Determinação de impurezas elementares em suplementos alimentares por espectrometria de absorção atômica
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações do UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/20851 |
Resumo: | This work presents a study of the determination of arsenic, cadmium and lead in food supplements by atomic absorption spectrometry. Food supplements are obtained in synthetic form and derived from plants, and contamination of metals and metalloids may occur due to the industrial environment, soil geochemical characteristics, among other forms. The methods for the determination of Pb and Cd were developed in high resolution atomic absorption spectrometer with continuous source equipped with graphite furnace with direct sampling and the method for the determination of As was developed in atomic absorption spectrometer with generation of hydrides with decomposition of the samples by acid digestion. The concentration of lead, cadmium and arsenic were determined in 72 food supplements available in the Brazilian market. For the methods developed in HR-CS SS GFAAS the platforms were coated with Zr and the use of Pd(NO3)2 and Mg(NO3)2 with chemical modifiers presented better analytical performance. The performance parameters of the methods were in accordance with the standards of the American Pharmacopoeia for inorganic analysis in food supplements. The precision, expressed as relative standard deviation, was less than 5% for the HR-CS SS GFAAS methods and less than 6.1% for the HGAAS method, and the detection limits were 2.16 pg for Pb, 0.47 pg Cd and 0.37 μg/L As. The content of metals and metalloids in the samples ranged from 0.04 to 1.68 μg / g for Pb, 0.01 to 0.37 μg/g for Cd and As content varied from 0.02 to 0.73 μg/g. The American Famacopeia recommends limits of 10 μg / day Pb and 5 μg / day Cd. Four products had amounts of Pb above the allowed one and a sample had Cd above the acceptable amounts. Contamination of dietary supplements by these elements is of concern, even at low concentrations, since chronic exposure can cause serious deleterious health effects. |
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2021-05-12T18:03:56Z2021-05-12T18:03:56Z2018-08-02http://repositorio.ufsm.br/handle/1/20851This work presents a study of the determination of arsenic, cadmium and lead in food supplements by atomic absorption spectrometry. Food supplements are obtained in synthetic form and derived from plants, and contamination of metals and metalloids may occur due to the industrial environment, soil geochemical characteristics, among other forms. The methods for the determination of Pb and Cd were developed in high resolution atomic absorption spectrometer with continuous source equipped with graphite furnace with direct sampling and the method for the determination of As was developed in atomic absorption spectrometer with generation of hydrides with decomposition of the samples by acid digestion. The concentration of lead, cadmium and arsenic were determined in 72 food supplements available in the Brazilian market. For the methods developed in HR-CS SS GFAAS the platforms were coated with Zr and the use of Pd(NO3)2 and Mg(NO3)2 with chemical modifiers presented better analytical performance. The performance parameters of the methods were in accordance with the standards of the American Pharmacopoeia for inorganic analysis in food supplements. The precision, expressed as relative standard deviation, was less than 5% for the HR-CS SS GFAAS methods and less than 6.1% for the HGAAS method, and the detection limits were 2.16 pg for Pb, 0.47 pg Cd and 0.37 μg/L As. The content of metals and metalloids in the samples ranged from 0.04 to 1.68 μg / g for Pb, 0.01 to 0.37 μg/g for Cd and As content varied from 0.02 to 0.73 μg/g. The American Famacopeia recommends limits of 10 μg / day Pb and 5 μg / day Cd. Four products had amounts of Pb above the allowed one and a sample had Cd above the acceptable amounts. Contamination of dietary supplements by these elements is of concern, even at low concentrations, since chronic exposure can cause serious deleterious health effects.Este trabalho apresenta um estudo de determinação de arsênio (As), cádmio (Cd) e chumbo (Pb) em suplementos