Efeitos da dieta suplementada com disseleneto de difenila sobre a toxicidade induzida por mercúrio em camundongos e peixes
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações do UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/17565 |
Resumo: | With the increase of industrial and agricultural activities, several contaminants are released into the environment. Contaminants such as mercury (Hg) can come from the use of agricultural practices, burning of fossil fuels and mining activities, and this is highlighted in Brazil. Once released into the environment Hg reaches the aquatic and terrestrial environments and consequently the organisms that live there. In order to minimize possible toxic effects on non-target organisms, the use of food additives with antioxidant properties may be a good alternative. Diphenyl diselenide (PhSe)2, is an organic compound of selenium with antioxidant properties, and has beneficial effects in the treatment of animals exposed to heavy metals. Thus, the objective of this work was to evaluate the effect of a diet supplemented with (PhSe)2 on mercury chloride (HgCl2) -induced toxicity. Adult jundias (40-50g) and albino Swiss mice (25-30g) were used which were treated for 30 consecutive days with feed supplemented with (PhSe)2 or control ration. After 25 days of treatment the animals received a daily dose of HgCl2 solution (1.7mg / kg, fish, 5.0mg / kg mice) for 5 days. The animals were euthanized 24 hours after the last administration of HgCl2 and blood, renal and hepatic tissues were collected for analysis of the activity of the enzyme δ-aminolevulinate dehydratase (δ-ALA-D). Hepatic toxicity parameters (aspartate aminotransferase AST and alanine aminotransferase ALT), renal (urea and creatinine) and oxidative parameters (TBARS, total and non-protein thiols and reactive oxygen species) were evaluated. Fish exposed to Hg showed inhibition of δ-ALA-D activity of kidney and blood, increase in serum creatinine levels and decrease of TBARS, total thiols and non-protein thiols of kidney. Hg accumulated in the liver and kidneys of the fish causing alteration in zinc (Zn) homeostasis in the liver and blood tissues. Feeding with (PhSe)2 partially prevented the inhibition of renal δ-ALA-D, elevated serum creatinine levels, decreased levels of TBARS and non-protein thiols, as well as alteration in blood Zn homeostasis. Mice exposed to Hg showed inhibition of blood δ-ALA-D and serum ALT activity, increased urea and creatinine levels, decreased levels of TBARS and total renal thiols and increased levels of non-protein thiols in the kidney. Hg accumulated in the liver and kidney of mice and caused alteration in kidney Zn homeostasis. O (PhSe)2 completely prevented inhibition of blood δ-ALA-D, increase in urea and creatinine, and decrease of total kidney thiols and partially inhibition of serum ALT. Considering the results, it is believed that (PhSe)2 may prove to be a potential additive against Hg poisoning for both fish and mammals. |
id |
UFSM_74efd13351e6a2c7019cd61cf4ac70f0 |
---|---|
oai_identifier_str |
oai:repositorio.ufsm.br:1/17565 |
network_acronym_str |
UFSM |
network_name_str |
Biblioteca Digital de Teses e Dissertações do UFSM |
repository_id_str |
|
spelling |
