Aloe vera, uma planta de interesse do sistema único de saúde: revisão sistemática sobre os mecanismos pró-cicatriciais

Detalhes bibliográficos
Autor(a) principal: Marques, Liana Pinheiro Santos
Data de Publicação: 2021
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Manancial - Repositório Digital da UFSM
dARK ID: ark:/26339/001300001485m
Texto Completo: http://repositorio.ufsm.br/handle/1/23260
Resumo: The aging of the Brazilian population is a reality, and this demographic transition is accompanied by an increase in the prevalence of non-communicable chronic diseases and conditions, including skin diseases and injuries. These are considered a serious health problem. In Brazil, although there are few robust studies on the incidence and prevalence of injuries, their occurrences are high, ranging from 10.6% to 62%, depending on the study. The elderly, due to physiological cutaneous changes, are more susceptible to skin lesions, which, once established, require greater efforts for healing, as in addition to the expected changes, non-communicable chronic diseases collaborate to the chronicity of wounds. Given the context, the search for alternatives that can help in the treatment of skin lesions, optimizing tissue repair, is justified. Aloe vera (AV) is a plant widely used for healing and has been studied in search of evidence that its elements can help in the healing process. Given the magnitude of the problem of skin lesions and taking into account that aging skin is more likely to develop lesions and, consequently, more difficult to resolve them, reviewing and seeking scientific evidence on the causal mechanisms of VA benefits is relevant. Thus, the aim of this study was to conduct a systematic review of VA, one of the medicinal plants present in the Unified Health System and its healing potential. A search was performed in PUBMED and Scielo databases, with the combination of the following descriptors: "Aloe vera" AND "Wound healing", "Aloe Vera and wound healing" "Aloe Vera Y Cicatrización de heridas, with a time frame of 10 years old. The following were excluded: articles that were not in English, Portuguese or Spanish, review articles, any study that associated Aloe vera with another molecule or plant; any and all articles whose main objective was not skin healing related to VA treatment. A total of 201 studies were identified, which, after screening for exclusion criteria, were reduced to 29 articles, which were read in full. Of these 14 were in vivo studies, 8 were clinical trials, 5 were in vitro studies and 2 were translational studies. The evidence produced indicates AV modulation in the inflammatory, proliferative, maturation and regeneration phases. Studies suggest that VA has pro-scarring actives in its constitution, which optimize tissue repair, by stimulating the migration and cell proliferation of leukocytes, fibroblasts and keratinocytes, induction of neoangiogenesis and collagen deposition.
id UFSM_b7ae01c6785bc8e0fddfed4618d2d7d6
oai_identifier_str oai:repositorio.ufsm.br:1/23260
network_acronym_str UFSM
network_name_str Manancial - Repositório Digital da UFSM
repository_id_str
spelling Aloe vera, uma planta de interesse do sistema único de saúde: revisão sistemática sobre os mecanismos pró-cicatriciaisAloe vera, a plant of interest of the unique health system: systematic review on pro-cicatricial mechanismsPlantas medicinaisCicatrizaçãoFitoterapiaEnvelhecimentoAloe veraMedicinal plantsHealingPhytotherapyAgingCNPQ::CIENCIAS DA SAUDEThe aging of the Brazilian population is a reality, and this demographic transition is accompanied by an increase in the prevalence of non-communicable chronic diseases and conditions, including skin diseases and injuries. These are considered a serious health problem. In Brazil, although there are few robust studies on the incidence and prevalence of injuries, their occurrences are high, ranging from 10.6% to 62%, depending on the study. The elderly, due to physiological cutaneous changes, are more susceptible to skin lesions, which, once established, require greater efforts for healing, as in addition to the expected changes, non-communicable chronic diseases collaborate to the chronicity of wounds. Given the context, the search for alternatives that can help in the treatment of skin lesions, optimizing tissue repair, is justified. Aloe vera (AV) is a plant widely used for healing and has been studied in search of evidence that its elements can help in the healing process. Given the magnitude of the problem of skin lesions and taking into account that aging skin is more likely to develop lesions and, consequently, more difficult to resolve them, reviewing and seeking scientific evidence on the causal mechanisms of VA benefits is relevant. Thus, the aim of this study was to conduct a systematic review of VA, one of the medicinal plants present in the Unified Health System and its healing potential. A search was performed in PUBMED and Scielo databases, with the combination of the following descriptors: "Aloe