alimentares por espectrometria de absorção atômica. Os suplementos alimentares são obtidos de forma sintética e derivados de plantas, podendo ocorrer a contaminação de metais e metaloides devido ao ambiente industrial, características geoquímicas do solo, entre outras formas. Os métodos para a determinação de Pb e Cd foram desenvolvidos em espectrômetro de absorção atômica de alta resolução com fonte continua equipado com forno de grafite com amostragem direta (HR-CS SS GFAAS) e o método para a determinação de As foi desenvolvido em espectrômetro de absorção atômica com geração de hidretos (HGAAS) com decomposição das amostras por digestão ácida. A quantidade de Pb, Cd e As foram determinadas em 72 suplementos alimentares disponíveis no mercado brasileiro. Para os métodos desenvolvidos em HR-CS SS GFAAS as plataformas foram revestidas com zircônio e o uso de Pd(NO3)2 e Mg(NO3)2 como modificadores químicos aumentaram o desempenho analítico. Os parâmetros de desempenho dos métodos estavam de acordo com as normas da Farmacopeia Americana para análise inorgânica em suplementos alimentares. A precisão, expressa como desvio padrão relativo, foi de menor que 5% para os métodos por HR-CS SS GFAAS e menor que 6,1% para o método por HG AAS. Os limites de detecção foram 2,16 pg para Pb, 0,47 pg Cd e 0,37 μg/L As. Os conteúdos dos elementos nas amostras variaram na faixa de 0,04 a 1,68 μg/g para o Pb, 0,01 a 0,37 μg/g para o Cd e o conteúdo de As variou na faixa de 0,02 a 0,73 μg/g. A famacopeia americana preconiza limites de 10 μg/dia Pb e 5 μg/dia Cd. Quatro produtos apresentaram quantidades de Pb acima do permitido e uma amostra apresentou Cd acima das quantidades aceitáveis. A contaminação de suplementos alimentares por estes elementos é preocupante, mesmo em baixas concentrações, uma vez que a exposição crônica pode causar graves efeitos deletérios à saúde.Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPqporUniversidade Federal de Santa MariaCentro de Ciências da SaúdePrograma de Pós-Graduação em Ciências FarmacêuticasUFSMBrasilAnálises Clínicas e ToxicológicasAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAbsorção atômicaMetaisMetalóideSuplementos alimentaresAtomic absorptionMetalsMetalloidsFood supplementsCNPQ::CIENCIAS DA SAUDE::FARMACIADeterminação de impurezas elementares em suplementos alimentares por espectrometria de absorção atômicaDetermination of elementary impurities in food supplements by atomic absorption spectrometryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisSilva, Carine Vianahttp://lattes.cnpq.br/2004872342535591Gomes, PatríciaFlores, Liziane Maahshttp://lattes.cnpq.br/0442154869416839Leal, Gabriela Camera40030000000560060060060060088e93e45-5e33-4094-a525-3ae55aa2e39e410f4490-c6b3-4b4c-a7ef-6953bd59523812c355e5-3354-4ff7-ba9d-770e850b24ef86fbc89e-fb46-476a-8f41-39b8e661e84ereponame:Biblioteca Digital de Teses e Dissertações do UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALDIS_PPGCF_2018_LEAL_GABRIELA.pdfDIS_PPGCF_2018_LEAL_GABRIELA.pdfDissertaçãoapplication/pdf2154976http://repositorio.ufsm.br/bitstream/1/20851/1/DIS_PPGCF_2018_LEAL_GABRIELA.pdf40ed6b0f490ce472ad17950788a273fdMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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dc.title.por.fl_str_mv |
Determinação de impurezas elementares em suplementos alimentares por espectrometria de absorção atômica |
dc.title.alternative.eng.fl_str_mv |
Determination of elementary impurities in food supplements by atomic absorption spectrometry |
title |
Determinação de impurezas elementares em suplementos alimentares por espectrometria de absorção atômica |
spellingShingle |
Determinação de impurezas elementares em suplementos alimentares por espectrometria de absorção atômica Leal, Gabriela Camera Absorção atômica Metais Metalóide Suplementos alimentares Atomic absorption Metals Metalloids Food supplements CNPQ::CIENCIAS DA SAUDE::FARMACIA |
title_short |
Determinação de impurezas elementares em suplementos alimentares por espectrometria de absorção atômica |
title_full |
Determinação de impurezas elementares em suplementos alimentares por espectrometria de absorção atômica |
title_fullStr |
Determinação de impurezas elementares em suplementos alimentares por espectrometria de absorção atômica |
