Avaliação clínica de diferentes protocolos de laser de baixa potência em mucosite bucal induzida por 5-fluouracil em hamsters
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Manancial - Repositório Digital da UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/17523 |
Resumo: | Aims: The purpose of this study was to investigate the effects of different of low level laser (LLL) protocols on induced-oral mucositis by 5-fluoracil (5-FU) in hamsters. Introduction: The oral mucositis is a ordinary side effect from antineoplasic therapy. Development of effective interventions to its prevention and treatment are priory on caring of the oncology patients. Metodologia: In the present study 96 hamsters were used and randomly allocated into 4 groups: Control (without treatment), Preventive (laser from day -5 to day +5), Therapeutic (laser from day +5 to day +15) and Combined (laser from day -5 to day +15). Mucositis was induced in hamsters by intraperitoneal injection of 5- fluorouracil (5-FU) at days 0 and 2 and superficial scratching in cheek pouch mucosa. The irradiation was carried out using diode LLL, 660 nm, 40mW of power, 6,0J/cm2 during 6seconds/point. At days 0, 5, 10 and 15, six animals from each group were sacrificed, weighted and the cheek pouch mucosa was clinically analyzed. Statistical analysis was made considering the time x treatment interaction through the SPSS Statistics 18.0® software. The multiple comparison was made by the Generalized Estimation Equation test and adjusted by the Bonferroni test. Results: The animals from the Control group had significant lose of weight at the 10th day of the experiment. The laser treatment at preventive, therapeutic and combined form presented mucosits scratching reduction in comparison to the control group. However there was no statistic difference between the mucositis scores at the groups that received treatment. Conclusion: The low level laser, independent of the used protocol, is efficient to clinical reducing oral-inducted mucositis by 5-FU in hamsters. |
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Avaliação clínica de diferentes protocolos de laser de baixa potência em mucosite bucal induzida por 5-fluouracil em hamstersClinical assesment of diferent of low level laser protocols in induced-oral mucositis by 5-fluouracil in hamsterLaserterapiaQuimioterapiaEfeito adversoMucosa bucalSide effectLaser therapyChemotherapyOral mucosaCNPQ::CIENCIAS DA SAUDE::ODONTOLOGIAAims: The purpose of this study was to investigate the effects of different of low level laser (LLL) protocols on induced-oral mucositis by 5-fluoracil (5-FU) in hamsters. Introduction: The oral mucositis is a ordinary side effect from antineoplasic therapy. Development of effective interventions to its prevention and treatment are priory on caring of the oncology patients. Metodologia: In the present study 96 hamsters were used and randomly allocated into 4 groups: Control (without treatment), Preventive (laser from day -5 to day +5), Therapeutic (laser from day +5 to day +15) and Combined (laser from day -5 to day +15). Mucositis was induced in hamsters by intraperitoneal injection of 5- fluorouracil (5-FU) at days 0 and 2 and superficial scratching in cheek pouch mucosa. The irradiation was carried out using diode LLL, 660 nm, 40mW of power, 6,0J/cm2 during 6seconds/point. At days 0, 5, 10 and 15, six animals from each group were sacrificed, weighted and the cheek pouch mucosa was clinically analyzed. Statistical analysis was made considering the time x treatment interaction through the SPSS Statistics 18.0® software. The multiple comparison was made by the Generalized Estimation Equation test and adjusted by the Bonferroni test. Results: The animals from the Control group had significant lose of weight at the 10th day of the experiment. The laser treatment at preventive, therapeutic and combined form presented mucosits scratching reduction in comparison to the control group. However there was no statistic difference between the mucositis scores at the groups that received treatment. Conclusion: The low level laser, independent of the used protocol, is efficient to clinical reducing oral-inducted mucositis by 5-FU in hamsters.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESObjetivos: O objetivo do presente estudo foi investigar o efeito de diferentes protocolos de laser de baixa potência (LBP) na mucosite bucal induzida por 5-fluouracil (5-FU) em hamsters. Introdução: A mucosite bucal é uma complicação comum da terapia antineoplásica. O desenvolvimento de intervenções efetivas para sua prevenção e tratamento é visto como prioridade nos cuidados de suporte ao paciente oncológico. Metodologia: Foram utilizados 96 hamsters divididos aleatoriamente em 4 grupos: Controle (sem tratamento), Preventivo (laser do Dia -7 ao Dia +5); Terapêutico (laser do Dia +5 ao Dia +15) e Conjugado (laser do Dia -7 ao Dia +15). Os animais receberam injeção intraperitoneal de 5-FU nos dias 0 e 2 e escarificação da mucosa jugal nos dias 3 e 4. A irradiação foi realizada com LBP de diodo (InGaAlP), 660 nm, 40 mW de potência, 6,0 J/cm2 por 6 segundos/ponto. Nos dias 0, 5, 10 e 15 foram sacrificados seis animais de cada grupo, pesados e a mucosa jugal foi analisada clinicamente. Foi realizada análise estatística para a interação tempo x tratamento através do programa SPSS Statistics 18.0®. As comparações múltiplas foram feitas pelo teste de Equações de Estimação Generalizada e ajustado pelo teste de Bonferroni. Resultados: Houve significativa perde de peso dos animais do grupo controle no dia 10 do experimento. Os tratamentos com laser tanto na forma preventiva, terapêutica e conjugada exibiram redução dos escores de mucosite de forma estatisticamente significante quando comparados ao grupo controle. Todavia, não