligantes derivados do piridoxal

• Autor(a) principal: Fontana, Liniquer André
• Data de Publicação: 2017
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Manancial - Repositório Digital da UFSM
• dARK ID: ark:/26339/001300000tt38
• Texto Completo: http://repositorio.ufsm.br/handle/1/12160
• topic: Piridoxal; Cobalto; Difração de raios X; Peroxidase; Pyridoxal; Cobalt; X-ray diffraction; CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA

This work treat with the synthesis and characterization of new cobalt complexes with ligands derived from pyridoxal and their application as mimetics of the enzyme peroxidase. The complexes were structurally characterized by monocrystal X-ray diffraction and their redox behavior was studied by cyclic voltammetry. In the synthesis of the complexes, a reactivity pattern was observed with respect to the cobalt salts used, by selecting appropriately between Co(CH3COO)2 and CoCl2(PPh3)2, it was possible to obtain two sets of analogous mononuclear complexes. In one, the C-S bonds are cleaved from the organic ligands and in other hand, the cleavage of the C-S bond is not observed. Was also evidenced, it was evidenced the formation of dinuclear zwitterionic and tetranuclear complexes, due to the different coordination modes of the ligands used and the methodological differences. The complexes obtained were tested as mimetics of the enzyme peroxidase, presenting promising results.