2019-07-26T12:49:57Z2019-07-26T12:49:57Z2019-01-18http://repositorio.ufsm.br/handle/1/17565With the increase of industrial and agricultural activities, several contaminants are released into the environment. Contaminants such as mercury (Hg) can come from the use of agricultural practices, burning of fossil fuels and mining activities, and this is highlighted in Brazil. Once released into the environment Hg reaches the aquatic and terrestrial environments and consequently the organisms that live there. In order to minimize possible toxic effects on non-target organisms, the use of food additives with antioxidant properties may be a good alternative. Diphenyl diselenide (PhSe)2, is an organic compound of selenium with antioxidant properties, and has beneficial effects in the treatment of animals exposed to heavy metals. Thus, the objective of this work was to evaluate the effect of a diet supplemented with (PhSe)2 on mercury chloride (HgCl2) -induced toxicity. Adult jundias (40-50g) and albino Swiss mice (25-30g) were used which were treated for 30 consecutive days with feed supplemented with (PhSe)2 or control ration. After 25 days of treatment the animals received a daily dose of HgCl2 solution (1.7mg / kg, fish, 5.0mg / kg mice) for 5 days. The animals were euthanized 24 hours after the last administration of HgCl2 and blood, renal and hepatic tissues were collected for analysis of the activity of the enzyme δ-aminolevulinate dehydratase (δ-ALA-D). Hepatic toxicity parameters (aspartate aminotransferase AST and alanine aminotransferase ALT), renal (urea and creatinine) and oxidative parameters (TBARS, total and non-protein thiols and reactive oxygen species) were evaluated. Fish exposed to Hg showed inhibition of δ-ALA-D activity of kidney and blood, increase in serum creatinine levels and decrease of TBARS, total thiols and non-protein thiols of kidney. Hg accumulated in the liver and kidneys of the fish causing alteration in zinc (Zn) homeostasis in the liver and blood tissues. Feeding with (PhSe)2 partially prevented the inhibition of renal δ-ALA-D, elevated serum creatinine levels, decreased levels of TBARS and non-protein thiols, as well as alteration in blood Zn homeostasis. Mice exposed to Hg showed inhibition of blood δ-ALA-D and serum ALT activity, increased urea and creatinine levels, decreased levels of TBARS and total renal thiols and increased levels of non-protein thiols in the kidney. Hg accumulated in the liver and kidney of mice and caused alteration in kidney Zn homeostasis. O (PhSe)2 completely prevented inhibition of blood δ-ALA-D, increase in urea and creatinine, and decrease of total kidney thiols and partially inhibition of serum ALT. Considering the results, it is believed that (PhSe)2 may prove to be a potential additive against Hg poisoning for both fish and mammals.Com o aumento de atividades industriais e agrícolas, diversos contaminantes são liberados no meio ambiente. Contaminantes como o mercúrio (Hg) podem ser provenientes do uso das práticas agrícolas, queima de combustíveis fósseis e atividades de mineração, sendo que esta atividade se destaca no Brasil. Uma vez liberado no meio ambiente o Hg atinge os ambientes aquáticos e terrestres e consequentemente os organismos que ali habitam. Com o objetivo de minimizar possíveis efeitos tóxicos em organismos vivos, o uso de aditivos alimentares com propriedades antioxidantes pode representar uma boa alternativa. O disseleneto de difenila (PhSe)2 é um composto orgânico de selênio com propriedades antioxidantes, e possui efeitos benéficos na terapêutica de animais expostos a metais pesados. Dessa forma, o objetivo deste trabalho foi avaliar o efeito de uma dieta suplementada com (PhSe)2 sobre a toxicidade induzida pelo cloreto de mercúrio (HgCl2). Jundiás adultos (40 - 50g) e camundongos Swiss albinos (25–30g) foram tratados durante 30 dias consecutivos com ração suplementada com (PhSe)2 ou ração controle. Após 25 dias de tratamento os animais receberam uma dose diária de solução de HgCl2 (1,7mg/kg, peixes, 5,0mg/kg camundongos) durante 5 dias. Os animais foram eutanasiados 24h após a última administração de HgCl2 e os tecidos sanguíneo, renal e hepático foram coletados para análise da atividade da enzima δ-aminolevulinato desidratase (δ-ALA-D). Foram avaliados parâmetros de toxicidade hepática (aspartato aminotransferase