Estudo químico e biológico de Conyza bonariensis (L.) Cronquist (Asteraceae)
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Manancial - Repositório Digital da UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/5876 |
Resumo: | Conyza bonariensis (L.) is a native plant of South America, easily found in the south area. It s popular name is buva or margaridinha-do-campo. This plant is very used in folk medicine for rheumatism, gout, cystitis, nephrite, dysmenorrhea, tooth pain, headache. The main secondary metabolits present in the species Conyza bonariensis (L.) were flavonoids, saponins, organics acids, cardyotonic and phenols. In the volatile oil of the var. bonariensis two major constituents were identified, the ester cis-lachnophyllum methyl (78,69%) and ester matricaria methyl (17,67%) present in the roots, and the components cis-lachnophyllum methyl ester (44,31%) and the caryophyllene oxide (22,0%) present in the leaves. In the var. microcephala, the major constituents found in the root were the ester cis-lachnophyllum methyl (88,87%), and in the leaves the ester trans-lachnophyllum methyl (43,05%). The volatile oils of the var. bonariensis displayed antimicrobial activity against microorganisms Klebsiella pneumoniae, Escherichia coli, Candida albicans Saccharomyces cerevisiae. The plant didn't demonstrate acute oral toxicity, in the concentrations 250,500,1000 and 2000 mg/kg in mice. The ethyl acetate and buthanol fractions exhibided a significative antioxidant activity by DPPH and β-carotene method in the concentration of 62,5 μg/ml. The crude extract and the buthanol fraction expressed larger cytotoxic activity with CL50 27,35μg/ml, as the volatile oil of the roots of the var. bonariensis CL50 0,48μg/ml against Artemia salina. Thus, the present work aimed at contributing to the studies of the native herbs of the state of Rio Grande do Sul. |
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Estudo químico e biológico de Conyza bonariensis (L.) Cronquist (Asteraceae)Chemical and biological study of Conyza bonariensis (L.) Cronquist (Asteraceae)Conyza bonariensisAtividade antimicrobianaAtividade antioxidanteÓleos voláteisConyza bonariensisAntibacterial activityAntioxidant activityVolatile oilCNPQ::CIENCIAS DA SAUDE::FARMACIAConyza bonariensis (L.) is a native plant of South America, easily found in the south area. It s popular name is buva or margaridinha-do-campo. This plant is very used in folk medicine for rheumatism, gout, cystitis, nephrite, dysmenorrhea, tooth pain, headache. The main secondary metabolits present in the species Conyza bonariensis (L.) were flavonoids, saponins, organics acids, cardyotonic and phenols. In the volatile oil of the var. bonariensis two major constituents were identified, the ester cis-lachnophyllum methyl (78,69%) and ester matricaria methyl (17,67%) present in the roots, and the components cis-lachnophyllum methyl ester (44,31%) and the caryophyllene oxide (22,0%) present in the leaves. In the var. microcephala, the major constituents found in the root were the ester cis-lachnophyllum methyl (88,87%), and in the leaves the ester trans-lachnophyllum methyl (43,05%). The volatile oils of the var. bonariensis displayed antimicrobial activity against microorganisms Klebsiella pneumoniae, Escherichia coli, Candida albicans Saccharomyces cerevisiae. The plant didn't demonstrate acute oral toxicity, in the concentrations 250,500,1000 and 2000 mg/kg in mice. The ethyl acetate and buthanol fractions exhibided a significative antioxidant activity by DPPH and β-carotene method in the concentration of 62,5 μg/ml. The crude extract and the buthanol fraction expressed larger cytotoxic activity with CL50 27,35μg/ml, as the volatile oil of the roots of the var. bonariensis CL50 