title_full_unstemmed |
Determinação de impurezas elementares em suplementos alimentares por espectrometria de absorção atômica |
title_sort |
Determinação de impurezas elementares em suplementos alimentares por espectrometria de absorção atômica |
author |
Leal, Gabriela Camera |
author_facet |
Leal, Gabriela Camera |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Silva, Carine Viana |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/2004872342535591 |
dc.contributor.referee1.fl_str_mv |
Gomes, Patrícia |
dc.contributor.referee2.fl_str_mv |
Flores, Liziane Maahs |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/0442154869416839 |
dc.contributor.author.fl_str_mv |
Leal, Gabriela Camera |
contributor_str_mv |
Silva, Carine Viana Gomes, Patrícia Flores, Liziane Maahs |
dc.subject.por.fl_str_mv |
Absorção atômica Metais Metalóide Suplementos alimentares |
topic |
Absorção atômica Metais Metalóide Suplementos alimentares Atomic absorption Metals Metalloids Food supplements CNPQ::CIENCIAS DA SAUDE::FARMACIA |
dc.subject.eng.fl_str_mv |
Atomic absorption Metals Metalloids Food supplements |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS DA SAUDE::FARMACIA |
description |
This work presents a study of the determination of arsenic, cadmium and lead in food supplements by atomic absorption spectrometry. Food supplements are obtained in synthetic form and derived from plants, and contamination of metals and metalloids may occur due to the industrial environment, soil geochemical characteristics, among other forms. The methods for the determination of Pb and Cd were developed in high resolution atomic absorption spectrometer with continuous source equipped with graphite furnace with direct sampling and the method for the determination of As was developed in atomic absorption spectrometer with generation of hydrides with decomposition of the samples by acid digestion. The concentration of lead, cadmium and arsenic were determined in 72 food supplements available in the Brazilian market. For the methods developed in HR-CS SS GFAAS the platforms were coated with Zr and the use of Pd(NO3)2 and Mg(NO3)2 with chemical modifiers presented better analytical performance. The performance parameters of the methods were in accordance with the standards of the American Pharmacopoeia for inorganic analysis in food supplements. The precision, expressed as relative standard deviation, was less than 5% for the HR-CS SS GFAAS methods and less than 6.1% for the HGAAS method, and the detection limits were 2.16 pg for Pb, 0.47 pg Cd and 0.37 μg/L As. The content of metals and metalloids in the samples ranged from 0.04 to 1.68 μg / g for Pb, 0.01 to 0.37 μg/g for Cd and As content varied from 0.02 to 0.73 μg/g. The American Famacopeia recommends limits of 10 μg / day Pb and 5 μg / day Cd. Four products had amounts of Pb above the allowed one and a sample had Cd above the acceptable amounts. Contamination of dietary supplements by these elements is of concern, even at low concentrations, since chronic exposure can cause serious deleterious health effects. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018-08-02 |
dc.date.accessioned.fl_str_mv |
2021-05-12T18:03:56Z |
dc.date.available.fl_str_mv |
2021-05-12T18:03:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/20851 |
url |
http://repositorio.ufsm.br/handle/1/20851 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
400300000005 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 600 |
dc.relation.authority.fl_str_mv |
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dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências da Saúde |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Ciências Farmacêuticas |
dc.publisher.initials.fl_str_mv |
UFSM |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Análises Clínicas e Toxicológicas |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Centro de Ciências da Saúde |
dc.source.none.fl_str_mv |
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UFSM |
reponame_str |
Biblioteca Digital de Teses e Dissertações do UFSM |
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Biblioteca Digital de Teses e Dissertações do UFSM |
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