AST e alanina aminotrasferase ALT), renal (uréia e creatinina) e parâmetros oxidativos (TBARS, tióis totais e não proteicos e espécies reativas de oxigênio). Os peixes expostos ao Hg apresentaram inibição da atividade da δ-ALA-D do rim e sangue, aumento nos níveis de creatinina sérica e diminuição dos níveis de TBARS, tióis totais e tióis não protéicos de rim. O Hg acumulou-se no fígado e nos rins dos peixes causando alteração na homeostase do zinco (Zn) nos tecidos hepático e sanguíneo. A alimentação com (PhSe)2 preveniu parcialmente a inibição da δ-ALA-D renal, elevação dos níveis de creatinina sérica, diminuição dos níveis de TBARS e tióis não proteicos, bem como a alteração na homeostase do Zn no sangue. Os camundongos expostos ao Hg apresentaram inibição da atividade da δ-ALA-D sanguínea e ALT sérica, aumento nos níveis de ureia e creatinina, diminuição dos níveis de TBARS e tióis total renal e aumento nos níveis de tióis não proteicos no rim. O Hg acumulou-se no fígado e no rim dos camundongos e causou alteração na homeostase do Zn nos rins. O (PhSe)2 preveniu totalmente a inibição da δ-ALA-D de sangue, o aumento na ureia e creatinina e a diminuição dos tiois totais de rim e parcialmente a inibição da ALT sérica. Considerando os resultados, acredita-se que o (PhSe)2 pode vir a ser um aditivo em potencial contra a intoxicação por Hg tanto para peixes como para mamíferos.porUniversidade Federal de Santa MariaCentro de Ciências Naturais e ExatasPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaUFSMBrasilBioquímicaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessDisseleneto de difenilaMercúrioδ-aminolevulinato desidrataseEstresse oxidativoDiphenyl diselenideMercuryδ-aminolevulinate dehydrataseOxidative stressCNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICAEfeitos da dieta suplementada com disseleneto de difenila sobre a toxicidade induzida por mercúrio em camundongos e peixesEffects of diet supplemented with diphenyl dissellene on mercury-induced toxicity in mice and fishinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisLoro, Vania Luciahttp://lattes.cnpq.br/6392817606416780Pereira, Maria Esterhttp://lattes.cnpq.br/9299114496157799Clasen, Barbara Estevaohttp://lattes.cnpq.br/4618772929333729Martinez, Cláudia Bueno dos Reishttp://lattes.cnpq.br/4215849919453600http://lattes.cnpq.br/3353430363923515Fiuza, Tiago da Luz200800000002600b0918185-c6b7-49df-b8d6-d245d73535b899587d7b-c737-40c1-8e9f-bc249de49c2d6055a017-a1ce-4841-9dc2-cb8e485b489d51c562b9-17a6-42cf-8430-1fd3f3aeafb128a37c3f-eb36-4335-a29e-ecc3a583f1b9reponame:Biblioteca Digital de Teses e Dissertações do UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALTES_PPGCBBT_2019_FIUZA_TIAGO.pdfTES_PPGCBBT_2019_FIUZA_TIAGO.pdfTese de Doutoradoapplication/pdf1117284http://repositorio.ufsm.br/bitstream/1/17565/1/TES_PPGCBBT_2019_FIUZA_TIAGO.pdf8d0f53528b77bc3e0358803a6e7fa169MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805http://repositorio.ufsm.br/bitstream/1/17565/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81956http://repositorio.ufsm.br/bitstream/1/17565/3/license.txt2f0571ecee68693bd5cd3f17c1e075dfMD53TEXTTES_PPGCBBT_2019_FIUZA_TIAGO.pdf.txtTES_PPGCBBT_2019_FIUZA_TIAGO.pdf.txtExtracted texttext/plain152784http://repositorio.ufsm.br/bitstream/1/17565/4/TES_PPGCBBT_2019_FIUZA_TIAGO.pdf.txt1bbd386d366a5b87909f1e5b6bce0524MD54THUMBNAILTES_PPGCBBT_2019_FIUZA_TIAGO.pdf.jpgTES_PPGCBBT_2019_FIUZA_TIAGO.pdf.jpgIM Thumbnailimage/jpeg5050http://repositorio.ufsm.br/bitstream/1/17565/5/TES_PPGCBBT_2019_FIUZA_TIAGO.pdf.jpgf55e3c728de370134f95a1fdcdcf1da4MD551/175652019-07-27 03:02:11.211oai:repositorio.ufsm.br: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 Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2019-07-27T06:02:11Biblioteca Digital de Teses e Dissertações do UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Efeitos da dieta suplementada com disseleneto de difenila sobre a toxicidade induzida por mercúrio em camundongos e peixes |
