Sarcoma histiocítico em cães
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações do UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/30087 |
Resumo: | Histiocytic sarcoma is a malignant, progressive, and uncommon neoplasm that is part of a group of proliferative histiocytic diseases. This form of cancer originates from histiocytic cells, such as antigen-presenting cells, including Langerhans cells, and macrophages. The tumor can affect different species, but it is most commonly diagnosed in dogs. Epidemiologically, it is known that there is a predilection for large dogs and for some specific breeds, such as the Bernese Mountain dog. Article 1 of this thesis presents the results of a retrospective study aimed at definitively diagnosing and characterizing the epidemiology, anatomopathology and immunophenotypic behavior of histiocytic sarcoma. Histopathology results were obtained that reinforce some classic concepts, such as the importance in the presence of mono, bi and multinucleated giant cells for a strong diagnostic suspicion, as well as others that expand the knowledge about this form of cancer, such as the predisposition in Rottweiler dogs. Article 2 of this thesis presents the description of three cases of hemophagocytic histiocytic sarcoma, a rare variant that leads to hemolytic crisis and its consequences. The diagnosis was made by the association of clinical, laboratory, anatomopathological, and immunohistochemistry. In both articles it was possible to describe the immunophenotypic behavior of neoplastic cells against markers CD204, MHC-II and CD11d. Histiocytic sarcoma has become an increasingly frequent diagnosis in dogs in the routine of the laboratory of veterinary pathology, presenting itself as an interesting form of cancer to be studied, for a better understanding of its pathogenic mechanisms and variations regarding to immunophenotyping. |
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2023-08-28T13:39:23Z2023-08-28T13:39:23Z2022-03-31http://repositorio.ufsm.br/handle/1/30087Histiocytic sarcoma is a malignant, progressive, and uncommon neoplasm that is part of a group of proliferative histiocytic diseases. This form of cancer originates from histiocytic cells, such as antigen-presenting cells, including Langerhans cells, and macrophages. The tumor can affect different species, but it is most commonly diagnosed in dogs. Epidemiologically, it is known that there is a predilection for large dogs and for some specific breeds, such as the Bernese Mountain dog. Article 1 of this thesis presents the results of a retrospective study aimed at definitively diagnosing and characterizing the epidemiology, anatomopathology and immunophenotypic behavior of histiocytic sarcoma. Histopathology results were obtained that reinforce some classic concepts, such as the importance in the presence of mono, bi and multinucleated giant cells for a strong diagnostic suspicion, as well as others that expand the knowledge about this form of cancer, such as the predisposition in Rottweiler dogs. Article 2 of this thesis presents the description of three cases of hemophagocytic histiocytic sarcoma, a rare variant that leads to hemolytic crisis and its consequences. The diagnosis was made by the association of clinical, laboratory, anatomopathological, and immunohistochemistry. In both articles it was possible to describe the immunophenotypic behavior of neoplastic cells against markers CD204, MHC-II and CD11d. Histiocytic sarcoma has become an increasingly frequent diagnosis in dogs in the routine of the laboratory of veterinary pathology, presenting itself as an interesting form of cancer to be studied, for a better understanding of its pathogenic mechanisms and variations regarding to immunophenotyping.O sarcoma histiocítico é uma neoplasia maligna, progressiva e incomum, que faz parte de um grupo de doenças histiocíticas proliferativas. Essa forma de câncer origina-se de células histiocíticas, como células apresentadoras de antígenos, incluindo células de Langerhans, e macrófagos. O tumor pode afetar diferentes espécies, mas é mais comumente diagnosticado em cães. Epidemiologicamente sabe-se haver predileção por cães de grande porte e por algumas raças específicas, como o Boiadeiro Bernês. O Artigo 1 desta tese traz os resultados de um estudo retrospectivo que visou diagnosticar e caracterizar a epidemiologia, a anatomopatologia e o comportamento imunofenotípico do sarcoma histiocítico. Histopatologicamente foram obtidos resultados que reforçam alguns conceitos clássicos, como a importância na presença de células gigantes mono, bi e multinucleadas para uma forte suspeita diagnóstica, bem como outros que ampliam o conhecimento acerca dessa forma de câncer, como a predisposição em cães da raça Rottweiler. O Artigo 2 desta tese apresenta a descrição de três casos de sarcoma histiocítico hemofagocítico, uma rara variante que cursa com crise hemolítica e suas consequências. O diagnóstico foi realizado pela associação dos achados clínicos, laboratoriais, anatomopatológicos e imunohistoquímica. Em ambos os artigos foi possível descrever o comportamento imunofenotípico das células neoplásicas frente aos marcadores CD204, MHC-II e CD11d. O sarcoma histiocítico tem se tornado um diagnóstico cada vez mais frequente em cães da rotina de laboratórios de patologia veterinária, se apresentando como uma interessante forma de câncer a ser estudada, para melhor compreensão dos seus mecanismos patogênicos e variações quanto à imunofenotipagem.porUniversidade Federal de Santa MariaCentro de Ciências RuraisPrograma de Pós-Graduação em Medicina VeterináriaUFSMBrasilMedicina VeterináriaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessCâncerCãesHistiócitosMacrófagosSarcomaCancerDogsHistiocytesMacrophagesCNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIASarcoma histiocítico em cãesHistiocytic sarcoma in dogsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisFighera, Rafael Almeidahttp://lattes.cnpq.br/6223365736139655Krause, AlexandreTonin, Alexandre AlbertoCogliati, BrunoGrecco, Fabiane Borellihttp://lattes.cnpq.br/8955014668583611Luz, Flávia Serena da500500000007600600600600600600600e1b2f8ee-da7a-403f-acb4-f6cc848ea946d6246d31-cfde-4410-90da-86ebc202329a48b1731f-9fa9-4553-ab4a-18302b9fc5148871060e-86c0-4dd7-9756-a75f60fe53d01afac622-73e1-4781-ae70-ed65c9f8b28cc8e42e38-4dd8-4a56-9dc4-ffe5e09eb23freponame:Biblioteca Digital de Teses e Dissertações do UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALTES_PPGMV_2022_LUZ_FLAVIA.pdfTES_PPGMV_2022_LUZ_FLAVIA.pdfTese de doutoradoapplication/pdf5087824http://repositorio.ufsm.br/bitstream/1/30087/1/TES_PPGMV_2022_LUZ_FLAVIA.pdf34000d2873957aba4299ca8589173112MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805http://repositorio.ufsm.br/bitstream/1/30087/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81956http://repositorio.ufsm.br/bitstream/1/30087/3/license.txt2f0571ecee68693bd5cd3f17c1e075dfMD531/300872023-08-28 10:39:24.213oai:repositorio.ufsm.br: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 Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2023-08-28T13:39:24Biblioteca Digital de Teses e Dissertações do UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Sarcoma histiocítico em cães |
dc.title.alternative.eng.fl_str_mv |
Histiocytic sarcoma in dogs |
title |
Sarcoma histiocítico em cães |
spellingShingle |
Sarcoma histiocítico em cães Luz, Flávia Serena da Câncer Cães Histiócitos Macrófagos Sarcoma Cancer Dogs Histiocytes Macrophages CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
title_short |
Sarcoma histiocítico em cães |
title_full |
Sarcoma histiocítico em cães |
title_fullStr |
Sarcoma histiocítico em cães |
title_full_unstemmed |
Sarcoma histiocítico em cães |
title_sort |
Sarcoma histiocítico em cães |
author |
Luz, Flávia Serena da |
author_facet |
Luz, Flávia Serena da |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Fighera, Rafael Almeida |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/6223365736139655 |
dc.contributor.referee1.fl_str_mv |
Krause, Alexandre |
dc.contributor.referee2.fl_str_mv |
Tonin, Alexandre Alberto |
dc.contributor.referee3.fl_str_mv |
Cogliati, Bruno |
dc.contributor.referee4.fl_str_mv |
Grecco, Fabiane Borelli |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/8955014668583611 |
dc.contributor.author.fl_str_mv |
Luz, Flávia Serena da |
contributor_str_mv |
Fighera, Rafael Almeida Krause, Alexandre Tonin, Alexandre Alberto Cogliati, Bruno Grecco, Fabiane Borelli |
dc.subject.por.fl_str_mv |
Câncer Cães Histiócitos Macrófagos Sarcoma |
topic |
Câncer Cães Histiócitos Macrófagos Sarcoma Cancer Dogs Histiocytes Macrophages CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
dc.subject.eng.fl_str_mv |
Cancer Dogs Histiocytes Macrophages |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
description |
Histiocytic sarcoma is a malignant, progressive, and uncommon neoplasm that is part of a group of proliferative histiocytic diseases. This form of cancer originates from histiocytic cells, such as antigen-presenting cells, including Langerhans cells, and macrophages. The tumor can affect different species, but it is most commonly diagnosed in dogs. Epidemiologically, it is known that there is a predilection for large dogs and for some specific breeds, such as the Bernese Mountain dog. Article 1 of this thesis presents the results of a retrospective study aimed at definitively diagnosing and characterizing the epidemiology, anatomopathology and immunophenotypic behavior of histiocytic sarcoma. Histopathology results were obtained that reinforce some classic concepts, such as the importance in the presence of mono, bi and multinucleated giant cells for a strong diagnostic suspicion, as well as others that expand the knowledge about this form of cancer, such as the predisposition in Rottweiler dogs. Article 2 of this thesis presents the description of three cases of hemophagocytic histiocytic sarcoma, a rare variant that leads to hemolytic crisis and its consequences. The diagnosis was made by the association of clinical, laboratory, anatomopathological, and immunohistochemistry. In both articles it was possible to describe the immunophenotypic behavior of neoplastic cells against markers CD204, MHC-II and CD11d. Histiocytic sarcoma has become an increasingly frequent diagnosis in dogs in the routine of the laboratory of veterinary pathology, presenting itself as an interesting form of cancer to be studied, for a better understanding of its pathogenic mechanisms and variations regarding to immunophenotyping. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022-03-31 |
dc.date.accessioned.fl_str_mv |
2023-08-28T13:39:23Z |
dc.date.available.fl_str_mv |
2023-08-28T13:39:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
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doctoralThesis |
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http://repositorio.ufsm.br/handle/1/30087 |
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http://repositorio.ufsm.br/handle/1/30087 |
dc.language.iso.fl_str_mv |
por |
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por |
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500500000007 |
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600 600 600 600 600 600 600 |
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Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências Rurais |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Medicina Veterinária |
dc.publisher.initials.fl_str_mv |
UFSM |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Medicina Veterinária |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências Rurais |
dc.source.none.fl_str_mv |
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