houve diferença estatisticamente significativa entre escores de mucosites nos grupos que receberam tratamento laser. Conclusão: O laser de baixa intensidade, independente do protocolo utilizado, é eficaz na redução clínica da mucosite bucal induzida por 5-FU em hamsters.Universidade Federal de Santa MariaBrasilOdontologiaUFSMPrograma de Pós-Graduação em Ciências OdontológicasCentro de Ciências da SaúdeMartins, Manoela Domingueshttp://lattes.cnpq.br/4958184722611235Hildebrand, Laura de Camposhttp://lattes.cnpq.br/9389175033734431Lamers, Marcelo Lazzaronhttp://lattes.cnpq.br/9421062861957581Kaefer, Thieni2019-07-22T19:36:22Z2019-07-22T19:36:22Z2012-08-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://repositorio.ufsm.br/handle/1/17523porAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM2019-07-23T06:00:56Zoai:repositorio.ufsm.br:1/17523Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2019-07-23T06:00:56Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.none.fl_str_mv |
Avaliação clínica de diferentes protocolos de laser de baixa potência em mucosite bucal induzida por 5-fluouracil em hamsters Clinical assesment of diferent of low level laser protocols in induced-oral mucositis by 5-fluouracil in hamster |
title |
Avaliação clínica de diferentes protocolos de laser de baixa potência em mucosite bucal induzida por 5-fluouracil em hamsters |
spellingShingle |
Avaliação clínica de diferentes protocolos de laser de baixa potência em mucosite bucal induzida por 5-fluouracil em hamsters Kaefer, Thieni Laserterapia Quimioterapia Efeito adverso Mucosa bucal Side effect Laser therapy Chemotherapy Oral mucosa CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
title_short |
Avaliação clínica de diferentes protocolos de laser de baixa potência em mucosite bucal induzida por 5-fluouracil em hamsters |
title_full |
Avaliação clínica de diferentes protocolos de laser de baixa potência em mucosite bucal induzida por 5-fluouracil em hamsters |
title_fullStr |
Avaliação clínica de diferentes protocolos de laser de baixa potência em mucosite bucal induzida por 5-fluouracil em hamsters |
title_full_unstemmed |
Avaliação clínica de diferentes protocolos de laser de baixa potência em mucosite bucal induzida por 5-fluouracil em hamsters |
title_sort |
Avaliação clínica de diferentes protocolos de laser de baixa potência em mucosite bucal induzida por 5-fluouracil em hamsters |
author |
Kaefer, Thieni |
author_facet |
Kaefer, Thieni |
author_role |
author |
dc.contributor.none.fl_str_mv |
Martins, Manoela Domingues http://lattes.cnpq.br/4958184722611235 Hildebrand, Laura de Campos http://lattes.cnpq.br/9389175033734431 Lamers, Marcelo Lazzaron http://lattes.cnpq.br/9421062861957581 |
dc.contributor.author.fl_str_mv |
Kaefer, Thieni |
dc.subject.por.fl_str_mv |
Laserterapia Quimioterapia Efeito adverso Mucosa bucal Side effect Laser therapy Chemotherapy Oral mucosa CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
topic |
Laserterapia Quimioterapia Efeito adverso Mucosa bucal Side effect Laser therapy Chemotherapy Oral mucosa CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA |
description |
Aims: The purpose of this study was to investigate the effects of different of low level laser (LLL) protocols on induced-oral mucositis by 5-fluoracil (5-FU) in hamsters. Introduction: The oral mucositis is a ordinary side effect from antineoplasic therapy. Development of effective interventions to its prevention and treatment are priory on caring of the oncology patients. Metodologia: In the present study 96 hamsters were used and randomly allocated into 4 groups: Control (without treatment), Preventive (laser from day -5 to day +5), Therapeutic (laser from day +5 to day +15) and Combined (laser from day -5 to day +15). Mucositis was induced in hamsters by intraperitoneal injection of 5- fluorouracil (5-FU) at days 0 and 2 and superficial scratching in cheek pouch mucosa. The irradiation was carried out using diode LLL, 660 nm, 40mW of power, 6,0J/cm2 during 6seconds/point. At days 0, 5, 10 and 15, six animals from each group were sacrificed, weighted and the cheek pouch mucosa was clinically analyzed. Statistical analysis was made considering the time x treatment interaction through the SPSS Statistics 18.0® software. The multiple comparison was made by the Generalized Estimation Equation test and adjusted by the Bonferroni test. Results: The animals from the Control group had significant lose of weight at the 10th day of the experiment. The laser treatment at preventive, therapeutic and combined form presented mucosits scratching reduction in comparison to the control group. However there was no statistic difference between the mucositis scores at the groups that received treatment. Conclusion: The low level laser, independent of the used protocol, is efficient to clinical reducing oral-inducted mucositis by 5-FU in hamsters. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-08-29 2019-07-22T19:36:22Z 2019-07-22T19:36:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/17523 |
url |
http://repositorio.ufsm.br/handle/1/17523 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Brasil Odontologia UFSM Programa de Pós-Graduação em Ciências Odontológicas Centro de Ciências da Saúde |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria Brasil Odontologia UFSM Programa de Pós-Graduação em Ciências Odontológicas Centro de Ciências da Saúde |
dc.source.none.fl_str_mv |
reponame:Manancial - Repositório Digital da UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Manancial - Repositório Digital da UFSM |
collection |
Manancial - Repositório Digital da UFSM |
repository.name.fl_str_mv |
Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
atendimento.sib@ufsm.br||tedebc@gmail.com |
_version_ |
1805922027495751680 |