dc.title.alternative.eng.fl_str_mv |
Effects of diet supplemented with diphenyl dissellene on mercury-induced toxicity in mice and fish |
title |
Efeitos da dieta suplementada com disseleneto de difenila sobre a toxicidade induzida por mercúrio em camundongos e peixes |
spellingShingle |
Efeitos da dieta suplementada com disseleneto de difenila sobre a toxicidade induzida por mercúrio em camundongos e peixes Fiuza, Tiago da Luz Disseleneto de difenila Mercúrio δ-aminolevulinato desidratase Estresse oxidativo Diphenyl diselenide Mercury δ-aminolevulinate dehydratase Oxidative stress CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
title_short |
Efeitos da dieta suplementada com disseleneto de difenila sobre a toxicidade induzida por mercúrio em camundongos e peixes |
title_full |
Efeitos da dieta suplementada com disseleneto de difenila sobre a toxicidade induzida por mercúrio em camundongos e peixes |
title_fullStr |
Efeitos da dieta suplementada com disseleneto de difenila sobre a toxicidade induzida por mercúrio em camundongos e peixes |
title_full_unstemmed |
Efeitos da dieta suplementada com disseleneto de difenila sobre a toxicidade induzida por mercúrio em camundongos e peixes |
title_sort |
Efeitos da dieta suplementada com disseleneto de difenila sobre a toxicidade induzida por mercúrio em camundongos e peixes |
author |
Fiuza, Tiago da Luz |
author_facet |
Fiuza, Tiago da Luz |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Loro, Vania Lucia |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/6392817606416780 |
dc.contributor.advisor-co1.fl_str_mv |
Pereira, Maria Ester |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/9299114496157799 |
dc.contributor.referee1.fl_str_mv |
Clasen, Barbara Estevao |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/4618772929333729 |
dc.contributor.referee2.fl_str_mv |
Martinez, Cláudia Bueno dos Reis |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/4215849919453600 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/3353430363923515 |
dc.contributor.author.fl_str_mv |
Fiuza, Tiago da Luz |
contributor_str_mv |
Loro, Vania Lucia Pereira, Maria Ester Clasen, Barbara Estevao Martinez, Cláudia Bueno dos Reis |
dc.subject.por.fl_str_mv |
Disseleneto de difenila Mercúrio δ-aminolevulinato desidratase Estresse oxidativo |
topic |
Disseleneto de difenila Mercúrio δ-aminolevulinato desidratase Estresse oxidativo Diphenyl diselenide Mercury δ-aminolevulinate dehydratase Oxidative stress CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
dc.subject.eng.fl_str_mv |
Diphenyl diselenide Mercury δ-aminolevulinate dehydratase Oxidative stress |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
description |
With the increase of industrial and agricultural activities, several contaminants are released into the environment. Contaminants such as mercury (Hg) can come from the use of agricultural practices, burning of fossil fuels and mining activities, and this is highlighted in Brazil. Once released into the environment Hg reaches the aquatic and terrestrial environments and consequently the organisms that live there. In order to minimize possible toxic effects on non-target organisms, the use of food additives with antioxidant properties may be a good alternative. Diphenyl diselenide (PhSe)2, is an organic compound of selenium with antioxidant properties, and has beneficial effects in the treatment of animals exposed to heavy metals. Thus, the objective of this work was to evaluate the effect of a diet supplemented with (PhSe)2 on mercury chloride (HgCl2) -induced toxicity. Adult