0,48μg/ml against Artemia salina. Thus, the present work aimed at contributing to the studies of the native herbs of the state of Rio Grande do Sul.Conyza bonariensis (L.) é uma planta nativa da América do Sul, facilmente encontrada na região sul. É conhecida popularmente como buva ou margaridinha-do-campo. É utilizada na medicina popular para o reumatismo, gota, cistite, nefrites, dismenorréia, dor de dente, dor de cabeça. Os principais metabólitos secundários presentes na espécie Conyza bonariensis (L.) foram flavonóides, saponinas, ácidos orgânicos, cardiotônicos e fenóis. No óleo volátil da var. bonariensis identificou-se 2 componentes majoritários, o cis-lachnophyllum metil éster (78,69%) e matricaria metil éster (17,67%) presente nas raízes, e os compostos cis-lachnophyllum metil éster (44,31%) e o óxido de cariofileno (22,0%) presente nas folhas. Na variedade microcephala, o composto majoritário encontrado na raiz foi o cis-lachnophyllum metil éster (88,87%), e nas folhas o trans-lachnophyllum metil éster (43,05%). Os óleos voláteis da var. bonariensis apresentaram atividade antimicrobiana frente aos microrganismos Klebsiella pneumoniae, Escherichia coli, Candida albicans Saccharomyces cerevisiae. A planta não demonstrou toxicidade aguda, por via oral, nas concentrações 250, 500,1000 e 2000 mg/kg em camundongos. As frações acetato de etila e butanólica apresentaram boa atividade antioxidante pelo método DPPH e β-caroteno na concentração de 62,5 μg/ml. O extrato bruto e a fração butanólica expressaram maior atividade citotóxica com CL50 27,35μg/ml, bem como o óleo volátil das raízes da var. bonariensis CL50 0,48μg/ml frente à Artemia salina. Pretendeu-se com o presente trabalho contribuir para os estudos da flora nativa do Rio Grande do SulUniversidade Federal de Santa MariaBRFarmáciaUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasHoelzel, Solange Cristina da Silva Martinshttp://lattes.cnpq.br/3371198135113385Morel, Ademir Fariashttp://lattes.cnpq.br/3554994385525333Manfron, Melânia Palermohttp://lattes.cnpq.br/6737713729653264Favila, Miguel Antonio Correa2006-11-072006-11-072006-06-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfapplication/pdfapplication/pdfFAVILA, Miguel Antonio Correa. Chemical and biological study of Conyza bonariensis (L.) Cronquist (Asteraceae). 2006. 109 f. Dissertação (Mestrado em Farmacologia) - Universidade Federal de Santa Maria, Santa Maria, 2006.http://repositorio.ufsm.br/handle/1/5876porinfo:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM2022-10-13T17:53:08Zoai:repositorio.ufsm.br:1/5876Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2022-10-13T17:53:08Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.none.fl_str_mv |
Estudo químico e biológico de Conyza bonariensis (L.) Cronquist (Asteraceae) Chemical and biological study of Conyza bonariensis (L.) Cronquist (Asteraceae) |
title |
Estudo químico e biológico de Conyza bonariensis (L.) Cronquist (Asteraceae) |
spellingShingle |
Estudo químico e biológico de Conyza bonariensis (L.) Cronquist (Asteraceae) Favila, Miguel Antonio Correa Conyza bonariensis Atividade antimicrobiana Atividade antioxidante Óleos voláteis Conyza bonariensis Antibacterial activity Antioxidant activity Volatile oil CNPQ::CIENCIAS DA SAUDE::FARMACIA |
title_short |
Estudo químico e biológico de Conyza bonariensis (L.) Cronquist (Asteraceae) |
title_full |
Estudo químico e biológico de Conyza bonariensis (L.) Cronquist (Asteraceae) |
title_fullStr |
Estudo químico e biológico de Conyza bonariensis (L.) Cronquist (Asteraceae) |
title_full_unstemmed |
Estudo químico e biológico de Conyza bonariensis (L.) Cronquist (Asteraceae) |
title_sort |
Estudo químico e biológico de Conyza bonariensis (L.) Cronquist (Asteraceae) |
author |
