Associação entre marcadores bioquímicos, oxidativos e autopercepção de sequelas funcionais relacionadas à infecção por SARS-CoV-2 na pessoa idosa
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Manancial - Repositório Digital da UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/30487 |
Resumo: | Introduction: The Coronavirus Disease 2019 (COVID-19) pandemic established in 2020 reached all countries in the world, including Brazil. Especially in the states of the Northern Region, in Amazonas there was a great initial impact of this disease, with the elderly population being the most affected age group. The state of Amazonas had a high mortality rate and the appearance of more serious forms of the disease in elderly people younger than those reported in other states. These results suggested that the elderly population of Amazonas could have a higher prevalence of developing sequelae left by the disease. Considering that COVID-19 is ultimately considered a state of hyperinflammation, it is possible that such sequelae are associated with the establishment of chronic oxidative and metabolic conditions and can be identified through the analysis of blood markers. Objective: to analyze the association between biochemical and oxidative markers and self-perception of functional sequelae related to SARS-CoV-2 infection in elderly people. Methodology: Methodology: A prospective longitudinal study, with six months of follow-up. Conducted in the city of Manaus-AM, using an opportunistic sample of 55 elderly people with a previous history of SARS-CoV-2 infection, selected from the Open University of the Third Age Foundation (FUnATI). Initially, their vital signs were checked and an anamnesis was taken via structured interview, then a socioeconomic and demographic survey of the study population was carried out, and a research instrument was applied to analyze the Functional Clinical Vulnerability Index (IVCF-20). In a second stage, a Likert-type self-report scale was developed and applied with the aim of evaluating the occurrence, type and severity of functional sequelae related to COVID-19 in the elderly and together with a collection of venous blood to carry out analysis. biochemical and oxidative laboratory tests. Results: Our data indicate that a significant proportion of elderly survivors of COVID-19 self-reported the occurrence and persistence of functional sequelae that generate a negative impact on their health after infection, highlighting the persistence of symptoms, such as coughing, shortness of breath and changes in physical and mental conditions, presence of fatigue, mobility difficulties and changes in appetite and weight. And the association of the sequelae observed with biochemical markers such as changes in levels of glucose, cholesterol and other indicators, while in oxidative markers, an increase in lipid peroxidation in the long term was observed. Conclusion: A significant number of elderly people who survived COVID-19 self-reported the presence and persistence of functional sequelae that had a negative impact on their post-infection health. This study offers deeper insight into the long-term effects of COVID-19 on the elderly population, highlighting the importance of long-term health monitoring for this population, including interventions that aim to improve quality of life and manage persistent sequelae. |
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Associação entre marcadores bioquímicos, oxidativos e autopercepção de sequelas funcionais relacionadas à infecção por SARS-CoV-2 na pessoa idosaAssociation between biochemical, oxidative markers and self-perception of functional sequelares related to SARS-CoV-2 infection in elderly peopleCovid-19Marcadores sanguíneosEvolução de sequelasBlood markersEvolution of sequelaeCNPQ::CIENCIAS DA SAUDEIntroduction: The Coronavirus Disease 2019 (COVID-19) pandemic established in 2020 reached all countries in the world, including Brazil. Especially in the states of the Northern Region, in Amazonas there was a great initial impact of this disease, with the elderly population being the most affected age group. The state of Amazonas had a high mortality rate and the appearance of more serious forms of the disease in elderly people younger than those reported in other states. These results suggested that the elderly population of Amazonas could have a higher prevalence of developing sequelae left by the disease. Considering that COVID-19 is ultimately considered a state of hyperinflammation, it is possible that such sequelae are associated with the establishment of chronic oxidative and metabolic conditions and can be identified through the analysis of blood markers. Objective: to analyze the association between biochemical and oxidative markers and self-perception of functional sequelae related to SARS-CoV-2 infection in elderly people. Methodology: Methodology: A prospective longitudinal study, with six months of follow-up. Conducted in the city of Manaus-AM, using an opportunistic sample of 55 elderly people with a previous history of SARS-CoV-2 infection, selected from the Open University of the Third Age Foundation (FUnATI). Initially, their vital signs were checked and an anamnesis was taken via structured interview, then a socioeconomic and demographic survey of the study population was carried out, and a research instrument was applied to analyze the Functional Clinical Vulnerability Index (IVCF-20). In a second stage, a Likert-type self-report scale was developed and applied with the aim of evaluating the occurrence, type and severity of functional sequelae related