vera" AND "Wound healing", "Aloe Vera and wound healing" "Aloe Vera Y Cicatrización de heridas, with a time frame of 10 years old. The following were excluded: articles that were not in English, Portuguese or Spanish, review articles, any study that associated Aloe vera with another molecule or plant; any and all articles whose main objective was not skin healing related to VA treatment. A total of 201 studies were identified, which, after screening for exclusion criteria, were reduced to 29 articles, which were read in full. Of these 14 were in vivo studies, 8 were clinical trials, 5 were in vitro studies and 2 were translational studies. The evidence produced indicates AV modulation in the inflammatory, proliferative, maturation and regeneration phases. Studies suggest that VA has pro-scarring actives in its constitution, which optimize tissue repair, by stimulating the migration and cell proliferation of leukocytes, fibroblasts and keratinocytes, induction of neoangiogenesis and collagen deposition.O envelhecimento da população brasileira é uma realidade, e esta transição demográfica, é acompanhada pelo aumento na prevalência de doenças e agravos crônicos não transmissíveis, dentre os quais, as doenças e lesões de pele. Estas são consideradas um problema grave de saúde. No Brasil, embora existam poucos trabalhos robustos sobre incidência e prevalência de lesões, as ocorrências dessas são altas, variando de 10,6% a 62%, dependendo do estudo. O idoso, devido à alterações fisiológicas cutâneas, apresenta maior suscetibilidade à lesões na pele, que depois de estabelecidas, necessitam de maior empenho para cicatrização, pois além das alterações esperadas, as doenças crônicas não transmissíveis colaboram para a cronificação das feridas. Diante do contexto justifica-se a busca de alternativas que possam auxiliar no tratamento das lesões de pele, otimizando o reparo tecidual. A Aloe vera (AV) é uma planta muito utilizada para cicatrização e tem sido estudada, na busca de evidências de que seus elementos possam auxiliar no processo cicatricial. Dada a magnitude da problemática das lesões de pele e levando em conta que uma pele envelhecida tem maior propensão ao desenvolvimento de lesões e consequentemente maior dificuldade na resolução destas, revisar e buscar evidências científicas sobre os mecanismos causais dos benefícios da AV é relevante. Assim, o objetivo deste estudo foi realizar uma revisão sistemática sobre a AV, uma das plantas medicinais presentes no Sistema Único de Saúde e seu potencial cicatrizante. Foi realizada uma busca em base de dados PUBMED e Scielo, com a combinação dos seguintes descritores: "Aloe vera" AND "Wound healing", "Aloe Vera E Cicatrização de feridas" "Aloe Vera Y Cicatrización de heridas, com recorte temporal de 10 anos. Foram excluídos: artigos que não estivessem em inglês, português ou espanhol, artigos de revisão, qualquer estudo que associasse Aloe vera a outra molécula ou planta; todo e qualquer artigo cujo objetivo principal não fosse a cicatrização da pele relacionada ao tratamento com AV. Foram identificados 201 estudos, que após triagem de critérios de exclusão, foram reduzidos para 29 artigos, que foram lidos na íntegra. Destes 14 eram estudos in vivo, 8 eram ensaios clínicos, 5 estudos in vitro e 2 estudos translacionais. As evidências produzidas indicam modulação da AV nas fases inflamatória, proliferativa, maturação e regeneração. Os estudos sugerem que AV apresenta ativos pró cicatricias em sua constituição, que otimizam o reparo tecidual, através do estímulo à migração e proliferação celular de leucócitos, fibroblastos e queratinócitos, da indução de neoangiogênese e da deposição de colágeno.Universidade Federal de Santa MariaBrasilCiências da SaúdeUFSMPrograma de Pós-Graduação em GerontologiaCentro de Educação Física e DesportosBarbisan, Fernandahttp://lattes.cnpq.br/1428674947616182Cruz, Ivana Beatrice Mânica daPellenz, Neida Luiza KasparyDallepiane, Loiva BeatrizMarques, Liana Pinheiro Santos2021-12-13T12:24:37Z2021-12-13T12:24:37Z2021-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://repositorio.ufsm.br/handle/1/23260ark:/26339/001300001485mporAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM2021-12-30T12:20:57Zoai:repositorio.ufsm.br:1/23260Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2021-12-30T12:20:57Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false
dc.title.none.fl_str_mv Aloe vera, uma planta de interesse do sistema único de saúde: revisão sistemática sobre os mecanismos pró-cicatriciais
Aloe vera, a plant of interest of the unique health system: systematic review on pro-cicatricial mechanisms
title Aloe vera, uma planta de interesse do sistema único de saúde: revisão sistemática sobre os mecanismos pró-cicatriciais
spellingShingle Aloe vera, uma planta de interesse do sistema único de saúde: revisão sistemática sobre os mecanismos pró-cicatriciais
Marques, Liana Pinheiro Santos
Plantas medicinais
Cicatrização
Fitoterapia
Envelhecimento
Aloe vera
Medicinal plants
Healing
Phytotherapy
Aging
