Avaliação do potencial antinociceptivo de novos 3-Metil-1H-1-pirazol metil esteres 5-substituídos em Camundongos
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Manancial - Repositório Digital da UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/11073 |
Resumo: | In the present study the antinociceptive activity of six 1-H-1-pyrazol methyl ester derivatives in the hot-plate test and Complete Freund s Adjuvant (CFA)-induced inflammation in mice was investigated. The administration of 3,5-dimethyl-1H-1-pyrazole methyl ester (1), 3-methyl-5-trichloromethyl-1H-1-pyrazole methyl ester (2), 5-dichloromethyl-5-hydroxy-3-methyl-4,5-dihydro-1H-1-pyrazole methyl ester (4), 5-(chloro-difluoro-methyl)-5-hydroxy-3-methyl-4,5-dihydro-1H-1-pyrazole methyl ester (5) (20 1000 μmol/kg, i.p.) produced antinociception in the hot plate test. All compounds, except compound 4, did not cause motor alterations in the rotarod and open field tests. The compounds 3 and 6 did not produce antinocicpetive effects. Since compound 2 presented good antinociceptive activity in the hot plate test and was devoid of motor effects, we tested whether it caused antinociception in an animal model of chronic pain. Compound 2 (0.6 20 μmol/kg, i.p.) effectively reduced CFA-induced mechanical allodynia (83 ± 8%) and paw edema. The results of the present study suggest that novel 1-H-1-pyrazol methyl ester derivatives, particularly compound 2, have a good analgesic potential against acute and chronic pain. |
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Avaliação do potencial antinociceptivo de novos 3-Metil-1H-1-pirazol metil esteres 5-substituídos em CamundongosAssessment of the antinociceptive potential of novel 3-Methyl-1H-1-pyrazol methyl esters 5-substituted in mice.FarmacologiaBioquímicaPirazolínicosCNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICAIn the present study the antinociceptive activity of six 1-H-1-pyrazol methyl ester derivatives in the hot-plate test and Complete Freund s Adjuvant (CFA)-induced inflammation in mice was investigated. The administration of 3,5-dimethyl-1H-1-pyrazole methyl ester (1), 3-methyl-5-trichloromethyl-1H-1-pyrazole methyl ester (2), 5-dichloromethyl-5-hydroxy-3-methyl-4,5-dihydro-1H-1-pyrazole methyl ester (4), 5-(chloro-difluoro-methyl)-5-hydroxy-3-methyl-4,5-dihydro-1H-1-pyrazole methyl ester (5) (20 1000 μmol/kg, i.p.) produced antinociception in the hot plate test. All compounds, except compound 4, did not cause motor alterations in the rotarod and open field tests. The compounds 3 and 6 did not produce antinocicpetive effects. Since compound 2 presented good antinociceptive activity in the hot plate test and was devoid of motor effects, we tested whether it caused antinociception in an animal model of chronic pain. Compound 2 (0.6 20 μmol/kg, i.p.) effectively reduced CFA-induced mechanical allodynia (83 ± 8%) and paw edema. The results of the present study suggest that novel 1-H-1-pyrazol methyl ester derivatives, particularly compound 2, have a good analgesic potential against acute and chronic pain.No presente estudo nós investigamos a atividade antinociceptiva de seis derivados 1-H-1-pirazol metil ester no teste da placa quente e inflamação causada por Adjuvante Completo de Freund (CFA) em camundongos. A administração de 3,5-dimetil-1H-1-pirazol metil ester (1), 3-metil-5-triclorometil-1H-1-pirazol metil ester (2), 5-diclorometil-5-hidroxi-3-metil-4,5-dihidro-1H-1-pirazol metil ester (4), 5-(cloro-difluor-metil)-5-hidroxi-3-metil-4,5-dihidro-1H-1-pirazol metil ester (5) (20 1000 μmol/kg, i.p.) produziram antinocicepção no teste da placa quente. Todos os compostos, exceto o composto 4, não causaram alterações motoras nos testes de locomoção forçada em cilindro giratório e campo aberto. Os compostos 3 e 6 não tiveram efeito antinociceptivo no teste da placa quente. O composto 2 por apresentar boa atividade antinociceptiva no teste da placa quente e ser desprovido de efeitos motores, foi testado em um modelo de dor crônica. O composto 2 (0.6 20 μmol/kg, i.p.) efetivamente reduziu alodínia mecânica causada por CFA (83 ± 8 %) e edema de pata. Os resultados do presente estudo sugerem que os novos derivados 1-H-1-pirazol metil ester, particularmente o composto 2, tem um bom potencial analgésico contra dores aguda e crônica.Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaRubin, Maribel Antonellohttp://lattes.cnpq.br/7237734243628134Fighera, Michele Rechiahttp://lattes.cnpq.br/8583392747509231Zanatta, Nilohttp://lattes.cnpq.br/0719465062354576Mai, Carla Mirelle Giotto2017-04-202017-04-202007-08-31info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfapplication/pdfMAI, Carla Mirelle Giotto. Assessment of the antinociceptive potential of novel 3-Methyl-1H-1-pyrazol methyl esters 5-substituted in mice.. 2007. 93 f. Dissertação (Mestrado em Bioquímica) - Universidade Federal de Santa Maria, Santa Maria, 2007.http://repositorio.ufsm.br/handle/1/11073porinfo:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM2023-01-24T19:12:41Zoai:repositorio.ufsm.br:1/11073Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2023-01-24T19:12:41Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.none.fl_str_mv |