jundias (40-50g) and albino Swiss mice (25-30g) were used which were treated for 30 consecutive days with feed supplemented with (PhSe)2 or control ration. After 25 days of treatment the animals received a daily dose of HgCl2 solution (1.7mg / kg, fish, 5.0mg / kg mice) for 5 days. The animals were euthanized 24 hours after the last administration of HgCl2 and blood, renal and hepatic tissues were collected for analysis of the activity of the enzyme δ-aminolevulinate dehydratase (δ-ALA-D). Hepatic toxicity parameters (aspartate aminotransferase AST and alanine aminotransferase ALT), renal (urea and creatinine) and oxidative parameters (TBARS, total and non-protein thiols and reactive oxygen species) were evaluated. Fish exposed to Hg showed inhibition of δ-ALA-D activity of kidney and blood, increase in serum creatinine levels and decrease of TBARS, total thiols and non-protein thiols of kidney. Hg accumulated in the liver and kidneys of the fish causing alteration in zinc (Zn) homeostasis in the liver and blood tissues. Feeding with (PhSe)2 partially prevented the inhibition of renal δ-ALA-D, elevated serum creatinine levels, decreased levels of TBARS and non-protein thiols, as well as alteration in blood Zn homeostasis. Mice exposed to Hg showed inhibition of blood δ-ALA-D and serum ALT activity, increased urea and creatinine levels, decreased levels of TBARS and total renal thiols and increased levels of non-protein thiols in the kidney. Hg accumulated in the liver and kidney of mice and caused alteration in kidney Zn homeostasis. O (PhSe)2 completely prevented inhibition of blood δ-ALA-D, increase in urea and creatinine, and decrease of total kidney thiols and partially inhibition of serum ALT. Considering the results, it is believed that (PhSe)2 may prove to be a potential additive against Hg poisoning for both fish and mammals. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-07-26T12:49:57Z |
dc.date.available.fl_str_mv |
2019-07-26T12:49:57Z |
dc.date.issued.fl_str_mv |
2019-01-18 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/17565 |
url |
http://repositorio.ufsm.br/handle/1/17565 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
200800000002 |
dc.relation.confidence.fl_str_mv |
600 |
dc.relation.authority.fl_str_mv |
b0918185-c6b7-49df-b8d6-d245d73535b8 99587d7b-c737-40c1-8e9f-bc249de49c2d 6055a017-a1ce-4841-9dc2-cb8e485b489d 51c562b9-17a6-42cf-8430-1fd3f3aeafb1 28a37c3f-eb36-4335-a29e-ecc3a583f1b9 |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências Naturais e Exatas |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica |
dc.publisher.initials.fl_str_mv |
UFSM |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Bioquímica |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências Naturais e Exatas |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações do UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Biblioteca Digital de Teses e Dissertações do UFSM |
collection |
Biblioteca Digital de Teses e Dissertações do UFSM |
bitstream.url.fl_str_mv |
http://repositorio.ufsm.br/bitstream/1/17565/1/TES_PPGCBBT_2019_FIUZA_TIAGO.pdf http://repositorio.ufsm.br/bitstream/1/17565/2/license_rdf http://repositorio.ufsm.br/bitstream/1/17565/3/license.txt http://repositorio.ufsm.br/bitstream/1/17565/4/TES_PPGCBBT_2019_FIUZA_TIAGO.pdf.txt http://repositorio.ufsm.br/bitstream/1/17565/5/TES_PPGCBBT_2019_FIUZA_TIAGO.pdf.jpg |
bitstream.checksum.fl_str_mv |
8d0f53528b77bc3e0358803a6e7fa169 4460e5956bc1d1639be9ae6146a50347 2f0571ecee68693bd5cd3f17c1e075df 1bbd386d366a5b87909f1e5b6bce0524 f55e3c728de370134f95a1fdcdcf1da4 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações do UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
atendimento.sib@ufsm.br||tedebc@gmail.com |
_version_ |
1801485347597582336 |