to COVID-19 in the elderly and together with a collection of venous blood to carry out analysis. biochemical and oxidative laboratory tests. Results: Our data indicate that a significant proportion of elderly survivors of COVID-19 self-reported the occurrence and persistence of functional sequelae that generate a negative impact on their health after infection, highlighting the persistence of symptoms, such as coughing, shortness of breath and changes in physical and mental conditions, presence of fatigue, mobility difficulties and changes in appetite and weight. And the association of the sequelae observed with biochemical markers such as changes in levels of glucose, cholesterol and other indicators, while in oxidative markers, an increase in lipid peroxidation in the long term was observed. Conclusion: A significant number of elderly people who survived COVID-19 self-reported the presence and persistence of functional sequelae that had a negative impact on their post-infection health. This study offers deeper insight into the long-term effects of COVID-19 on the elderly population, highlighting the importance of long-term health monitoring for this population, including interventions that aim to improve quality of life and manage persistent sequelae.Introdução: A pandemia do Coronavírus Disease 2019 (COVID-19) estabelecida em 2020 atingiu todos os países do mundo incluindo o Brasil. Especialmente os Estados da Região Norte, no Amazonas ocorreu grande impacto inicial desta doença, sendo a população idosa a faixa etária mais atingida. O estado do Amazonas apresentou uma alta taxa de mortalidade e aparecimento de formas mais graves da doença em pessoas idosas com idade inferior as relatadas em demais estados. Estes resultados sugeriram que a população idosa do Amazonas poderia apresentar uma maior prevalência de desenvolvimento de sequelas deixadas pela doença. Considerando que a COVID-19 é considerada em última análise um estado de hiperinflamação é possível que tais sequelas estejam associadas ao estabelecimento de quadros oxidativos e metabólicos crônicos e passiveis de serem identificados através da análise de marcadores sanguíneos. Objetivo: analisar a associação entre marcadores bioquímicos, oxidativos e autopercepção de sequelas funcionais relacionadas a infecção por SARS-CoV-2 em pessoas idosas. Metodologia: Um estudo longitudinal prospectivo, com seis meses de acompanhamento. Conduzido na cidade de Manaus-AM, utilizando uma amostra oportunística de 55 idosos com histórico prévio de infecção por SARS-CoV-2, selecionados na Fundação Universidade Aberta da Terceira Idade (FUnATI). Inicialmente foi aferido seus sinais vitais e aplicado uma anamnese via entrevista estruturada, logo foi realizado um levantamento socioeconômico e demográfico da população do estudo, e aplicação de um instrumento de pesquisa para análise do Índice de Vulnerabilidade Clínico Funcional (IVCF-20). Em uma segunda etapa foi realizado o desenvolvimento e aplicação de uma escala de autorrelato do tipo Likert com objetivo de avaliar a ocorrência, tipo e gravidade de sequelas funcionais relacionadas a COVID-19 em idosos e em conjunto uma coleta de sangue venoso para realização de análises laboratoriais bioquímicas e oxidativas. Resultados: Nossos dados indicam que uma proporção significativa de idosos sobreviventes à COVID-19 autorrelatou a ocorrência e persistência de sequelas funcionais que geram um impacto negativo em sua saúde após a infecção, destacou-se a persistência de sintomas, como tosse, falta de ar e alterações nas condiçoes física e mental, presença de fadiga, dificuldades de mobilidade e mudanças no apetite e peso. E a associação das sequelas observadas a marcadores bioquímicos como alterações em níveis de glicose, colesterol e outros indicadores já nos marcadores oxidativos foi observado um aumento na peroxidação lipídica a longo prazo. Conclusão: Uma parcela significativa de idosos que sobreviveram à COVID-19 autorrelataram a presença e persistência de sequelas funcionais que geram impacto negativo em sua saúde pós-infecção. Este estudo oferece uma visão mais profunda dos efeitos a longo prazo da COVID-19 sobre a população idosa destacando a importância de um acompanhamento de saúde de longo prazo para essa população, incluindo intervenções que visam melhorar a qualidade de vida e gerenciar sequelas persistentes.Universidade Federal de Santa MariaBrasilCiências da SaúdeUFSMPrograma de Pós-Graduação em GerontologiaCentro de Educação Física e DesportosAzzolin, Verônica Farinahttp://lattes.cnpq.br/2668411219019981Mastella , Moisés HenriqueBarbisan, FernandaTeixeira, Cibele FerreiraMaia, Railla da Silva2023-11-13T15:38:36Z2023-11-13T15:38:36Z2023-10-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://repositorio.ufsm.br/handle/1/30487porAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM2023-11-13T15:38:36Zoai:repositorio.ufsm.br:1/30487Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2023-11-13T15:38:36Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.none.fl_str_mv |
Associação entre marcadores bioquímicos, oxidativos e autopercepção de sequelas funcionais relacionadas à infecção por SARS-CoV-2 na pessoa idosa Association between biochemical, oxidative markers and self-perception of functional sequelares related to SARS-CoV-2 infection in elderly people |
title |
Associação entre marcadores bioquímicos, oxidativos e autopercepção de sequelas funcionais relacionadas à infecção por SARS-CoV-2 na pessoa idosa |
spellingShingle |