Avaliação do potencial antinociceptivo de novos 3-Metil-1H-1-pirazol metil esteres 5-substituídos em Camundongos Assessment of the antinociceptive potential of novel 3-Methyl-1H-1-pyrazol methyl esters 5-substituted in mice. |
title |
Avaliação do potencial antinociceptivo de novos 3-Metil-1H-1-pirazol metil esteres 5-substituídos em Camundongos |
spellingShingle |
Avaliação do potencial antinociceptivo de novos 3-Metil-1H-1-pirazol metil esteres 5-substituídos em Camundongos Mai, Carla Mirelle Giotto Farmacologia Bioquímica Pirazolínicos CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
title_short |
Avaliação do potencial antinociceptivo de novos 3-Metil-1H-1-pirazol metil esteres 5-substituídos em Camundongos |
title_full |
Avaliação do potencial antinociceptivo de novos 3-Metil-1H-1-pirazol metil esteres 5-substituídos em Camundongos |
title_fullStr |
Avaliação do potencial antinociceptivo de novos 3-Metil-1H-1-pirazol metil esteres 5-substituídos em Camundongos |
title_full_unstemmed |
Avaliação do potencial antinociceptivo de novos 3-Metil-1H-1-pirazol metil esteres 5-substituídos em Camundongos |
title_sort |
Avaliação do potencial antinociceptivo de novos 3-Metil-1H-1-pirazol metil esteres 5-substituídos em Camundongos |
author |
Mai, Carla Mirelle Giotto |
author_facet |
Mai, Carla Mirelle Giotto |
author_role |
author |
dc.contributor.none.fl_str_mv |
Rubin, Maribel Antonello http://lattes.cnpq.br/7237734243628134 Fighera, Michele Rechia http://lattes.cnpq.br/8583392747509231 Zanatta, Nilo http://lattes.cnpq.br/0719465062354576 |
dc.contributor.author.fl_str_mv |
Mai, Carla Mirelle Giotto |
dc.subject.por.fl_str_mv |
Farmacologia Bioquímica Pirazolínicos CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
topic |
Farmacologia Bioquímica Pirazolínicos CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
description |
In the present study the antinociceptive activity of six 1-H-1-pyrazol methyl ester derivatives in the hot-plate test and Complete Freund s Adjuvant (CFA)-induced inflammation in mice was investigated. The administration of 3,5-dimethyl-1H-1-pyrazole methyl ester (1), 3-methyl-5-trichloromethyl-1H-1-pyrazole methyl ester (2), 5-dichloromethyl-5-hydroxy-3-methyl-4,5-dihydro-1H-1-pyrazole methyl ester (4), 5-(chloro-difluoro-methyl)-5-hydroxy-3-methyl-4,5-dihydro-1H-1-pyrazole methyl ester (5) (20 1000 μmol/kg, i.p.) produced antinociception in the hot plate test. All compounds, except compound 4, did not cause motor alterations in the rotarod and open field tests. The compounds 3 and 6 did not produce antinocicpetive effects. Since compound 2 presented good antinociceptive activity in the hot plate test and was devoid of motor effects, we tested whether it caused antinociception in an animal model of chronic pain. Compound 2 (0.6 20 μmol/kg, i.p.) effectively reduced CFA-induced mechanical allodynia (83 ± 8%) and paw edema. The results of the present study suggest that novel 1-H-1-pyrazol methyl ester derivatives, particularly compound 2, have a good analgesic potential against acute and chronic pain. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-08-31 2017-04-20 2017-04-20 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
MAI, Carla Mirelle Giotto. Assessment of the antinociceptive potential of novel 3-Methyl-1H-1-pyrazol methyl esters 5-substituted in mice.. 2007. 93 f. Dissertação (Mestrado em Bioquímica) - Universidade Federal de Santa Maria, Santa Maria, 2007. http://repositorio.ufsm.br/handle/1/11073 |
identifier_str_mv |
MAI, Carla Mirelle Giotto. Assessment of the antinociceptive potential of novel 3-Methyl-1H-1-pyrazol methyl esters 5-substituted in mice.. 2007. 93 f. Dissertação (Mestrado em Bioquímica) - Universidade Federal de Santa Maria, Santa Maria, 2007. |
url |
http://repositorio.ufsm.br/handle/1/11073 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria BR Bioquímica UFSM Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria BR Bioquímica UFSM Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica |
dc.source.none.fl_str_mv |
reponame:Manancial - Repositório Digital da UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Manancial - Repositório Digital da UFSM |
collection |
Manancial - Repositório Digital da UFSM |
repository.name.fl_str_mv |
Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
atendimento.sib@ufsm.br||tedebc@gmail.com |
_version_ |
1805922109372760064 |