CNPQ::CIENCIAS DA SAUDE
title_short Aloe vera, uma planta de interesse do sistema único de saúde: revisão sistemática sobre os mecanismos pró-cicatriciais
title_full Aloe vera, uma planta de interesse do sistema único de saúde: revisão sistemática sobre os mecanismos pró-cicatriciais
title_fullStr Aloe vera, uma planta de interesse do sistema único de saúde: revisão sistemática sobre os mecanismos pró-cicatriciais
title_full_unstemmed Aloe vera, uma planta de interesse do sistema único de saúde: revisão sistemática sobre os mecanismos pró-cicatriciais
title_sort Aloe vera, uma planta de interesse do sistema único de saúde: revisão sistemática sobre os mecanismos pró-cicatriciais
author Marques, Liana Pinheiro Santos
author_facet Marques, Liana Pinheiro Santos
author_role author
dc.contributor.none.fl_str_mv Barbisan, Fernanda
http://lattes.cnpq.br/1428674947616182
Cruz, Ivana Beatrice Mânica da
Pellenz, Neida Luiza Kaspary
Dallepiane, Loiva Beatriz
dc.contributor.author.fl_str_mv Marques, Liana Pinheiro Santos
dc.subject.por.fl_str_mv Plantas medicinais
Cicatrização
Fitoterapia
Envelhecimento
Aloe vera
Medicinal plants
Healing
Phytotherapy
Aging
CNPQ::CIENCIAS DA SAUDE
topic Plantas medicinais
Cicatrização
Fitoterapia
Envelhecimento
Aloe vera
Medicinal plants
Healing
Phytotherapy
Aging
CNPQ::CIENCIAS DA SAUDE
description The aging of the Brazilian population is a reality, and this demographic transition is accompanied by an increase in the prevalence of non-communicable chronic diseases and conditions, including skin diseases and injuries. These are considered a serious health problem. In Brazil, although there are few robust studies on the incidence and prevalence of injuries, their occurrences are high, ranging from 10.6% to 62%, depending on the study. The elderly, due to physiological cutaneous changes, are more susceptible to skin lesions, which, once established, require greater efforts for healing, as in addition to the expected changes, non-communicable chronic diseases collaborate to the chronicity of wounds. Given the context, the search for alternatives that can help in the treatment of skin lesions, optimizing tissue repair, is justified. Aloe vera (AV) is a plant widely used for healing and has been studied in search of evidence that its elements can help in the healing process. Given the magnitude of the problem of skin lesions and taking into account that aging skin is more likely to develop lesions and, consequently, more difficult to resolve them, reviewing and seeking scientific evidence on the causal mechanisms of VA benefits is relevant. Thus, the aim of this study was to conduct a systematic review of VA, one of the medicinal plants present in the Unified Health System and its healing potential. A search was performed in PUBMED and Scielo databases, with the combination of the following descriptors: "Aloe vera" AND "Wound healing", "Aloe Vera and wound healing" "Aloe Vera Y Cicatrización de heridas, with a time frame of 10 years old. The following were excluded: articles that were not in English, Portuguese or Spanish, review articles, any study that associated Aloe vera with another molecule or plant; any and all articles whose main objective was not skin healing related to VA treatment. A total of 201 studies were identified, which, after screening for exclusion criteria, were reduced to 29 articles, which were read in full. Of these 14 were in vivo studies, 8 were clinical trials, 5 were in vitro studies and 2 were translational studies. The evidence produced indicates AV modulation in the inflammatory, proliferative, maturation and regeneration phases. Studies suggest that VA has pro-scarring actives in its constitution, which optimize tissue repair, by stimulating the migration and cell proliferation of leukocytes, fibroblasts and keratinocytes, induction of neoangiogenesis and collagen deposition.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-13T12:24:37Z
2021-12-13T12:24:37Z
2021-10-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufsm.br/handle/1/23260
dc.identifier.dark.fl_str_mv ark:/26339/001300001485m
url http://repositorio.ufsm.br/handle/1/23260
identifier_str_mv ark:/26339/001300001485m
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
Brasil
Ciências da Saúde
UFSM
Programa de Pós-Graduação em Gerontologia
Centro de Educação Física e Desportos
publisher.none.fl_str_mv Universidade Federal de Santa Maria
Brasil
Ciências da Saúde
UFSM
Programa de Pós-Graduação em Gerontologia
Centro de Educação Física e Desportos
dc.source.none.fl_str_mv reponame:Manancial - Repositório Digital da UFSM
instname:Universidade Federal de Santa Maria (UFSM)
instacron:UFSM
instname_str Universidade Federal de Santa Maria (UFSM)
instacron_str UFSM
institution UFSM
reponame_str Manancial - Repositório Digital da UFSM
collection Manancial - Repositório Digital da UFSM
repository.name.fl_str_mv Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)
repository.mail.fl_str_mv atendimento.sib@ufsm.br||tedebc@gmail.com
_version_ 1815172446198693888