Associação entre marcadores bioquímicos, oxidativos e autopercepção de sequelas funcionais relacionadas à infecção por SARS-CoV-2 na pessoa idosa Maia, Railla da Silva Covid-19 Marcadores sanguíneos Evolução de sequelas Blood markers Evolution of sequelae CNPQ::CIENCIAS DA SAUDE |
title_short |
Associação entre marcadores bioquímicos, oxidativos e autopercepção de sequelas funcionais relacionadas à infecção por SARS-CoV-2 na pessoa idosa |
title_full |
Associação entre marcadores bioquímicos, oxidativos e autopercepção de sequelas funcionais relacionadas à infecção por SARS-CoV-2 na pessoa idosa |
title_fullStr |
Associação entre marcadores bioquímicos, oxidativos e autopercepção de sequelas funcionais relacionadas à infecção por SARS-CoV-2 na pessoa idosa |
title_full_unstemmed |
Associação entre marcadores bioquímicos, oxidativos e autopercepção de sequelas funcionais relacionadas à infecção por SARS-CoV-2 na pessoa idosa |
title_sort |
Associação entre marcadores bioquímicos, oxidativos e autopercepção de sequelas funcionais relacionadas à infecção por SARS-CoV-2 na pessoa idosa |
author |
Maia, Railla da Silva |
author_facet |
Maia, Railla da Silva |
author_role |
author |
dc.contributor.none.fl_str_mv |
Azzolin, Verônica Farina http://lattes.cnpq.br/2668411219019981 Mastella , Moisés Henrique Barbisan, Fernanda Teixeira, Cibele Ferreira |
dc.contributor.author.fl_str_mv |
Maia, Railla da Silva |
dc.subject.por.fl_str_mv |
Covid-19 Marcadores sanguíneos Evolução de sequelas Blood markers Evolution of sequelae CNPQ::CIENCIAS DA SAUDE |
topic |
Covid-19 Marcadores sanguíneos Evolução de sequelas Blood markers Evolution of sequelae CNPQ::CIENCIAS DA SAUDE |
description |
Introduction: The Coronavirus Disease 2019 (COVID-19) pandemic established in 2020 reached all countries in the world, including Brazil. Especially in the states of the Northern Region, in Amazonas there was a great initial impact of this disease, with the elderly population being the most affected age group. The state of Amazonas had a high mortality rate and the appearance of more serious forms of the disease in elderly people younger than those reported in other states. These results suggested that the elderly population of Amazonas could have a higher prevalence of developing sequelae left by the disease. Considering that COVID-19 is ultimately considered a state of hyperinflammation, it is possible that such sequelae are associated with the establishment of chronic oxidative and metabolic conditions and can be identified through the analysis of blood markers. Objective: to analyze the association between biochemical and oxidative markers and self-perception of functional sequelae related to SARS-CoV-2 infection in elderly people. Methodology: Methodology: A prospective longitudinal study, with six months of follow-up. Conducted in the city of Manaus-AM, using an opportunistic sample of 55 elderly people with a previous history of SARS-CoV-2 infection, selected from the Open University of the Third Age Foundation (FUnATI). Initially, their vital signs were checked and an anamnesis was taken via structured interview, then a socioeconomic and demographic survey of the study population was carried out, and a research instrument was applied to analyze the Functional Clinical Vulnerability Index (IVCF-20). In a second stage, a Likert-type self-report scale was developed and applied with the aim of evaluating the occurrence, type and severity of functional sequelae related to COVID-19 in the elderly and together with a collection of venous blood to carry out analysis. biochemical and oxidative laboratory tests. Results: Our data indicate that a significant proportion of elderly survivors of COVID-19 self-reported the occurrence and persistence of functional sequelae that generate a negative impact on their health after infection, highlighting the persistence of symptoms, such as coughing, shortness of breath and changes in physical and mental conditions, presence of fatigue, mobility difficulties and changes in appetite and weight. And the association of the sequelae observed with biochemical markers such as changes in levels of glucose, cholesterol and other indicators, while in oxidative markers, an increase in lipid peroxidation in the long term was observed. Conclusion: A significant number of elderly people who survived COVID-19 self-reported the presence and persistence of functional sequelae that had a negative impact on their post-infection health. This study offers deeper insight into the long-term effects of COVID-19 on the elderly population, highlighting the importance of long-term health monitoring for this population, including interventions that aim to improve quality of life and manage persistent sequelae. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-11-13T15:38:36Z 2023-11-13T15:38:36Z 2023-10-05 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/30487 |
url |
http://repositorio.ufsm.br/handle/1/30487 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Brasil Ciências da Saúde UFSM Programa de Pós-Graduação em Gerontologia Centro de Educação Física e Desportos |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Brasil Ciências da Saúde UFSM Programa de Pós-Graduação em Gerontologia Centro de Educação Física e Desportos |
dc.source.none.fl_str_mv |
reponame:Manancial - Repositório Digital da UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Manancial - Repositório Digital da UFSM |
collection |
Manancial - Repositório Digital da UFSM |
repository.name.fl_str_mv |
Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
atendimento.sib@ufsm.br||tedebc@gmail.com |
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1805922173949313024 |