Favila, Miguel Antonio Correa |
author_facet |
Favila, Miguel Antonio Correa |
author_role |
author |
dc.contributor.none.fl_str_mv |
Hoelzel, Solange Cristina da Silva Martins http://lattes.cnpq.br/3371198135113385 Morel, Ademir Farias http://lattes.cnpq.br/3554994385525333 Manfron, Melânia Palermo http://lattes.cnpq.br/6737713729653264 |
dc.contributor.author.fl_str_mv |
Favila, Miguel Antonio Correa |
dc.subject.por.fl_str_mv |
Conyza bonariensis Atividade antimicrobiana Atividade antioxidante Óleos voláteis Conyza bonariensis Antibacterial activity Antioxidant activity Volatile oil CNPQ::CIENCIAS DA SAUDE::FARMACIA |
topic |
Conyza bonariensis Atividade antimicrobiana Atividade antioxidante Óleos voláteis Conyza bonariensis Antibacterial activity Antioxidant activity Volatile oil CNPQ::CIENCIAS DA SAUDE::FARMACIA |
description |
Conyza bonariensis (L.) is a native plant of South America, easily found in the south area. It s popular name is buva or margaridinha-do-campo. This plant is very used in folk medicine for rheumatism, gout, cystitis, nephrite, dysmenorrhea, tooth pain, headache. The main secondary metabolits present in the species Conyza bonariensis (L.) were flavonoids, saponins, organics acids, cardyotonic and phenols. In the volatile oil of the var. bonariensis two major constituents were identified, the ester cis-lachnophyllum methyl (78,69%) and ester matricaria methyl (17,67%) present in the roots, and the components cis-lachnophyllum methyl ester (44,31%) and the caryophyllene oxide (22,0%) present in the leaves. In the var. microcephala, the major constituents found in the root were the ester cis-lachnophyllum methyl (88,87%), and in the leaves the ester trans-lachnophyllum methyl (43,05%). The volatile oils of the var. bonariensis displayed antimicrobial activity against microorganisms Klebsiella pneumoniae, Escherichia coli, Candida albicans Saccharomyces cerevisiae. The plant didn't demonstrate acute oral toxicity, in the concentrations 250,500,1000 and 2000 mg/kg in mice. The ethyl acetate and buthanol fractions exhibided a significative antioxidant activity by DPPH and β-carotene method in the concentration of 62,5 μg/ml. The crude extract and the buthanol fraction expressed larger cytotoxic activity with CL50 27,35μg/ml, as the volatile oil of the roots of the var. bonariensis CL50 0,48μg/ml against Artemia salina. Thus, the present work aimed at contributing to the studies of the native herbs of the state of Rio Grande do Sul. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-11-07 2006-11-07 2006-06-09 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
FAVILA, Miguel Antonio Correa. Chemical and biological study of Conyza bonariensis (L.) Cronquist (Asteraceae). 2006. 109 f. Dissertação (Mestrado em Farmacologia) - Universidade Federal de Santa Maria, Santa Maria, 2006. http://repositorio.ufsm.br/handle/1/5876 |
identifier_str_mv |
FAVILA, Miguel Antonio Correa. Chemical and biological study of Conyza bonariensis (L.) Cronquist (Asteraceae). 2006. 109 f. Dissertação (Mestrado em Farmacologia) - Universidade Federal de Santa Maria, Santa Maria, 2006. |
url |
http://repositorio.ufsm.br/handle/1/5876 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria BR Farmácia UFSM Programa de Pós-Graduação em Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria BR Farmácia UFSM Programa de Pós-Graduação em Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
reponame:Manancial - Repositório Digital da UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Manancial - Repositório Digital da UFSM |
collection |
Manancial - Repositório Digital da UFSM |
repository.name.fl_str_mv |
Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
atendimento.sib@ufsm.br||tedebc@gmail.com |
_version_ |
1805922105275973632 |